The unfolded protein response is activated in Alzheimer's disease

Acta Neuropathologica

Volumn 110, Issue 2, 2005, Pages 165-172

  Hoozemans, J J M ^a   Veerhuis, R ^b   Van Haastert, E S ^a   Rozemuller, J M ^a   Baas, F ^a   Eikelenboom, P ^a,b   Scheper, W ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Alzheimer's disease; BiP GRP78; Neuropathology; PERK; Unfolded protein response

Indexed keywords

CHAPERONE; GLUCOSE REGULATED PROTEIN 78; PROTEIN KINASE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN NERVE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOLOGY; DATA ANALYSIS; DEMENTIA; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPROTECTION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN LOCALIZATION; TEMPORAL CORTEX; UPREGULATION; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BLOTTING, WESTERN; BRAIN; EIF-2 KINASE; ENDOPLASMIC RETICULUM; FEMALE; HEAT-SHOCK PROTEINS; HUMANS; MALE; MIDDLE AGED; MOLECULAR CHAPERONES; NEUROFIBRILLARY TANGLES; NEURONS; PROTEIN FOLDING;

EID: 24344489466     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-005-1038-0     Document Type: Article

References (22)

1. Benn SC, Woolf CJ (2004) Adult neuron survival strategies - slamming on the brakes. Nat Rev Neurosci 5:686-700
2. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239-259 10.1007/BF00308809
3. Braak H, Braak E (1995) Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16:271-8; discussion 278-284 10.1016/0197-4580(95)00021-6
4. Chang RC, Wong AK, Ng HK, Hugon J (2002) Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. Neuroreport 13:2429-2432 10.1097/ 00001756-200212200-00011
5. Cook DG, Forman MS, Sung JC, Leight S, Kolson DL, Iwatsubo T, Lee VM, Doms RW (1997) Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nat Med 3:1021-1023
6. Forman MS, Lee VM, Trojanowski JQ (2003) 'Unfolding' pathways in neurodegenerative disease. Trends Neurosci 26:407-410 10.1016/ S0166-2236(03)00197-8
7. Hamos JE, Oblas B, Pulaski-Salo D, Welch WJ, Bole DG, Drachman DA (1991) Expression of heat shock proteins in Alzheimer's disease. Neurology 41:345-350 1:STN:280:By6C2s3ktFQ%3D
8. Harding HP, Zhang Y, Ron D (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397:271-274 1:CAS:528:DyaK1MXpvVGrtA%3D%3D
9. Hartmann T, Bieger SC, Bruhl B, Tienari PJ, Ida N, Allsop D, Roberts GW, Masters CL, Dotti CG, Unsicker K, Beyreuther K (1997) Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med 3:1016-1020
10. Katayama T, Imaizumi K, Sato N, Miyoshi K, Kudo T, Hitomi J, Morihara T, Yoneda T, Gomi F, Mori Y, Nakano Y, Takeda J, Tsuda T, Itoyama Y, Murayama O, Takashima A, St George-Hyslop P, Takeda M, Tohyama M (1999) Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol 1:479-485 10.1038/70265
11. Kozutsumi Y, Segal M, Normington K, Gething MJ, Sambrook J (1988) The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature 332:462-464
12. Onuki R, Bando Y, Suyama E, Katayama T, Kawasaki H, Baba T, Tohyama M, Taira K (2004) An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. EMBO J 23:959-968 10.1038/sj.emboj.7600049
13. Piccini A, Fassio A, Pasqualetto E, Vitali A, Borghi R, Palmieri D, Nacmias B, Sorbi S, Sitia R, Tabaton M (2004) Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Abeta42 in response to tunicamycin. Neurobiol Dis 15:380-386
14. Reisberg B, Ferris SH, Leon MJ de, Crook T (1982) The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 139:1136-1139 1:STN:280:Bi2B1c7ot1E%3D
15. Rutkowski DT, Kaufman RJ (2004) A trip to the ER: Coping with stress. Trends Cell Biol 14:20-28 10.1016/j.tcb.2003.11.001
16. Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G (2000) Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nat Cell Biol 2:863-870
17. Scheper W, Hol E (2005) Protein quality control in Alzheimer's disease: a fatal saviour. Curr Drug Targets CNS Neurol Disord 4:283-292 1:CAS:528:DC%2BD2MXkvF2ls7g%3D
18. Suen KC, Lin KF, Elyaman W, So KF, Chang RC, Hugon J (2003) Reduction of calcium release from the endoplasmic reticulum could only provide partial neuroprotection against beta-amyloid peptide toxicity. J Neurochem 87:1413-1426 1:CAS:528:DC%2BD2cXit1Ol
19. Suen KC, Yu MS, So KF, Chang RC, Hugon J (2003) Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity. J Biol Chem 278:49819-49827
20. Taylor JP, Hardy J, Fischbeck KH (2002) Toxic proteins in neurodegenerative disease. Science 296:1991-1995 10.1126/science.1067122
21. Yamaguchi H, Haga C, Hirai S, Nakazato Y, Kosaka K (1990) Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain. Acta Neuropathol 79:569-572 10.1007/ BF00296119
22. Yu Z, Luo H, Fu W, Mattson MP (1999) The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: Suppression of oxidative stress and stabilization of calcium homeostasis. Exp Neurol 155:302-314 1:CAS:528:DyaK1MXhs1Smu7Y%3D