The response to and repair of RAG-mediated DNA double-strand breaks

Annual Review of Immunology

Volumn 30, Issue , 2012, Pages 175-202

  Helmink, Beth A ^a   Sleckman, Barry P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen receptor genes; DNA damage responses; Genomic stability; Lymphocyte development; Lymphoid tumors

Indexed keywords

ARTEMISINIC ACID; ATM PROTEIN; CHECKPOINT KINASE 2; DNA NUCLEOTIDYLEXOTRANSFERASE; FAS ANTIGEN; HISTONE H2AX; HOLOENZYME; IMATINIB; IMMUNOGLOBULIN; KU ANTIGEN; MRE11 PROTEIN; NIBRIN; NUCLEAR PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PRE B CELL RECEPTOR; PROTEIN 53BP1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE PHOSPHATASE; PUMA PROTEIN; RAD50 PROTEIN; RAG1 PROTEIN; RAG2 PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; UNINDEXED DRUG; XRCC4 PROTEIN;

BIOSYNTHESIS; BURKITT LYMPHOMA; CELL GROWTH; CELL MATURATION; CHROMOSOMAL LOCALIZATION; CHROMOSOME TRANSLOCATION; DNA CLEAVAGE; DNA DAMAGE; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; FOLLICULAR LYMPHOMA; G1 PHASE CELL CYCLE CHECKPOINT; GENE ACTIVATION; GENE EXPRESSION; GENETIC CODE; GENETIC RECOMBINATION; GENETIC REGULATION; GENOMIC INSTABILITY; GENOTOXICITY; HUMAN; IMMUNE RESPONSE; LYMPHATIC SYSTEM TUMOR; LYMPHOCYTE; NONHUMAN; PHOSPHORYLATION; PLASMID; PRIORITY JOURNAL; PROTEIN ASSEMBLY; REVIEW; SEVERE COMBINED IMMUNODEFICIENCY; T LYMPHOCYTE RECEPTOR GENE;

ANIMALS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; GENOMIC INSTABILITY; HUMANS; LYMPHOCYTES; RECEPTORS, ANTIGEN; V(D)J RECOMBINATION;

EID: 84859394323     PISSN: 07320582     EISSN: 15453278     Source Type: Book Series    
DOI: 10.1146/annurev-immunol-030409-101320     Document Type: Review

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