메뉴 건너뛰기




Volumn 10, Issue 6, 2009, Pages 629-635

Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DNA DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; KRAB ASSOCIATED PROTEIN 1; MRE11 PROTEIN; P53 BINDING PROTEIN; PROTEIN EXO1; PROTEIN KINASE; PROTEIN P53; REPLICATION FACTOR A; STRUCTURAL MAINTENANCE OF CHROMOSOMES 1; UNCLASSIFIED DRUG;

EID: 67349288164     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2009.60     Document Type: Article
Times cited : (103)

References (28)
  • 1
    • 33646795891 scopus 로고    scopus 로고
    • Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex
    • Adams KE, Medhurst AL, Dart DA, Lakin ND (2006) Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex. Oncogene 25: 3894-3904
    • (2006) Oncogene , vol.25 , pp. 3894-3904
    • Adams, K.E.1    Medhurst, A.L.2    Dart, D.A.3    Lakin, N.D.4
  • 2
    • 3242886503 scopus 로고    scopus 로고
    • Role of DNA-PK in the cellular response to DNA double-strand breaks
    • Burma S, Chen DJ (2004) Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair 3: 909-918
    • (2004) DNA Repair , vol.3 , pp. 909-918
    • Burma, S.1    Chen, D.J.2
  • 4
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ (2001) ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 276: 42462-42467
    • (2001) J Biol Chem , vol.276 , pp. 42462-42467
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kurimasa, A.4    Chen, D.J.5
  • 5
    • 33747889722 scopus 로고    scopus 로고
    • Role of non-homologous end joining (NHEJ) in maintaining genomic integrity
    • Burma S, Chen BP, Chen DJ (2006) Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair 5: 1042-1048
    • (2006) DNA Repair , vol.5 , pp. 1042-1048
    • Burma, S.1    Chen, B.P.2    Chen, D.J.3
  • 6
    • 47749141560 scopus 로고    scopus 로고
    • ATR: An essential regulator of genome integrity
    • Cimprich KA, Cortez D (2008) ATR: An essential regulator of genome integrity. Nat Rev Mol Cell Biol 9: 616-627
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 8
    • 33845543587 scopus 로고    scopus 로고
    • ATR activation in response to ionizing radiation: Still ATM territory
    • Cuadrado M, Martinez-Pastor B, Fernandez-Capetillo O (2006b) ATR activation in response to ionizing radiation: Still ATM territory. Cell Div 1: 7
    • (2006) Cell Div , vol.1 , pp. 7
    • Cuadrado, M.1    Martinez-Pastor, B.2    Fernandez-Capetillo, O.3
  • 9
    • 47349107760 scopus 로고    scopus 로고
    • ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    • Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Lobrich M, Jeggo PA (2008) ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol Cell 31: 167-177
    • (2008) Mol Cell , vol.31 , pp. 167-177
    • Goodarzi, A.A.1    Noon, A.T.2    Deckbar, D.3    Ziv, Y.4    Shiloh, Y.5    Lobrich, M.6    Jeggo, P.A.7
  • 10
    • 53649090109 scopus 로고    scopus 로고
    • DNA helicases Sgs1 and BLM promote DNA double-strand break resection
    • Gravel S, Chapman JR, Magill C, Jackson SP (2008) DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev 22: 2767-2772
    • (2008) Genes Dev , vol.22 , pp. 2767-2772
    • Gravel, S.1    Chapman, J.R.2    Magill, C.3    Jackson, S.P.4
  • 11
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • Harper JW, Elledge SJ (2007) The DNA damage response: Ten years after. Mol Cell 28: 739-745
    • (2007) Mol Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 13
    • 2642528031 scopus 로고    scopus 로고
    • DNA damage-induced activation of ATM and ATM-dependent signaling pathways
    • Kurz EU, Lees-Miller SP (2004) DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair 3: 889-900
    • (2004) DNA Repair , vol.3 , pp. 889-900
    • Kurz, E.U.1    Lees-Miller, S.P.2
  • 14
    • 15744386741 scopus 로고    scopus 로고
    • Regulation of CHK2 by DNA-dependent protein kinase
    • Li J, Stern DF (2005) Regulation of CHK2 by DNA-dependent protein kinase. J Biol Chem 280: 12041-12050
    • (2005) J Biol Chem , vol.280 , pp. 12041-12050
    • Li, J.1    Stern, D.F.2
  • 15
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    • Mimitou EP, Symington LS (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455: 770-774
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 17
  • 18
    • 33646777679 scopus 로고    scopus 로고
    • Rapid activation of ATR by ionizing radiation requires ATM and Mre11
    • Myers JS, Cortez D (2006) Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem 281: 9346-9350
    • (2006) J Biol Chem , vol.281 , pp. 9346-9350
    • Myers, J.S.1    Cortez, D.2
  • 19
    • 63249124451 scopus 로고    scopus 로고
    • Chromatin remodeling finds its place in the DNA double-strand break response
    • Pandita TK, Richardson C (2009) Chromatin remodeling finds its place in the DNA double-strand break response. Nucleic Acids Res 37: 1363-1377
    • (2009) Nucleic Acids Res , vol.37 , pp. 1363-1377
    • Pandita, T.K.1    Richardson, C.2
  • 20
    • 55749093286 scopus 로고    scopus 로고
    • DNA double-strand break processing: The beginning of the end
    • Raynard S, Niu H, Sung P (2008) DNA double-strand break processing: The beginning of the end. Genes Dev 22: 2903-2907
    • (2008) Genes Dev , vol.22 , pp. 2903-2907
    • Raynard, S.1    Niu, H.2    Sung, P.3
  • 21
    • 0032189483 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
    • Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT (1998) Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res 58: 4375-4382
    • (1998) Cancer Res , vol.58 , pp. 4375-4382
    • Sarkaria, J.N.1    Tibbetts, R.S.2    Busby, E.C.3    Kennedy, A.P.4    Hill, D.E.5    Abraham, R.T.6
  • 22
    • 33745823159 scopus 로고    scopus 로고
    • The ATM-mediated DNA-damage response: Taking shape
    • Shiloh Y (2006) The ATM-mediated DNA-damage response: Taking shape. Trends Biochem Sci 31: 402-410
    • (2006) Trends Biochem Sci , vol.31 , pp. 402-410
    • Shiloh, Y.1
  • 23
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
    • Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Lobrich M, Jeggo PA (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res 64: 2390-2396
    • (2004) Cancer Res , vol.64 , pp. 2390-2396
    • Stiff, T.1    O'Driscoll, M.2    Rief, N.3    Iwabuchi, K.4    Lobrich, M.5    Jeggo, P.A.6
  • 24
    • 33846194613 scopus 로고    scopus 로고
    • KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions
    • White DE, Negorev D, Peng H, Ivanov AV, Maul GG, Rauscher FJ III (2006) KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. Cancer Res 66 11594-11599
    • (2006) Cancer Res , vol.66 , pp. 11594-11599
    • White, D.E.1    Negorev, D.2    Peng, H.3    Ivanov, A.V.4    Maul, G.G.5    Rauscher III, F.J.6
  • 25
    • 0036146085 scopus 로고    scopus 로고
    • Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation
    • Xu B, Kim ST, Lim DS, Kastan MB (2002) Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 22: 1049-1059
    • (2002) Mol Cell Biol , vol.22 , pp. 1049-1059
    • Xu, B.1    Kim, S.T.2    Lim, D.S.3    Kastan, M.B.4
  • 26
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu Z, Chung WH, Shim EY, Lee SE, Ira G (2008) Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134: 981-994
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.