메뉴 건너뛰기




Volumn 108, Issue 5, 2011, Pages 2022-2027

Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation

Author keywords

DNA repair; Lymphocyte development; Lymphoid tumors

Indexed keywords

ATM PROTEIN; CELL DNA; DNA DEPENDENT PROTEIN KINASE;

EID: 79952149345     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1013295108     Document Type: Article
Times cited : (56)

References (46)
  • 2
    • 3242887420 scopus 로고    scopus 로고
    • The role of the non-homologous end-joining pathway in lymphocyte development
    • DOI 10.1111/j.0105-2896.2004.00165.x
    • Rooney S, Chaudhuri J, Alt FW (2004) The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev 200:115-131. (Pubitemid 38998197)
    • (2004) Immunological Reviews , vol.200 , pp. 115-131
    • Rooney, S.1    Chaudhuri, J.2    Alt, F.W.3
  • 3
    • 3242879122 scopus 로고    scopus 로고
    • The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination
    • DOI 10.1016/j.dnarep.2004.03.015, PII S1568786404000746
    • Lieber MR, Ma Y, Pannicke U, Schwarz K (2004) The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst) 3:817-826. (Pubitemid 39004089)
    • (2004) DNA Repair , vol.3 , Issue.8-9 , pp. 817-826
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 4
    • 0028801363 scopus 로고
    • Formation and resolution of double-strand break intermediates in V(D)J rearrangement
    • Ramsden DA, Gellert M (1995) Formation and resolution of double-strand break intermediates in V(D)J rearrangement. Genes Dev 9:2409-2420.
    • (1995) Genes Dev , vol.9 , pp. 2409-2420
    • Ramsden, D.A.1    Gellert, M.2
  • 5
    • 0028958942 scopus 로고
    • Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination
    • Zhu C, Roth DB (1995) Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination. Immunity 2:101-112.
    • (1995) Immunity , vol.2 , pp. 101-112
    • Zhu, C.1    Roth, D.B.2
  • 6
    • 49349083288 scopus 로고    scopus 로고
    • Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination
    • Li G, et al. (2008) Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell 31:631-640.
    • (2008) Mol Cell , vol.31 , pp. 631-640
    • Li, G.1
  • 7
    • 0032167446 scopus 로고    scopus 로고
    • A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
    • DOI 10.1016/S1074-7613(00)80619-6
    • Gao Y, et al. (1998) A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 9:367-376. (Pubitemid 28462757)
    • (1998) Immunity , vol.9 , Issue.3 , pp. 367-376
    • Gao, Y.1    Chaudhuri, J.2    Zhu, C.3    Davidson, L.4    Weaver, D.T.5    Alt, F.W.6
  • 8
    • 0023801238 scopus 로고
    • The defect inmurine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
    • LieberMR, et al. (1988) The defect inmurine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination. Cell 55:7-16.
    • (1988) Cell , vol.55 , pp. 7-16
    • Lieber, M.R.1
  • 10
    • 0034132349 scopus 로고    scopus 로고
    • Analyses of TCR(B) rearrangements substantiate a profound deficit in recombination signal sequence joining in SCID foals: Implications for the role of DNA-dependent protein kinase in V(D)J recombination
    • Shin EK, Rijkers T, Pastink A, Meek K (2000) Analyses of TCRB rearrangements substantiate a profound deficit in recombination signal sequence joining in SCID foals: Implications for the role of DNA-dependent protein kinase in V(D)J recombination. J Immunol 164:1416-1424. (Pubitemid 30067256)
    • (2000) Journal of Immunology , vol.164 , Issue.3 , pp. 1416-1424
    • Shin, E.K.1    Rijkers, T.2    Pastink, A.3    Meek, K.4
  • 11
    • 0032438115 scopus 로고    scopus 로고
    • Analysis of variable (diversity) joining recombination in DNA-dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation
    • DOI 10.1073/pnas.95.26.15559
    • Bogue MA, Jhappan C, Roth DB (1998) Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation. Proc Natl Acad Sci USA 95:15559-15564. (Pubitemid 29018738)
    • (1998) Proceedings of the National Academy of Sciences of the United States of America , vol.95 , Issue.26 , pp. 15559-15564
    • Bogue, M.A.1    Jhappan, C.2    Roth, D.B.3
  • 14
    • 33645072212 scopus 로고    scopus 로고
    • ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: The DSB connection
    • Matei IR, Guidos CJ, Danska JS (2006) ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: The DSB connection. Immunol Rev 209:142-158.
    • (2006) Immunol Rev , vol.209 , pp. 142-158
    • Matei, I.R.1    Guidos, C.J.2    Danska, J.S.3
  • 16
    • 0027304013 scopus 로고
    • V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder
    • Hsieh CL, Arlett CF, Lieber MR (1993) V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J Biol Chem 268:20105-20109. (Pubitemid 23278908)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.27 , pp. 20105-20109
    • Hsieh, C.-L.1    Arlett, C.F.2    Lieber, M.R.3
  • 17
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou BB, Elledge SJ (2000) The DNA damage response: Putting checkpoints in perspective. Nature 408:433-439.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 19
    • 65549111779 scopus 로고    scopus 로고
    • Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes
    • Callén E, et al. (2009) Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell 34:285-297.
    • (2009) Mol Cell , vol.34 , pp. 285-297
    • Callén, E.1
  • 20
    • 67349288164 scopus 로고    scopus 로고
    • Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells
    • Tomimatsu N, Mukherjee B, Burma S (2009) Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO Rep 10:629-635.
    • (2009) EMBO Rep , vol.10 , pp. 629-635
    • Tomimatsu, N.1    Mukherjee, B.2    Burma, S.3
  • 21
    • 0035125901 scopus 로고    scopus 로고
    • csduring murine embryogenesis
    • DOI 10.1016/S0960-9822(01)00048-3
    • Gurley KE, Kemp CJ (2001) Synthetic lethality between mutation in Atm and DNA-PK (cs) during murine embryogenesis. Curr Biol 11:191-194. (Pubitemid 32152105)
    • (2001) Current Biology , vol.11 , Issue.3 , pp. 191-194
    • Gurley, K.E.1    Kemp, C.J.2
  • 23
    • 0037232230 scopus 로고    scopus 로고
    • A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines
    • DOI 10.1038/ni870
    • Muljo SA, Schlissel MS (2003) A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat Immunol 4:31-37. (Pubitemid 36104705)
    • (2003) Nature Immunology , vol.4 , Issue.1 , pp. 31-37
    • Muljo, S.A.1    Schlissel, M.S.2
  • 24
    • 0034623860 scopus 로고    scopus 로고
    • Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX
    • Chen HT, et al. (2000) Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX. Science 290:1962-1965.
    • (2000) Science , vol.290 , pp. 1962-1965
    • Chen, H.T.1
  • 25
    • 65549129613 scopus 로고    scopus 로고
    • Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin
    • Savic V, et al. (2009) Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell 34:298-310.
    • (2009) Mol Cell , vol.34 , pp. 298-310
    • Savic, V.1
  • 26
    • 78651406669 scopus 로고    scopus 로고
    • H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes
    • Helmink BA, et al. (2011) H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature 469:245-249.
    • (2011) Nature , vol.469 , pp. 245-249
    • Helmink, B.A.1
  • 27
    • 70849094673 scopus 로고    scopus 로고
    • Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis
    • Mahowald GK, et al. (2009) Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proc Natl Acad Sci USA 106:18339-18344.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 18339-18344
    • Mahowald, G.K.1
  • 28
    • 0842346435 scopus 로고    scopus 로고
    • Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system
    • DOI 10.1016/j.dnarep.2003.11.005
    • Lee KJ, Jovanovic M, Udayakumar D, Bladen CL, Dynan WS (2004) Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system. DNA Repair (Amst) 3:267-276. (Pubitemid 38177248)
    • (2004) DNA Repair , vol.3 , Issue.3 , pp. 267-276
    • Lee, K.-J.1    Jovanovic, M.2    Udayakumar, D.3    Bladen, C.L.4    Dynan, W.S.5
  • 29
    • 22044445683 scopus 로고    scopus 로고
    • DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining
    • DOI 10.1016/j.dnarep.2005.05.003, PII S156878640500114X
    • Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP (2005) DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. DNA Repair (Amst) 4:1006-1018. (Pubitemid 40966971)
    • (2005) DNA Repair , vol.4 , Issue.9 , pp. 1006-1018
    • Douglas, P.1    Gupta, S.2    Morrice, N.3    Meek, K.4    Lees-Miller, S.P.5
  • 30
    • 4444224512 scopus 로고    scopus 로고
    • Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase
    • DOI 10.1074/jbc.M401217200
    • Wang YG, Nnakwe C, Lane WS, Modesti M, Frank KM (2004) Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase. J Biol Chem 279:37282-37290. (Pubitemid 39195434)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.36 , pp. 37282-37290
    • Wang, Y.-G.1    Nnakwe, C.2    Lane, W.S.3    Modesti, M.4    Frank, K.M.5
  • 31
    • 52049117396 scopus 로고    scopus 로고
    • DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks
    • Yu Y, et al. (2008) DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. DNA Repair (Amst) 7:1680-1692.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1680-1692
    • Yu, Y.1
  • 32
    • 0035818603 scopus 로고    scopus 로고
    • Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends
    • Jones JM, Gellert M (2001) Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends. Proc Natl Acad Sci USA 98:12926-12931.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12926-12931
    • Jones, J.M.1    Gellert, M.2
  • 33
    • 0033510231 scopus 로고    scopus 로고
    • V(D)J recombination catalyzed by mutant RAG proteins lacking consensus DNA-PK phosphorylation sites
    • Lin JM, Landree MA, Roth DB (1999) V(D)J recombination catalyzed by mutant RAG proteins lacking consensus DNA-PK phosphorylation sites. Mol Immunol 36:1263-1269.
    • (1999) Mol Immunol , vol.36 , pp. 1263-1269
    • Lin, J.M.1    Landree, M.A.2    Roth, D.B.3
  • 34
    • 34249751138 scopus 로고    scopus 로고
    • DNA-dependent protein kinase mediates V(D)J recombination via RAG2 phosphorylation
    • Hah YS, Lee JH, Kim DR (2007) DNA-dependent protein kinase mediates V(D)J recombination via RAG2 phosphorylation. J Biochem Mol Biol 40:432-438.
    • (2007) J Biochem Mol Biol , vol.40 , pp. 432-438
    • Hah, Y.S.1    Lee, J.H.2    Kim, D.R.3
  • 35
    • 34248231265 scopus 로고    scopus 로고
    • Trans autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining
    • DOI 10.1128/MCB.02366-06
    • Meek K, Douglas P, Cui X, Ding Q, Lees-Miller SP (2007) trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining. Mol Cell Biol 27:3881-3890. (Pubitemid 46726193)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.10 , pp. 3881-3890
    • Meek, K.1    Douglas, P.2    Cui, X.3    Ding, Q.4    Lees-Miller, S.P.5
  • 38
    • 28544448011 scopus 로고    scopus 로고
    • Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice
    • Cui X, et al. (2005) Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Mol Cell Biol 25:10842-10852.
    • (2005) Mol Cell Biol , vol.25 , pp. 10842-10852
    • Cui, X.1
  • 41
    • 33745132455 scopus 로고    scopus 로고
    • Genomic instability due to V(D)J recombination-associated transposition
    • Reddy YV, Perkins EJ, Ramsden DA (2006) Genomic instability due to V(D)J recombination-associated transposition. Genes Dev 20:1575-1582.
    • (2006) Genes Dev , vol.20 , pp. 1575-1582
    • Reddy, Y.V.1    Perkins, E.J.2    Ramsden, D.A.3
  • 42
    • 32044434448 scopus 로고    scopus 로고
    • Mobilization of RAG-generated signal ends by transposition and insertion in vivo
    • DOI 10.1128/MCB.26.4.1558-1568.2006
    • Chatterji M, Tsai CL, Schatz DG (2006) Mobilization of RAG-generated signal ends by transposition and insertion in vivo. Mol Cell Biol 26:1558-1568. (Pubitemid 43202579)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.4 , pp. 1558-1568
    • Chatterji, M.1    Tsai, C.-L.2    Schatz, D.G.3
  • 43
    • 0036242313 scopus 로고    scopus 로고
    • The V(D)J recombinase efficiently cleaves and transposes signal joints
    • Neiditch MB, Lee GS, Huye LE, Brandt VL, Roth DB (2002) The V(D)J recombinase efficiently cleaves and transposes signal joints. Mol Cell 9:871-878.
    • (2002) Mol Cell , vol.9 , pp. 871-878
    • Neiditch, M.B.1    Lee, G.S.2    Huye, L.E.3    Brandt, V.L.4    Roth, D.B.5
  • 44
    • 58849135489 scopus 로고    scopus 로고
    • Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS
    • Shull ER, et al. (2009) Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev 23:171-180.
    • (2009) Genes Dev , vol.23 , pp. 171-180
    • Shull, E.R.1
  • 46
    • 63449084054 scopus 로고    scopus 로고
    • MRN complex function in the repair of chromosomal Ragmediated DNA double-strand breaks
    • Helmink BA, et al. (2009) MRN complex function in the repair of chromosomal Ragmediated DNA double-strand breaks. J Exp Med 206:669-679.
    • (2009) J Exp Med , vol.206 , pp. 669-679
    • Helmink, B.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.