Positional stability of single double-strand breaks in mammalian cells

Nature Cell Biology

Volumn 9, Issue 6, 2007, Pages 675-682

  Soutoglou, Evi ^a   Dorn, Jonas F ^b   Sengupta, Kundan ^a   Jasin, Maria ^c   Nussenzweig, Andre ^a   Ried, Thomas ^a   Danuser, Gaudenz ^b   Misteli, Tom ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DOUBLE STRANDED DNA; HISTONE H2AX; PROTEIN KU80; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CELL NUCLEUS ANTIGEN; COHESINS; DNA; H2AX PROTEIN, MOUSE; HISTONE; KU ANTIGEN; NONHISTONE PROTEIN; NUCLEAR PROTEIN;

ARTICLE; CELL NUCLEUS; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CORRELATION FUNCTION; DNA REPAIR; DNA STRAND BREAKAGE; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR STABILITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; ANIMAL; CELL STRAIN 3T3; CELL TRANSFORMATION; CHROMOSOME; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; GENE TRANSLOCATION; GENETICS; MACROMOLECULE; METABOLISM; MOUSE;

MAMMALIA;

ANIMALS; ANTIGENS, NUCLEAR; CELL CYCLE PROTEINS; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOMES; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; GENOMIC INSTABILITY; HISTONES; MACROMOLECULAR SUBSTANCES; MICE; NIH 3T3 CELLS; NUCLEAR PROTEINS; TRANSLOCATION, GENETIC;

EID: 34447574977     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1591     Document Type: Article

References (32)

1. Kanaar, R., Hoeijmakers, J. H. & van Gent, D. C. Molecular mechanisms of DNA double strand break repair. Trends Cell Biol. 8, 483-489 (1998).
2. Khanna, K. K. & Jackson, S. P. DNA double-strand breaks: Signaling, repair and the cancer connection. Nature Genet 27, 247-254 (2001).
3. Elliott, B. & Jasin, M. Double-strand breaks and translocations in cancer. Cell. Mol. Life Sci. 59, 373-385 (2002).
4. Meaburn, K. J., Misteli, T. & Soutoglou, E. Spatial genome organization in the formation of chromosomal translocations. Semin. Cancer Biol. 17, 80-90 (2007).
5. Nikiforova, M. N. et al. Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells. Science 290, 138-141 (2000).
6. Aten, J. A. et al. Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains. Science 303, 92-95 (2004).
7. Nelms, B. E., Maser, R. S., MacKay, J. F., Legally, M. G. & Petrini, J. H. In situ visualization of DNA double-strand break repair in human fibroblasts. Science 280, 590-592 (1998).
8. Kruhlak, M. J. et al. Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J. Cell Biol. 172, 823-834 (2006).
9. Lisby, M., Antunez de Mayolo, A., Mortensen, U. H. & Rothstein, R. Cell cycle-regulated centers of DNA double-strand break repair. Cell Cycle 2, 479-483 (2003).
10. Lobachev, K., Vitriol, E., Stemple, J., Resnick, M. A. & Bloom, K. Chromosome fragmentation after induction of a double-strand break is an active process prevented by the RMX repair complex. Curr. Biol. 14, 2107-2112 (2004).
11. Kaye, J. A. et al. DNA breaks promote genomic instability by impeding proper chromosome segregation. Curr. Biol. 14, 2096-2106 (2004).
12. Haber, J. E. & Leung, W. Y. Lack of chromosome territoriality in yeast: promiscuous rejoining of broken chromosome ends. Proc. Natl Acad. Sci. USA 93, 13949-13954 (1996).
13. Lisby, M., Mortensen, U. H. & Rothstein, R. Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre. Nature Cell Biol. 5, 572-577 (2003).
14. Rouet, P., Smih, F. & Jasin, M. Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol. Cell Biol. 14, 8096-8106 (1994).
15. Martinez, E. D., Rayasam, G. V., Dull, A. B., Walker, D. A. & Hager, G. L. An estrogen receptor chimera senses ligands by nuclear translocation. J. Steroid Biochem. Mol. Biol. 97, 307-321 (2005).
16. Bekker-Jensen, S., Lukas, C., Melander, F., Bartek, J. & Lukas, J. Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J. Cell Biol. 170, 201-211 (2005).
17. Villalobos, M. J. Detection of DNA double-strand breaks and chromosome translocations using ligation-mediated PCR and inverse PCR. Methods Mol. Biol. 314 109-121 (2006).
18. Vazquez, J., Belmont, A. S. & Sedat, J. W. Multiple regimes of constrained chromosome motion are regulated in the interphase Drosophila nucleus. Curr. Biol. 11, 1227-1239 (2001).
19. Gerlich, D. et al. Global chromosome positions are transmitted through mitosis in mammalian cells. Cell 112, 751-764 (2003).
20. Bornfleth, H., Edelmann, P., Zink, D., Cremer, T. & Cremer, C. Quantitative motion analysis of subchromosomal foci in living cells using four-dimensional microscopy. Biophys. J. 77, 2871-2886 (1999).
21. Celeste, A. et al. H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell 114, 371-383 (2003).
22. Bassing, C. H. et al. Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors. Cell 114, 359-370 (2003).
23. Franco, S. et al. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol. Cell 21, 201-214 (2006).
24. Downs, J. A. & Jackson, S. P. A means to a DNA end: The many roles of Ku. Nature Rev. Mol. Cell Biol. 5, 367-378 (2004).
25. Bassing, C. H. & Alt, F. W. H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle 3 149-153 (2004).
26. Wyman, C. & Kanaar, R. Chromosome organization: Reaching out to embrace new models. Curr. Biol. 12, R446-R448 (2002).
27. Celeste, A. et al. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nature Cell Biol. 5, 675-679 (2003).
28. Branco, M. R. & Pombo, A. Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations. PLoS Biol 4, e138 (2006).
29. Sourtoglou, E. et al. The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. Mol. Cell Biol. 25, 4092-4104 (2005).
30. Lee, A. C., Fernandez-Capetillo, O., Pisupati, V., Jackson, S. P. & Nussenzweig, A. Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage. Cell Cycle 4, 177-182 (2005).
31. Difilippantonio, S. et al. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nature Cell Biol. 7, 675-685 (2005).
32. Thomann, D., Dorn, J., Sorger, P. K. & Danuser, G. Automatic fluorescent tag localization II: Improvement in super-resolution by relative tracking. J. Microsc. 211, 230-248 (2003).