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Volumn 2, Issue 12, 2001, Pages 877-886

Chk2 kinase - A busy messenger

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[No Author keywords available]

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EUKARYOTA;

EID: 0035656415     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/35103059     Document Type: Review
Times cited : (344)

References (97)
  • 1
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • Elledge, S. J. Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672 (1996).
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 2
    • 0032483562 scopus 로고    scopus 로고
    • DNA damage and checkpoint pathways: Molecular anatomy and interactions with repair
    • Weinert, T. DNA damage and checkpoint pathways: molecular anatomy and interactions with repair. Cell 94, 555-558 (1998).
    • (1998) Cell , vol.94 , pp. 555-558
    • Weinert, T.1
  • 3
    • 0033710224 scopus 로고    scopus 로고
    • Cell-cycle checkpoint kinases: Checking in on the cell cycle
    • Walworth, N. C. Cell-cycle checkpoint kinases: checking in on the cell cycle. Curr. Opin. Cell Biol. 12, 697-704 (2000).
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 697-704
    • Walworth, N.C.1
  • 4
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers, J. H. Genome maintenance mechanisms for preventing cancer. Nature 411, 366-374 (2001).
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 5
    • 0030985116 scopus 로고    scopus 로고
    • The ATM gene and protein: Possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress
    • Rotman, G. & Shiloh, Y. The ATM gene and protein: possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress. Cancer Surv. 29, 285-304 (1997).
    • (1997) Cancer Surv. , vol.29 , pp. 285-304
    • Rotman, G.1    Shiloh, Y.2
  • 6
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell, L. H. & Kastan, M. B. Cell cycle control and cancer. Science 266, 1821-1828 (1994).
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 7
    • 0026452949 scopus 로고
    • Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
    • Hartwell, L. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 71, 543-546 (1992).
    • (1992) Cell , vol.71 , pp. 543-546
    • Hartwell, L.1
  • 8
    • 0030988654 scopus 로고    scopus 로고
    • Yeast checkpoint controls and relevance to cancer
    • Weinert, T. Yeast checkpoint controls and relevance to cancer. Cancer Surv. 29, 109-132 (1997).
    • (1997) Cancer Surv. , vol.29 , pp. 109-132
    • Weinert, T.1
  • 9
    • 0033590179 scopus 로고    scopus 로고
    • DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
    • Dasika, G. K. et al. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene 18, 7883-7899 (1999).
    • (1999) Oncogene , vol.18 , pp. 7883-7899
    • Dasika, G.K.1
  • 10
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham, R. T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 11
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B. B. & Elledge, S. J. The DNA damage response: putting checkpoints in perspective. Nature 408, 433-439 (2000).
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 13
    • 0035313706 scopus 로고    scopus 로고
    • DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
    • Durocher, D. & Jackson, S. P. DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr. Opin. Cell Biol. 13, 225-231 (2001).
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 225-231
    • Durocher, D.1    Jackson, S.P.2
  • 14
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna, K. K. & Jackson, S. P. DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genet. 27, 247-254 (2001).
    • (2001) Nature Genet. , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 15
    • 0031044684 scopus 로고    scopus 로고
    • Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway
    • Carr, A. M. Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway. Curr. Opin. Genet. Dev. 7, 93-98 (1997).
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 93-98
    • Carr, A.M.1
  • 16
    • 0028962292 scopus 로고
    • The genetics of cell cycle checkpoints
    • Murray, A. W. The genetics of cell cycle checkpoints. Curr. Opin. Genet. Dev. 5, 5-11 (1995).
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 5-11
    • Murray, A.W.1
  • 17
    • 0034576494 scopus 로고    scopus 로고
    • The many substrates and functions of ATM
    • Kastan, M. B. & Lim, D. S. The many substrates and functions of ATM. Nature Rev. Mol. Cell Biol. 1, 179-186 (2000).
    • (2000) Nature Rev. Mol. Cell Biol. , vol.1 , pp. 179-186
    • Kastan, M.B.1    Lim, D.S.2
  • 18
    • 0035253615 scopus 로고    scopus 로고
    • ATM and ATR: Networking cellular responses to DNA damage
    • Shiloh, Y. ATM and ATR: networking cellular responses to DNA damage. Curr. Opin. Genet. Dev. 11, 71-77 (2001).
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 71-77
    • Shiloh, Y.1
  • 19
    • 0029820057 scopus 로고    scopus 로고
    • Ataxia-telangiectasia and the ATM gene: Linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints
    • Shiloh, Y. & Rotman, G. Ataxia-telangiectasia and the ATM gene: linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints. J. Clin. Immunol. 16, 254-260 (1996).
    • (1996) J. Clin. Immunol. , vol.16 , pp. 254-260
    • Shiloh, Y.1    Rotman, G.2
  • 20
    • 0030933152 scopus 로고    scopus 로고
    • The genetic defect in ataxiatelangiectasia
    • Lavin, M. F. & Shiloh, Y. The genetic defect in ataxiatelangiectasia. Annu. Rev. Immunol. 15, 177-202 (1997).
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 177-202
    • Lavin, M.F.1    Shiloh, Y.2
  • 21
    • 0034472434 scopus 로고    scopus 로고
    • Cnk1 and Cds1: Linchpins of the DNA damage and replication checkpoint pathways
    • Rhind, N. & Russell, P. Cnk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways. J. Cell Sci. 113, 3889-3896 (2000).
    • (2000) J. Cell Sci. , vol.113 , pp. 3889-3896
    • Rhind, N.1    Russell, P.2
  • 22
    • 0032484084 scopus 로고    scopus 로고
    • Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    • Matsuoka, S., Huang, M. & Elledge, S. J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282, 1893-1897 (1998). The cloning of human and mouse Chk2. Together with references 23-26, this report shows that mammalian Chk2 is a functional homologue of S. cerevisiae Rad53 and S. pombe cds1, and a downstream effector of ATM.
    • (1998) Science , vol.282 , pp. 1893-1897
    • Matsuoka, S.1    Huang, M.2    Elledge, S.J.3
  • 23
    • 0033552873 scopus 로고    scopus 로고
    • A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
    • Blasina, A. et al. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr. Biol. 9, 1-10 (1999).
    • (1999) Curr. Biol. , vol.9 , pp. 1-10
    • Blasina, A.1
  • 24
    • 0033616828 scopus 로고    scopus 로고
    • A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
    • Brown, A. L. et al. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc. Natl Acad. Sci. USA 96, 3745-3750 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 3745-3750
    • Brown, A.L.1
  • 25
    • 0033615647 scopus 로고    scopus 로고
    • Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53
    • Tominaga, K. et al. Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53. J. Biol. Chem. 274, 31463-31467 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 31463-31467
    • Tominaga, K.1
  • 26
    • 0033566082 scopus 로고    scopus 로고
    • Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
    • Chaturvedi, P. et al. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogens 18, 4047-4054 (1999).
    • (1999) Oncogens , vol.18 , pp. 4047-4054
    • Chaturvedi, P.1
  • 27
    • 0024425887 scopus 로고
    • Checkpoints: Controls that ensure the order of cell cycle events
    • Hartwell, L. H. & Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle events. Science 246, 629-634 (1989).
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 28
    • 0027968012 scopus 로고
    • The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast
    • Allen, J. B., Zhou, Z., Siede, W., Friedberg, E. C. & Elledge, S. J. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 8, 2401-2415 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 2401-2415
    • Allen, J.B.1    Zhou, Z.2    Siede, W.3    Friedberg, E.C.4    Elledge, S.J.5
  • 29
    • 0028945424 scopus 로고
    • A kinase from fission yeast responsible for blocking mitosis in S phase
    • Murakami, H. & Okayama, H. A kinase from fission yeast responsible for blocking mitosis in S phase. Nature 374, 817-819 (1995).
    • (1995) Nature , vol.374 , pp. 817-819
    • Murakami, H.1    Okayama, H.2
  • 30
    • 0343294336 scopus 로고    scopus 로고
    • Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends
    • Guo, Z. & Dunphy, W. G. Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends. Mol. Biol. Cell 11, 1535-1546 (2000).
    • (2000) Mol. Biol. Cell , vol.11 , pp. 1535-1546
    • Guo, Z.1    Dunphy, W.G.2
  • 31
    • 0034680760 scopus 로고    scopus 로고
    • Caenorhabditis elegans Chk2-like gene is essential for meiosis but dispensable for DNA repair
    • Higashitani, A. et al. Caenorhabditis elegans Chk2-like gene is essential for meiosis but dispensable for DNA repair. FEBS Lett. 485, 35-39 (2000).
    • (2000) FEBS Lett. , vol.485 , pp. 35-39
    • Higashitani, A.1
  • 32
    • 0035142832 scopus 로고    scopus 로고
    • Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination
    • Oishi, I. et al. Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination. Mol. Cell. Biol. 21, 1329-1335 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1329-1335
    • Oishi, I.1
  • 33
    • 0035394976 scopus 로고    scopus 로고
    • Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2
    • MacQueen, A. J. & Villeneuve, A. M. Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2. Genes Dev. 15, 1674-1687 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 1674-1687
    • MacQueen, A.J.1    Villeneuve, A.M.2
  • 34
    • 18844477320 scopus 로고    scopus 로고
    • A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment
    • Oishi, I. et al. A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment. Mech. Dev. 71, 49-63 (1998).
    • (1998) Mech. Dev. , vol.71 , pp. 49-63
    • Oishi, I.1
  • 35
    • 0026267294 scopus 로고
    • A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination
    • Rockmill, B. & Roeder, G. S. A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Genes Dev. 5, 2392-2404 (1991).
    • (1991) Genes Dev. , vol.5 , pp. 2392-2404
    • Rockmill, B.1    Roeder, G.S.2
  • 36
    • 0034641724 scopus 로고    scopus 로고
    • Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
    • Matsuoka, S. et al. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl Acad. Sci. USA 97, 10389-10394 (2000). This study and references 37 and 38 provide evidence for direct phosphorylation of Chk2 by the ATM and ATR kinases in vitro. ATM-dependent phosphorylation of threonine 68 was shown to be required for ionizing-radiation-induced Chk2 activation, also in vivo.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 10389-10394
    • Matsuoka, S.1
  • 37
    • 0034306332 scopus 로고    scopus 로고
    • Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
    • Melchionna, R., Chen, X. B., Blasina, A. & McGowan, C. H. Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. Nature Cell Biol. 2, 762-765 (2000).
    • (2000) Nature Cell Biol. , vol.2 , pp. 762-765
    • Melchionna, R.1    Chen, X.B.2    Blasina, A.3    McGowan, C.H.4
  • 38
    • 0034326802 scopus 로고    scopus 로고
    • Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
    • Ahn, J. Y., Schwarz, J. K., Piwnica-Worms, H. & Canman, C. E. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res. 60, 5934-5936 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 5934-5936
    • Ahn, J.Y.1    Schwarz, J.K.2    Piwnica-Worms, H.3    Canman, C.E.4
  • 39
    • 0035034925 scopus 로고    scopus 로고
    • Threonine-11, phosphorylated by Rad3 and ATM in vitro, is required for activation of fission yeast checkpoint kinase Cds1
    • Tanaka, K., Boddy, M. N., Chen, X. B., McGowan, C. H. & Russell, P. Threonine-11, phosphorylated by Rad3 and ATM in vitro, is required for activation of fission yeast checkpoint kinase Cds1. Mol. Cell. Biol. 21, 3398-3404 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3398-3404
    • Tanaka, K.1    Boddy, M.N.2    Chen, X.B.3    McGowan, C.H.4    Russell, P.5
  • 40
    • 0029360452 scopus 로고
    • The FHa domain: A putative nuclear signalling domain found in protein kinases and transcription factors
    • Hofmann, K. & Bucher, P. The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem. Sci. 20, 347-349 (1995).
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 347-349
    • Hofmann, K.1    Bucher, P.2
  • 41
    • 0034531364 scopus 로고    scopus 로고
    • The FHA domain mediates phosphoprotein interactions
    • Li, J., Lee, G. I., Van Doren, S. R. & Walker, J. C. The FHA domain mediates phosphoprotein interactions. J. Cell Sci. 113, 4143-4149 (2000).
    • (2000) J. Cell Sci. , vol.113 , pp. 4143-4149
    • Li, J.1    Lee, G.I.2    Van Doren, S.R.3    Walker, J.C.4
  • 42
    • 0032504069 scopus 로고    scopus 로고
    • Rad53 FHA domain associated with phosphorylated Rad9 in the DNA, damage checkpoint
    • Sun, Z., Hsiao, J., Fay, D. S. & Stern, D. F. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA, damage checkpoint. Science 281, 272-274 (1998). The original report that identifies a role for the Rad53 FHA2 domain in phosphospecific interactions between Rad9 and Rad53.
    • (1998) Science , vol.281 , pp. 272-274
    • Sun, Z.1    Hsiao, J.2    Fay, D.S.3    Stern, D.F.4
  • 43
    • 0033529330 scopus 로고    scopus 로고
    • Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain
    • Li, J., Smith, G. P. & Walker, J. C. Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain. Proc. Natl Acad. Sci. USA 96, 7821-7826 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 7821-7826
    • Li, J.1    Smith, G.P.2    Walker, J.C.3
  • 44
    • 0033197541 scopus 로고    scopus 로고
    • The FHa domain is a modular phosphopeptide recognition motif
    • Durocher, D., Henckel, J., Fersht, A. R. & Jackson, S. P. The FHA domain is a modular phosphopeptide recognition motif. Mol. Cell 4, 387-394 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 387-394
    • Durocher, D.1    Henckel, J.2    Fersht, A.R.3    Jackson, S.P.4
  • 45
    • 0033638454 scopus 로고    scopus 로고
    • The molecular basis of FHA domain: Phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms
    • Durocher, D. et al. The molecular basis of FHA domain: phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol. Cell 6, 1169-1182 (2000). A detailed in vitro binding analysis, which shows that FHA domains have high affinity for phosphothreonine residues. The FHA optimal recognition motif was identified as pTXXD (in which T is threonine, D is aspartic acid and X is any amino acid).
    • (2000) Mol. Cell , vol.6 , pp. 1169-1182
    • Durocher, D.1
  • 46
    • 0035839526 scopus 로고    scopus 로고
    • The hCds1 (Chk2)-FHa domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation
    • Lee, C. H. & Chung, J. H. The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation. J. Biol. Chem. 276, 30537-30541 (2001). Evidence for an essential role of the Chk2 FHA domain and autophosphorylation of threonines 383 and 387 in the Chk2 activation loop for the full activation of the kinase.
    • (2001) J. Biol. Chem. , vol.276 , pp. 30537-30541
    • Lee, C.H.1    Chung, J.H.2
  • 47
    • 0034881760 scopus 로고    scopus 로고
    • Budding yeast Rad9 is an ATP-dependent Rad53 activating machine
    • Gilbert, C. S., Green, C. M. & Lowndes, N. F. Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. Mol. Cell 8, 129-136 (2001). This study proposes an intriguing model of Rad53 activation whereby Mec1/Tel1-dependent phosphorylation of Rad9 converts the latter protein to a scaffold that brings two Rad53 molecules into close proximity.
    • (2001) Mol. Cell , vol.8 , pp. 129-136
    • Gilbert, C.S.1    Green, C.M.2    Lowndes, N.F.3
  • 48
    • 0035930536 scopus 로고    scopus 로고
    • Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks
    • in the press
    • Ward, I. M., Wu, X. & Chen, J. Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. J. Biol. Chem. (in the press).
    • J. Biol. Chem.
    • Ward, I.M.1    Wu, X.2    Chen, J.3
  • 49
    • 0031046294 scopus 로고    scopus 로고
    • A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins
    • Bork, P. et al. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11, 68-76 (1997).
    • (1997) FASEB J. , vol.11 , pp. 68-76
    • Bork, P.1
  • 50
    • 0033634679 scopus 로고    scopus 로고
    • Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
    • Kumagai, A. & Dunphy, W. G. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol. Cell 6, 839-849 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 839-849
    • Kumagai, A.1    Dunphy, W.G.2
  • 51
    • 0035735472 scopus 로고    scopus 로고
    • Mrc1 transduces signals of DNA replication stress to activate Rad53
    • Alcasabas, A. A. et al. Mrc1 transduces signals of DNA replication stress to activate Rad53. Nature Cell Biol. 3, 958-965 (2001). This study and reference 52 indicates that in yeast, Mrc1 might serve as a replicative counterpart of Rad9 and crb2 in activation of the Rad53 and cds1 kinases, respectively.
    • (2001) Nature Cell Biol. , vol.3 , pp. 958-965
    • Alcasabas, A.A.1
  • 52
    • 0035736486 scopus 로고    scopus 로고
    • Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1
    • Tanaka, K. & Russell, P. Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1. Nature Cell Biol. 3, 966-972 (2001).
    • (2001) Nature Cell Biol. , vol.3 , pp. 966-972
    • Tanaka, K.1    Russell, P.2
  • 53
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    • Shieh, S. Y., Ahn, J., Tamai, K., Taya, Y. & Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14, 289-300 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 289-300
    • Shieh, S.Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 54
    • 0033598754 scopus 로고    scopus 로고
    • Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
    • Chehab, N. H., Malikzay, A., Stavridi, E. S. & Halazonetis, T. D. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc. Natl Acad. Sci. USA 96, 13777-13782 (1999). Phosphorylation of the serine 20 residue of p53 was shown to be required for its DNA-damage-dependent stabilization. This was soon followed by identification of Chk1 and Chk2 as the kinases that mediate this phosphorylation (references 53 and 55).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 13777-13782
    • Chehab, N.H.1    Malikzay, A.2    Stavridi, E.S.3    Halazonetis, T.D.4
  • 55
    • 0034142325 scopus 로고    scopus 로고
    • Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
    • Chehab, N. H., Malikzay, A., Appel, M. & Halazonetis, T. D. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev. 14, 278-288 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 278-288
    • Chehab, N.H.1    Malikzay, A.2    Appel, M.3    Halazonetis, T.D.4
  • 56
  • 57
    • 0035370483 scopus 로고    scopus 로고
    • Regulation and function of the p53 tumor suppressor protein
    • Ryan, K. M., Phillips, A. C. & Vousden, K. H. Regulation and function of the p53 tumor suppressor protein. Curr. Opin. Cell Biol. 13, 332-337 (2001).
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 332-337
    • Ryan, K.M.1    Phillips, A.C.2    Vousden, K.H.3
  • 58
    • 0034629072 scopus 로고    scopus 로고
    • DNA damage-induced activation of p53 by the checkpoint kinase Chk2
    • Hirao, A. et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287, 1824-1827 (2000). The first - and, so far, the only - report on Chk2-knockout mouse embryo fibroblasts, which indicates an involvement of Chk2 in DNA-damage-dependent stabilization of p53 and G2/M checkpoint arrest.
    • (2000) Science , vol.287 , pp. 1824-1827
    • Hirao, A.1
  • 59
    • 0034624718 scopus 로고    scopus 로고
    • HCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
    • Lee, J. S., Collins, K. M., Brown, A. L., Lee, C. H. & Chung, J. H. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201-204 (2000). The association with, and phosphorylation of, BRCA1 by Chk2 was identified as an important event in BRCA1-dependent DNA-damage checkpoint function.
    • (2000) Nature , vol.404 , pp. 201-204
    • Lee, J.S.1    Collins, K.M.2    Brown, A.L.3    Lee, C.H.4    Chung, J.H.5
  • 60
    • 0034707053 scopus 로고    scopus 로고
    • In search of the tumour-suppressor functions of BRCA1 and BRCA2
    • Scully, R. & Livingston, D. M. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429-432 (2000).
    • (2000) Nature , vol.408 , pp. 429-432
    • Scully, R.1    Livingston, D.M.2
  • 61
    • 0035032649 scopus 로고    scopus 로고
    • Involvement of BRCA1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
    • Xu, B., Kim, S. & Kastan, M. B. Involvement of BRCA1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol. Cell. Biol. 21, 3445-3450 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3445-3450
    • Xu, B.1    Kim, S.2    Kastan, M.B.3
  • 62
    • 0034655991 scopus 로고    scopus 로고
    • BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    • Wang, Y. et al. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 14, 927-939 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 927-939
    • Wang, Y.1
  • 63
    • 0030867582 scopus 로고    scopus 로고
    • Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
    • Sanchez, Y. et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497-1501 (1997).
    • (1997) Science , vol.277 , pp. 1497-1501
    • Sanchez, Y.1
  • 64
    • 0030611095 scopus 로고    scopus 로고
    • Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
    • Peng, C. Y. et al. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501-1505 (1997).
    • (1997) Science , vol.277 , pp. 1501-1505
    • Peng, C.Y.1
  • 65
    • 0032746942 scopus 로고    scopus 로고
    • DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding
    • Zeng, Y. & Piwnica-Worms, H. DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding. Mol. Cell. Biol. 19, 7410-7419 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7410-7419
    • Zeng, Y.1    Piwnica-Worms, H.2
  • 66
    • 0035810050 scopus 로고    scopus 로고
    • Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding
    • Graves, P. R., Lovly, C. M., Uy, G. L & Piwnica-Worms, H. Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding. Oncogene 20, 1839-1851 (2001).
    • (2001) Oncogene , vol.20 , pp. 1839-1851
    • Graves, P.R.1    Lovly, C.M.2    Uy, G.L.3    Piwnica-Worms, H.4
  • 67
    • 0035848819 scopus 로고    scopus 로고
    • The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
    • Falck, J., Mailand, N., Syljuåsen, R. G., Bartek, J. & Lukas, J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842-847 (2001). Identification of the Chk2-mediated degradation of the Cdc25A phosphatase as a rate-limiting step in the DNA damage intra-S-phase checkpoint in response to ionizing radiation.
    • (2001) Nature , vol.410 , pp. 842-847
    • Falck, J.1    Mailand, N.2    Syljuåsen, R.G.3    Bartek, J.4    Lukas, J.5
  • 68
    • 0034717309 scopus 로고    scopus 로고
    • Rapid destruction of human Cdc25A in response to DNA damage
    • Mailand, N. et al. Rapid destruction of human Cdc25A in response to DNA damage. Science 288, 1425-1429 (2000). This report and reference 69 shows a rapid, checkpoint-dependent degradation of Cdc25A in response to ultraviolet radiation and stalled replication, respectively.
    • (2000) Science , vol.288 , pp. 1425-1429
    • Mailand, N.1
  • 69
    • 0034232093 scopus 로고    scopus 로고
    • Human Cdc25A inactivation in response to S phase inhibition and its role in preventing premature mitosis
    • Molinari, M., Mercurio, C., Dominguez, J., Goubin, F. & Draetta, G. F. Human Cdc25A inactivation in response to S phase inhibition and its role in preventing premature mitosis. EMBO Rep. 1, 71-79 (2000).
    • (2000) EMBO Rep. , vol.1 , pp. 71-79
    • Molinari, M.1    Mercurio, C.2    Dominguez, J.3    Goubin, F.4    Draetta, G.F.5
  • 70
    • 0034020464 scopus 로고    scopus 로고
    • The Mre11 complex and ATM: Collaborating to navigate S phase
    • Petrini, J. H. The Mre11 complex and ATM: collaborating to navigate S phase. Curr. Opin. Cell Biol. 12, 293-296.
    • Curr. Opin. Cell Biol. , vol.12 , pp. 293-296
    • Petrini, J.H.1
  • 71
    • 0035848867 scopus 로고    scopus 로고
    • Cell cycle. Checking two steps
    • Kastan, M. B. Cell cycle. Checking two steps. Nature 410, 766-767 (2001).
    • (2001) Nature , vol.410 , pp. 766-767
    • Kastan, M.B.1
  • 72
    • 0032508504 scopus 로고    scopus 로고
    • Enhanced phosphorylation of p53 by ATM in response to DNA damage
    • Banin, S. et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281, 1674-1677 (1998).
    • (1998) Science , vol.281 , pp. 1674-1677
    • Banin, S.1
  • 73
    • 0032508608 scopus 로고    scopus 로고
    • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    • Canman, C. E. et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281, 1677-1679 (1998).
    • (1998) Science , vol.281 , pp. 1677-1679
    • Canman, C.E.1
  • 74
    • 0035339357 scopus 로고    scopus 로고
    • ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage
    • Maya, R. et al. ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev. 15, 1067-1077 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 1067-1077
    • Maya, R.1
  • 75
    • 0033527717 scopus 로고    scopus 로고
    • Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks
    • Cortez, D., Wang, Y. Qin, J. & Elledge, S. J. Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks. Science 286, 1162-1166 (1999).
    • (1999) Science , vol.286 , pp. 1162-1166
    • Cortez, D.1    Wang, Y.2    Qin, J.3    Elledge, S.J.4
  • 76
    • 0033637170 scopus 로고    scopus 로고
    • Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
    • Tibbetts, R. S. et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 14, 2989-3002 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2989-3002
    • Tibbetts, R.S.1
  • 77
    • 0034644220 scopus 로고    scopus 로고
    • Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
    • Li, S. et al. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406, 210-215 (2000).
    • (2000) Nature , vol.406 , pp. 210-215
    • Li, S.1
  • 78
    • 12944316603 scopus 로고    scopus 로고
    • ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation
    • Barlow, C. et al. ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation. Proc. Natl Acad. Sci. USA 97, 871-876 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 871-876
    • Barlow, C.1
  • 79
    • 0035393594 scopus 로고    scopus 로고
    • DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology
    • Lukas, C. et al. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Res. 61, 4990-4993 (2001). This study highlights the striking differences between human CHK2 and CHK1, and reports an unexpected correlation of CHK2 expression with tissue biology.
    • (2001) Cancer Res. , vol.61 , pp. 4990-4993
    • Lukas, C.1
  • 80
    • 0035855627 scopus 로고    scopus 로고
    • Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours
    • Bartkova, J. et al. Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours. Oncogens 20, 5897-5902 (2001).
    • (2001) Oncogens , vol.20 , pp. 5897-5902
    • Bartkova, J.1
  • 81
    • 13144282737 scopus 로고    scopus 로고
    • ATM-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
    • Flaggs, G. et al. ATM-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes. Curr. Biol. 7, 977-986 (1997).
    • (1997) Curr. Biol. , vol.7 , pp. 977-986
    • Flaggs, G.1
  • 82
    • 0033600182 scopus 로고    scopus 로고
    • Cell cycle-dependent and ATM-independent expression of human Chk1 kinase
    • Kaneko, Y. et al. Cell cycle-dependent and ATM-independent expression of human Chk1 kinase. Oncogens 18, 3673-3681 (1999).
    • (1999) Oncogens , vol.18 , pp. 3673-3681
    • Kaneko, Y.1
  • 83
    • 0035545996 scopus 로고    scopus 로고
    • Mammalian G1 - And S-phase checkpoints in response to DNA damage
    • in the press
    • Bartek, J. & Lukas, J. Mammalian G1 - and S-phase checkpoints in response to DNA damage. Curr. Opin. Cell Biol. (in the press).
    • Curr. Opin. Cell Biol.
    • Bartek, J.1    Lukas, J.2
  • 84
    • 0033601346 scopus 로고    scopus 로고
    • Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
    • Bell, D. W. et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286, 2528-2531 (1999). The Identification of germline mutations in the CHK2 gene in Li-Fraumeni families with wild-type p53, which indicates a role for CHK2 as a tumour suppressor. Subsequently, identical and additional mutations were found In sporadic cancers of different origin (references 86-88).
    • (1999) Science , vol.286 , pp. 2528-2531
    • Bell, D.W.1
  • 85
    • 0034697958 scopus 로고    scopus 로고
    • Screening for hCHK2 mutations
    • Sodha, N. et al. Screening for hCHK2 mutations. Science 289, 359 (2000).
    • (2000) Science , vol.289 , pp. 359
    • Sodha, N.1
  • 86
    • 0034282984 scopus 로고    scopus 로고
    • Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer
    • Haruki, N. et al. Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer. Cancer Res. 60, 4689-4692 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 4689-4692
    • Haruki, N.1
  • 87
    • 0035126617 scopus 로고    scopus 로고
    • Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias
    • Hofman, W.-K. et al. Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias. Leuk. Res. 25, 333-338 (2001).
    • (2001) Leuk. Res. , vol.25 , pp. 333-338
    • Hofman, W.-K.1
  • 88
    • 0035421321 scopus 로고    scopus 로고
    • p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: Further evidence of CHK2 in inherited cancer predisposition
    • Vahteristo, P. et al. p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition. Cancer Res. 61, 5718-5722 (2001).
    • (2001) Cancer Res , vol.61 , pp. 5718-5722
    • Vahteristo, P.1
  • 89
    • 0035817764 scopus 로고    scopus 로고
    • Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway
    • Falck, J. et al. Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway. Oncogene 20, 5503-5510 (2001). Evidence that the concomitant mutation of p53 and CHK2 might provide a selective advantage to tumour cells.
    • (2001) Oncogene , vol.20 , pp. 5503-5510
    • Falck, J.1
  • 90
    • 0035951809 scopus 로고    scopus 로고
    • Characterization of tumor-associated Chk2 mutations
    • Wu, X., Webster, S. R. & Chen, J. Characterization of tumor-associated Chk2 mutations. J. Biol. Chem. 274, 2971-2974 (2001).
    • (2001) J. Biol. Chem. , vol.274 , pp. 2971-2974
    • Wu, X.1    Webster, S.R.2    Chen, J.3
  • 91
    • 0035878816 scopus 로고    scopus 로고
    • Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer
    • Matsuoka, S. et al. Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer. Cancer Res. 61, 5362-5355 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 5362-15355
    • Matsuoka, S.1
  • 92
    • 16044371194 scopus 로고    scopus 로고
    • Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase
    • Yao, S. L. et al. Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase. Nature Med. 2, 1140-1143 (1996).
    • (1996) Nature Med. , vol.2 , pp. 1140-1143
    • Yao, S.L.1
  • 93
    • 0033406451 scopus 로고    scopus 로고
    • Sensitization of cancer cells to DNA damage-induced cell death by specific cell cycle G2 checkpoint abrogation
    • Suganuma, M., Kawabe, T., Hori, H., Funabiki, T. & Okamoto, T. Sensitization of cancer cells to DNA damage-induced cell death by specific cell cycle G2 checkpoint abrogation. Cancer Res. 59, 5887-5891 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 5887-5891
    • Suganuma, M.1    Kawabe, T.2    Hori, H.3    Funabiki, T.4    Okamoto, T.5
  • 94
    • 0035979213 scopus 로고    scopus 로고
    • ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation
    • Nghiem, P., Park, P. K., Kim, Y. Vaziri, C. & Schreiber, S. L. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc. Natl Acad. Sci. USA 98, 9092-9097 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 9092-9097
    • Nghiem, P.1    Park, P.K.2    Kim, Y.3    Vaziri, C.4    Schreiber, S.L.5
  • 95
    • 0032509403 scopus 로고    scopus 로고
    • UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase
    • Yu, L. et al. UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase. J. Biol. Chem. 273, 33455-33464 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 33455-33464
    • Yu, L.1
  • 96
    • 0034053130 scopus 로고    scopus 로고
    • The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
    • Graves, P. R. et al. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J. Biol. Chem. 275, 5600-5605 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 5600-5605
    • Graves, P.R.1


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