-
1
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham, R. T. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2177-2196.
-
(2001)
Genes Dev.
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
2
-
-
0035134286
-
Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage
-
Anderson, L., C. Henderson, and Y. Adachi. 2001. Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage. Mol. Cell. Biol. 21:1719-1729.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1719-1729
-
-
Anderson, L.1
Henderson, C.2
Adachi, Y.3
-
3
-
-
15844426692
-
ATM-deficient mice: A paradigm of ataxia telangiectasia
-
Barlow, C., S. Hirotsune, R. Paylor, M. Liyanage, M. Eckhaus, F. Collins, Y. Shiloh, J. N. Crawley, T. Ried, D. Tagle, and A. Wynshaw-Boris. 1996. ATM-deficient mice: a paradigm of ataxia telangiectasia. Cell 86:159-171.
-
(1996)
Cell
, vol.86
, pp. 159-171
-
-
Barlow, C.1
Hirotsune, S.2
Paylor, R.3
Liyanage, M.4
Eckhaus, M.5
Collins, F.6
Shiloh, Y.7
Crawley, J.N.8
Ried, T.9
Tagle, D.10
Wynshaw-Boris, A.11
-
5
-
-
0031031787
-
From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair
-
Callebaut, I., and J. P. Mornon. 1997. From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett. 400:25-30.
-
(1997)
FEBS Lett.
, vol.400
, pp. 25-30
-
-
Callebaut, I.1
Mornon, J.P.2
-
6
-
-
0037012845
-
Genomic instability in mice lacking histone H2AX
-
Celeste, A., S. Petersen, P. J. Romanienko, O. Fernandez-Capetillo, H. T. Chen, O. A. Sedelnikova, B. Reina-San-Martin, V. Coppola, E. Meffre, M. J. Difilippantonio, C. Redon, D. R. Pilch, A. Olaru, M. Eckhaus, R. D. Camerini-Otero, L. Tessarollo, F. Livak, K. Manova, W. M. Bonner, M. C. Nussenzweig, and A. Nussenzweig. 2002. Genomic instability in mice lacking histone H2AX. Science 296:922-927.
-
(2002)
Science
, vol.296
, pp. 922-927
-
-
Celeste, A.1
Petersen, S.2
Romanienko, P.J.3
Fernandez-Capetillo, O.4
Chen, H.T.5
Sedelnikova, O.A.6
Reina-San-Martin, B.7
Coppola, V.8
Meffre, E.9
Difilippantonio, M.J.10
Redon, C.11
Pilch, D.R.12
Olaru, A.13
Eckhaus, M.14
Camerini-Otero, R.D.15
Tessarollo, L.16
Livak, F.17
Manova, K.18
Bonner, W.M.19
Nussenzweig, M.C.20
Nussenzweig, A.21
more..
-
7
-
-
0037099666
-
Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor
-
Derbyshire, D. J., B. P. Basu, L. C. Serpell, W. S. Joo, T. Date, K. Iwabuchi, and A. J. Doherty. 2002. Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor. EMBO J. 21:3863-3872.
-
(2002)
EMBO J.
, vol.21
, pp. 3863-3872
-
-
Derbyshire, D.J.1
Basu, B.P.2
Serpell, L.C.3
Joo, W.S.4
Date, T.5
Iwabuchi, K.6
Doherty, A.J.7
-
8
-
-
0037136318
-
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification
-
Difilippantonio, M. J., S. Petersen, H. T. Chen, R. Johnson, M. Jasin, R. Kanaar, T. Ried, and A. Nussenzweig. 2002. Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J. Exp. Med. 196:469-480.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 469-480
-
-
Difilippantonio, M.J.1
Petersen, S.2
Chen, H.T.3
Johnson, R.4
Jasin, M.5
Kanaar, R.6
Ried, T.7
Nussenzweig, A.8
-
9
-
-
0029848286
-
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
-
Elson, A., Y. Wang, C. J. Daugherty, C. C. Morton, F. Zhou, J. Campos-Torres, and P. Leder. 1996. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc. Natl. Acad. Sci. USA 93:13084-13089.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13084-13089
-
-
Elson, A.1
Wang, Y.2
Daugherty, C.J.3
Morton, C.C.4
Zhou, F.5
Campos-Torres, J.6
Leder, P.7
-
10
-
-
0034599981
-
Homologous and non-homologous recombination differentially affect DNA damage repair in mice
-
Essers, J., H. van Steeg, J. de Wit, S. M. Swagemakers, M. Vermeij, J. H. Hoeijmakers, and R. Kanaar. 2000. Homologous and non-homologous recombination differentially affect DNA damage repair in mice. EMBO J. 19:1703-1710.
-
(2000)
EMBO J.
, vol.19
, pp. 1703-1710
-
-
Essers, J.1
Van Steeg, H.2
De Wit, J.3
Swagemakers, S.M.4
Vermeij, M.5
Hoeijmakers, J.H.6
Kanaar, R.7
-
11
-
-
0036903037
-
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BPJ
-
Fernandez-Capetillo, O., H. T. Chen, A. Celeste, I. Ward, P. J. Romanienko, & J. C. Morales, K. Naka, Z. Xia, R. D. Camerini-Otero, N. Motoyama, P. B. Carpenter, W. M. Bonner, J. Chen, and A. Nussenzweig. 2002. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BPJ. Nat. Cell Biol. 4:993-997.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 993-997
-
-
Fernandez-Capetillo, O.1
Chen, H.T.2
Celeste, A.3
Ward, I.4
Romanienko, P.J.5
Morales, J.C.6
Naka, K.7
Xia, Z.8
Camerini-Otero, R.D.9
Motoyama, N.10
Carpenter, P.B.11
Bonner, W.M.12
Chen, J.13
Nussenzweig, A.14
-
12
-
-
0036724625
-
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
-
Hirao, A., A. Cheung, G. Duncan, P. M. Girard, A. J. Elia, A. Wakeham, H. Okada, T. Sarkissian, J. A. Wong, T. Sakai, E. De Stanchina, R. G. Bristow, T. Suda, S. W. Lowe, P. A. Jeggo, S. J. Elledge, and T. W. Mak. 2002. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol. Cell. Biol. 22:6521-6532.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 6521-6532
-
-
Hirao, A.1
Cheung, A.2
Duncan, G.3
Girard, P.M.4
Elia, A.J.5
Wakeham, A.6
Okada, H.7
Sarkissian, T.8
Wong, J.A.9
Sakai, T.10
De Stanchina, E.11
Bristow, R.G.12
Suda, T.13
Lowe, S.W.14
Jeggo, P.A.15
Elledge, S.J.16
Mak, T.W.17
-
13
-
-
0028242909
-
Two cellular proteins that bind to wild-type but not mutant p53
-
Iwabuchi, K., P. L. Bartel, B. Li, R. Marraccino, and S. Fields. 1994. Two cellular proteins that bind to wild-type but not mutant p53. Proc. Natl. Acad. Sci. USA 91:6098-6102.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 6098-6102
-
-
Iwabuchi, K.1
Bartel, P.L.2
Li, B.3
Marraccino, R.4
Fields, S.5
-
14
-
-
0032475885
-
Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2
-
Iwabuchi, K., B. Li, H. F. Massa, B. J. Trask, T. Date, and S. Fields. 1998. Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. J. Biol. Chem. 273:26061-26068.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26061-26068
-
-
Iwabuchi, K.1
Li, B.2
Massa, H.F.3
Trask, B.J.4
Date, T.5
Fields, S.6
-
15
-
-
0036500691
-
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
-
Joo, W. S., P. D. Jeffrey, S. B. Cantor, M. S. Finnin, D. M. Livingston, and N. P. Pavletich. 2002. Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev. 16:583-593.
-
(2002)
Genes Dev.
, vol.16
, pp. 583-593
-
-
Joo, W.S.1
Jeffrey, P.D.2
Cantor, S.B.3
Finnin, M.S.4
Livingston, D.M.5
Pavletich, N.P.6
-
16
-
-
0036150875
-
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
-
Jullien, D., P. Vagnarelli, W. C. Earnshaw, and Y. Adachi. 2002. Kinetochore localisation of the DNA damage response component 53BP1 during mitosis. J. Cell Sci. 115:71-79.
-
(2002)
J. Cell Sci.
, vol.115
, pp. 71-79
-
-
Jullien, D.1
Vagnarelli, P.2
Earnshaw, W.C.3
Adachi, Y.4
-
19
-
-
0034641724
-
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
-
Matsuoka, S., G. Rotman, A. Ogawa, Y. Shiloh, K. Tamai, and S. J. Elledge. 2000. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl. Acad. Sci. USA 97:10389-10394.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 10389-10394
-
-
Matsuoka, S.1
Rotman, G.2
Ogawa, A.3
Shiloh, Y.4
Tamai, K.5
Elledge, S.J.6
-
20
-
-
0034306332
-
Threonine 68 is required for radiation-induced phosphorylation and activation of Cdsl
-
Melchionna, R., X. B. Chen, A. Blasina, and C. H. McGowan. 2000. Threonine 68 is required for radiation-induced phosphorylation and activation of Cdsl. Nat. Cell Biol. 2:762-765.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 762-765
-
-
Melchionna, R.1
Chen, X.B.2
Blasina, A.3
McGowan, C.H.4
-
21
-
-
0343280013
-
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
-
Paull, T. T., E. P. Rogakou, V. Yamazaki, C. U. Kirchgessner, M. Gellert, and W. M. Bonner. 2000. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10:886-895.
-
(2000)
Curr. Biol.
, vol.10
, pp. 886-895
-
-
Paull, T.T.1
Rogakou, E.P.2
Yamazaki, V.3
Kirchgessner, C.U.4
Gellert, M.5
Bonner, W.M.6
-
22
-
-
0035972194
-
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways
-
Rappold, I., K. Iwabuchi, T. Date, and J. Chen. 2001. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J. Cell Biol. 153:613-620.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 613-620
-
-
Rappold, I.1
Iwabuchi, K.2
Date, T.3
Chen, J.4
-
23
-
-
0034739853
-
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
-
Schultz, L. B., N. H. Chehab, A. Malikzay, and T. D. Halazonetis. 2000. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J. Cell Biol. 151:1381-1390.
-
(2000)
J. Cell Biol.
, vol.151
, pp. 1381-1390
-
-
Schultz, L.B.1
Chehab, N.H.2
Malikzay, A.3
Halazonetis, T.D.4
-
24
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai, H., K. Naka, Y. Okada, M. Watanabe, N. Harada, S. Salto, C. W. Anderson, E. Appella, M. Nakanishi, H. Suzuki, K. Nagashima, H. Sawa, K. Ikeda, and N. Motoyama. 2002. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21:5195-5205.
-
(2002)
EMBO J.
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
Naka, K.2
Okada, Y.3
Watanabe, M.4
Harada, N.5
Salto, S.6
Anderson, C.W.7
Appella, E.8
Nakanishi, M.9
Suzuki, H.10
Nagashima, K.11
Sawa, H.12
Ikeda, K.13
Motoyama, N.14
-
25
-
-
0037112212
-
53BP1, a mediator of the DNA damage checkpoint
-
Wang, B., S. Matsuoka, P. B. Carpenter, and S. J. Elledge. 2002. 53BP1, a mediator of the DNA damage checkpoint. Science 283:1435-1438.
-
(2002)
Science
, vol.283
, pp. 1435-1438
-
-
Wang, B.1
Matsuoka, S.2
Carpenter, P.B.3
Elledge, S.J.4
-
26
-
-
0035930537
-
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
-
Ward, I. M., and J. Chen. 2001. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276:47759-47762.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47759-47762
-
-
Ward, I.M.1
Chen, J.2
-
27
-
-
0035930536
-
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks
-
Ward, I. M., X. Wu, and J. Chen. 2001. Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. J. Biol. Chem. 276:47755-47758.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47755-47758
-
-
Ward, I.M.1
Wu, X.2
Chen, J.3
-
28
-
-
0035951850
-
Negative cell cycle regulation and DNA damage inducible phosphorylation of the BRCT protein 53BP1
-
Xia, Z., J. C. Morales, W. G. Dunphy, and P. B. Carpenter. 2001. Negative cell cycle regulation and DNA damage inducible phosphorylation of the BRCT protein 53BP1. J. Biol. Chem. 276:2708-2718.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 2708-2718
-
-
Xia, Z.1
Morales, J.C.2
Dunphy, W.G.3
Carpenter, P.B.4
-
30
-
-
0029844048
-
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
-
Xu, Y., T. Ashley, E. E. Brainerd, R. T. Bronson, M. S. Meyn, and D. Baltimore. 1996. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10:2411-2422.
-
(1996)
Genes Dev.
, vol.10
, pp. 2411-2422
-
-
Xu, Y.1
Ashley, T.2
Brainerd, E.E.3
Bronson, R.T.4
Meyn, M.S.5
Baltimore, D.6
-
31
-
-
0037188898
-
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations
-
Zhu, C., K. D. Mills, D. O. Ferguson, C. Lee, J. Manis, J. Fleming, Y. Gao, C. C. Morton, and F. W. Alt. 2002. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 109:811-821.
-
(2002)
Cell
, vol.109
, pp. 811-821
-
-
Zhu, C.1
Mills, K.D.2
Ferguson, D.O.3
Lee, C.4
Manis, J.5
Fleming, J.6
Gao, Y.7
Morton, C.C.8
Alt, F.W.9
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