Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

Journal of Experimental Medicine

Volumn 196, Issue 4, 2002, Pages 469-480

  Difilippantonio, Michael J ^a   Petersen, Simone ^a   Chen, Hua Tang ^a   Johnson, Roger ^b   Jasin, Maria ^b   Kanaar, Roland ^c   Ried, Thomas ^a   Nussenzweig, André ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Bridge fusion breakage; Gene amplification; Nonhomologous end joining; Nonreciprocal translocations; Tumorigenesis

Indexed keywords

CELL PROTEIN; DOUBLE STRANDED DNA; GENE PRODUCT; PROTEIN P53;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; GENE AMPLIFICATION; GENE FUSION; GENE TRANSLOCATION; GENETIC STABILITY; IMMUNOGLOBULIN GENE; LYMPHOMA; MOUSE; NONHUMAN; ONCOGENE MYC; PRIORITY JOURNAL; TELOMERE; TUMOR MODEL;

ANIMALS; ANTIGENS, NUCLEAR; BASE SEQUENCE; DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; GENE AMPLIFICATION; GENE REARRANGEMENT; IMMUNOGLOBULIN HEAVY CHAINS; LYMPHOMA, B-CELL; MICE; MICE, KNOCKOUT; MICE, SCID; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; ONCOGENES; PROTO-ONCOGENE PROTEINS C-MYC; TELOMERE; THYMUS NEOPLASMS; TRANSLOCATION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037136318     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020851     Document Type: Article

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