-
1
-
-
1842411320
-
Crystal structure of the nucleosome core particle at 2.8 Å resolution
-
Luger K., Mader A.W., Richmond R.K., Sargent D.F., Richmond T.J. Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature. 389:1997;251-260
-
(1997)
Nature
, vol.389
, pp. 251-260
-
-
Luger, K.1
Mader, A.W.2
Richmond, R.K.3
Sargent, D.F.4
Richmond, T.J.5
-
2
-
-
0019319471
-
Histone 2A, a heteromorphous family of eight protein species
-
West M.H., Bonner W.M. Histone 2A, a heteromorphous family of eight protein species. Biochemistry. 19:1980;3238-3245
-
(1980)
Biochemistry
, vol.19
, pp. 3238-3245
-
-
West, M.H.1
Bonner, W.M.2
-
3
-
-
0024395794
-
H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3′ processing signals
-
Mannironi C., Bonner W.M., Hatch C.L. H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3′ processing signals. Nucleic Acids Res. 17:1989;9113-9126
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 9113-9126
-
-
Mannironi, C.1
Bonner, W.M.2
Hatch, C.L.3
-
4
-
-
0036531895
-
Histone H2A variants H2AX and H2AZ
-
Redon C., Pilch D., Rogakou E., Sedelnikova O., Newrock K., Bonner W. Histone H2A variants H2AX and H2AZ. Curr. Opin. Genet. Dev. 12:2002;162-169
-
(2002)
Curr. Opin. Genet. Dev.
, vol.12
, pp. 162-169
-
-
Redon, C.1
Pilch, D.2
Rogakou, E.3
Sedelnikova, O.4
Newrock, K.5
Bonner, W.6
-
5
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273:1998;5858-5868
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
6
-
-
33847625163
-
Complexity and variability of the histone complement
-
Zweidler A. Complexity and variability of the histone complement. Life Sci. Res. Rep. 4:1976;187-196
-
(1976)
Life Sci. Res. Rep.
, vol.4
, pp. 187-196
-
-
Zweidler, A.1
-
8
-
-
0035093737
-
DNA double-strand breaks: Signaling, repair and the cancer connection
-
Khanna K.K., Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27:2001;247-254
-
(2001)
Nat. Genet.
, vol.27
, pp. 247-254
-
-
Khanna, K.K.1
Jackson, S.P.2
-
9
-
-
0032861343
-
Megabase chromatin domains involved in DNA double-strand breaks in vivo
-
Rogakou E.P., Boon C., Redon C., Bonner W.M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146:1999;905-916
-
(1999)
J. Cell Biol.
, vol.146
, pp. 905-916
-
-
Rogakou, E.P.1
Boon, C.2
Redon, C.3
Bonner, W.M.4
-
10
-
-
0036402522
-
Photobleaching of GFP-labeled H2AX in chromatin: H2AX has low diffusional mobility in the nucleus
-
Siino J.S., Nazarov I.B., Svetlova M.P., Solovjeva L.V., Adamson R.H., Zalenskaya I.A., Yau P.M., Bradbury E.M., Tomilin N.V. Photobleaching of GFP-labeled H2AX in chromatin: H2AX has low diffusional mobility in the nucleus. Biochem. Biophys. Res. Commun. 297:2002;1318-1323
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.297
, pp. 1318-1323
-
-
Siino, J.S.1
Nazarov, I.B.2
Svetlova, M.P.3
Solovjeva, L.V.4
Adamson, R.H.5
Zalenskaya, I.A.6
Yau, P.M.7
Bradbury, E.M.8
Tomilin, N.V.9
-
11
-
-
0036789173
-
Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody
-
Sedelnikova O.A., Rogakou E.P., Panyutin I.G., Bonner W.M. Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat. Res. 158:2002;486-492
-
(2002)
Radiat. Res.
, vol.158
, pp. 486-492
-
-
Sedelnikova, O.A.1
Rogakou, E.P.2
Panyutin, I.G.3
Bonner, W.M.4
-
12
-
-
0343280013
-
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
-
Paull T.T., Rogakou E.P., Yamazaki V., Kirchgessner C.U., Gellert M., Bonner W.M. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10:2000;886-895
-
(2000)
Curr. Biol.
, vol.10
, pp. 886-895
-
-
Paull, T.T.1
Rogakou, E.P.2
Yamazaki, V.3
Kirchgessner, C.U.4
Gellert, M.5
Bonner, W.M.6
-
13
-
-
0038820065
-
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes
-
Furuta T., Takemura H., Liao Z.Y., Aune G.J., Redon C., Sedelnikova O.A., Pilch D.R., Rogakou E.P., Celeste A., Chen H.T., Nussenzweig A., Aladjem M.I., Bonner W.M., Pommier Y. Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J. Biol. Chem. 278:2003;20303-20312
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20303-20312
-
-
Furuta, T.1
Takemura, H.2
Liao, Z.Y.3
Aune, G.J.4
Redon, C.5
Sedelnikova, O.A.6
Pilch, D.R.7
Rogakou, E.P.8
Celeste, A.9
Chen, H.T.10
Nussenzweig, A.11
Aladjem, M.I.12
Bonner, W.M.13
Pommier, Y.14
-
14
-
-
0035930537
-
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
-
Ward I.M., Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276:2001;47759-47762
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47759-47762
-
-
Ward, I.M.1
Chen, J.2
-
15
-
-
0034737439
-
Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
-
Rogakou E.P., Nieves-Neira W., Boon C., Pommier Y., Bonner W.M. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J. Biol. Chem. 275:2000;9390-9395
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9390-9395
-
-
Rogakou, E.P.1
Nieves-Neira, W.2
Boon, C.3
Pommier, Y.4
Bonner, W.M.5
-
16
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., Fiegler H., Carr P., Von Zglinicki T., Saretzki G., Carter N.P., Jackson S.P. A DNA damage checkpoint response in telomere-initiated senescence. Nature. 426:2003;194-198
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
D'Adda Di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
Von Zglinicki, T.6
Saretzki, G.7
Carter, N.P.8
Jackson, S.P.9
-
18
-
-
0042632901
-
Pathways of DNA double-strand break repair during the mammalian cell cycle
-
Rothkamm K., Kruger I., Thompson L.H., Lobrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell Biol. 23:2003;5706-5715
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 5706-5715
-
-
Rothkamm, K.1
Kruger, I.2
Thompson, L.H.3
Lobrich, M.4
-
19
-
-
0035097808
-
Recombinational DNA double-strand breaks in mice precede synapsis
-
Mahadevaiah S.K., Turner J.M., Baudat F., Rogakou E.P., de Boer P., Blanco-Rodriguez J., Jasin M., Keeney S., Bonner W.M., Burgoyne P.S. Recombinational DNA double-strand breaks in mice precede synapsis. Nat. Genet. 27:2001;271-276
-
(2001)
Nat. Genet
, vol.27
, pp. 271-276
-
-
Mahadevaiah, S.K.1
Turner, J.M.2
Baudat, F.3
Rogakou, E.P.4
De Boer, P.5
Blanco-Rodriguez, J.6
Jasin, M.7
Keeney, S.8
Bonner, W.M.9
Burgoyne, P.S.10
-
20
-
-
0035818990
-
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching
-
Petersen S., Casellas R., Reina-San-Martin B., Chen H.T., Difilippantonio M.J., Wilson P.C., Hanitsch L., Celeste A., Muramatsu M., Pilch D.R., Redon C., Ried T., Bonner W.M., Honjo T., Nussenzweig M.C., Nussenzweig A. AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature. 414:2001;660-665
-
(2001)
Nature
, vol.414
, pp. 660-665
-
-
Petersen, S.1
Casellas, R.2
Reina-San-Martin, B.3
Chen, H.T.4
Difilippantonio, M.J.5
Wilson, P.C.6
Hanitsch, L.7
Celeste, A.8
Muramatsu, M.9
Pilch, D.R.10
Redon, C.11
Ried, T.12
Bonner, W.M.13
Honjo, T.14
Nussenzweig, M.C.15
Nussenzweig, A.16
-
21
-
-
0034623860
-
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX
-
Chen H.T., Bhandoola A., Difilippantonio M.J., Zhu J., Brown M.J., Tai X., Rogakou E.P., Brotz T.M., Bonner W.M., Ried T., Nussenzweig A. Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX. Science. 290:2000;1962-1965
-
(2000)
Science
, vol.290
, pp. 1962-1965
-
-
Chen, H.T.1
Bhandoola, A.2
Difilippantonio, M.J.3
Zhu, J.4
Brown, M.J.5
Tai, X.6
Rogakou, E.P.7
Brotz, T.M.8
Bonner, W.M.9
Ried, T.10
Nussenzweig, A.11
-
22
-
-
0037178748
-
Interfaces between the detection, signaling, and repair of DNA damage
-
Rouse J., Jackson S.P. Interfaces between the detection, signaling, and repair of DNA damage. Science. 297:2002;547-551
-
(2002)
Science
, vol.297
, pp. 547-551
-
-
Rouse, J.1
Jackson, S.P.2
-
23
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou B.B., Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature. 408:2000;433-439
-
(2000)
Nature
, vol.408
, pp. 433-439
-
-
Zhou, B.B.1
Elledge, S.J.2
-
24
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer. 3:2003;155-168
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
25
-
-
0035253615
-
ATM and ATR: Networking cellular responses to DNA damage
-
Shiloh Y. ATM and ATR: networking cellular responses to DNA damage. Curr. Opin. Genet. Dev. 11:2001;71-77
-
(2001)
Curr. Opin. Genet. Dev.
, vol.11
, pp. 71-77
-
-
Shiloh, Y.1
-
26
-
-
0037039463
-
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization
-
Limoli C.L., Giedzinski E., Bonner W.M., Cleaver J.E. UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. Proc. Natl. Acad. Sci. U.S.A. 99:2002;233-238
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 233-238
-
-
Limoli, C.L.1
Giedzinski, E.2
Bonner, W.M.3
Cleaver, J.E.4
-
27
-
-
0035834693
-
ATM phosphorylates histone H2AX in response to DNA double-strand breaks
-
Burma S., Chen B.P., Murphy M., Kurimasa A., Chen D.J. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276:2001;42462-42467
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42462-42467
-
-
Burma, S.1
Chen, B.P.2
Murphy, M.3
Kurimasa, A.4
Chen, D.J.5
-
28
-
-
0036903037
-
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
-
Fernandez-Capetillo O., Chen H.T., Celeste A., Ward I., Romanienko P.J., Morales J.C., Naka K., Xia Z., Camerini-Otero R.D., Motoyama N., Carpenter P.B., Bonner W.M., Chen J., Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 4:2002;993-997
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 993-997
-
-
Fernandez-Capetillo, O.1
Chen, H.T.2
Celeste, A.3
Ward, I.4
Romanienko, P.J.5
Morales, J.C.6
Naka, K.7
Xia, Z.8
Camerini-Otero, R.D.9
Motoyama, N.10
Carpenter, P.B.11
Bonner, W.M.12
Chen, J.13
Nussenzweig, A.14
-
30
-
-
0037335861
-
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
-
Brown E.J., Baltimore D. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 17:2003;615-628
-
(2003)
Genes Dev.
, vol.17
, pp. 615-628
-
-
Brown, E.J.1
Baltimore, D.2
-
31
-
-
0346634937
-
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis
-
Fernandez-Capetillo O., Mahadevaiah S.K., Celeste A., Romanienko P.J., Camerini-Otero R.D., Bonner W.M., Manova K., Burgoyne P., Nussenzweig A. H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev. Cell. 4:2003;497-508
-
(2003)
Dev. Cell
, vol.4
, pp. 497-508
-
-
Fernandez-Capetillo, O.1
Mahadevaiah, S.K.2
Celeste, A.3
Romanienko, P.J.4
Camerini-Otero, R.D.5
Bonner, W.M.6
Manova, K.7
Burgoyne, P.8
Nussenzweig, A.9
-
32
-
-
0034739853
-
P53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
-
Schultz L.B., Chehab N.H., Malikzay A., Halazonetis T.D. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J. Cell Biol. 151:2000;1381-1390
-
(2000)
J. Cell Biol.
, vol.151
, pp. 1381-1390
-
-
Schultz, L.B.1
Chehab, N.H.2
Malikzay, A.3
Halazonetis, T.D.4
-
33
-
-
0037468169
-
MDC1 is required for the intra-S-phase DNA damage checkpoint
-
Goldberg M., Stucki M., Falck J., D'Amours D., Rahman D., Pappin D., Bartek J., Jackson S.P. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature. 421:2003;952-956
-
(2003)
Nature
, vol.421
, pp. 952-956
-
-
Goldberg, M.1
Stucki, M.2
Falck, J.3
D'Amours, D.4
Rahman, D.5
Pappin, D.6
Bartek, J.7
Jackson, S.P.8
-
34
-
-
0035972194
-
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways
-
Rappold I., Iwabuchi K., Date T., Chen J. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J. Cell Biol. 153:2001;613-620
-
(2001)
J. Cell Biol.
, vol.153
, pp. 613-620
-
-
Rappold, I.1
Iwabuchi, K.2
Date, T.3
Chen, J.4
-
35
-
-
0037468192
-
MDC1 is a mediator of the mammalian DNA damage checkpoint
-
Stewart G.S., Wang B., Bignell C.R., Taylor A.M., Elledge S.J. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 421:2003;961-966
-
(2003)
Nature
, vol.421
, pp. 961-966
-
-
Stewart, G.S.1
Wang, B.2
Bignell, C.R.3
Taylor, A.M.4
Elledge, S.J.5
-
36
-
-
0037468232
-
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
-
Lou Z., Minter-Dykhouse K., Wu X., Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature. 421:2003;957-961
-
(2003)
Nature
, vol.421
, pp. 957-961
-
-
Lou, Z.1
Minter-Dykhouse, K.2
Wu, X.3
Chen, J.4
-
37
-
-
0037711771
-
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
-
Celeste A., Fernandez-Capetillo O., Kruhlak M.J., Pilch D.R., Staudt D.W., Lee A., Bonner R.F., Bonner W.M., Nussenzweig A. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat. Cell Biol. 5:2003;675-679
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 675-679
-
-
Celeste, A.1
Fernandez-Capetillo, O.2
Kruhlak, M.J.3
Pilch, D.R.4
Staudt, D.W.5
Lee, A.6
Bonner, R.F.7
Bonner, W.M.8
Nussenzweig, A.9
-
38
-
-
0038143321
-
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
-
Ward I.M., Minn K., Jorda K.G., Chen J. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J. Biol. Chem. 278:2003;19579-19582
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19579-19582
-
-
Ward, I.M.1
Minn, K.2
Jorda, K.G.3
Chen, J.4
-
39
-
-
0037012845
-
Genomic instability in mice lacking histone H2AX
-
Celeste A., Petersen S., Romanienko P.J., Fernandez-Capetillo O., Chen H.T., Sedelnikova O.A., Reina-San-Martin B., Coppola V., Meffre E., Difilippantonio M.J., Redon C., Pilch D.R., Olaru A., Eckhaus M., Camerini-Otero R.D., Tessarollo L., Livak F., Manova K., Bonner W.M., Nussenzweig M.C., Nussenzweig A. Genomic instability in mice lacking histone H2AX. Science. 296:2002;922-927
-
(2002)
Science
, vol.296
, pp. 922-927
-
-
Celeste, A.1
Petersen, S.2
Romanienko, P.J.3
Fernandez-Capetillo, O.4
Chen, H.T.5
Sedelnikova, O.A.6
Reina-San-Martin, B.7
Coppola, V.8
Meffre, E.9
Difilippantonio, M.J.10
Redon, C.11
Pilch, D.R.12
Olaru, A.13
Eckhaus, M.14
Camerini-Otero, R.D.15
Tessarollo, L.16
Livak, F.17
Manova, K.18
Bonner, W.M.19
Nussenzweig, M.C.20
Nussenzweig, A.21
more..
-
40
-
-
0037062492
-
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
-
Bassing C.H., Chua K.F., Sekiguchi J., Suh H., Whitlow S.R., Fleming J.C., Monroe B.C., Ciccone D.N., Yan C., Vlasakova K., Livingston D.M., Ferguson D.O., Scully R., Alt F.W. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc. Natl. Acad. Sci. U.S.A. 99:2002;8173-8178
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 8173-8178
-
-
Bassing, C.H.1
Chua, K.F.2
Sekiguchi, J.3
Suh, H.4
Whitlow, S.R.5
Fleming, J.C.6
Monroe, B.C.7
Ciccone, D.N.8
Yan, C.9
Vlasakova, K.10
Livingston, D.M.11
Ferguson, D.O.12
Scully, R.13
Alt, F.W.14
-
41
-
-
18644367144
-
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
-
Kobayashi J., Tauchi H., Sakamoto S., Nakamura A., Morishima K., Matsuura S., Kobayashi T., Tamai K., Tanimoto K., Komatsu K. NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain. Curr. Biol. 12:2002;1846-1851
-
(2002)
Curr. Biol.
, vol.12
, pp. 1846-1851
-
-
Kobayashi, J.1
Tauchi, H.2
Sakamoto, S.3
Nakamura, A.4
Morishima, K.5
Matsuura, S.6
Kobayashi, T.7
Tamai, K.8
Tanimoto, K.9
Komatsu, K.10
-
42
-
-
0141780833
-
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors
-
Xu X., Stern D.F. NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J. 17:2003;1842-1848
-
(2003)
FASEB J.
, vol.17
, pp. 1842-1848
-
-
Xu, X.1
Stern, D.F.2
-
43
-
-
0037341599
-
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
-
Lukas C., Falck J., Bartkova J., Bartek J., Lukas J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat. Cell Biol. 5:2003;255-260
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 255-260
-
-
Lukas, C.1
Falck, J.2
Bartkova, J.3
Bartek, J.4
Lukas, J.5
-
44
-
-
0037866984
-
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
-
Reina-San-Martin B., Difilippantonio S., Hanitsch L., Masilamani R.F., Nussenzweig A., Nussenzweig M.C. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J. Exp. Med. 197:2003;1767-1778
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1767-1778
-
-
Reina-San-Martin, B.1
Difilippantonio, S.2
Hanitsch, L.3
Masilamani, R.F.4
Nussenzweig, A.5
Nussenzweig, M.C.6
-
45
-
-
0141740426
-
Focusing on Foci: H2AX and the recruitment of DNA-damage response factors
-
Fernandez-Capetillo O., Celeste A., Nussenzweig A. Focusing on Foci: H2AX and the recruitment of DNA-damage response factors. Cell Cycle. 2:2003;426-427
-
(2003)
Cell Cycle
, vol.2
, pp. 426-427
-
-
Fernandez-Capetillo, O.1
Celeste, A.2
Nussenzweig, A.3
-
46
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:2003;499-506
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
47
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
Uziel T., Lerenthal Y., Moyal L., Andegeko Y., Mittelman L., Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 22:2003;5612-5621
-
(2003)
EMBO J.
, vol.22
, pp. 5612-5621
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
Andegeko, Y.4
Mittelman, L.5
Shiloh, Y.6
-
48
-
-
0037435418
-
Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage. Version 5
-
Friedberg E.C., Meira L.B. Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage. Version 5. DNA Repair. 2:2003;501-530
-
(2003)
DNA Repair
, vol.2
, pp. 501-530
-
-
Friedberg, E.C.1
Meira, L.B.2
-
49
-
-
0042991383
-
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility
-
Celeste A., Difilippantonio S., Difilippantonio M.J., Fernandez-Capetillo O., Pilch D.R., Sedelnikova O.A., Eckhaus M., Ried T., Bonner W.M., Nussenzweig A. H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell. 114:2003;371-383
-
(2003)
Cell
, vol.114
, pp. 371-383
-
-
Celeste, A.1
Difilippantonio, S.2
Difilippantonio, M.J.3
Fernandez-Capetillo, O.4
Pilch, D.R.5
Sedelnikova, O.A.6
Eckhaus, M.7
Ried, T.8
Bonner, W.M.9
Nussenzweig, A.10
-
50
-
-
0042991379
-
Histone H2AX. a dosage-dependent suppressor of oncogenic translocations and tumors
-
Bassing C.H., Suh H., Ferguson D.O., Chua K.F., Manis J., Eckersdorff M., Gleason M., Bronson R., Lee C., Alt F.W. Histone H2AX. A dosage-dependent suppressor of oncogenic translocations and tumors. Cell. 114:2003;359-370
-
(2003)
Cell
, vol.114
, pp. 359-370
-
-
Bassing, C.H.1
Suh, H.2
Ferguson, D.O.3
Chua, K.F.4
Manis, J.5
Eckersdorff, M.6
Gleason, M.7
Bronson, R.8
Lee, C.9
Alt, F.W.10
-
51
-
-
0034700511
-
A role for Saccharomyces cerevisiae histone H2A in DNA repair
-
Downs J.A., Lowndes N.F., Jackson S.P. A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature. 408:2000;1001-1004
-
(2000)
Nature
, vol.408
, pp. 1001-1004
-
-
Downs, J.A.1
Lowndes, N.F.2
Jackson, S.P.3
-
52
-
-
0043066728
-
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage
-
Redon C., Pilch D.R., Rogakou E.P., Orr A.H., Lowndes N.F., Bonner W.M. Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage. EMBO Rep. 4:2003;678-684
-
(2003)
EMBO Rep.
, vol.4
, pp. 678-684
-
-
Redon, C.1
Pilch, D.R.2
Rogakou, E.P.3
Orr, A.H.4
Lowndes, N.F.5
Bonner, W.M.6
-
53
-
-
0036902410
-
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
-
DiTullio R.A. Jr., Mochan T.A., Venere M., Bartkova J., Sehested M., Bartek J., Halazonetis T.D. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat. Cell Biol. 4:2002;998-1002
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 998-1002
-
-
Ditullio Jr., R.A.1
Mochan, T.A.2
Venere, M.3
Bartkova, J.4
Sehested, M.5
Bartek, J.6
Halazonetis, T.D.7
-
54
-
-
0037112212
-
53BP1, a mediator of the DNA damage checkpoint
-
Wang B., Matsuoka S., Carpenter P.B., Elledge S.J. 53BP1, a mediator of the DNA damage checkpoint. Science. 298:2002;1435-1438
-
(2002)
Science
, vol.298
, pp. 1435-1438
-
-
Wang, B.1
Matsuoka, S.2
Carpenter, P.B.3
Elledge, S.J.4
-
55
-
-
0037178761
-
Connecting chromosomes, crisis, and cancer
-
Maser R.S., DePinho R.A. Connecting chromosomes, crisis, and cancer. Science. 297:2002;565-569
-
(2002)
Science
, vol.297
, pp. 565-569
-
-
Maser, R.S.1
Depinho, R.A.2
-
56
-
-
0036566036
-
Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres
-
Espejel S., Franco S., Rodriguez-Perales S., Bouffler S.D., Cigudosa J.C., Blasco M.A. Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J. 21:2002;2207-2219
-
(2002)
EMBO J.
, vol.21
, pp. 2207-2219
-
-
Espejel, S.1
Franco, S.2
Rodriguez-Perales, S.3
Bouffler, S.D.4
Cigudosa, J.C.5
Blasco, M.A.6
-
57
-
-
0036792871
-
DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2
-
Smogorzewska A., Karlseder J., Holtgreve-Grez H., Jauch A., de Lange T. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr. Biol. 12:2002;1635-1644
-
(2002)
Curr. Biol.
, vol.12
, pp. 1635-1644
-
-
Smogorzewska, A.1
Karlseder, J.2
Holtgreve-Grez, H.3
Jauch, A.4
De Lange, T.5
-
58
-
-
0035854362
-
The single-end invasion: An asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination
-
Hunter N., Kleckner N. The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination. Cell. 106:2001;59-70
-
(2001)
Cell
, vol.106
, pp. 59-70
-
-
Hunter, N.1
Kleckner, N.2
-
59
-
-
0016164149
-
The behavior of the XY pair in mammals
-
Solari A.J. The behavior of the XY pair in mammals. Int. Rev. Cytol. 38:1974;273-317
-
(1974)
Int. Rev. Cytol.
, vol.38
, pp. 273-317
-
-
Solari, A.J.1
-
60
-
-
0034989039
-
How do meiotic chromosomes meet their homologous partners?: Lessons from fission yeast
-
Yamamoto A., Hiraoka Y. How do meiotic chromosomes meet their homologous partners?: lessons from fission yeast. Bioessays. 23:2001;526-533
-
(2001)
Bioessays
, vol.23
, pp. 526-533
-
-
Yamamoto, A.1
Hiraoka, Y.2
-
62
-
-
0025607289
-
The initiation of meiotic chromosome pairing: The cytological view
-
Loidl J. The initiation of meiotic chromosome pairing: the cytological view. Genome. 33:1990;759-778
-
(1990)
Genome
, vol.33
, pp. 759-778
-
-
Loidl, J.1
-
63
-
-
0033000784
-
Atm inactivation results in aberrant telomere clustering during meiotic prophase
-
Pandita T.K., Westphal C.H., Anger M., Sawant S.G., Geard C.R., Pandita R.K., Scherthan H. Atm inactivation results in aberrant telomere clustering during meiotic prophase. Mol. Cell Biol. 19:1999;5096-5105
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 5096-5105
-
-
Pandita, T.K.1
Westphal, C.H.2
Anger, M.3
Sawant, S.G.4
Geard, C.R.5
Pandita, R.K.6
Scherthan, H.7
-
64
-
-
0030932869
-
Gatekeepers and caretakers
-
Kinzler K.W., Vogelstein B. Gatekeepers and caretakers. Nature. 386:1997;761-763
-
(1997)
Nature
, vol.386
, pp. 761-763
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
65
-
-
0034094425
-
The RAG proteins and V(D)J recombination: Complexes, ends, and transposition
-
Fugmann S.D., Lee A.I., Shockett P.E., Villey I.J., Schatz D.G. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu. Rev. Immunol. 18:2000;495-527
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 495-527
-
-
Fugmann, S.D.1
Lee, A.I.2
Shockett, P.E.3
Villey, I.J.4
Schatz, D.G.5
-
66
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 102:2000;553-563
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
Kinoshita, K.2
Fagarasan, S.3
Yamada, S.4
Shinkai, Y.5
Honjo, T.6
-
67
-
-
0034264851
-
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
-
Revy P., Muto T., Levy Y., Geissmann F., Plebani A., Sanal O., Catalan N., Forveille M., Dufourcq-Labelouse R., Gennery A., Tezcan I., Ersoy F., Kayserili H., Ugazio A.G., Brousse N., Muramatsu M., Notarangelo L.D., Kinoshita K., Honjo T., Fischer A., Durandy A. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell. 102:2000;565-575
-
(2000)
Cell
, vol.102
, pp. 565-575
-
-
Revy, P.1
Muto, T.2
Levy, Y.3
Geissmann, F.4
Plebani, A.5
Sanal, O.6
Catalan, N.7
Forveille, M.8
Dufourcq-Labelouse, R.9
Gennery, A.10
Tezcan, I.11
Ersoy, F.12
Kayserili, H.13
Ugazio, A.G.14
Brousse, N.15
Muramatsu, M.16
Notarangelo, L.D.17
Kinoshita, K.18
Honjo, T.19
Fischer, A.20
Durandy, A.21
more..
-
68
-
-
0032522564
-
Ku80 is required for immunoglobulin isotype switching
-
Casellas R., Nussenzweig A., Wuerffel R., Pelanda R., Reichlin A., Suh H., Qin X.F., Besmer E., Kenter A., Rajewsky K., Nussenzweig M.C. Ku80 is required for immunoglobulin isotype switching. EMBO J. 17:1998;2404-2411
-
(1998)
EMBO J.
, vol.17
, pp. 2404-2411
-
-
Casellas, R.1
Nussenzweig, A.2
Wuerffel, R.3
Pelanda, R.4
Reichlin, A.5
Suh, H.6
Qin, X.F.7
Besmer, E.8
Kenter, A.9
Rajewsky, K.10
Nussenzweig, M.C.11
-
69
-
-
0032526290
-
Ku70 is required for late B cell development and immunoglobulin heavy chain class switching
-
Manis J.P., Gu Y., Lansford R., Sonoda E., Ferrini R., Davidson L., Rajewsky K., Alt F.W. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J. Exp. Med. 187:1998;2081-2089
-
(1998)
J. Exp. Med.
, vol.187
, pp. 2081-2089
-
-
Manis, J.P.1
Gu, Y.2
Lansford, R.3
Sonoda, E.4
Ferrini, R.5
Davidson, L.6
Rajewsky, K.7
Alt, F.W.8
-
70
-
-
0037011116
-
DNA-dependent protein kinase activity is not required for immunoglobulin class switching
-
Bosma G.C., Kim J., Urich T., Fath D.M., Cotticelli M.G., Ruetsch N.R., Radic M.Z., Bosma M.J. DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J. Exp. Med. 196:2002;1483-1495
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1483-1495
-
-
Bosma, G.C.1
Kim, J.2
Urich, T.3
Fath, D.M.4
Cotticelli, M.G.5
Ruetsch, N.R.6
Radic, M.Z.7
Bosma, M.J.8
-
71
-
-
0036224604
-
IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells
-
Manis J.P., Dudley D., Kaylor L., Alt F.W. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity. 16:2002;607-617
-
(2002)
Immunity
, vol.16
, pp. 607-617
-
-
Manis, J.P.1
Dudley, D.2
Kaylor, L.3
Alt, F.W.4
-
72
-
-
0029844048
-
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
-
Xu Y., Ashley T., Brainerd E.E., Bronson R.T., Meyn M.S., Baltimore D. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10:1996;2411-2422
-
(1996)
Genes Dev.
, vol.10
, pp. 2411-2422
-
-
Xu, Y.1
Ashley, T.2
Brainerd, E.E.3
Bronson, R.T.4
Meyn, M.S.5
Baltimore, D.6
-
73
-
-
0032084698
-
Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
-
Hiom K., Gellert M. Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination. Mol. Cell. 1:1998;1011-1019
-
(1998)
Mol. Cell
, vol.1
, pp. 1011-1019
-
-
Hiom, K.1
Gellert, M.2
-
74
-
-
0030887862
-
RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
-
Agrawal A., Schatz D.G. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell. 89:1997;43-53
-
(1997)
Cell
, vol.89
, pp. 43-53
-
-
Agrawal, A.1
Schatz, D.G.2
-
75
-
-
0035035480
-
11q deletions in hematological malignancies
-
Monni O., Knuutila S. 11q deletions in hematological malignancies. Leuk. Lymphoma. 40:2001;259-266
-
(2001)
Leuk. Lymphoma
, vol.40
, pp. 259-266
-
-
Monni, O.1
Knuutila, S.2
-
76
-
-
0036020959
-
ATM mutations in sporadic lymphoid tumours
-
Stankovi T., Stewart G.S., Byrd P., Fegan C., Moss P.A., Taylor A.M. ATM mutations in sporadic lymphoid tumours. Leuk. Lymphoma. 43:2002;1563-1571
-
(2002)
Leuk. Lymphoma
, vol.43
, pp. 1563-1571
-
-
Stankovi, T.1
Stewart, G.S.2
Byrd, P.3
Fegan, C.4
Moss, P.A.5
Taylor, A.M.6
-
77
-
-
0037387904
-
Absence of constitutional H2AX gene mutations in 101 hereditary breast cancer families
-
Monteiro A.N., Zhang S., Phelan C.M., Narod S.A. Absence of constitutional H2AX gene mutations in 101 hereditary breast cancer families. J. Med. Genet. 40:2003;e51
-
(2003)
J. Med. Genet.
, vol.40
, pp. 51
-
-
Monteiro, A.N.1
Zhang, S.2
Phelan, C.M.3
Narod, S.A.4
|