-
1
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou, B.B., and S.J. Elledge. 2000. The DNA damage response: putting checkpoints in perspective. Nature. 408:433-439.
-
(2000)
Nature
, vol.408
, pp. 433-439
-
-
Zhou, B.B.1
Elledge, S.J.2
-
2
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh, Y. 2003. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer. 3:155-168.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
3
-
-
0037178748
-
Interfaces between the detection, signaling, and repair of DNA damage
-
Rouse, J., and S.P. Jackson. 2002. Interfaces between the detection, signaling, and repair of DNA damage. Science. 297:547-551.
-
(2002)
Science
, vol.297
, pp. 547-551
-
-
Rouse, J.1
Jackson, S.P.2
-
4
-
-
33845604556
-
DNA double-strand break repair: All's well that ends well
-
Wyman, C., and R. Kanaar. 2006. DNA double-strand break repair: all's well that ends well. Annu. Rev. Genet. 40:363-383.
-
(2006)
Annu. Rev. Genet
, vol.40
, pp. 363-383
-
-
Wyman, C.1
Kanaar, R.2
-
5
-
-
3242891189
-
The Mre11 complex and the metabolism of chromosome breaks: The importance of communicating and holding things together
-
Stracker, T.H., J.W. Theunissen, M. Morales, and J.H. Petrini. 2004. The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair(Amst.). 3:845-854.
-
(2004)
DNA Repair(Amst.)
, vol.3
, pp. 845-854
-
-
Stracker, T.H.1
Theunissen, J.W.2
Morales, M.3
Petrini, J.H.4
-
6
-
-
0036276388
-
The Mre11 complex: At the crossroads of dna repair and checkpoint signalling
-
D'Amours, D., and S.P. Jackson. 2002. The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat. Rev. Mol. Cell Biol. 3:317-327.
-
(2002)
Nat. Rev. Mol. Cell Biol
, vol.3
, pp. 317-327
-
-
D'Amours, D.1
Jackson, S.P.2
-
7
-
-
0030764691
-
hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
-
Maser, R.S., K.J. Monsen, B.E. Nelms, and J.H. Petrini. 1997. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol. Cell. Biol. 17:6087-6096.
-
(1997)
Mol. Cell. Biol
, vol.17
, pp. 6087-6096
-
-
Maser, R.S.1
Monsen, K.J.2
Nelms, B.E.3
Petrini, J.H.4
-
8
-
-
0032562595
-
In situ visualization of DNA double-strand break repair in human fibroblasts
-
Nelms, B.E., R.S. Maser, J.F. MacKay, M.G. Lagally, and J.H. Petrini. 1998. In situ visualization of DNA double-strand break repair in human fibroblasts. Science. 280:590-592.
-
(1998)
Science
, vol.280
, pp. 590-592
-
-
Nelms, B.E.1
Maser, R.S.2
MacKay, J.F.3
Lagally, M.G.4
Petrini, J.H.5
-
9
-
-
22144462810
-
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
-
Difilippantonio, S., A. Celeste, O. Fernandez-Capetillo, H.T. Chen, B. Reina San Martin, F. Van Laethem, Y.P. Yang, G.V. Petukhova, M. Eckhaus, L. Feigenbaum, et al. 2005. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat. Cell Biol. 7:675-685.
-
(2005)
Nat. Cell Biol
, vol.7
, pp. 675-685
-
-
Difilippantonio, S.1
Celeste, A.2
Fernandez-Capetillo, O.3
Chen, H.T.4
Reina San Martin, B.5
Van Laethem, F.6
Yang, Y.P.7
Petukhova, G.V.8
Eckhaus, M.9
Feigenbaum, L.10
-
10
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
Uziel, T., Y. Lerenthal, L. Moyal, Y. Andegeko, L. Mittelman, and Y. Shiloh. 2003. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 22:5612-5621.
-
(2003)
EMBO J
, vol.22
, pp. 5612-5621
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
Andegeko, Y.4
Mittelman, L.5
Shiloh, Y.6
-
11
-
-
1842431822
-
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
-
Lee, J.H., and T.T. Paull. 2004. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science. 304:93-96.
-
(2004)
Science
, vol.304
, pp. 93-96
-
-
Lee, J.H.1
Paull, T.T.2
-
12
-
-
17644409069
-
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
-
Lee, J.H., and T.T. Paull. 2005. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science. 308:551-554.
-
(2005)
Science
, vol.308
, pp. 551-554
-
-
Lee, J.H.1
Paull, T.T.2
-
13
-
-
34248579748
-
The carboxy terminus of NBS1 is required for induction of apop- tosis by the MRE11 complex
-
Stracker, T.H., M. Morales, S.S. Couto, H. Hussein, and J.H. Petrini. 2007. The carboxy terminus of NBS1 is required for induction of apop- tosis by the MRE11 complex. Nature. 447:218-221.
-
(2007)
Nature
, vol.447
, pp. 218-221
-
-
Stracker, T.H.1
Morales, M.2
Couto, S.S.3
Hussein, H.4
Petrini, J.H.5
-
14
-
-
64549160253
-
-
Difilippantonio, S, A. Celeste, M.J. Kruhlak, Y. Lee, M.J. Difilippantonio, L. Feigenbaum, S.P. J ackson, P.J. McKinnon, and A. Nussenzweig
-
Difilippantonio, S., A. Celeste, M.J. Kruhlak, Y. Lee, M.J. Difilippantonio, L. Feigenbaum, S.P. J ackson, P.J. McKinnon, and A. Nussenzweig.
-
-
-
-
15
-
-
34249048548
-
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis
-
2007. Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J. Exp. Med. 204:1003-1011.
-
(2007)
J. Exp. Med
, vol.204
, pp. 1003-1011
-
-
-
16
-
-
52949149420
-
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair
-
Williams, R.S., G. Moncalian, J.S. Williams, Y. Yamada, O. Limbo, D.S. Shin, L.M. Groocock, D. Cahill, C. Hitomi, G. Guenther, et al. 2008. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell. 135:97-109.
-
(2008)
Cell
, vol.135
, pp. 97-109
-
-
Williams, R.S.1
Moncalian, G.2
Williams, J.S.3
Yamada, Y.4
Limbo, O.5
Shin, D.S.6
Groocock, L.M.7
Cahill, D.8
Hitomi, C.9
Guenther, G.10
-
17
-
-
0035813227
-
Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy
-
Anderson, D.E., K.M. Trujillo, P. Sung, and H.P. Erickson. 2001. Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy. J. Biol. Chem. 276:37027-37033.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 37027-37033
-
-
Anderson, D.E.1
Trujillo, K.M.2
Sung, P.3
Erickson, H.P.4
-
18
-
-
0035930329
-
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
-
de Jager, M., J. van Noort, D.C. van Gent, C. Dekker, R. Kanaar, and C. Wyman. 2001. Human Rad50/Mre11 is a flexible complex that can tether DNA ends. Mol. Cell. 8:1129-1135.
-
(2001)
Mol. Cell
, vol.8
, pp. 1129-1135
-
-
de Jager, M.1
van Noort, J.2
van Gent, D.C.3
Dekker, C.4
Kanaar, R.5
Wyman, C.6
-
19
-
-
20444468899
-
The Rad50 hook domain is a critical determinant of Mre11 complex functions
-
Wiltzius, J.J., M. Hohl, J.C. Fleming, and J.H. Petrini. 2005. The Rad50 hook domain is a critical determinant of Mre11 complex functions. Nat. Struct. Mol. Biol. 12:403-407.
-
(2005)
Nat. Struct. Mol. Biol
, vol.12
, pp. 403-407
-
-
Wiltzius, J.J.1
Hohl, M.2
Fleming, J.C.3
Petrini, J.H.4
-
20
-
-
64549134670
-
-
Hopfner, K.P, L. Craig, G. Moncalian, R.A. Zinkel, T. Usui, B.A. Owen, A. Karcher, B. Henderson, J.L. Bodmer, C.T. McMurray, et al
-
Hopfner, K.P., L. Craig, G. Moncalian, R.A. Zinkel, T. Usui, B.A. Owen, A. Karcher, B. Henderson, J.L. Bodmer, C.T. McMurray, et al.
-
-
-
-
21
-
-
0036682314
-
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair
-
2002. The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature. 418:562-566.
-
(2002)
Nature
, vol.418
, pp. 562-566
-
-
-
22
-
-
24944540931
-
Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA
-
Moreno-Herrero, F., M. de Jager, N.H. Dekker, R. Kanaar, C. Wyman, and C. Dekker. 2005. Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA. Nature. 437:440-443.
-
(2005)
Nature
, vol.437
, pp. 440-443
-
-
Moreno-Herrero, F.1
de Jager, M.2
Dekker, N.H.3
Kanaar, R.4
Wyman, C.5
Dekker, C.6
-
23
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka, S., B.A. Ballif, A. Smogorzewska, E.R. McDonald III, K.E. Hurov, J. Luo, C.E. Bakalarski, Z. Zhao, N. Solimini, Y. Lerenthal, et al. 2007. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 316:1160-1166.
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald III, E.R.4
Hurov, K.E.5
Luo, J.6
Bakalarski, C.E.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
-
24
-
-
0034106722
-
ATM-dependent phosphorylation of nibrin in response to radiation exposure
-
Gatei, M., D. Young, K.M. Cerosaletti, A. Desai-Mehta, K. Spring, S. Kozlov, M.F. Lavin, R.A. Gatti, P. Concannon, and K. Khanna. 2000. ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat. Genet. 25:115-119.
-
(2000)
Nat. Genet
, vol.25
, pp. 115-119
-
-
Gatei, M.1
Young, D.2
Cerosaletti, K.M.3
Desai-Mehta, A.4
Spring, K.5
Kozlov, S.6
Lavin, M.F.7
Gatti, R.A.8
Concannon, P.9
Khanna, K.10
-
25
-
-
0034713466
-
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
-
Wu, X., V. Ranganathan, D.S. Weisman, W.F. Heine, D.N. Ciccone, T.B. O'Neill, K.E. Crick, K.A. Pierce, W.S. Lane, G. Rathbun, et al. 2000. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature. 405:477-482.
-
(2000)
Nature
, vol.405
, pp. 477-482
-
-
Wu, X.1
Ranganathan, V.2
Weisman, D.S.3
Heine, W.F.4
Ciccone, D.N.5
O'Neill, T.B.6
Crick, K.E.7
Pierce, K.A.8
Lane, W.S.9
Rathbun, G.10
-
26
-
-
0034611728
-
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
-
Lim, D.S., S.T. Kim, B. Xu, R.S. Maser, J. Lin, J.H. Petrini, and M.B. Kastan. 2000. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature. 404:613-617.
-
(2000)
Nature
, vol.404
, pp. 613-617
-
-
Lim, D.S.1
Kim, S.T.2
Xu, B.3
Maser, R.S.4
Lin, J.5
Petrini, J.H.6
Kastan, M.B.7
-
27
-
-
0036464515
-
Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction
-
Huang, J., and W.S. Dynan. 2002. Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction. Nucleic Acids Res. 30:667-674.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 667-674
-
-
Huang, J.1
Dynan, W.S.2
-
28
-
-
28544436537
-
Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11
-
Di Virgilio, M., and J. Gautier. 2005. Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J. Cell Biol. 171:765-771.
-
(2005)
J. Cell Biol
, vol.171
, pp. 765-771
-
-
Di Virgilio, M.1
Gautier, J.2
-
29
-
-
0029976325
-
Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae
-
Moore, J.K., and J.E. Haber. 1996. Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:2164-2173.
-
(1996)
Mol. Cell. Biol
, vol.16
, pp. 2164-2173
-
-
Moore, J.K.1
Haber, J.E.2
-
30
-
-
0032536861
-
Components of the Ku-depen- dent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
-
Boulton, S.J., and S.P. Jackson. 1998. Components of the Ku-depen- dent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17:1819-1828.
-
(1998)
EMBO J
, vol.17
, pp. 1819-1828
-
-
Boulton, S.J.1
Jackson, S.P.2
-
31
-
-
0035862948
-
Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe
-
Manolis, K.G., E.R. Nimmo, E. Hartsuiker, A.M. Carr, P.A. Jeggo, and R.C. Allshire. 2001. Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe. EMBO J. 20:210-221.
-
(2001)
EMBO J
, vol.20
, pp. 210-221
-
-
Manolis, K.G.1
Nimmo, E.R.2
Hartsuiker, E.3
Carr, A.M.4
Jeggo, P.A.5
Allshire, R.C.6
-
32
-
-
30444445118
-
Interplay between human DNA repair proteins at a unique double-strand break in vivo
-
Rodrigue, A., M. Lafrance, M.C. Gauthier, D. McDonald, M. Hendzel, S.C. West, M. Jasin, and J.Y. Masson. 2006. Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J. 25:222-231.
-
(2006)
EMBO J
, vol.25
, pp. 222-231
-
-
Rodrigue, A.1
Lafrance, M.2
Gauthier, M.C.3
McDonald, D.4
Hendzel, M.5
West, S.C.6
Jasin, M.7
Masson, J.Y.8
-
33
-
-
33751583362
-
Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks
-
Yang, Y.G., A. Saidi, P.O. Frappart, W. Min, C. Barrucand, V. Dumon- Jones, J. Michelon, Z. Herceg, and Z.Q. Wang. 2006. Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks. EMBO J. 25:5527-5538.
-
(2006)
EMBO J
, vol.25
, pp. 5527-5538
-
-
Yang, Y.G.1
Saidi, A.2
Frappart, P.O.3
Min, W.4
Barrucand, C.5
Dumon- Jones, V.6
Michelon, J.7
Herceg, Z.8
Wang, Z.Q.9
-
34
-
-
0020534965
-
Somatic generation of antibody diversity
-
Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature. 302:575-581
-
(1983)
Nature
, vol.302
, pp. 575-581
-
-
Tonegawa, S.1
-
35
-
-
0034738918
-
V(D)J recombination: Site-specific cleavage and repair
-
Kim, D.R., S.J. Park, and M.A. Oettinger. 2000. V(D)J recombination: site-specific cleavage and repair. Mol. Cells. 10:367-374.
-
(2000)
Mol. Cells
, vol.10
, pp. 367-374
-
-
Kim, D.R.1
Park, S.J.2
Oettinger, M.A.3
-
36
-
-
0034094425
-
The RAG proteins and V(D)J recombination: Complexes, ends, and transposition
-
Fugmann, S.D., A.I. Lee, P.E. Shockett, I.J. Villey, and D.G. Schatz. 2000. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu. Rev. Immunol. 18:495-527.
-
(2000)
Annu. Rev. Immunol
, vol.18
, pp. 495-527
-
-
Fugmann, S.D.1
Lee, A.I.2
Shockett, P.E.3
Villey, I.J.4
Schatz, D.G.5
-
38
-
-
3242887420
-
The role of the non-homologous end-joining pathway in lymphocyte development
-
Rooney, S., J. Chaudhuri, and F.W. Alt. 2004. The role of the non-homologous end-joining pathway in lymphocyte development. Immunol. Rev. 200:115-131.
-
(2004)
Immunol. Rev
, vol.200
, pp. 115-131
-
-
Rooney, S.1
Chaudhuri, J.2
Alt, F.W.3
-
39
-
-
0036240127
-
The mechanism and regulation of chromosomal V(D)J recombination
-
Bassing, C.H., W. Swat, and F.W. Alt. 2002. The mechanism and regulation of chromosomal V(D)J recombination. Cell. 109(Suppl):S45-S55.
-
(2002)
Cell
, vol.109
, Issue.SUPPL.
-
-
Bassing, C.H.1
Swat, W.2
Alt, F.W.3
-
40
-
-
0037086702
-
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
-
Kang, J., R.T. Bronson, and Y. Xu. 2002. Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J. 21:1447-1455.
-
(2002)
EMBO J
, vol.21
, pp. 1447-1455
-
-
Kang, J.1
Bronson, R.T.2
Xu, Y.3
-
41
-
-
0037117410
-
A murine model of Nijmegen breakage syndrome
-
Williams, B.R., O.K. Mirzoeva, W.F. Morgan, J. Lin, W. Dunnick, and J.H. Petrini. 2002. A murine model of Nijmegen breakage syndrome. Curr. Biol. 12:648-653.
-
(2002)
Curr. Biol
, vol.12
, pp. 648-653
-
-
Williams, B.R.1
Mirzoeva, O.K.2
Morgan, W.F.3
Lin, J.4
Dunnick, W.5
Petrini, J.H.6
-
42
-
-
0346156075
-
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ ATLD1) mice
-
Theunissen, J.W., M.I. Kaplan, P.A. Hunt, B.R. Williams, D.O. Ferguson, F.W. Alt, and J.H. Petrini. 2003. Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ ATLD1) mice. Mol. Cell. 12:1511-1523.
-
(2003)
Mol. Cell
, vol.12
, pp. 1511-1523
-
-
Theunissen, J.W.1
Kaplan, M.I.2
Hunt, P.A.3
Williams, B.R.4
Ferguson, D.O.5
Alt, F.W.6
Petrini, J.H.7
-
43
-
-
3242892589
-
Nijmegen breakage syndrome: Clinical manifestation of defective response to DNA double-strand breaks
-
Digweed, M., and K. Sperling. 2004. Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks. DNA Repair(Amst.). 3:1207-1217.
-
(2004)
DNA Repair(Amst.)
, vol.3
, pp. 1207-1217
-
-
Digweed, M.1
Sperling, K.2
-
44
-
-
3242889151
-
Ataxia-telangiectasia- like disorder(ATLD)-its clinical presentation and molecular basis
-
Taylor, A.M., A. Groom, and P.J. Byrd. 2004. Ataxia-telangiectasia- like disorder(ATLD)-its clinical presentation and molecular basis. DNA Repair(Amst.). 3:1219-1225.
-
(2004)
DNA Repair(Amst.)
, vol.3
, pp. 1219-1225
-
-
Taylor, A.M.1
Groom, A.2
Byrd, P.J.3
-
45
-
-
0033594904
-
Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
-
Luo, G., M.S. Yao, C.F. Bender, M. Mills, A.R. Bladl, A. Bradley, and J.H. Petrini. 1999. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc. Natl. Acad. Sci. USA. 96:7376-7381.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7376-7381
-
-
Luo, G.1
Yao, M.S.2
Bender, C.F.3
Mills, M.4
Bladl, A.R.5
Bradley, A.6
Petrini, J.H.7
-
46
-
-
0030749867
-
Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
-
Xiao, Y., and D.T. Weaver. 1997. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 25:2985-2991.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 2985-2991
-
-
Xiao, Y.1
Weaver, D.T.2
-
47
-
-
0035936554
-
Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
-
Zhu, J., S. Petersen, L. Tessarollo, and A. Nussenzweig. 2001. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr. Biol. 11:105-109.
-
(2001)
Curr. Biol
, vol.11
, pp. 105-109
-
-
Zhu, J.1
Petersen, S.2
Tessarollo, L.3
Nussenzweig, A.4
-
48
-
-
34250374139
-
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes
-
Huang, C.Y., G.G. Sharma, L.M. Walker, C.H. Bassing, T.K. Pandita, and B.P. Sleckman. 2007. Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes. J. Exp. Med. 204:1371-1381.
-
(2007)
J. Exp. Med
, vol.204
, pp. 1371-1381
-
-
Huang, C.Y.1
Sharma, G.G.2
Walker, L.M.3
Bassing, C.H.4
Pandita, T.K.5
Sleckman, B.P.6
-
49
-
-
34447093903
-
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes
-
Callen, E., M. Jankovic, S. Difilippantonio, J.A. Daniel, H.T. Chen, A. Celeste, M. Pellegrini, K. McBride, D. Wangsa, A.L. Bredemeyer, et al. 2007. ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell. 130:63-75.
-
(2007)
Cell
, vol.130
, pp. 63-75
-
-
Callen, E.1
Jankovic, M.2
Difilippantonio, S.3
Daniel, J.A.4
Chen, H.T.5
Celeste, A.6
Pellegrini, M.7
McBride, K.8
Wangsa, D.9
Bredemeyer, A.L.10
-
50
-
-
57649114834
-
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes
-
Bredemeyer, A.L., B.A. Helmink, C.L. Innes, B. Calderon, L.M. McGinnis, G.K. Mahowald, E.J. Gapud, L.M. Walker, J.B. Collins, B.K. Weaver, et al. 2008. DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature. 456:819-823.
-
(2008)
Nature
, vol.456
, pp. 819-823
-
-
Bredemeyer, A.L.1
Helmink, B.A.2
Innes, C.L.3
Calderon, B.4
McGinnis, L.M.5
Mahowald, G.K.6
Gapud, E.J.7
Walker, L.M.8
Collins, J.B.9
Weaver, B.K.10
-
51
-
-
53149091313
-
Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining
-
Bredemeyer, A.L., C.Y. Huang, L.M. Walker, C.H. Bassing, and B.P. Sleckman. 2008. Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining. J. Immunol. 181:2620-2625.
-
(2008)
J. Immunol
, vol.181
, pp. 2620-2625
-
-
Bredemeyer, A.L.1
Huang, C.Y.2
Walker, L.M.3
Bassing, C.H.4
Sleckman, B.P.5
-
52
-
-
33747097562
-
ATM stabilizes DNA double-strand- break complexes during V(D)J recombination
-
Bredemeyer, A.L., G.G. Sharma, C.Y. Huang, B.A. Helmink, L.M. Walker, K.C. Khor, B. Nuskey, K.E. Sullivan, T.K. Pandita, C.H. Bassing, and B.P. Sleckman. 2006. ATM stabilizes DNA double-strand- break complexes during V(D)J recombination. Nature. 442:466-470.
-
(2006)
Nature
, vol.442
, pp. 466-470
-
-
Bredemeyer, A.L.1
Sharma, G.G.2
Huang, C.Y.3
Helmink, B.A.4
Walker, L.M.5
Khor, K.C.6
Nuskey, B.7
Sullivan, K.E.8
Pandita, T.K.9
Bassing, C.H.10
Sleckman, B.P.11
-
53
-
-
34447106461
-
ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor {alpha} locus coding end breaks
-
Vacchio, M.S., A. Olaru, F. Livak, and R.J. Hodes. 2007. ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor {alpha} locus coding end breaks. Proc. Natl. Acad. Sci. USA. 104:6323-6328.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 6323-6328
-
-
Vacchio, M.S.1
Olaru, A.2
Livak, F.3
Hodes, R.J.4
-
55
-
-
0037080679
-
Sensing of intermediates in V(D)J recombination by ATM
-
Perkins, E.J., A. Nair, D.O. Cowley, T. Van Dyke, Y. Chang, and D.A. Ramsden. 2002. Sensing of intermediates in V(D)J recombination by ATM. Genes Dev. 16:159-164.
-
(2002)
Genes Dev
, vol.16
, pp. 159-164
-
-
Perkins, E.J.1
Nair, A.2
Cowley, D.O.3
Van Dyke, T.4
Chang, Y.5
Ramsden, D.A.6
-
56
-
-
0034623860
-
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX
-
Chen, H.T., A. Bhandoola, M.J. Difilippantonio, J. Zhu, M.J. Brown, X. Tai, E.P. Rogakou, T.M. Brotz, W.M. Bonner, T. Ried, and A. Nussenzweig. 2000. Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX. Science. 290:1962-1965.
-
(2000)
Science
, vol.290
, pp. 1962-1965
-
-
Chen, H.T.1
Bhandoola, A.2
Difilippantonio, M.J.3
Zhu, J.4
Brown, M.J.5
Tai, X.6
Rogakou, E.P.7
Brotz, T.M.8
Bonner, W.M.9
Ried, T.10
Nussenzweig, A.11
-
57
-
-
20144369145
-
The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast
-
Clatworthy, A.E., M.A. Valencia-Burton, J.E. Haber, and M.A. Oettinger. 2005. The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast. J. Biol. Chem. 280:20247-20252.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 20247-20252
-
-
Clatworthy, A.E.1
Valencia-Burton, M.A.2
Haber, J.E.3
Oettinger, M.A.4
-
58
-
-
0035085624
-
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome
-
Harfst, E., S. Cooper, S. Neubauer, L. Distel, and U. Grawunder. 2000. Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome. Mol. Immunol. 37:915-929.
-
(2000)
Mol. Immunol
, vol.37
, pp. 915-929
-
-
Harfst, E.1
Cooper, S.2
Neubauer, S.3
Distel, L.4
Grawunder, U.5
-
59
-
-
34250200743
-
Defective signal joint recombination in fanconi anemia fibro-blasts reveals a role for Rad50 in V(D)J recombination
-
Donahue, S.L., A.A. Tabah, K. Schmitz, A. Aaron, and C. Campbell. 2007. Defective signal joint recombination in fanconi anemia fibro-blasts reveals a role for Rad50 in V(D)J recombination. J. Mol. Biol. 370:449-458.
-
(2007)
J. Mol. Biol
, vol.370
, pp. 449-458
-
-
Donahue, S.L.1
Tabah, A.A.2
Schmitz, K.3
Aaron, A.4
Campbell, C.5
-
60
-
-
52949109260
-
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation
-
Buis, J., Y. Wu, Y. Deng, J. Leddon, G. Westfield, M. Eckersdorff, J.M. Sekiguchi, S. Chang, and D.O. Ferguson. 2008. Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell. 135:85-96.
-
(2008)
Cell
, vol.135
, pp. 85-96
-
-
Buis, J.1
Wu, Y.2
Deng, Y.3
Leddon, J.4
Westfield, G.5
Eckersdorff, M.6
Sekiguchi, J.M.7
Chang, S.8
Ferguson, D.O.9
-
61
-
-
0037232230
-
A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines
-
Muljo, S.A., and M.S. Schlissel. 2003. A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat. Immunol. 4:31-37.
-
(2003)
Nat. Immunol
, vol.4
, pp. 31-37
-
-
Muljo, S.A.1
Schlissel, M.S.2
-
62
-
-
0024286288
-
Unusual immunoglobulin gene rearrangement leads to replacement of recombi- national signal sequences
-
Morzycka-Wroblewska, E., F.E. Lee, and S.V. Desiderio. 1988. Unusual immunoglobulin gene rearrangement leads to replacement of recombi- national signal sequences. Science. 242:261-263.
-
(1988)
Science
, vol.242
, pp. 261-263
-
-
Morzycka-Wroblewska, E.1
Lee, F.E.2
Desiderio, S.V.3
-
63
-
-
0024255703
-
Novel strand exchanges in V(D)J recombination
-
Lewis, S.M., J.E. Hesse, K. Mizuuchi, and M. Gellert. 1988. Novel strand exchanges in V(D)J recombination. Cell. 55:1099-1107.
-
(1988)
Cell
, vol.55
, pp. 1099-1107
-
-
Lewis, S.M.1
Hesse, J.E.2
Mizuuchi, K.3
Gellert, M.4
-
64
-
-
0037155703
-
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
-
Ma, Y., U. Pannicke, K. Schwarz, and M.R. Lieber. 2002. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell. 108:781-794.
-
(2002)
Cell
, vol.108
, pp. 781-794
-
-
Ma, Y.1
Pannicke, U.2
Schwarz, K.3
Lieber, M.R.4
-
65
-
-
33746601439
-
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
-
Ziv, Y., D. Bielopolski, Y. Galanty, C. Lukas, Y. Taya, D.C. Schultz, J. Lukas, S. Bekker-Jensen, J. Bartek, and Y. Shiloh. 2006. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat. Cell Biol. 8:870-876.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 870-876
-
-
Ziv, Y.1
Bielopolski, D.2
Galanty, Y.3
Lukas, C.4
Taya, Y.5
Schultz, D.C.6
Lukas, J.7
Bekker-Jensen, S.8
Bartek, J.9
Shiloh, Y.10
-
66
-
-
12944328742
-
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice
-
Borghesani, P.R., F.W. Alt, A. Bottaro, L. Davidson, S. Aksoy, G.A. Rathbun, T.M. Roberts, W. Swat, R.A. Segal, and Y. Gu. 2000. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc. Natl. Acad. Sci. USA. 97:3336-3341.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 3336-3341
-
-
Borghesani, P.R.1
Alt, F.W.2
Bottaro, A.3
Davidson, L.4
Aksoy, S.5
Rathbun, G.A.6
Roberts, T.M.7
Swat, W.8
Segal, R.A.9
Gu, Y.10
-
67
-
-
26444469505
-
Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development
-
Huang, C.Y., B.P. Sleckman, and O. Kanagawa. 2005. Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development. Proc. Natl. Acad. Sci. USA. 102:14356-14361.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 14356-14361
-
-
Huang, C.Y.1
Sleckman, B.P.2
Kanagawa, O.3
-
68
-
-
0000858524
-
V(D)J rearrangement in Nijmegen breakage syndrome
-
Yeo, T.C., D. Xia, S. Hassouneh, X.O. Yang, D.E. Sabath, K. Sperling, R.A. Gatti, P. Concannon, and D.M. Willerford. 2000. V(D)J rearrangement in Nijmegen breakage syndrome. Mol. Immunol. 37:1131-1139.
-
(2000)
Mol. Immunol
, vol.37
, pp. 1131-1139
-
-
Yeo, T.C.1
Xia, D.2
Hassouneh, S.3
Yang, X.O.4
Sabath, D.E.5
Sperling, K.6
Gatti, R.A.7
Concannon, P.8
Willerford, D.M.9
-
69
-
-
0027304013
-
V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associ- ated immunodeficiency disorder
-
Hsieh, C.L., C.F. Arlett, and M.R. Lieber. 1993. V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associ- ated immunodeficiency disorder. J. Biol. Chem. 268:20105-20109.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 20105-20109
-
-
Hsieh, C.L.1
Arlett, C.F.2
Lieber, M.R.3
-
70
-
-
49349083288
-
Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination
-
Li, G., F.W. Alt, H.L. Cheng, J.W. Brush, P.H. Goff, M.M. Murphy, S. Franco, Y. Zhang, and S. Zha. 2008. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol. Cell. 31:631-640.
-
(2008)
Mol. Cell
, vol.31
, pp. 631-640
-
-
Li, G.1
Alt, F.W.2
Cheng, H.L.3
Brush, J.W.4
Goff, P.H.5
Murphy, M.M.6
Franco, S.7
Zhang, Y.8
Zha, S.9
-
71
-
-
15844426692
-
Atm-deficient mice: A paradigm of ataxia telangiectasia
-
Barlow, C., S. Hirotsune, R. Paylor, M. Liyanage, M. Eckhaus, F. Collins, Y. Shiloh, J.N. Crawley, T. Ried, D. Tagle, and A. Wynshaw- Boris. 1996. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell. 86:159-171.
-
(1996)
Cell
, vol.86
, pp. 159-171
-
-
Barlow, C.1
Hirotsune, S.2
Paylor, R.3
Liyanage, M.4
Eckhaus, M.5
Collins, F.6
Shiloh, Y.7
Crawley, J.N.8
Ried, T.9
Tagle, D.10
Wynshaw- Boris, A.11
-
72
-
-
0036932453
-
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice
-
Rooney, S., J. Sekiguchi, C. Zhu, H.L. Cheng, J. Manis, S. Whitlow, J. DeVido, D. Foy, J. Chaudhuri, D. Lombard, and F.W. Alt. 2002. Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol. Cell. 10:1379-1390.
-
(2002)
Mol. Cell
, vol.10
, pp. 1379-1390
-
-
Rooney, S.1
Sekiguchi, J.2
Zhu, C.3
Cheng, H.L.4
Manis, J.5
Whitlow, S.6
DeVido, J.7
Foy, D.8
Chaudhuri, J.9
Lombard, D.10
Alt, F.W.11
-
73
-
-
0025786164
-
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
-
Strasser, A., A.W. Harris, and S. Cory. 1991. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell. 67:889-899.
-
(1991)
Cell
, vol.67
, pp. 889-899
-
-
Strasser, A.1
Harris, A.W.2
Cory, S.3
-
74
-
-
33644555829
-
Mammalian Rad9 plays a role in telomere stability, S- and G2- phase-specific cell survival, and homologous recombinational repair
-
Pandita, R.K., G.G. Sharma, A. Laszlo, K.M. Hopkins, S. Davey, M. Chakhparonian, A. Gupta, R.J. Wellinger, J. Zhang, S.N. Powell, et al. 2006. Mammalian Rad9 plays a role in telomere stability, S- and G2- phase-specific cell survival, and homologous recombinational repair. Mol. Cell. Biol. 26:1850-1864.
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 1850-1864
-
-
Pandita, R.K.1
Sharma, G.G.2
Laszlo, A.3
Hopkins, K.M.4
Davey, S.5
Chakhparonian, M.6
Gupta, A.7
Wellinger, R.J.8
Zhang, J.9
Powell, S.N.10
-
75
-
-
34248158282
-
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status
-
Hunt, C.R., R.K. Pandita, A. Laszlo, R. Higashikubo, M. Agarwal, T. Kitamura, A. Gupta, N. Rief, N. Horikoshi, R. Baskaran, et al. 2007. Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res. 67:3010-3017.
-
(2007)
Cancer Res
, vol.67
, pp. 3010-3017
-
-
Hunt, C.R.1
Pandita, R.K.2
Laszlo, A.3
Higashikubo, R.4
Agarwal, M.5
Kitamura, T.6
Gupta, A.7
Rief, N.8
Horikoshi, N.9
Baskaran, R.10
|