Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 11, 2007, Pages 4518-4523

  Zha, Shan ^a   Alt, Frederick W ^a   Cheng, Hwei Ling ^a   Brush, James W ^a   Li, Gang ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Nonhomologous DNA end joining; Severe combined immunodeficiency; V(D)J recombination

Indexed keywords

DOUBLE STRANDED DNA; GENE PRODUCT; PROTEIN CERNUNNOS XLF; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; RECOMBINASE; XLF PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CERNUNNOS XLF GENE; COMBINED IMMUNODEFICIENCY; DNA REPAIR; DNA STRAND BREAKAGE; EMBRYONIC STEM CELL; EXON; GENE; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; GENETIC RECOMBINATION; GENOMIC INSTABILITY; IONIZING RADIATION; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RADIOSENSITIVITY; ALLELE; ANIMAL; CELL LINE; CYTOLOGY; DNA DAMAGE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENETICS; LYMPHOCYTE; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

MAMMALIA; MURINAE; MUS;

ALLELES; ANIMALS; CELL LINE; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; EXONS; GENE DELETION; GENOMIC INSTABILITY; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; MICE; PROTEIN STRUCTURE, TERTIARY; RECOMBINATION, GENETIC; VDJ RECOMBINASES;

EID: 34248400443     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0611734104     Document Type: Article

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