Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination

Journal of Experimental Medicine

Volumn 206, Issue 12, 2009, Pages 2625-2639

  Yin, Bu ^a,b,c   Savic, Velibor ^a,b,c   Juntilla, Marisa M ^a,b   Bredemeyer, Andrea L ^d   Yang Iott, Katherine S ^b,c   Helmink, Beth A ^d   Koretzky, Gary A ^a,b   Sleckman, Barry P ^d   Bassing, Craig H ^a,b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENDONUCLEASE; ENDONUCLEASE RAG; HISTONE H2AX; IMMUNOGLOBULIN KAPPA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; UNCLASSIFIED DRUG; ATR PROTEIN, MOUSE; CELL CYCLE PROTEIN; H2AX PROTEIN, MOUSE; HISTONE; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DISSOCIATION; DNA RECOMBINATION; DNA STRAND; GENE LOCUS; GENE TRANSLOCATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; THYMOCYTE; VDJ EXON; ANIMAL; B LYMPHOCYTE; CELL LINE; CHROMATIN; DOUBLE STRANDED DNA BREAK; GENETIC RECOMBINATION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY; QUANTITATIVE TRAIT LOCUS;

ANIMALS; B-LYMPHOCYTES; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CHROMATIN; CHROMOSOME BREAKAGE; DNA BREAKS, DOUBLE-STRANDED; G1 PHASE; HISTONES; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; QUANTITATIVE TRAIT LOCI; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINATION, GENETIC; VDJ EXONS;

EID: 73349135369     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20091320     Document Type: Article

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