-
1
-
-
0035289717
-
Chromosomal stability and the DNA double-stranded break connection
-
van Gent, D.C., Hoeijmakers, J.H. & Kanaar, R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2, 196-206 (2001).
-
(2001)
Nat. Rev. Genet.
, vol.2
, pp. 196-206
-
-
van Gent, D.C.1
Hoeijmakers, J.H.2
Kanaar, R.3
-
2
-
-
0037660900
-
The role of DNA breaks in genomic instability and tumorigenesis
-
Mills, K.D., Ferguson, D.O. & Alt, F.W. The role of DNA breaks in genomic instability and tumorigenesis. Immunol. Rev. 194, 77-95 (2003).
-
(2003)
Immunol. Rev.
, vol.194
, pp. 77-95
-
-
Mills, K.D.1
Ferguson, D.O.2
Alt, F.W.3
-
3
-
-
0036261707
-
Sensing and repairing DNA double-strand breaks
-
Jackson, S.P. Sensing and repairing DNA double-strand breaks. Carcinogenesis 23, 687-696 (2002).
-
(2002)
Carcinogenesis
, vol.23
, pp. 687-696
-
-
Jackson, S.P.1
-
4
-
-
0036240127
-
The mechanism and regulation of chromosomal V(D)J recombination
-
Bassing, C.H., Swat, W. & Alt, F.W. The mechanism and regulation of chromosomal V(D)J recombination. Cell 109, S45-S55 (2002).
-
(2002)
Cell
, vol.109
-
-
Bassing, C.H.1
Swat, W.2
Alt, F.W.3
-
5
-
-
0036152242
-
Mechanism and control of class-switch recombination
-
Manis, J.P., Tian, M. & Alt, F.W. Mechanism and control of class-switch recombination. Trends Immunol. 23, 31-39 (2002).
-
(2002)
Trends Immunol.
, vol.23
, pp. 31-39
-
-
Manis, J.P.1
Tian, M.2
Alt, F.W.3
-
6
-
-
0842303307
-
Unraveling V(D)J recombination: Insights into gene regulation
-
Jung, D. & Alt, F.W. Unraveling V(D)J recombination: Insights into gene regulation. Cell 116, 299-311 (2004).
-
(2004)
Cell
, vol.116
, pp. 299-311
-
-
Jung, D.1
Alt, F.W.2
-
7
-
-
0037195272
-
Immunoglobulin genes: Generating diversity with AID and UNG
-
Storb, U. & Stavnezer, J. Immunoglobulin genes: generating diversity with AID and UNG. Curr. Biol. 12, 725-727 (2002).
-
(2002)
Curr. Biol.
, vol.12
, pp. 725-727
-
-
Storb, U.1
Stavnezer, J.2
-
8
-
-
0036234455
-
Somatic hypermutation of immunoglobulin genes: Merging mechanisms for genetic diversity
-
Papavasiliou, F.N. & Schatz, D.G. Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell 109, S35-44 (2002).
-
(2002)
Cell
, vol.109
-
-
Papavasiliou, F.N.1
Schatz, D.G.2
-
9
-
-
0034264851
-
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)
-
Revy, P. et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 102, 565-575 (2000).
-
(2000)
Cell
, vol.102
, pp. 565-575
-
-
Revy, P.1
-
10
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-563 (2000).
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
-
11
-
-
0037452080
-
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
-
Chaudhuri, J. et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422, 726-730 (2003).
-
(2003)
Nature
, vol.422
, pp. 726-730
-
-
Chaudhuri, J.1
-
12
-
-
0038293484
-
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
-
Ramiro, A.R., Stavropoulos, P., Jankovic, M. & Nussenzweig, M.C. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4, 452-456 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, pp. 452-456
-
-
Ramiro, A.R.1
Stavropoulos, P.2
Jankovic, M.3
Nussenzweig, M.C.4
-
13
-
-
0037388165
-
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
-
Bransteitter, R., Pham, P., Scharff, M.D. & Goodman, M.F. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA 100, 4102-4107 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4102-4107
-
-
Bransteitter, R.1
Pham, P.2
Scharff, M.D.3
Goodman, M.F.4
-
14
-
-
0037561998
-
AID mediates hypermutation by deaminating single stranded DNA
-
Dickerson, S.K., Market, E., Besmer, E. & Papavasiliou, F.N. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197, 1291-1296 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1291-1296
-
-
Dickerson, S.K.1
Market, E.2
Besmer, E.3
Papavasiliou, F.N.4
-
15
-
-
0038713344
-
Immunity through DNA deamination
-
Neuberger, M.S., Harris, R.S., Di Noia, J. & Petersen-Mahrt, S.K. Immunity through DNA deamination. Trends Biochem. Sci. 28, 305-312 (2003).
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 305-312
-
-
Neuberger, M.S.1
Harris, R.S.2
Di Noia, J.3
Petersen-Mahrt, S.K.4
-
16
-
-
0347758541
-
The generation of antibody diversity through somatic hypermutation and class switch recombination
-
Li, Z., Woo, C.J., Iglesias-Ussel, M.D., Ronai, D. & Scharff, M.D. The generation of antibody diversity through somatic hypermutation and class switch recombination. Genes Dev. 18, 1-11 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 1-11
-
-
Li, Z.1
Woo, C.J.2
Iglesias-Ussel, M.D.3
Ronai, D.4
Scharff, M.D.5
-
17
-
-
0037029631
-
The function of AID in somatic mutation and class switch recombination: Upstream or downstream of DNA breaks
-
Chua, K.F., Alt, F.W. & Manis, J.P. The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks. J. Exp. Med. 195, F37-41 (2002).
-
(2002)
J. Exp. Med.
, vol.195
-
-
Chua, K.F.1
Alt, F.W.2
Manis, J.P.3
-
18
-
-
0037625159
-
What role for AID: Mutator, or assembler of the immunoglobulin mutasome?
-
Reynaud, C.A., Aoufouchi, S., Faili, A. & Weill, J.C. What role for AID: mutator, or assembler of the immunoglobulin mutasome? Nat. Immunol. 4, 631-638 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, pp. 631-638
-
-
Reynaud, C.A.1
Aoufouchi, S.2
Faili, A.3
Weill, J.C.4
-
19
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou, B.B. & Elledge, S.J. The DNA damage response: putting checkpoints in perspective. Nature 408, 433-439 (2000).
-
(2000)
Nature
, vol.408
, pp. 433-439
-
-
Zhou, B.B.1
Elledge, S.J.2
-
20
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham, R.T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
21
-
-
0035951850
-
Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1
-
Xia, Z., Morales, J.C., Dunphy, W.G. & Carpenter, P.B. Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1. J. Biol. Chem. 276, 2708-2718 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 2708-2718
-
-
Xia, Z.1
Morales, J.C.2
Dunphy, W.G.3
Carpenter, P.B.4
-
22
-
-
0034739853
-
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
-
Schultz, L.B., Chehab, N.H., Malikzay, A. & Halazonetis, T.D. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J. Cell. Biol. 151, 1381-1390 (2000).
-
(2000)
J. Cell. Biol.
, vol.151
, pp. 1381-1390
-
-
Schultz, L.B.1
Chehab, N.H.2
Malikzay, A.3
Halazonetis, T.D.4
-
23
-
-
0035134286
-
Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage
-
Anderson, L., Henderson, C. & Adachi, Y. Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage. Mol. Cell. Biol. 21, 1719-1729 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1719-1729
-
-
Anderson, L.1
Henderson, C.2
Adachi, Y.3
-
24
-
-
0035972194
-
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways
-
Rappold, I., Iwabuchi, K., Date, T. & Chen, J. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J. Cell Biol. 153, 613-620 (2001).
-
(2001)
J. Cell Biol.
, vol.153
, pp. 613-620
-
-
Rappold, I.1
Iwabuchi, K.2
Date, T.3
Chen, J.4
-
25
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou, E.P., Pilch, D.R., Orr, A.H., Ivanova, V.S. & Bonner, W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-5868 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
26
-
-
0037772381
-
Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability
-
Morales, J.C. et al. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J. Biol. Chem. 278, 14971-14977 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14971-14977
-
-
Morales, J.C.1
-
27
-
-
0037378527
-
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
-
Ward, I.M., Minn, K., van Deursen, J. & Chen, J. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol. Cell. Biol. 23, 2556-2563 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 2556-2563
-
-
Ward, I.M.1
Minn, K.2
van Deursen, J.3
Chen, J.4
-
28
-
-
0030022218
-
Antibody class switching
-
Stavnezer, J. Antibody class switching. Adv. Immunol. 61, 79-146 (1996).
-
(1996)
Adv. Immunol.
, vol.61
, pp. 79-146
-
-
Stavnezer, J.1
-
29
-
-
0027169028
-
DNA rearrangement can account for in vitro switching to IgG1
-
Chu, C.C., Max, E.E. & Paul, W.E. DNA rearrangement can account for in vitro switching to IgG1. J. Exp. Med. 178, 1381-1390 (1993).
-
(1993)
J. Exp. Med.
, vol.178
, pp. 1381-1390
-
-
Chu, C.C.1
Max, E.E.2
Paul, W.E.3
-
30
-
-
0023932604
-
Structure and expression of germ line immunoglobulin γ2b transcripts
-
Lutzker, S. & Alt, F.W. Structure and expression of germ line immunoglobulin γ2b transcripts. Mol. Cell. Biol. 8, 1849-1852 (1988).
-
(1988)
Mol. Cell. Biol.
, vol.8
, pp. 1849-1852
-
-
Lutzker, S.1
Alt, F.W.2
-
31
-
-
0242268033
-
Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism
-
Yu, K. & Lieber, M.R. Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism. DNA Repair (Amst) 2, 1163-1174 (2003).
-
(2003)
DNA Repair (Amst)
, vol.2
, pp. 1163-1174
-
-
Yu, K.1
Lieber, M.R.2
-
32
-
-
0030037519
-
B cell differentiation and isotype switching is related to division cycle number
-
Hodgkin, P.D., Lee, J.H. & Lyons, A.B. B cell differentiation and isotype switching is related to division cycle number. J. Exp. Med. 184, 277-281 (1996).
-
(1996)
J. Exp. Med.
, vol.184
, pp. 277-281
-
-
Hodgkin, P.D.1
Lee, J.H.2
Lyons, A.B.3
-
33
-
-
0030845386
-
Rapid methods for the analysis of immunoglobulin gene hypermutation: Application to transgenic and gene targeted mice
-
Jolly, C.J., Klix, N. & Neuberger, M.S. Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice. Nucleic Acids Res. 25, 1913-1919 (1997).
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 1913-1919
-
-
Jolly, C.J.1
Klix, N.2
Neuberger, M.S.3
-
34
-
-
0141815630
-
Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA
-
Iwabuchi, K. et al. Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J. Biol. Chem. 278, 36487-36495 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 36487-36495
-
-
Iwabuchi, K.1
-
35
-
-
0029844048
-
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
-
Xu, Y. et al. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10, 2411-2422 (1996).
-
(1996)
Genes Dev.
, vol.10
, pp. 2411-2422
-
-
Xu, Y.1
-
36
-
-
0036224604
-
IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells
-
Manis, J.P., Dudley, D., Kaylor, L. & Alt, F.W. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity 16, 607-617 (2002).
-
(2002)
Immunity
, vol.16
, pp. 607-617
-
-
Manis, J.P.1
Dudley, D.2
Kaylor, L.3
Alt, F.W.4
-
37
-
-
0037011116
-
DNA-dependent protein kinase activity is not required for immunoglobulin class switching
-
Bosma, G.C. et al. DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J. Exp. Med. 196, 1483-1495 (2002).
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1483-1495
-
-
Bosma, G.C.1
-
38
-
-
0345735841
-
Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions
-
Cook, A.J. et al. Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. J. Immunol. 171, 6556-6564 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 6556-6564
-
-
Cook, A.J.1
-
39
-
-
0036903037
-
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
-
Fernandez-Capetillo, O. et al. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 4, 993-997 (2002).
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 993-997
-
-
Fernandez-Capetillo, O.1
-
40
-
-
0037112212
-
53BP1, a mediator of the DNA damage checkpoint
-
Wang, B., Matsuoka, S., Carpenter, P.B. & Elledge, S.J. 53BP1, a mediator of the DNA damage checkpoint. Science 298, 1435-1438 (2002).
-
(2002)
Science
, vol.298
, pp. 1435-1438
-
-
Wang, B.1
Matsuoka, S.2
Carpenter, P.B.3
Elledge, S.J.4
-
41
-
-
0036902410
-
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
-
DiTullio, R.A., Jr. et al. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat. Cell. Biol. 4, 998-1002 (2002).
-
(2002)
Nat. Cell. Biol.
, vol.4
, pp. 998-1002
-
-
DiTullio Jr., R.A.1
-
42
-
-
0035818990
-
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
-
Petersen, S. et al. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching. Nature 414, 660-665 (2001).
-
(2001)
Nature
, vol.414
, pp. 660-665
-
-
Petersen, S.1
-
43
-
-
0037062492
-
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
-
Bassing, C.H. et al. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc. Natl. Acad. Sci. USA 99, 8173-8178 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8173-8178
-
-
Bassing, C.H.1
-
44
-
-
0037866984
-
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
-
Reina-San-Martin, B. et al. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J. Exp. Med. 197, 1767-1778 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1767-1778
-
-
Reina-San-Martin, B.1
-
45
-
-
0037012845
-
Genomic instability in mice lacking histone H2AX
-
Celeste, A. et al. Genomic instability in mice lacking histone H2AX. Science 296, 922-927 (2002).
-
(2002)
Science
, vol.296
, pp. 922-927
-
-
Celeste, A.1
-
46
-
-
2442706035
-
H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity
-
Bassing, C.H. & Alt, F.W. H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle 3, e119-e123 (2004).
-
(2004)
Cell Cycle
, vol.3
-
-
Bassing, C.H.1
Alt, F.W.2
-
47
-
-
0027275497
-
The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
-
Li, Y.S., Hayakawa, K. & Hardy, R.R. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178, 951-960 (1993).
-
(1993)
J. Exp. Med.
, vol.178
, pp. 951-960
-
-
Li, Y.S.1
Hayakawa, K.2
Hardy, R.R.3
-
48
-
-
0033564878
-
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
-
Ehrenstein, M.R. & Neuberger, M.S. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. EMBO J. 18, 3484-3490 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 3484-3490
-
-
Ehrenstein, M.R.1
Neuberger, M.S.2
-
49
-
-
1542377328
-
B cell receptor signal strength determines B cell fate
-
Casola, S. et al. B cell receptor signal strength determines B cell fate. Nat. Immunol. 5, 317-327 (2004).
-
(2004)
Nat. Immunol.
, vol.5
, pp. 317-327
-
-
Casola, S.1
|