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Volumn 5, Issue 5, 2004, Pages 481-487

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DOUBLE STRANDED DNA; IMMUNOGLOBULIN HEAVY CHAIN; PROTEIN P53; PROTEIN P53 BINDING PROTEIN 1; UNCLASSIFIED DRUG;

EID: 2442707746     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1067     Document Type: Article
Times cited : (280)

References (49)
  • 1
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • van Gent, D.C., Hoeijmakers, J.H. & Kanaar, R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2, 196-206 (2001).
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 196-206
    • van Gent, D.C.1    Hoeijmakers, J.H.2    Kanaar, R.3
  • 2
    • 0037660900 scopus 로고    scopus 로고
    • The role of DNA breaks in genomic instability and tumorigenesis
    • Mills, K.D., Ferguson, D.O. & Alt, F.W. The role of DNA breaks in genomic instability and tumorigenesis. Immunol. Rev. 194, 77-95 (2003).
    • (2003) Immunol. Rev. , vol.194 , pp. 77-95
    • Mills, K.D.1    Ferguson, D.O.2    Alt, F.W.3
  • 3
    • 0036261707 scopus 로고    scopus 로고
    • Sensing and repairing DNA double-strand breaks
    • Jackson, S.P. Sensing and repairing DNA double-strand breaks. Carcinogenesis 23, 687-696 (2002).
    • (2002) Carcinogenesis , vol.23 , pp. 687-696
    • Jackson, S.P.1
  • 4
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal V(D)J recombination
    • Bassing, C.H., Swat, W. & Alt, F.W. The mechanism and regulation of chromosomal V(D)J recombination. Cell 109, S45-S55 (2002).
    • (2002) Cell , vol.109
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 5
    • 0036152242 scopus 로고    scopus 로고
    • Mechanism and control of class-switch recombination
    • Manis, J.P., Tian, M. & Alt, F.W. Mechanism and control of class-switch recombination. Trends Immunol. 23, 31-39 (2002).
    • (2002) Trends Immunol. , vol.23 , pp. 31-39
    • Manis, J.P.1    Tian, M.2    Alt, F.W.3
  • 6
    • 0842303307 scopus 로고    scopus 로고
    • Unraveling V(D)J recombination: Insights into gene regulation
    • Jung, D. & Alt, F.W. Unraveling V(D)J recombination: Insights into gene regulation. Cell 116, 299-311 (2004).
    • (2004) Cell , vol.116 , pp. 299-311
    • Jung, D.1    Alt, F.W.2
  • 7
    • 0037195272 scopus 로고    scopus 로고
    • Immunoglobulin genes: Generating diversity with AID and UNG
    • Storb, U. & Stavnezer, J. Immunoglobulin genes: generating diversity with AID and UNG. Curr. Biol. 12, 725-727 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 725-727
    • Storb, U.1    Stavnezer, J.2
  • 8
    • 0036234455 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes: Merging mechanisms for genetic diversity
    • Papavasiliou, F.N. & Schatz, D.G. Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell 109, S35-44 (2002).
    • (2002) Cell , vol.109
    • Papavasiliou, F.N.1    Schatz, D.G.2
  • 9
    • 0034264851 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)
    • Revy, P. et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 102, 565-575 (2000).
    • (2000) Cell , vol.102 , pp. 565-575
    • Revy, P.1
  • 10
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-563 (2000).
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1
  • 11
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri, J. et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422, 726-730 (2003).
    • (2003) Nature , vol.422 , pp. 726-730
    • Chaudhuri, J.1
  • 12
    • 0038293484 scopus 로고    scopus 로고
    • Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
    • Ramiro, A.R., Stavropoulos, P., Jankovic, M. & Nussenzweig, M.C. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4, 452-456 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 452-456
    • Ramiro, A.R.1    Stavropoulos, P.2    Jankovic, M.3    Nussenzweig, M.C.4
  • 13
    • 0037388165 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    • Bransteitter, R., Pham, P., Scharff, M.D. & Goodman, M.F. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA 100, 4102-4107 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4102-4107
    • Bransteitter, R.1    Pham, P.2    Scharff, M.D.3    Goodman, M.F.4
  • 14
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single stranded DNA
    • Dickerson, S.K., Market, E., Besmer, E. & Papavasiliou, F.N. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197, 1291-1296 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 16
    • 0347758541 scopus 로고    scopus 로고
    • The generation of antibody diversity through somatic hypermutation and class switch recombination
    • Li, Z., Woo, C.J., Iglesias-Ussel, M.D., Ronai, D. & Scharff, M.D. The generation of antibody diversity through somatic hypermutation and class switch recombination. Genes Dev. 18, 1-11 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 1-11
    • Li, Z.1    Woo, C.J.2    Iglesias-Ussel, M.D.3    Ronai, D.4    Scharff, M.D.5
  • 17
    • 0037029631 scopus 로고    scopus 로고
    • The function of AID in somatic mutation and class switch recombination: Upstream or downstream of DNA breaks
    • Chua, K.F., Alt, F.W. & Manis, J.P. The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks. J. Exp. Med. 195, F37-41 (2002).
    • (2002) J. Exp. Med. , vol.195
    • Chua, K.F.1    Alt, F.W.2    Manis, J.P.3
  • 18
    • 0037625159 scopus 로고    scopus 로고
    • What role for AID: Mutator, or assembler of the immunoglobulin mutasome?
    • Reynaud, C.A., Aoufouchi, S., Faili, A. & Weill, J.C. What role for AID: mutator, or assembler of the immunoglobulin mutasome? Nat. Immunol. 4, 631-638 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 631-638
    • Reynaud, C.A.1    Aoufouchi, S.2    Faili, A.3    Weill, J.C.4
  • 19
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B.B. & Elledge, S.J. The DNA damage response: putting checkpoints in perspective. Nature 408, 433-439 (2000).
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 20
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham, R.T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 21
    • 0035951850 scopus 로고    scopus 로고
    • Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1
    • Xia, Z., Morales, J.C., Dunphy, W.G. & Carpenter, P.B. Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1. J. Biol. Chem. 276, 2708-2718 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 2708-2718
    • Xia, Z.1    Morales, J.C.2    Dunphy, W.G.3    Carpenter, P.B.4
  • 22
    • 0034739853 scopus 로고    scopus 로고
    • p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
    • Schultz, L.B., Chehab, N.H., Malikzay, A. & Halazonetis, T.D. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J. Cell. Biol. 151, 1381-1390 (2000).
    • (2000) J. Cell. Biol. , vol.151 , pp. 1381-1390
    • Schultz, L.B.1    Chehab, N.H.2    Malikzay, A.3    Halazonetis, T.D.4
  • 23
    • 0035134286 scopus 로고    scopus 로고
    • Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage
    • Anderson, L., Henderson, C. & Adachi, Y. Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage. Mol. Cell. Biol. 21, 1719-1729 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1719-1729
    • Anderson, L.1    Henderson, C.2    Adachi, Y.3
  • 24
    • 0035972194 scopus 로고    scopus 로고
    • Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways
    • Rappold, I., Iwabuchi, K., Date, T. & Chen, J. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J. Cell Biol. 153, 613-620 (2001).
    • (2001) J. Cell Biol. , vol.153 , pp. 613-620
    • Rappold, I.1    Iwabuchi, K.2    Date, T.3    Chen, J.4
  • 25
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou, E.P., Pilch, D.R., Orr, A.H., Ivanova, V.S. & Bonner, W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-5868 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 26
    • 0037772381 scopus 로고    scopus 로고
    • Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability
    • Morales, J.C. et al. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J. Biol. Chem. 278, 14971-14977 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 14971-14977
    • Morales, J.C.1
  • 27
    • 0037378527 scopus 로고    scopus 로고
    • p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
    • Ward, I.M., Minn, K., van Deursen, J. & Chen, J. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol. Cell. Biol. 23, 2556-2563 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 2556-2563
    • Ward, I.M.1    Minn, K.2    van Deursen, J.3    Chen, J.4
  • 28
    • 0030022218 scopus 로고    scopus 로고
    • Antibody class switching
    • Stavnezer, J. Antibody class switching. Adv. Immunol. 61, 79-146 (1996).
    • (1996) Adv. Immunol. , vol.61 , pp. 79-146
    • Stavnezer, J.1
  • 29
    • 0027169028 scopus 로고
    • DNA rearrangement can account for in vitro switching to IgG1
    • Chu, C.C., Max, E.E. & Paul, W.E. DNA rearrangement can account for in vitro switching to IgG1. J. Exp. Med. 178, 1381-1390 (1993).
    • (1993) J. Exp. Med. , vol.178 , pp. 1381-1390
    • Chu, C.C.1    Max, E.E.2    Paul, W.E.3
  • 30
    • 0023932604 scopus 로고
    • Structure and expression of germ line immunoglobulin γ2b transcripts
    • Lutzker, S. & Alt, F.W. Structure and expression of germ line immunoglobulin γ2b transcripts. Mol. Cell. Biol. 8, 1849-1852 (1988).
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 1849-1852
    • Lutzker, S.1    Alt, F.W.2
  • 31
    • 0242268033 scopus 로고    scopus 로고
    • Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism
    • Yu, K. & Lieber, M.R. Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism. DNA Repair (Amst) 2, 1163-1174 (2003).
    • (2003) DNA Repair (Amst) , vol.2 , pp. 1163-1174
    • Yu, K.1    Lieber, M.R.2
  • 32
    • 0030037519 scopus 로고    scopus 로고
    • B cell differentiation and isotype switching is related to division cycle number
    • Hodgkin, P.D., Lee, J.H. & Lyons, A.B. B cell differentiation and isotype switching is related to division cycle number. J. Exp. Med. 184, 277-281 (1996).
    • (1996) J. Exp. Med. , vol.184 , pp. 277-281
    • Hodgkin, P.D.1    Lee, J.H.2    Lyons, A.B.3
  • 33
    • 0030845386 scopus 로고    scopus 로고
    • Rapid methods for the analysis of immunoglobulin gene hypermutation: Application to transgenic and gene targeted mice
    • Jolly, C.J., Klix, N. & Neuberger, M.S. Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice. Nucleic Acids Res. 25, 1913-1919 (1997).
    • (1997) Nucleic Acids Res. , vol.25 , pp. 1913-1919
    • Jolly, C.J.1    Klix, N.2    Neuberger, M.S.3
  • 34
    • 0141815630 scopus 로고    scopus 로고
    • Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA
    • Iwabuchi, K. et al. Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J. Biol. Chem. 278, 36487-36495 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 36487-36495
    • Iwabuchi, K.1
  • 35
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Xu, Y. et al. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10, 2411-2422 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 2411-2422
    • Xu, Y.1
  • 36
    • 0036224604 scopus 로고    scopus 로고
    • IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells
    • Manis, J.P., Dudley, D., Kaylor, L. & Alt, F.W. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity 16, 607-617 (2002).
    • (2002) Immunity , vol.16 , pp. 607-617
    • Manis, J.P.1    Dudley, D.2    Kaylor, L.3    Alt, F.W.4
  • 37
    • 0037011116 scopus 로고    scopus 로고
    • DNA-dependent protein kinase activity is not required for immunoglobulin class switching
    • Bosma, G.C. et al. DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J. Exp. Med. 196, 1483-1495 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 1483-1495
    • Bosma, G.C.1
  • 38
    • 0345735841 scopus 로고    scopus 로고
    • Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions
    • Cook, A.J. et al. Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. J. Immunol. 171, 6556-6564 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 6556-6564
    • Cook, A.J.1
  • 39
    • 0036903037 scopus 로고    scopus 로고
    • DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
    • Fernandez-Capetillo, O. et al. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 4, 993-997 (2002).
    • (2002) Nat. Cell Biol. , vol.4 , pp. 993-997
    • Fernandez-Capetillo, O.1
  • 40
    • 0037112212 scopus 로고    scopus 로고
    • 53BP1, a mediator of the DNA damage checkpoint
    • Wang, B., Matsuoka, S., Carpenter, P.B. & Elledge, S.J. 53BP1, a mediator of the DNA damage checkpoint. Science 298, 1435-1438 (2002).
    • (2002) Science , vol.298 , pp. 1435-1438
    • Wang, B.1    Matsuoka, S.2    Carpenter, P.B.3    Elledge, S.J.4
  • 41
    • 0036902410 scopus 로고    scopus 로고
    • 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
    • DiTullio, R.A., Jr. et al. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat. Cell. Biol. 4, 998-1002 (2002).
    • (2002) Nat. Cell. Biol. , vol.4 , pp. 998-1002
    • DiTullio Jr., R.A.1
  • 42
    • 0035818990 scopus 로고    scopus 로고
    • AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
    • Petersen, S. et al. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching. Nature 414, 660-665 (2001).
    • (2001) Nature , vol.414 , pp. 660-665
    • Petersen, S.1
  • 43
    • 0037062492 scopus 로고    scopus 로고
    • Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
    • Bassing, C.H. et al. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc. Natl. Acad. Sci. USA 99, 8173-8178 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 8173-8178
    • Bassing, C.H.1
  • 44
    • 0037866984 scopus 로고    scopus 로고
    • H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
    • Reina-San-Martin, B. et al. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J. Exp. Med. 197, 1767-1778 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 1767-1778
    • Reina-San-Martin, B.1
  • 45
    • 0037012845 scopus 로고    scopus 로고
    • Genomic instability in mice lacking histone H2AX
    • Celeste, A. et al. Genomic instability in mice lacking histone H2AX. Science 296, 922-927 (2002).
    • (2002) Science , vol.296 , pp. 922-927
    • Celeste, A.1
  • 46
    • 2442706035 scopus 로고    scopus 로고
    • H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity
    • Bassing, C.H. & Alt, F.W. H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle 3, e119-e123 (2004).
    • (2004) Cell Cycle , vol.3
    • Bassing, C.H.1    Alt, F.W.2
  • 47
    • 0027275497 scopus 로고
    • The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
    • Li, Y.S., Hayakawa, K. & Hardy, R.R. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178, 951-960 (1993).
    • (1993) J. Exp. Med. , vol.178 , pp. 951-960
    • Li, Y.S.1    Hayakawa, K.2    Hardy, R.R.3
  • 48
    • 0033564878 scopus 로고    scopus 로고
    • Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
    • Ehrenstein, M.R. & Neuberger, M.S. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. EMBO J. 18, 3484-3490 (1999).
    • (1999) EMBO J. , vol.18 , pp. 3484-3490
    • Ehrenstein, M.R.1    Neuberger, M.S.2
  • 49
    • 1542377328 scopus 로고    scopus 로고
    • B cell receptor signal strength determines B cell fate
    • Casola, S. et al. B cell receptor signal strength determines B cell fate. Nat. Immunol. 5, 317-327 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 317-327
    • Casola, S.1


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