Synapsis of DNA ends by DNA-dependent protein kinase

EMBO Journal

Volumn 21, Issue 12, 2002, Pages 3192-3200

  DeFazio, Lisa G ^a   Stansel, Rachel M ^a   Griffith, Jack D ^a   Chu, Gilbert ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA repair electron microscopy; DNA dependent protein kinase; Non homologous end joining; V(D)J recombination

Indexed keywords

DNA; DNA DEPENDENT PROTEIN KINASE;

ARTICLE; CATALYSIS; CHROMOSOME PAIRING; COMPLEX FORMATION; DNA DETERMINATION; ELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME PURIFICATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIGENS, NUCLEAR; CHROMOSOME PAIRING; DNA; DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HELA CELLS; HUMANS; MODELS, GENETIC; NUCLEAR PROTEINS; NUCLEIC ACID CONFORMATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 0037124373     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf299     Document Type: Article

References (45)

1. The nuclear serine/threonine protein kinase DNA-PK
2. DNA end-joining catalyzed by human cell-free extracts
3. DNA looping by Ku and the DNA-dependent protein kinase
4. Ku80 is required for immunoglobulin isotype switching
5. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
6. Interactions of the DNA ligase IV-Xrcc4 complex with DNA ends and the DNA-dependent protein kinase
7. Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase
8. Double-strand break repair
9. Human Rad50/Mrel1 is a flexible complex that can tether DNA ends
10. HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex
11. DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
12. Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II
13. The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
14. Activity of DNA ligase IV stimulated by complex formation with Xrcc4 protein in mammalian cells
15. Electron microscope visualization of chromatin and other DNA-protein complexes
16. DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
17. Activation of DNA-dependent protein kinase by single-stranded DNA ends
18. Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair
19. DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
20. Competitive and noncompetitive inhibition of the DNA-dependent protein kinase
21. Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
22. The Xrcc4 gene product is a target for and interacts with the DNA-dependent protein kinase
23. Structure of DNA-dependent protein kinase: Implications for its regulation by DNA
24. The Xrcc4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
25. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
26. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching
27. DNA-dependent protein kinase catalytic subunit: Structural requirements for kinase activation by DNA ends
28. Ku recruits the Xrcc4-ligase IV complex to DNA ends
29. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
30. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
31. A mechanistic basis for Mre 11-directed DNA joining at microhomologies
32. Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-strand breaks
33. A DNA end-binding factor involved in double-strand break repair and V(D)J recombination
34. Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks
35. The SCID but not the RAG-2 gene product is required for S μ-S ε heavy chain class switching
36. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
37. The end-joining reaction in V(D)J recombination
38. Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA
39. The DNA-dependent protein kinase
40. KuSO: Product of the Xrcc5 gene and its role in DNA repair and V(D)J recombination
41. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mrel 1, and p95
42. Mechanism of topology simplification by type II DNA topoisomerases
43. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
44. Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic-force microscopy studies
45. Geometry of a complex formed by double strand break repair proteins at a single DNA end: Recruitment of DNA-PKcs induces inward translocation of Ku protein