Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 43, 2009, Pages 18339-18344

  Mahowald, Grace K ^a   Baron, Jason M ^a   Mahowald, Michael A ^a   Kulkarni, Shashikant ^a   Bredemeyer, Andrea L ^a   Bassing, Craig H ^b,c   Sleckman, Barry P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Ataxia telangiectasia mutated; Chromosomal translocation; DNA double strand break repair; V(D)J recombination

Indexed keywords

ATM PROTEIN; DOUBLE STRANDED DNA; RAG1 PROTEIN; RAG2 PROTEIN; RECOMBINASE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL LINE; CHROMOSOME BREAKAGE; CHROMOSOME DELETION; CHROMOSOME TRANSLOCATION; COHORT ANALYSIS; CONTROLLED STUDY; DNA STRAND BREAKAGE; DOUBLE STRANDED DNA BREAK; GENE TARGETING; GENETIC PREDISPOSITION; GENETIC SELECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VDJ EXON;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CHROMOSOME BREAKAGE; CHROMOSOMES, MAMMALIAN; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; HOMEODOMAIN PROTEINS; LYMPHOCYTES; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ANTIGEN; TRANSLOCATION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA; MUS;

EID: 70849094673     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0902545106     Document Type: Article

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