Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice

Current Biology

Volumn 11, Issue 2, 2001, Pages 105-109

  Zhu, Jie ^a   Petersen, Simone ^a   Tessarollo, Lino ^b   Nussenzweig, André ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0035936554     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00019-7     Document Type: Article

References (21)

1. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
2. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
3. An increased risk for malignant neoplasms in heterozygotes for a syndrome of microcephaly, normal intelligence, growth retardation, remarkable facies, immunodeficiency and chromosomal instability
4. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
5. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
6. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
7. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
8. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
9. DNA double strand break repair in mammalian cells
10. DNA repair: The Nijmegen breakage syndrome protein
11. In situ visualization of DNA double-strand break repair in human fibroblasts
12. Response to RAG-mediated V(D)J cleavage by NBS1 and γ-H2AX
13. Radioresistant DNA synthesis and human genetic diseases
14. Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation
15. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
16. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
17. The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae
18. Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells
19. Inaugural article: Polymerase eta deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair
20. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
21. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability