Defective DNA repair and increased genomic instability in Artemis-deficient murine cells

Journal of Experimental Medicine

Volumn 197, Issue 5, 2003, Pages 553-565

  Rooney, Sean ^a   Alt, Frederick W ^a   Lombard, David ^a,b   Whitlow, Scott ^a   Eckersdorff, Mark ^a   Fleming, James ^a   Fugmann, Sebastian ^c   Ferguson, David O ^a,b   Schatz, David G ^c   Sekiguchi, JoAnn ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Artemis; DNA repair; Genomic instablility; Telomere fusions; VDJ recombination

Indexed keywords

ARTEMIS PROTEIN; CELL PROTEIN; DNA; DNA DEPENDENT PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA REPAIR; EMBRYO; EMBRYO CELL; ENZYME ACTIVE SITE; GENE DELETION; GENETIC RECOMBINATION; GENETIC STABILITY; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIOSENSITIVITY; RODENT; TELOMERE;

ANIMALS; ANTINEOPLASTIC AGENTS; BLEOMYCIN; CELL LINE; CHROMOSOME ABERRATIONS; DNA; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; EMBRYO; GENE TARGETING; GENOME; HOMEODOMAIN PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MUTATION; NUCLEAR PROTEINS; RADIATION, IONIZING; RECOMBINATION, GENETIC; SEQUENCE ANALYSIS, DNA; SEVERE COMBINED IMMUNODEFICIENCY; STEM CELLS; TELOMERE;

EID: 0037416138     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021891     Document Type: Article

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