메뉴 건너뛰기




Volumn 3, Issue 5, 2002, Pages 317-327

The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MRE11 PROTEIN; NIBRIN; NUCLEASE; PROTEIN; PROTEIN XRS2; RAD50 PROTEIN; UNCLASSIFIED DRUG;

EID: 0036276388     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm805     Document Type: Review
Times cited : (727)

References (120)
  • 1
    • 0014303905 scopus 로고
    • The isolation, genetics and survival characteristics of ultraviolet light-sensitive mutants in yeast
    • (1968) Mutat. Res. , vol.6 , pp. 37-55
    • Cox, B.S.1    Parry, J.M.2
  • 2
    • 0009456253 scopus 로고
    • The gene-controlled radiation sensitivity of yeast. VII. Identification of the genes for the x-ray sensitivity
    • (1970) Genetika , vol.6 , pp. 158-163
    • Suslova, N.G.1    Zakharov, I.A.2
  • 5
    • 0028914077 scopus 로고
    • Interaction of Mre11 and Rad50: Two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiea
    • (1995) Genetics , vol.139 , pp. 1521-1532
    • Johzuka, K.1    Ogawa, H.2
  • 8
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11-hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double strand break repair to the cellular DNA damage response
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1
  • 9
  • 10
    • 0032076190 scopus 로고    scopus 로고
    • Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
    • (1998) Cell , vol.93 , pp. 467-476
    • Varon, R.1
  • 11
  • 14
    • 0033544724 scopus 로고    scopus 로고
    • The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
    • (1999) Cell , vol.99 , pp. 577-587
    • Stewart, G.S.1
  • 15
    • 0030749867 scopus 로고    scopus 로고
    • Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double strand break repair Mre11 protein in murine embryonic stem cells
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2985-2991
    • Xiao, Y.H.1    Weaver, D.T.2
  • 16
    • 0033594904 scopus 로고    scopus 로고
    • Disruption of mRad5O causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7376-7381
    • Luo, G.B.1
  • 19
    • 0032567108 scopus 로고    scopus 로고
    • Complex formation and functional versatility of Mre11 of budding yeast in recombination
    • (1998) Cell , vol.95 , pp. 705-716
    • Usui, T.1
  • 22
    • 0032476658 scopus 로고    scopus 로고
    • Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination
    • (1998) EMBO J. , vol.17 , pp. 6412-6425
    • Furuse, M.1
  • 23
    • 0032085295 scopus 로고    scopus 로고
    • The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double strand breaks
    • (1998) Mol. Cell , vol.1 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 24
    • 0028857690 scopus 로고
    • Structural and functional similarities between the SbcCD proteins of Escherichia coli and the Rad50 and Mre11 (Rad32) recombination and repair proteins of yeast
    • (1995) Mol. Microbiol. , vol.17 , pp. 1215-1217
    • Sharpies, G.J.1    Leach, D.R.F.2
  • 27
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11-Rad5O complex
    • (1999) Genes Dev. , vol.13 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 29
    • 0035869155 scopus 로고    scopus 로고
    • DNA-binding and strand-annealing activities of human Mre11: Implications for its roles in DNA double-strand break repair pathways
    • (2001) Nucleic Acids Res. , vol.29 , pp. 1317-1325
    • De Jager, M.1
  • 30
    • 0035930329 scopus 로고    scopus 로고
    • Human Rad50-Mre11 is a flexible complex that can tether DNA ends
    • (2001) Mol. Cell , vol.8 , pp. 1129-1135
    • De Jager, M.1
  • 32
    • 0024669753 scopus 로고
    • The yeast RAD50 gene encodes a predicted 153-kD protein containing a purine nucleotide-binding domain and two large heptad-repeat regions
    • (1989) Genetics , vol.122 , pp. 47-57
    • Alani, E.1    Subblah, S.2    Kleckner, N.3
  • 33
    • 0029742576 scopus 로고    scopus 로고
    • Human Rad50 is physically associated with human Mre11. Identification of a conserved multiprotein complex implicated in recombinational DNA repair
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4832-4841
    • Dolganov, G.M.1
  • 34
    • 0025334351 scopus 로고
    • Analysis of wild type and rad5O mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination
    • (1990) Cell , vol.61 , pp. 419-436
    • Alani, E.1    Padmore, R.2    Kleckner, N.3
  • 35
    • 0034705293 scopus 로고    scopus 로고
    • Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily
    • (2000) Cell , vol.101 , pp. 789-800
    • Hopfner, K.P.1
  • 36
  • 37
    • 0035906860 scopus 로고    scopus 로고
    • Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase
    • (2001) Cell , vol.105 , pp. 473-485
    • Hopfner, K.P.1
  • 38
    • 0037084037 scopus 로고    scopus 로고
    • The ABCs of SMC proteins: Two-armed ATPases for chromosome condensation, cohesion, and repair
    • (2002) Genes Dev. , vol.16 , pp. 399-414
    • Hirano, T.1
  • 45
    • 0026709385 scopus 로고
    • Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae
    • (1992) Genetics , vol.132 , pp. 387-402
    • Kadyk, L.C.1    Hartwell, L.H.2
  • 48
    • 0035808385 scopus 로고    scopus 로고
    • The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50-hMRE11-NBS1 complex DNA repair activity
    • (2001) J. Biol. Chem. , vol.276 , pp. 12-15
    • Tauchi, H.1
  • 49
    • 0031046294 scopus 로고    scopus 로고
    • A superfamily of conserved domains in DNA damage responsive cell cycle checkpoint proteins
    • (1997) FASEB J. , vol.11 , pp. 68-76
    • Bork, P.1
  • 54
    • 0034903925 scopus 로고    scopus 로고
    • Mre11 complex and DNA replication: Linkage to E2F and sites of DNA synthesis
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6006-6016
    • Maser, R.S.1
  • 57
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • (2000) Curr. Biol. , vol.10 , pp. 886-895
    • Paull, T.T.1
  • 58
    • 0034623860 scopus 로고    scopus 로고
    • Response to RAG-mediated V(D)J cleavage by NBS1 and γ-H2AX
    • (2000) Science , vol.290 , pp. 1962-1964
    • Chen, H.T.1
  • 59
    • 0035818990 scopus 로고    scopus 로고
    • AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
    • (2001) Nature , vol.414 , pp. 660-665
    • Petersen, S.1
  • 62
    • 0035839431 scopus 로고    scopus 로고
    • Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-G mutations, showing a less severe phenotype
    • (2001) J. Biol. Chem. , vol.276 , pp. 30133-30141
    • Stewart, G.S.1
  • 63
    • 0034106722 scopus 로고    scopus 로고
    • ATM-dependent phosphorylation of nibrin in response to radiation exposure
    • (2000) Nature Genet. , vol.25 , pp. 115-119
    • Gatel, M.1
  • 64
    • 0034611728 scopus 로고    scopus 로고
    • ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
    • (2000) Nature , vol.404 , pp. 613-617
    • Lim, D.S.1
  • 65
    • 0034713466 scopus 로고    scopus 로고
    • ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
    • (2000) Nature , vol.406 , pp. 477-482
    • Wu, X.H.1
  • 66
    • 0034713393 scopus 로고    scopus 로고
    • Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
    • (2000) Nature , vol.405 , pp. 473-477
    • Zhao, S.1
  • 67
    • 0034892653 scopus 로고    scopus 로고
    • Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication
    • (2001) Mol. Cell , vol.8 , pp. 137-147
    • Costanzo, V.1
  • 70
    • 0033575659 scopus 로고    scopus 로고
    • Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1-and Rad53-dependent checkpoint in budding yeast
    • (1999) EMBO J. , vol.18 , pp. 4485-4497
    • Neecke, H.1    Lucchini, G.2    Longhese, M.P.3
  • 77
    • 0035108094 scopus 로고    scopus 로고
    • Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Δ with other DNA repair genes in Saccharomyces cerevisiae
    • (2001) Genetics , vol.157 , pp. 557-565
    • Klein, H.L.1
  • 79
    • 0025315699 scopus 로고
    • A pathway for generation and processing of double strand breaks during meiotic recombination in Saccharomyces cerevisiae
    • (1990) Cell , vol.61 , pp. 1089-1101
    • Cao, L.1    Alani, E.2    Kleckner, N.3
  • 80
    • 0030885998 scopus 로고    scopus 로고
    • Mre11S - A yeast mutation that blocks double strand break processing and permits nonhomologous synapsis in meiosis
    • (1997) Genes Dev. , vol.11 , pp. 2272-2290
    • Nairz, K.1    Klein, F.2
  • 85
    • 0028246091 scopus 로고
    • Effect of mutations in genes affecting homologous recombination on restriction enzyme mediated and illegitimate recombination in Saccharomyces cerevisiae
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4493-4500
    • Schiestl, R.H.1    Zhu, J.2    Petes, T.D.3
  • 86
    • 0029976325 scopus 로고    scopus 로고
    • Cell cycle and genetic requirements of two pathways of nonhomologous end joining repair of double strand breaks in Saccharomyces cerevisiae
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2164-2173
    • Moore, J.K.1    Haber, J.E.2
  • 87
    • 0032536861 scopus 로고    scopus 로고
    • Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
    • (1998) EMBO J. , vol.17 , pp. 1819-1828
    • Boulton, S.J.1    Jackson, S.P.2
  • 88
    • 0035862948 scopus 로고    scopus 로고
    • Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe
    • (2001) EMBO J. , vol.20 , pp. 210-221
    • Manolis, K.G.1
  • 90
    • 0000858524 scopus 로고    scopus 로고
    • V(D)J rearrangement in Nijmegen breakage syndrome
    • (2000) Mol. Immunol. , vol.37 , pp. 1131-1139
    • Yeo, T.C.1
  • 91
    • 0033485758 scopus 로고    scopus 로고
    • Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells
    • (1999) EMBO J. , vol.18 , pp. 6619-6629
    • Yamaguchi-Iwai, Y.1
  • 94
  • 96
    • 0031466618 scopus 로고    scopus 로고
    • Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
    • (1997) Annu. Rev. Genet. , vol.31 , pp. 635-662
    • Shiloh, Y.1
  • 97
    • 0030786912 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome cells fail to induce the p 53 mediated DNA damage response following exposure to ionizing radiation
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5016-5022
    • Jongmans, W.1
  • 100
    • 0033053329 scopus 로고    scopus 로고
    • Impaired p53-mediated DNA damage response, cell-cycle disturbance and chromosome aberrations in Nijmegen breakage syndrome lymphoblastoid cell lines
    • (1999) Int. J. Rad. Biol. , vol.75 , pp. 583-591
    • Antoccia, A.1
  • 103
    • 0036500690 scopus 로고    scopus 로고
    • SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
    • (2002) Genes Dev. , vol.16 , pp. 571-582
    • Yazdi, P.T.1
  • 106
    • 0028882869 scopus 로고
    • Yeast checkpoint genes in DNA damage processing: Implications for repair and arrest
    • (1995) Science , vol.270 , pp. 1488-1491
    • Lydall, D.1    Weinert, T.2
  • 107
    • 0032493889 scopus 로고    scopus 로고
    • Saccharomyces Ku70, Mre11/Rad50, and RPA proteins regulate adaptation to G2/M arrest after DNA damage
    • (1998) Cell , vol.94 , pp. 399-409
    • Lee, S.E.1
  • 111
    • 0032554797 scopus 로고    scopus 로고
    • Telomere maintenance is dependent on activities required for end repair of double strand breaks
    • (1998) Curr. Biol. , vol.8 , pp. 657-660
    • Nugent, C.I.1
  • 113
    • 0035954284 scopus 로고    scopus 로고
    • Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit
    • (2000) Curr. Biol. , vol.11 , pp. 962-966
    • Ranganathan, V.1
  • 120
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • (1999) Cell , vol.97 , pp. 503-514
    • Griffith, J.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.