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Volumn 114, Issue 3, 2003, Pages 371-383

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; GLUTAMIC ACID; HISTONE H2A; HISTONE H2AX; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN P53; SERINE; UNCLASSIFIED DRUG;

EID: 0042991383     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(03)00567-1     Document Type: Article
Times cited : (495)

References (62)
  • 1
    • 0030887862 scopus 로고    scopus 로고
    • RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
    • Agrawal A., Schatz D.G. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell. 89:1997;43-53.
    • (1997) Cell , vol.89 , pp. 43-53
    • Agrawal, A.1    Schatz, D.G.2
  • 2
    • 0345268720 scopus 로고    scopus 로고
    • Mdm2 haploinsufficiency profoundly inhibits Myc-induced lymphomagenesis
    • Alt J.R., Greiner T.C., Cleveland J.L., Eischen C.M. Mdm2 haploinsufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J. 22:2003;1442-1450.
    • (2003) EMBO J. , vol.22 , pp. 1442-1450
    • Alt, J.R.1    Greiner, T.C.2    Cleveland, J.L.3    Eischen, C.M.4
  • 3
    • 0037317415 scopus 로고    scopus 로고
    • Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis
    • Bai F., Pei X.H., Godfrey V.L., Xiong Y. Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol. Cell. Biol. 23:2003;1269-1277.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1269-1277
    • Bai, F.1    Pei, X.H.2    Godfrey, V.L.3    Xiong, Y.4
  • 6
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal V(D)J recombination
    • b
    • Bassing C.H., Swat W., Alt F.W. The mechanism and regulation of chromosomal V(D)J recombination. Cell. 109:2002;S45-S55. b.
    • (2002) Cell , vol.109
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 11
    • 0034643955 scopus 로고    scopus 로고
    • Accommodating haploinsufficient tumor suppressor genes in Knudson's model
    • Cook W.D., McCaw B.J. Accommodating haploinsufficient tumor suppressor genes in Knudson's model. Oncogene. 19:2000;3434-3438.
    • (2000) Oncogene , vol.19 , pp. 3434-3438
    • Cook, W.D.1    McCaw, B.J.2
  • 12
    • 0030904279 scopus 로고    scopus 로고
    • Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons
    • Coquelle A., Pipiras E., Toledo F., Buttin G., Debatisse M. Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons. Cell. 89:1997;215-225.
    • (1997) Cell , vol.89 , pp. 215-225
    • Coquelle, A.1    Pipiras, E.2    Toledo, F.3    Buttin, G.4    Debatisse, M.5
  • 16
    • 0034700511 scopus 로고    scopus 로고
    • A role for Saccharomyces cerevisiae histone H2A in DNA repair
    • Downs J.A., Lowndes N.F., Jackson S.P. A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature. 408:2000;1001-1004.
    • (2000) Nature , vol.408 , pp. 1001-1004
    • Downs, J.A.1    Lowndes, N.F.2    Jackson, S.P.3
  • 20
    • 0032511848 scopus 로고    scopus 로고
    • The murine gene p27Kip1 is haplo-insufficient for tumour suppression
    • Fero M.L., Randel E., Gurley K.E., Roberts J.M., Kemp C.J. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature. 396:1998;177-180.
    • (1998) Nature , vol.396 , pp. 177-180
    • Fero, M.L.1    Randel, E.2    Gurley, K.E.3    Roberts, J.M.4    Kemp, C.J.5
  • 28
    • 0029858143 scopus 로고    scopus 로고
    • V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
    • Guidos C.J., Williams C.J., Grandal I., Knowles G., Huang M.T., Danska J.S. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev. 10:1996;2038-2054.
    • (1996) Genes Dev. , vol.10 , pp. 2038-2054
    • Guidos, C.J.1    Williams, C.J.2    Grandal, I.3    Knowles, G.4    Huang, M.T.5    Danska, J.S.6
  • 29
    • 0032084698 scopus 로고    scopus 로고
    • Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
    • Hiom K., Gellert M. Assembly of a 12/23 paired signal complex. a critical control point in V(D)J recombination Mol. Cell. 1:1998;1011-1019.
    • (1998) Mol. Cell , vol.1 , pp. 1011-1019
    • Hiom, K.1    Gellert, M.2
  • 30
    • 0035890273 scopus 로고    scopus 로고
    • Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas
    • Inoue K., Zindy F., Randle D.H., Rehg J.E., Sherr C.J. Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas. Genes Dev. 15:2001;2934-2939.
    • (2001) Genes Dev. , vol.15 , pp. 2934-2939
    • Inoue, K.1    Zindy, F.2    Randle, D.H.3    Rehg, J.E.4    Sherr, C.J.5
  • 31
    • 0033576687 scopus 로고    scopus 로고
    • The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts
    • Karanjawala Z.E., Grawunder U., Hsieh C.L., Lieber M.R. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts. Curr. Biol. 9:1999;1501-1504.
    • (1999) Curr. Biol. , vol.9 , pp. 1501-1504
    • Karanjawala, Z.E.1    Grawunder, U.2    Hsieh, C.L.3    Lieber, M.R.4
  • 32
    • 0030932869 scopus 로고    scopus 로고
    • Gatekeepers and caretakers
    • Kinzler K.W., Vogelstein B. Gatekeepers and caretakers. Nature. 386:1997;761-763.
    • (1997) Nature , vol.386 , pp. 761-763
    • Kinzler, K.W.1    Vogelstein, B.2
  • 33
    • 0021879645 scopus 로고
    • Hereditary cancer, oncogenes, and antioncogenes
    • Knudson A.G. Jr. Hereditary cancer, oncogenes, and antioncogenes. Cancer Res. 45:1985;1437-1443.
    • (1985) Cancer Res. , vol.45 , pp. 1437-1443
    • Knudson A.G., Jr.1
  • 36
    • 0037468232 scopus 로고    scopus 로고
    • MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
    • Lou Z., Minter-Dykhouse K., Wu X., Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature. 421:2003;957-961.
    • (2003) Nature , vol.421 , pp. 957-961
    • Lou, Z.1    Minter-Dykhouse, K.2    Wu, X.3    Chen, J.4
  • 37
    • 0042787650 scopus 로고    scopus 로고
    • Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation
    • Magee J.A., Abdulkadir S.A., Milbrandt J. Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation. Cancer Cell. 3:2003;273-283.
    • (2003) Cancer Cell , vol.3 , pp. 273-283
    • Magee, J.A.1    Abdulkadir, S.A.2    Milbrandt, J.3
  • 40
    • 0035035480 scopus 로고    scopus 로고
    • 11q deletions in hematological malignancies
    • Monni O., Knuutila S. 11q deletions in hematological malignancies. Leuk. Lymphoma. 40:2001;259-266.
    • (2001) Leuk. Lymphoma , vol.40 , pp. 259-266
    • Monni, O.1    Knuutila, S.2
  • 43
    • 0038799991 scopus 로고    scopus 로고
    • Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
    • Pâques F., Haber J.E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63:1999;349-404.
    • (1999) Microbiol. Mol. Biol. Rev. , vol.63 , pp. 349-404
    • Pâques, F.1    Haber, J.E.2
  • 44
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull T.T., Rogakou E.P., Yamazaki V., Kirchgessner C.U., Gellert M., Bonner W.M. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10:2000;886-895.
    • (2000) Curr. Biol. , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 46
    • 0035890321 scopus 로고    scopus 로고
    • Haplo-insufficiency? Let me count the ways
    • Quon K.C., Berns A. Haplo-insufficiency? Let me count the ways. Genes Dev. 15:2001;2917-2921.
    • (2001) Genes Dev. , vol.15 , pp. 2917-2921
    • Quon, K.C.1    Berns, A.2
  • 47
    • 0035972194 scopus 로고    scopus 로고
    • Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways
    • Rappold I., Iwabuchi K., Date T., Chen J. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J. Cell Biol. 153:2001;613-620.
    • (2001) J. Cell Biol. , vol.153 , pp. 613-620
    • Rappold, I.1    Iwabuchi, K.2    Date, T.3    Chen, J.4
  • 49
    • 0037866984 scopus 로고    scopus 로고
    • H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
    • Reina-San-Martin B., Difilippantonio S., Hanitsch L., Masilamani R.F., Nussenzweig A., Nussenzweig M.C. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J. Exp. Med. 197:2003;1767-1778.
    • (2003) J. Exp. Med. , vol.197 , pp. 1767-1778
    • Reina-San-Martin, B.1    Difilippantonio, S.2    Hanitsch, L.3    Masilamani, R.F.4    Nussenzweig, A.5    Nussenzweig, M.C.6
  • 50
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273:1998;5858-5868.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 51
    • 0034739853 scopus 로고    scopus 로고
    • P53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
    • Schultz L.B., Chehab N.H., Malikzay A., Halazonetis T.D. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J. Cell Biol. 151:2000;1381-1390.
    • (2000) J. Cell Biol. , vol.151 , pp. 1381-1390
    • Schultz, L.B.1    Chehab, N.H.2    Malikzay, A.3    Halazonetis, T.D.4
  • 56
    • 0032530658 scopus 로고    scopus 로고
    • Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
    • Takata M., Sasaki M.S., Sonoda E., Morrison C., Hashimoto M., Utsumi H., Yamaguchi-Iwai Y., Shinohara A., Takeda S. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J. 17:1998;5497-5508.
    • (1998) EMBO J. , vol.17 , pp. 5497-5508
    • Takata, M.1    Sasaki, M.S.2    Sonoda, E.3    Morrison, C.4    Hashimoto, M.5    Utsumi, H.6    Yamaguchi-Iwai, Y.7    Shinohara, A.8    Takeda, S.9
  • 58
    • 0032541321 scopus 로고    scopus 로고
    • Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation
    • Venkatachalam S., Shi Y.P., Jones S.N., Vogel H., Bradley A., Pinkel D., Donehower L.A. Retention of wild-type p53 in tumors from p53 heterozygous mice. reduction of p53 dosage can promote cancer formation EMBO J. 17:1998;4657-4667.
    • (1998) EMBO J. , vol.17 , pp. 4657-4667
    • Venkatachalam, S.1    Shi, Y.P.2    Jones, S.N.3    Vogel, H.4    Bradley, A.5    Pinkel, D.6    Donehower, L.A.7
  • 59
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward I.M., Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276:2001;47759-47762.
    • (2001) J. Biol. Chem. , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 62
    • 0037188898 scopus 로고    scopus 로고
    • Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations
    • Zhu C., Mills K.D., Ferguson D.O., Lee C., Manis J., Fleming J., Gao Y., Morton C.C., Alt F.W. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell. 109:2002;811-821.
    • (2002) Cell , vol.109 , pp. 811-821
    • Zhu, C.1    Mills, K.D.2    Ferguson, D.O.3    Lee, C.4    Manis, J.5    Fleming, J.6    Gao, Y.7    Morton, C.C.8    Alt, F.W.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.