-
1
-
-
0028048275
-
The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
-
Lewis SM: The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses. Adv Immunol 1994, 56:27-150.
-
(1994)
Adv Immunol
, vol.56
, pp. 27-150
-
-
Lewis, S.M.1
-
2
-
-
0030966099
-
Recent advances in understanding V(D)J recombination
-
Gellert M: Recent advances in understanding V(D)J recombination. Adv Immunol 1997, 64:39-64.
-
(1997)
Adv Immunol
, vol.64
, pp. 39-64
-
-
Gellert, M.1
-
3
-
-
0029886929
-
Mechanism of V(D)J recombination
-
Bogue M, Roth DB: Mechanism of V(D)J recombination. Curr Opin Immunol 1996, 8:175-180.
-
(1996)
Curr Opin Immunol
, vol.8
, pp. 175-180
-
-
Bogue, M.1
Roth, D.B.2
-
4
-
-
0028805853
-
Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
-
McBlane JF, van Gent DC, Ramsden DA, Romeo C, Cuomo CA, Gellert M, Oettinger MA: Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 1995, 83:387-395.
-
(1995)
Cell
, vol.83
, pp. 387-395
-
-
McBlane, J.F.1
Van Gent, D.C.2
Ramsden, D.A.3
Romeo, C.4
Cuomo, C.A.5
Gellert, M.6
Oettinger, M.A.7
-
5
-
-
0030964130
-
A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
-
Hiom K, Gellert M: A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage. Cell 1997, 88:65-72. Both RAG1 and RAG2 are required for high affinity, sequence specific binding to the RSS, paving the way for further studies on the nature of the protein-DNA interactions required for V(D)J cleavage.
-
(1997)
Cell
, vol.88
, pp. 65-72
-
-
Hiom, K.1
Gellert, M.2
-
6
-
-
0031826699
-
Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences
-
Akamatsu Y, Oettinger MA: Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences. Mol Cell Biol 1998, 18:4670-4678.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4670-4678
-
-
Akamatsu, Y.1
Oettinger, M.A.2
-
7
-
-
0031961996
-
Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination
-
Nagawa F, Ishiguro K, Tsuboi A, Yoshida T, Ishikawa A, Takemori T, Otsuka AJ, Sakano H: Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination. Mol Cell Biol 1998, 18:655-663.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 655-663
-
-
Nagawa, F.1
Ishiguro, K.2
Tsuboi, A.3
Yoshida, T.4
Ishikawa, A.5
Takemori, T.6
Otsuka, A.J.7
Sakano, H.8
-
8
-
-
0032126295
-
V(D)J recombination signal recognition: Distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2
-
Swanson PC, Desiderio S: V(D)J recombination signal recognition: Distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2. Immunity 1998, 9:115-125.
-
(1998)
Immunity
, vol.9
, pp. 115-125
-
-
Swanson, P.C.1
Desiderio, S.2
-
9
-
-
0030980386
-
V(D)J recombination: Modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins
-
Sawchuk DJ, Weis-Garcia F, Malik S, Besmer E, Bustin M, Nussenzweig MC, Cortes P: V(D)J recombination: Modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins. J Exp Med 1997, 185:2025-2032.
-
(1997)
J Exp Med
, vol.185
, pp. 2025-2032
-
-
Sawchuk, D.J.1
Weis-Garcia, F.2
Malik, S.3
Besmer, E.4
Bustin, M.5
Nussenzweig, M.C.6
Cortes, P.7
-
10
-
-
0030994385
-
Stimulation of V(D)J cleavage by high mobility group proteins
-
van Gent DC, Hiom K, Paull TT, Gellert M: Stimulation of V(D)J cleavage by high mobility group proteins. EMBO J 1997, 16:2665-2670.
-
(1997)
EMBO J
, vol.16
, pp. 2665-2670
-
-
Van Gent, D.C.1
Hiom, K.2
Paull, T.T.3
Gellert, M.4
-
11
-
-
0032084698
-
Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
-
Hiom K, Gellert M: Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination. Mol Cell 1998, 1:1011-1019. The physical existence of a paired complex containing two signal sequences held together by RAG protein is shown. This complex is preferentially formed with one 12RSS and one 23RSS, further defining the stage at which the '12/23' rule is enforced.
-
(1998)
Mol Cell
, vol.1
, pp. 1011-1019
-
-
Hiom, K.1
Gellert, M.2
-
12
-
-
0001316589
-
Functional analysis of co-ordinated cleavage in V(D)J recombination
-
Kim DR, Oettinger MA: Functional analysis of co-ordinated cleavage in V(D)J recombination. Mol Cell Biol 1998, 18:4679-4688.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4679-4688
-
-
Kim, D.R.1
Oettinger, M.A.2
-
13
-
-
0024691453
-
V(D)J recombination: A functional definition of the joining signals
-
Hesse JE, Lieber MR, Mizuuchi K, Gellert M: V(D)J recombination: A functional definition of the joining signals. Genes Dev 1989, 3:1053-1061.
-
(1989)
Genes Dev
, vol.3
, pp. 1053-1061
-
-
Hesse, J.E.1
Lieber, M.R.2
Mizuuchi, K.3
Gellert, M.4
-
14
-
-
0030155949
-
The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo
-
Steen SB, Gomelsky L, Roth DB: The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo. Genes Cells 1996, 1:543-553.
-
(1996)
Genes Cells
, vol.1
, pp. 543-553
-
-
Steen, S.B.1
Gomelsky, L.2
Roth, D.B.3
-
15
-
-
0029864993
-
Initiation of V(D)J recombination in vitro obeying the 12/23 rule
-
Eastman QM, Leu TM, Schatz DG: Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature 1996, 380:85-88.
-
(1996)
Nature
, vol.380
, pp. 85-88
-
-
Eastman, Q.M.1
Leu, T.M.2
Schatz, D.G.3
-
16
-
-
0030009253
-
The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
-
van Gent DC, Ramsden DA, Gellert M: The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 1996, 85:107-113.
-
(1996)
Cell
, vol.85
, pp. 107-113
-
-
Van Gent, D.C.1
Ramsden, D.A.2
Gellert, M.3
-
18
-
-
0030880960
-
Coding joint formation in a cell free V(D)J recombination system
-
Leu TM, Eastman QM, Schatz DG: Coding joint formation in a cell free V(D)J recombination system. Immunity 1997, 7:303-314. The authors describe one of several cell-free systems developed to try to study the steps in V(D)J recombination that occur after the initial cleavage events.
-
(1997)
Immunity
, vol.7
, pp. 303-314
-
-
Leu, T.M.1
Eastman, Q.M.2
Schatz, D.G.3
-
19
-
-
0030753633
-
Cell-free V(D)J recombination
-
Ramsden DA, Paull TT, Gellert M: Cell-free V(D)J recombination. Nature 1997, 388:488-491. See annotation [18•]. An ongoing requirement for RAG proteins after the initial cleavage event is also shown.
-
(1997)
Nature
, vol.388
, pp. 488-491
-
-
Ramsden, D.A.1
Paull, T.T.2
Gellert, M.3
-
20
-
-
0030808573
-
V(D)J recombination: In vitro coding joint formation
-
Weis-Garcia F, Besmer E, Sawchuk DJ, Yu W, Hu Y, Cassard S, Nussenzweig MC, Cortes P: V(D)J recombination: In vitro coding joint formation. Mol Cell Biol 1997, 17:6379-6385. See annotation [18•].
-
(1997)
Mol Cell Biol
, vol.17
, pp. 6379-6385
-
-
Weis-Garcia, F.1
Besmer, E.2
Sawchuk, D.J.3
Yu, W.4
Hu, Y.5
Cassard, S.6
Nussenzweig, M.C.7
Cortes, P.8
-
21
-
-
0030887862
-
RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
-
Agrawal A, Schatz DG: RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell 1997, 89:43-53.
-
(1997)
Cell
, vol.89
, pp. 43-53
-
-
Agrawal, A.1
Schatz, D.G.2
-
22
-
-
0032247578
-
Hairpin coding end opening is mediated by RAG1 and RAG2 proteins
-
Besmer E, Mansilla-Soto J, Cassard S, Sawchuk DJ, Brown G, Sadofsky M, Lewis SM, Nussenzweig MC, Cortes P: Hairpin coding end opening is mediated by RAG1 and RAG2 proteins. Mol Cell 1998, 2:817-828. This work reports that purified RAG1 and RAG proteins together can open hairpinned DNA, suggesting that the RAG proteins could provide the hairpin opening activity required to resolve the hairpinned coding ends prior to joining.
-
(1998)
Mol Cell
, vol.2
, pp. 817-828
-
-
Besmer, E.1
Mansilla-Soto, J.2
Cassard, S.3
Sawchuk, D.J.4
Brown, G.5
Sadofsky, M.6
Lewis, S.M.7
Nussenzweig, M.C.8
Cortes, P.9
-
23
-
-
0028908736
-
Recombination activating gene 1 (RAG1) in zebrafish and shark
-
Greenhalgh P, Steiner LA: Recombination activating gene 1 (RAG1) in zebrafish and shark. Immunogenetics 1995, 41:54-55.
-
(1995)
Immunogenetics
, vol.41
, pp. 54-55
-
-
Greenhalgh, P.1
Steiner, L.A.2
-
24
-
-
0018627375
-
Sequences at the somatic recombination sites of immunoglobulin light-chain genes
-
Sakano H, Huppi K, Heinrich G, Tonegawa S: Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature 1979, 280:288-294.
-
(1979)
Nature
, vol.280
, pp. 288-294
-
-
Sakano, H.1
Huppi, K.2
Heinrich, G.3
Tonegawa, S.4
-
25
-
-
0025301095
-
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
-
Oettinger MA, Schatz DG, Gorka C, Baltimore D: RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 1990, 248:1517-1523.
-
(1990)
Science
, vol.248
, pp. 1517-1523
-
-
Oettinger, M.A.1
Schatz, D.G.2
Gorka, C.3
Baltimore, D.4
-
26
-
-
0029967722
-
Similarities between initiation of V(D)J recombination and retroviral integration
-
van Gent DC, Mizuuchi K, Gellert M: Similarities between initiation of V(D)J recombination and retroviral integration. Science 1996. 271:1592-1594.
-
(1996)
Science
, vol.271
, pp. 1592-1594
-
-
Van Gent, D.C.1
Mizuuchi, K.2
Gellert, M.3
-
27
-
-
0032502886
-
Rejoining of DNA by the RAG1 and RAG2 proteins
-
Melek M, Gellert M, van Gent DC: Rejoining of DNA by the RAG1 and RAG2 proteins. Science 1998, 280:301-303. The RAG proteins can mediate the rejoining of a cleaved signal end to a hairpinned coding end by a reaction that is essentially the chemical reversal of the cleavage step. This work represents the first example of the RAG proteins carrying out a joining reaction, supporting the relation between the RAG proteins and transposases.
-
(1998)
Science
, vol.280
, pp. 301-303
-
-
Melek, M.1
Gellert, M.2
Van Gent, D.C.3
-
28
-
-
0026549933
-
Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus
-
Chow SA, Vincent KA, Ellison V, Brown PO: Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus. Science 1992, 255:723-726.
-
(1992)
Science
, vol.255
, pp. 723-726
-
-
Chow, S.A.1
Vincent, K.A.2
Ellison, V.3
Brown, P.O.4
-
29
-
-
0032551829
-
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
-
Agrawal A, Eastman QM, Schatz DG: Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 1998, 394:744-751. This work, together with [30••], demonstrated that the RAG proteins can carry out transposition, causing the insertion of DNA flanked by RSS elements into a nonspecific target DNA molecule.
-
(1998)
Nature
, vol.394
, pp. 744-751
-
-
Agrawal, A.1
Eastman, Q.M.2
Schatz, D.G.3
-
30
-
-
0032555758
-
DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations
-
Hiom K, Melek M, Gellert M: DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations. Cell 1998, 94:463-470. See annotation [29••].
-
(1998)
Cell
, vol.94
, pp. 463-470
-
-
Hiom, K.1
Melek, M.2
Gellert, M.3
-
31
-
-
0032475879
-
Tn10 transposition via a DNA hairpin intermediate
-
Kennedy AK, Guhathakurta A, Kleckner N, Haniford DB: Tn10 transposition via a DNA hairpin intermediate. Cell 1998, 95:125-134. This work demonstrates that a hairpin intermediate may be a more common mechanism for introducing a double-strand break than previously thought. Thus it indicated that the hairpin formation is another activity common to both the RAG proteins and more classical transposases.
-
(1998)
Cell
, vol.95
, pp. 125-134
-
-
Kennedy, A.K.1
Guhathakurta, A.2
Kleckner, N.3
Haniford, D.B.4
-
32
-
-
0028317055
-
Identification of residues in the mu transposase essential for catalysis
-
Baker TA, Luo L: Identification of residues in the mu transposase essential for catalysis. Proc Natl Acad Sci USA 1994, 91:6654-6658.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 6654-6658
-
-
Baker, T.A.1
Luo, L.2
-
33
-
-
0028886688
-
Unity in transposition reactions
-
Craig NL: Unity in transposition reactions. Science 1995, 270:253-254.
-
(1995)
Science
, vol.270
, pp. 253-254
-
-
Craig, N.L.1
-
34
-
-
0029609126
-
DNA transposition: From a black box to a color monitor
-
Grindley ND, Leschziner AE: DNA transposition: From a black box to a color monitor. Cell 1995, 83:1063-1066.
-
(1995)
Cell
, vol.83
, pp. 1063-1066
-
-
Grindley, N.D.1
Leschziner, A.E.2
-
35
-
-
0030959658
-
Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster
-
Bellon SF, Rodgers KK, Schatz DG, Coleman JE, Steitz TA: Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster. Nat Struct Biol 1997, 4:586-591.
-
(1997)
Nat Struct Biol
, vol.4
, pp. 586-591
-
-
Bellon, S.F.1
Rodgers, K.K.2
Schatz, D.G.3
Coleman, J.E.4
Steitz, T.A.5
-
36
-
-
0029983727
-
Accessibility control of antigenreceptor variable-region gene assembly: Role of cis-acting elements
-
Sleckman BP, Gorman JR, Alt FW: Accessibility control of antigenreceptor variable-region gene assembly: Role of cis-acting elements. Annu Rev Immunol 1996, 14:459-481.
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 459-481
-
-
Sleckman, B.P.1
Gorman, J.R.2
Alt, F.W.3
-
37
-
-
0032541328
-
Dual role of RAG2 in V(D)J recombination: Catalysis and regulation of ordered ig gene assembly
-
Kirch SA, Rathbun GA, Oettinger MA: Dual role of RAG2 in V(D)J recombination: Catalysis and regulation of ordered ig gene assembly. EMBO J 1998, 17:4881-4886.
-
(1998)
EMBO J
, vol.17
, pp. 4881-4886
-
-
Kirch, S.A.1
Rathbun, G.A.2
Oettinger, M.A.3
-
38
-
-
0032146072
-
Enhancer control of V(D)J recombination at the TCR beta locus: Differential effects on DNA cleavage and joining
-
Hempel WM, Stanhope-Baker P, Mathieu N, Huang F, Schlissel MS, Ferrier P: Enhancer control of V(D)J recombination at the TCR beta locus: Differential effects on DNA cleavage and joining. Genes Dev 1998, 12:2305-2317.
-
(1998)
Genes Dev
, vol.12
, pp. 2305-2317
-
-
Hempel, W.M.1
Stanhope-Baker, P.2
Mathieu, N.3
Huang, F.4
Schlissel, M.S.5
Ferrier, P.6
-
39
-
-
0029894165
-
Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro
-
Stanhope-Baker P, Hudson KM, Shaffer AL, Constantinescu A, Schlissel MS: Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell 1996, 85:887-897.
-
(1996)
Cell
, vol.85
, pp. 887-897
-
-
Stanhope-Baker, P.1
Hudson, K.M.2
Shaffer, A.L.3
Constantinescu, A.4
Schlissel, M.S.5
-
40
-
-
0032239155
-
Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1
-
Kwon J, Imbalzano AN, Matthews A, Oettinger MA: Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1. Mol Cell 1998, 2:829-839. V(D)J cleavage on mononucleosomes is used to begin to explore how access to cleavage sites within chromatin is regulated.
-
(1998)
Mol Cell
, vol.2
, pp. 829-839
-
-
Kwon, J.1
Imbalzano, A.N.2
Matthews, A.3
Oettinger, M.A.4
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