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Volumn 89, Issue 1, 1997, Pages 43-53

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; PROTEIN KINASE;

EID: 0030887862     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80181-6     Document Type: Article
Times cited : (261)

References (46)
  • 1
    • 0026069099 scopus 로고
    • Pseudomonas exotoxin fusion proteins are potent immunogens for raising antibodies against P-glycoprotein
    • Bruggemann, E.P., Chaudhary, V., Gottesman, M.M., and Pastan, I. (1991). Pseudomonas exotoxin fusion proteins are potent immunogens for raising antibodies against P-glycoprotein. Biotechniques 10, 202-209.
    • (1991) Biotechniques , vol.10 , pp. 202-209
    • Bruggemann, E.P.1    Chaudhary, V.2    Gottesman, M.M.3    Pastan, I.4
  • 2
    • 0024439764 scopus 로고
    • Preparation and application of immunological probes for nucleosomes
    • Bustin, M. (1989). Preparation and application of immunological probes for nucleosomes. Meth. Enzymol. 170, 214-251.
    • (1989) Meth. Enzymol. , vol.170 , pp. 214-251
    • Bustin, M.1
  • 3
    • 0030358586 scopus 로고    scopus 로고
    • High-mobility-group chromosomal proteins: Architectural components that facilitate chromatin function
    • Bustin, M., and Reeves, R. (1996). High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function. Prog. Nucleic Acid Res. Mol. Biol. 54, 35-100.
    • (1996) Prog. Nucleic Acid Res. Mol. Biol. , vol.54 , pp. 35-100
    • Bustin, M.1    Reeves, R.2
  • 4
    • 0025201179 scopus 로고
    • A DNA-activated protein kinase from hela cell nuclei
    • Carter, T., Vancurova, I., Sun, I., Lou, W., and DeLeon, S. (1990). A DNA-activated protein kinase from HeLa cell nuclei. Mol. Cell. Biol. 10, 6460-6471.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 6460-6471
    • Carter, T.1    Vancurova, I.2    Sun, I.3    Lou, W.4    Deleon, S.5
  • 5
    • 0030199188 scopus 로고    scopus 로고
    • DNA transposition: Jumping gene machine, some assembly required
    • Chaconas, G., Lavoie, B.D., and Watson, M.A. (1996). DNA transposition: jumping gene machine, some assembly required. Curr. Biol. 6, 817-820.
    • (1996) Curr. Biol. , vol.6 , pp. 817-820
    • Chaconas, G.1    Lavoie, B.D.2    Watson, M.A.3
  • 7
    • 0001265782 scopus 로고    scopus 로고
    • RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination
    • Difilippantonio, M.J., McMahan, C.J., Eastman, Q.M., Spanopoulou, E., and Schatz, D.G. (1996). RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination. Cell 87, 253-262.
    • (1996) Cell , vol.87 , pp. 253-262
    • Difilippantonio, M.J.1    McMahan, C.J.2    Eastman, Q.M.3    Spanopoulou, E.4    Schatz, D.G.5
  • 8
    • 0029864993 scopus 로고    scopus 로고
    • Initiation of V(D)J recombination in vitro obeying the 12/23 rule
    • Eastman, Q.M., Leu, T.M.J., and Schatz, D.G. (1996). Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature 380, 85-88.
    • (1996) Nature , vol.380 , pp. 85-88
    • Eastman, Q.M.1    Leu, T.M.J.2    Schatz, D.G.3
  • 9
    • 0022340978 scopus 로고
    • Isolation of monoclonal antibodies specific for the human c-myc protooncogene product
    • Evan, G.I., Lewis, G.K., Ramsay, G., and Bishop, J.M. (1985). Isolation of monoclonal antibodies specific for the human c-myc protooncogene product. Mol. Cell. Biol. 5, 3610-3616.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 3610-3616
    • Evan, G.I.1    Lewis, G.K.2    Ramsay, G.3    Bishop, J.M.4
  • 10
    • 0029858143 scopus 로고    scopus 로고
    • V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
    • Guidos, C.J., Williams, C.J., Grandal, I., Knowles, G., Manley, T.F.H., and Danska, J.S. (1996). V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev. 10, 2038-2054.
    • (1996) Genes Dev. , vol.10 , pp. 2038-2054
    • Guidos, C.J.1    Williams, C.J.2    Grandal, I.3    Knowles, G.4    Manley, T.F.H.5    Danska, J.S.6
  • 11
    • 0030964130 scopus 로고    scopus 로고
    • A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
    • Hiom, K., and Gellert, M. (1997). A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage. Cell 88, 65-72.
    • (1997) Cell , vol.88 , pp. 65-72
    • Hiom, K.1    Gellert, M.2
  • 12
    • 0029897210 scopus 로고    scopus 로고
    • Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest
    • Huang, L.C., Clarkin, K.C., and Wahl, G.M. (1996). Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. Proc. Natl. Acad. Sci. USA 93, 4827-4832.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4827-4832
    • Huang, L.C.1    Clarkin, K.C.2    Wahl, G.M.3
  • 13
    • 0028791446 scopus 로고
    • DNA double-strand break repair and V(D)J recombination - Involvement of DNA-PK
    • Jackson, S.P., and Jeggo, P.A. (1995). DNA double-strand break repair and V(D)J recombination - involvement of DNA-PK. Trends Biochem. Sci. 20, 412-415.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 412-415
    • Jackson, S.P.1    Jeggo, P.A.2
  • 14
    • 0022545522 scopus 로고
    • Host protein requirements for in vitro site-specific DNA inversion
    • Johnson, R.C., Bruist, M.F., and Simon, M.I. (1986). Host protein requirements for in vitro site-specific DNA inversion. Cell 46, 531-539.
    • (1986) Cell , vol.46 , pp. 531-539
    • Johnson, R.C.1    Bruist, M.F.2    Simon, M.I.3
  • 15
    • 0029982968 scopus 로고    scopus 로고
    • Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes
    • Kovalenko, O.V., Plug, A.W., Haaf, T., Gonda, D.K., Ashley, T., Ward, D.C., Radding, C.M., and Golub, E.I. (1996). Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. Proc. Natl. Acad. Sci. USA 93, 2958-2963.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2958-2963
    • Kovalenko, O.V.1    Plug, A.W.2    Haaf, T.3    Gonda, D.K.4    Ashley, T.5    Ward, D.C.6    Radding, C.M.7    Golub, E.I.8
  • 16
    • 0030020897 scopus 로고    scopus 로고
    • ClpX protein of escherichia coli activates bacteriophage Mu transposase in the strand transfer complex for initiation of Mu DNA synthesis
    • Kruklitis, R., Welty, D.J., and Nakai, H. (1996). ClpX protein of Escherichia coli activates bacteriophage Mu transposase in the strand transfer complex for initiation of Mu DNA synthesis. EMBO J. 15, 935-944.
    • (1996) EMBO J. , vol.15 , pp. 935-944
    • Kruklitis, R.1    Welty, D.J.2    Nakai, H.3
  • 17
    • 0029083695 scopus 로고
    • Rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent
    • Leu, T.M.J., and Schatz, D.G. (1995). Rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent. Mol. Cell. Biol. 15, 5657-5670.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5657-5670
    • Leu, T.M.J.1    Schatz, D.G.2
  • 18
    • 0028863006 scopus 로고
    • Disassembly of the Mu transposase tetramer by the ClpX chaperone
    • Levchenko, I., Luo, L., and Baker, T.A. (1995). Disassembly of the Mu transposase tetramer by the ClpX chaperone. Genes Dev. 9, 2399-2408.
    • (1995) Genes Dev. , vol.9 , pp. 2399-2408
    • Levchenko, I.1    Luo, L.2    Baker, T.A.3
  • 19
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
    • Lewis, S.M. (1994). The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56, 27-150.
    • (1994) Adv. Immunol. , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 20
    • 0024442890 scopus 로고
    • The mechanism of antigen receptor gene assembly
    • Lewis, S., and Gellert, M. (1989). The mechanism of antigen receptor gene assembly. Cell 59, 585-588.
    • (1989) Cell , vol.59 , pp. 585-588
    • Lewis, S.1    Gellert, M.2
  • 21
    • 0026052160 scopus 로고
    • Cutting and closing without recombination in V(D)J joining
    • Lewis, S.M., and Hesse, J.E. (1991). Cutting and closing without recombination in V(D)J joining. EMBO J. 10, 3631-3639.
    • (1991) EMBO J. , vol.10 , pp. 3631-3639
    • Lewis, S.M.1    Hesse, J.E.2
  • 22
    • 0029585872 scopus 로고
    • The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
    • Li, Z.Y., Otevrel, T., Gao, Y.J., Cheng, H.L., Seed, B., Stamato, T.D., Taccioli, G.E., and Alt, F.W. (1995). The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 83, 1079-1089.
    • (1995) Cell , vol.83 , pp. 1079-1089
    • Li, Z.Y.1    Otevrel, T.2    Gao, Y.J.3    Cheng, H.L.4    Seed, B.5    Stamato, T.D.6    Taccioli, G.E.7    Alt, F.W.8
  • 23
    • 0023801238 scopus 로고
    • The defect in murine severe combined immunodeficiency: Joining of signal sequences but not coding segments in V(D)J recombination
    • Lieber, M.R., Hesse, J.E., Lewis, S., Bosma, G.C., Rosenberg, N., Mizuuchi, K., Bosma, M.J., and Gellert, M. (1988). The defect in murine severe combined immunodeficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell 55, 7-16.
    • (1988) Cell , vol.55 , pp. 7-16
    • Lieber, M.R.1    Hesse, J.E.2    Lewis, S.3    Bosma, G.C.4    Rosenberg, N.5    Mizuuchi, K.6    Bosma, M.J.7    Gellert, M.8
  • 24
    • 0030069149 scopus 로고    scopus 로고
    • T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells
    • Livak, F., and Schatz, D.G. (1996). T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol. Cell. Biol. 16, 609-618.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 609-618
    • Livak, F.1    Schatz, D.G.2
  • 25
    • 0031582059 scopus 로고    scopus 로고
    • Identification of V(D)J recombination coding end intermediates in normal thymocytes
    • Livak, F., and Schatz, D.G. (1997). Identification of V(D)J recombination coding end intermediates in normal thymocytes. J. Mol. Biol. 267, 1-9.
    • (1997) J. Mol. Biol. , vol.267 , pp. 1-9
    • Livak, F.1    Schatz, D.G.2
  • 26
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
    • McBlane, J.F., van Gent, D.C., Ramsden, D.A., Romeo, C., Cuomo, C.A., Gellert, M., and Oettinger, M.A. (1995). Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83, 387-395.
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, J.F.1    Van Gent, D.C.2    Ramsden, D.A.3    Romeo, C.4    Cuomo, C.A.5    Gellert, M.6    Oettinger, M.A.7
  • 27
    • 0026637325 scopus 로고
    • Transpositional recombination: Mechanistic insights from studies of Mu and other elements
    • Mizuuchi, K. (1992). Transpositional recombination: mechanistic insights from studies of Mu and other elements. Annu. Rev. Biochem. 61, 1011-1051.
    • (1992) Annu. Rev. Biochem. , vol.61 , pp. 1011-1051
    • Mizuuchi, K.1
  • 28
    • 0025285536 scopus 로고
    • Bending and supercoiling of DNA at the attachment site of bateriophage λ
    • Nash, H.A. (1990). Bending and supercoiling of DNA at the attachment site of bateriophage λ. Trends Biochem. Sci. 15, 222-227.
    • (1990) Trends Biochem. Sci. , vol.15 , pp. 222-227
    • Nash, H.A.1
  • 30
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M.A., Schatz, D.G., Gorka, C., and Baltimore, D. (1990). RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517-1523.
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 32
    • 0027216519 scopus 로고
    • The nonspecific DNA-binding and DNA-bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures
    • Paull. T.T., Haykinson, M.J., and Johnson, R.C. (1993). The nonspecific DNA-binding and DNA-bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures. Genes Dev. 7, 1521-1534.
    • (1993) Genes Dev. , vol.7 , pp. 1521-1534
    • Paull, T.T.1    Haykinson, M.J.2    Johnson, R.C.3
  • 33
    • 0027245559 scopus 로고
    • V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair
    • Pergola, F., Zdzienicka, M.Z., and Lieber, M.R. (1993). V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair. Mol. Cell. Biol. 13, 3464-3471.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3464-3471
    • Pergola, F.1    Zdzienicka, M.Z.2    Lieber, M.R.3
  • 34
    • 0028801363 scopus 로고
    • Formation and resolution of double-strand break intermediates in V(D)J rearrangement
    • Ramsden, D.A., and Gellert, M. (1995). Formation and resolution of double-strand break intermediates in V(D)J rearrangement. Genes Dev. 9, 2409-2420.
    • (1995) Genes Dev. , vol.9 , pp. 2409-2420
    • Ramsden, D.A.1    Gellert, M.2
  • 35
    • 0026762509 scopus 로고
    • V(D)J recombination in mouse thymocytes: Double-stranded breaks near T cell receptor 8 rearrangement signals
    • Roth, D.B., Nakajima, P.B., Menetski, J.P., Bosma, M.J., and Gellert, M. (1992). V(D)J recombination in mouse thymocytes: double-stranded breaks near T cell receptor 8 rearrangement signals. Cell 69, 41-53.
    • (1992) Cell , vol.69 , pp. 41-53
    • Roth, D.B.1    Nakajima, P.B.2    Menetski, J.P.3    Bosma, M.J.4    Gellert, M.5
  • 36
    • 0027491330 scopus 로고
    • Characterization of broken DNA molecules associated with V(D)J recombination
    • Roth, D.B., Zhu, C.M., and Gellert, M. (1993). Characterization of broken DNA molecules associated with V(D)J recombination. Proc. Natl. Acad. Sci. USA 90, 10788-10792.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10788-10792
    • Roth, D.B.1    Zhu, C.M.2    Gellert, M.3
  • 37
    • 0031171937 scopus 로고    scopus 로고
    • V(D)J recombination moves in vitro
    • in press
    • Schatz, D.G. (1997). V(D)J recombination moves in vitro. Semin. Immunol. 9, in press.
    • (1997) Semin. Immunol. , vol.9
    • Schatz, D.G.1
  • 38
    • 0024846088 scopus 로고
    • The V(D)J recombination activating gene, RAG-1
    • Schatz, D.G., Oettinger, M.A., and Baltimore, D.A. (1989). The V(D)J recombination activating gene, RAG-1. Cell 59, 1035-1048.
    • (1989) Cell , vol.59 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.A.3
  • 39
    • 0030592523 scopus 로고    scopus 로고
    • The homeodomain of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination
    • Spanopoulou, E., Zaitseva, F., Wang, F.-H., Santagata, S., Baltimore, D., and Panayotou, G. (1996). The homeodomain of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination. Cell 87, 263-276.
    • (1996) Cell , vol.87 , pp. 263-276
    • Spanopoulou, E.1    Zaitseva, F.2    Wang, F.-H.3    Santagata, S.4    Baltimore, D.5    Panayotou, G.6
  • 40
    • 0027156278 scopus 로고
    • Impairment of V(D)J recombination in double-strand break repair mutants
    • Taccioli, G.E., Rathbun, G., Oltz, E., Stamato, T., Jeggo, P.A., and Alt, F.W. (1993). Impairment of V(D)J recombination in double-strand break repair mutants. Science 260, 207-210.
    • (1993) Science , vol.260 , pp. 207-210
    • Taccioli, G.E.1    Rathbun, G.2    Oltz, E.3    Stamato, T.4    Jeggo, P.A.5    Alt, F.W.6
  • 42
    • 0029967722 scopus 로고    scopus 로고
    • Similarities between initiation of V(D)J recombination and retroviral integration
    • van Gent, D.C., Mizuuchi, K., and Gellert, M. (1996a). Similarities between initiation of V(D)J recombination and retroviral integration. Science 277, 1592-1594.
    • (1996) Science , vol.277 , pp. 1592-1594
    • Van Gent, D.C.1    Mizuuchi, K.2    And Gellert, M.3
  • 43
    • 0030009253 scopus 로고    scopus 로고
    • The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
    • van Gent, D.C., Ramsden, D.A., and Gellert, M. (1996b). The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85, 107-113.
    • (1996) Cell , vol.85 , pp. 107-113
    • Van Gent, D.C.1    Ramsden, D.A.2    Gellert, M.3
  • 44
    • 0029117310 scopus 로고
    • What to do at an end-DNA double-strand-break repair
    • Weaver, D.T. (1995). What to do at an end-DNA double-strand-break repair. Trends Genet. 11, 388-392.
    • (1995) Trends Genet. , vol.11 , pp. 388-392
    • Weaver, D.T.1
  • 45
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
    • Zhu, C.M., Bogue, M.A., Lim, D.S., Hasty, P., and Roth, D.B. (1996). Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86, 379-389.
    • (1996) Cell , vol.86 , pp. 379-389
    • Zhu, C.M.1    Bogue, M.A.2    Lim, D.S.3    Hasty, P.4    Roth, D.B.5
  • 46
    • 0028921810 scopus 로고
    • High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors
    • Zwilling, S., König, H., and Wirth, T. (1995). High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. EMBO J. 14, 1198-1208.
    • (1995) EMBO J. , vol.14 , pp. 1198-1208
    • Zwilling, S.1    König, H.2    Wirth, T.3


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