ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor α locus coding end breaks

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 15, 2007, Pages 6323-6328

  Vacchio, Melanie S ^a   Olaru, Alexandru ^b   Livak, Ferenc ^b   Hodes, Richard J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Ataxia telangiectasia mutated; Recombination; T cell development

Indexed keywords

ATM PROTEIN; PROTEIN BCL 2; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL SURVIVAL; CHROMOSOME ABERRATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA STRAND BREAKAGE; GENE; GENE LOCUS; GENE REARRANGEMENT; GENOMIC INSTABILITY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE; THYMOCYTE; VDJ EXON;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL CYCLE PROTEINS; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GENE REARRANGEMENT, T-LYMPHOCYTE; GENOMIC INSTABILITY; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; THYMUS GLAND; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA; MUS;

EID: 34447106461     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0611222104     Document Type: Article

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