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Volumn , Issue , 2010, Pages 91-176

The Role of Drug Metabolism in Drug Discovery

Author keywords

Drug metabolism role in drug discovery; Drug drug interactions (DDIs) and drug metabolizing enzymes and transporters; Metabolite identification and reactive intermediates

Indexed keywords


EID: 79959433139     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470538951.ch5     Document Type: Chapter
Times cited : (9)

References (404)
  • 1
    • 1342281273 scopus 로고    scopus 로고
    • The integration of pharmacokinetics and pharmacodynamics: understanding dose-response
    • Abdel-Rahman S, Kauffman R. The integration of pharmacokinetics and pharmacodynamics: understanding dose-response. Annu Rev Pharmacol Toxicol 2004; 44: 111-136.
    • (2004) Annu Rev Pharmacol Toxicol , vol.44 , pp. 111-136
    • Abdel-Rahman, S.1    Kauffman, R.2
  • 2
    • 0027443904 scopus 로고
    • Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture
    • Abdel-Razzak Z, et al. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol 1993; 44: 707-715.
    • (1993) Mol Pharmacol , vol.44 , pp. 707-715
    • Abdel-Razzak, Z.1
  • 3
    • 0033856082 scopus 로고    scopus 로고
    • Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes
    • Abelo A, et al. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab Dispos 2000; 28 (8): 966-972.
    • (2000) Drug Metab Dispos , vol.28 , Issue.8 , pp. 966-972
    • Abelo, A.1
  • 5
    • 0026707265 scopus 로고
    • Glutathione-dependent toxicity
    • 9/10
    • Anders M, Dekant W, Vamvakas S. Glutathione-dependent toxicity. Xenobiotica 1992; 22 (9/10): 1135-1145.
    • (1992) Xenobiotica , vol.22 , pp. 1135-1145
    • Anders, M.1    Dekant, W.2    Vamvakas, S.3
  • 6
    • 0032549060 scopus 로고    scopus 로고
    • Sulfation of minoxidil by multiple human cytosolic sulfotransferases
    • 1-3
    • Anderson R, Kudlacek P, Clemens D. Sulfation of minoxidil by multiple human cytosolic sulfotransferases. Chem Biol Interact 1998; 109 (1-3): 53-67.
    • (1998) Chem Biol Interact , vol.109 , pp. 53-67
    • Anderson, R.1    Kudlacek, P.2    Clemens, D.3
  • 7
    • 0027935778 scopus 로고
    • Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms
    • Andersson T, et al. Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms. Br J Clin Pharmacol 1994; 38 (2): 131-137.
    • (1994) Br J Clin Pharmacol , vol.38 , Issue.2 , pp. 131-137
    • Andersson, T.1
  • 8
    • 0029019398 scopus 로고
    • Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonists
    • Andrews E, et al. Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonists. Bioorg Med Chem Lett 1995; 5 (13): 1365-1370.
    • (1995) Bioorg Med Chem Lett , vol.5 , Issue.13 , pp. 1365-1370
    • Andrews, E.1
  • 9
    • 27144477300 scopus 로고    scopus 로고
    • Cyanide trapping of iminium ion reactive intermediates followed by detection and structure identification using liquid chromatography-tandem mass spectrometry (LC-MS/MS)
    • Argoti D, et al. Cyanide trapping of iminium ion reactive intermediates followed by detection and structure identification using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Chem Res Toxicol 2005; 18: 1537-1544.
    • (2005) Chem Res Toxicol , vol.18 , pp. 1537-1544
    • Argoti, D.1
  • 10
    • 3242664369 scopus 로고    scopus 로고
    • Quantification of Doxorubicin and metabolites in rat plasma and small volume tissue samples by liquid chromatography/electrospray tandem mass spectroscopy
    • Arnold R, Slack J, Straubinger R. Quantification of Doxorubicin and metabolites in rat plasma and small volume tissue samples by liquid chromatography/electrospray tandem mass spectroscopy. J Chromatogr B Anal Technol Biomed Life Sci 2004; 808 (2): 141-152.
    • (2004) J Chromatogr B Anal Technol Biomed Life Sci , vol.808 , Issue.2 , pp. 141-152
    • Arnold, R.1    Slack, J.2    Straubinger, R.3
  • 11
    • 17944369889 scopus 로고    scopus 로고
    • Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey: in vitro / in vivo correlation and the role of aldehyde oxidase
    • 8-9
    • Austin N, et al. Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey: in vitro / in vivo correlation and the role of aldehyde oxidase. Xenobiotica 2001; 31 (8-9): 677-686.
    • (2001) Xenobiotica , vol.31 , pp. 677-686
    • Austin, N.1
  • 12
    • 48749108122 scopus 로고    scopus 로고
    • Role of transport proteins in drug discovery and development: a pharmaceutical perspective
    • 7/8
    • Ayrton A, Morgan P. Role of transport proteins in drug discovery and development: a pharmaceutical perspective. Xenobiotica 2008; 38 (7/8): 676-708.
    • (2008) Xenobiotica , vol.38 , pp. 676-708
    • Ayrton, A.1    Morgan, P.2
  • 13
    • 33644861762 scopus 로고    scopus 로고
    • Inhibition constants, inhibitor concentrations and the prediction of inhibitory drug drug interactions: pitfalls, progress and promise
    • Bachmann K. Inhibition constants, inhibitor concentrations and the prediction of inhibitory drug drug interactions: pitfalls, progress and promise. Curr Drug Metab 2006; 7: 1-14.
    • (2006) Curr Drug Metab , vol.7 , pp. 1-14
    • Bachmann, K.1
  • 14
    • 18844410849 scopus 로고    scopus 로고
    • Predicting inhibitory drug-drug interactions and evaluating drug interaction reports using inhibition constants
    • Bachmann K, Lewis J. Predicting inhibitory drug-drug interactions and evaluating drug interaction reports using inhibition constants. Ann Pharmacotherapy 2005; 39: 1064-1072.
    • (2005) Ann Pharmacotherapy , vol.39 , pp. 1064-1072
    • Bachmann, K.1    Lewis, J.2
  • 15
    • 0037422456 scopus 로고    scopus 로고
    • Acyl glucuronide reactivity in perspective: biological consequences
    • Bailey M, Dickinson R. Acyl glucuronide reactivity in perspective: biological consequences. Chem Biol Interact 2003; 145 (2): 117-137.
    • (2003) Chem Biol Interact , vol.145 , Issue.2 , pp. 117-137
    • Bailey, M.1    Dickinson, R.2
  • 16
    • 0031830305 scopus 로고    scopus 로고
    • Grapefruit juice-drug interactions
    • Bailey D, et al. Grapefruit juice-drug interactions. Br J Clin Pharmacol 1998; 46 (46): 101-110.
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.46 , pp. 101-110
    • Bailey, D.1
  • 17
    • 38949088196 scopus 로고    scopus 로고
    • Metabolism and toxicity of drugs Two decades of progress in industrial drug metabolism
    • Baillie T, Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism. Chem Res Toxicol 2008; 21 (1): 129-137.
    • (2008) Chem Res Toxicol , vol.21 , Issue.1 , pp. 129-137
    • Baillie, T.1
  • 18
    • 18644385994 scopus 로고    scopus 로고
    • Drug metabolites in safety testing
    • Baillie T, et al. Drug metabolites in safety testing. Toxicol Appl Pharmacol 2002; 182: 188-196.
    • (2002) Toxicol Appl Pharmacol , vol.182 , pp. 188-196
    • Baillie, T.1
  • 19
    • 27744584321 scopus 로고    scopus 로고
    • Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection
    • Balani S, et al. Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection. Curr Topics Med Chem 2005; 5: 1033-1038.
    • (2005) Curr Topics Med Chem , vol.5 , pp. 1033-1038
    • Balani, S.1
  • 20
    • 14844295815 scopus 로고    scopus 로고
    • Does inhibition of P-glycoprotein lead to drug-drug interactions?
    • Balayssac D, et al. Does inhibition of P-glycoprotein lead to drug-drug interactions? Toxicol Lett 2005; 156: 319-329.
    • (2005) Toxicol Lett , vol.156 , pp. 319-329
    • Balayssac, D.1
  • 21
    • 33746382906 scopus 로고    scopus 로고
    • Introduction to early in vitro identification of metabolites of new chemical entities in drug discovery and development
    • Baranczewski P, et al. Introduction to early in vitro identification of metabolites of new chemical entities in drug discovery and development. Pharmacol Rep 2006a; 58: 341-352.
    • (2006) Pharmacol Rep , vol.58 , pp. 341-352
    • Baranczewski, P.1
  • 22
    • 33748636018 scopus 로고    scopus 로고
    • Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development
    • Baranczewski P, et al. Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development. Pharmacol Rep 2006b; 58: 453-472.
    • (2006) Pharmacol Rep , vol.58 , pp. 453-472
    • Baranczewski, P.1
  • 23
    • 33845996187 scopus 로고    scopus 로고
    • Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver
    • Barter Z, et al. Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver. Curr Drug Metab 2007; 8: 33-45.
    • (2007) Curr Drug Metab , vol.8 , pp. 33-45
    • Barter, Z.1
  • 24
    • 0021687352 scopus 로고
    • Imipenem/cilastatin
    • Barza M. Imipenem/cilastatin. Eur J Clin Microbiol 1984; 3 (5): 453-455.
    • (1984) Eur J Clin Microbiol , vol.3 , Issue.5 , pp. 453-455
    • Barza, M.1
  • 25
    • 0036218554 scopus 로고    scopus 로고
    • Changes in plasma protein binding have little clinical relevance
    • Benet L, Hoener B-A. Changes in plasma protein binding have little clinical relevance. Clin Pharmacol Ther 2002; 71 (3): 115-121.
    • (2002) Clin Pharmacol Ther , vol.71 , Issue.3 , pp. 115-121
    • Benet, L.1    Hoener, B.-A.2
  • 26
    • 43949115541 scopus 로고    scopus 로고
    • Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center
    • Bent S. Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center. J Gen Intern Med 2008; 23 (6): 854-859.
    • (2008) J Gen Intern Med , vol.23 , Issue.6 , pp. 854-859
    • Bent, S.1
  • 27
    • 1642298042 scopus 로고    scopus 로고
    • Commonly used herbal medicines in the United States: a review
    • Bent S, Ko R. Commonly used herbal medicines in the United States: a review. Am J Med 2004; 116: 478-485.
    • (2004) Am J Med , vol.116 , pp. 478-485
    • Bent, S.1    Ko, R.2
  • 28
    • 0037369622 scopus 로고    scopus 로고
    • Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine
    • Bertelsen K, et al. Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine. Drug Metab Dispos 2003; 31 (3): 289-293.
    • (2003) Drug Metab Dispos , vol.31 , Issue.3 , pp. 289-293
    • Bertelsen, K.1
  • 29
    • 16244415933 scopus 로고    scopus 로고
    • Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes
    • Blanchard N, et al. Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes. EurJ Pharm Sci 2004; 23: 189-199.
    • (2004) EurJ Pharm Sci , vol.23 , pp. 189-199
    • Blanchard, N.1
  • 30
    • 54049115421 scopus 로고    scopus 로고
    • The heterozygous Sod2(+/-) mouse: modeling the mitochondrial role in drug toxicity
    • 21/22
    • Boelsterli U, Hsiao C-J. The heterozygous Sod2(+/-) mouse: modeling the mitochondrial role in drug toxicity. Drug Discovery Today 2008; 13 (21/22): 982-988.
    • (2008) Drug Discovery Today , vol.13 , pp. 982-988
    • Boelsterli, U.1    Hsiao, C.-J.2
  • 31
    • 0034454016 scopus 로고    scopus 로고
    • Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man
    • Bogaards J, et al. Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica 2000; 30 (12): 1131-1152.
    • (2000) Xenobiotica , vol.30 , Issue.12 , pp. 1131-1152
    • Bogaards, J.1
  • 32
    • 0030671176 scopus 로고    scopus 로고
    • Synthesis and reactivity of coumarin 3,4-epoxide
    • Born S, et al. Synthesis and reactivity of coumarin 3,4-epoxide. Drug Metab Dispos 1997; 25 (11): 1318-1324.
    • (1997) Drug Metab Dispos , vol.25 , Issue.11 , pp. 1318-1324
    • Born, S.1
  • 33
    • 0021010984 scopus 로고
    • Interspecies pharmacokinetic scaling and the Dedrick plots
    • Boxenbaum H, Ronfeld R. Interspecies pharmacokinetic scaling and the Dedrick plots. Am J Physiol 1983; 245 (6): R768-R775.
    • (1983) Am J Physiol , vol.245 , Issue.6
    • Boxenbaum, H.1    Ronfeld, R.2
  • 34
  • 35
    • 27444445468 scopus 로고    scopus 로고
    • Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant
    • Brown H, et al. Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant. Br J Clin Pharmacol 2005; 60 (5): 508-518.
    • (2005) Br J Clin Pharmacol , vol.60 , Issue.5 , pp. 508-518
    • Brown, H.1
  • 36
    • 33748946044 scopus 로고    scopus 로고
    • Prediction of in vivo drug-drug interactions from in vitro data: factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP
    • Brown H, et al. Prediction of in vivo drug-drug interactions from in vitro data: factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP. Clin Pharmacokinet 2006; 45 (10): 1035-1050.
    • (2006) Clin Pharmacokinet , vol.45 , Issue.10 , pp. 1035-1050
    • Brown, H.1
  • 37
    • 33846405266 scopus 로고    scopus 로고
    • Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance
    • Brown H, Griffin M, Houston J. Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance. Drug Metab Dispos 2007; 35 (2): 293-301.
    • (2007) Drug Metab Dispos , vol.35 , Issue.2 , pp. 293-301
    • Brown, H.1    Griffin, M.2    Houston, J.3
  • 38
    • 0035112838 scopus 로고    scopus 로고
    • Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells
    • Burkhart C, et al. Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells. Br J Pharmacol 2001; 132 (3): 623-630.
    • (2001) Br J Pharmacol , vol.132 , Issue.3 , pp. 623-630
    • Burkhart, C.1
  • 39
    • 0036104758 scopus 로고    scopus 로고
    • Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives
    • Campiani G, et al. Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives. Curr Pharm Des 2002; 8 (8): 615-657.
    • (2002) Curr Pharm Des , vol.8 , Issue.8 , pp. 615-657
    • Campiani, G.1
  • 40
    • 33847212842 scopus 로고    scopus 로고
    • Current and future trends in the application of HPLC-MS to metabolite-identification studies
    • Castro-Perez J. Current and future trends in the application of HPLC-MS to metabolite-identification studies. Drug Discovery Today 2007; 12 (5/6): 249-256.
    • (2007) Drug Discovery Today , vol.12 , Issue.5-6 , pp. 249-256
    • Castro-Perez, J.1
  • 41
    • 0002138183 scopus 로고    scopus 로고
    • Ezetimibe: a selective inhibitor of cholesterol absorption
    • Catapano A. Ezetimibe: a selective inhibitor of cholesterol absorption. Eur Heart J Suppl 2001; 3: E6-E10.
    • (2001) Eur Heart J Suppl , vol.3
    • Catapano, A.1
  • 42
    • 0033588906 scopus 로고    scopus 로고
    • Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity
    • Chambers R, et al. Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity. Bioorg Med Chem Lett 1999; 9 (18): 2773-2778.
    • (1999) Bioorg Med Chem Lett , vol.9 , Issue.18 , pp. 2773-2778
    • Chambers, R.1
  • 43
    • 3542995726 scopus 로고    scopus 로고
    • The complexities of hepatic drug transport: current knowledge and emerging concepts
    • Chandra P, Brouwer K. The complexities of hepatic drug transport: current knowledge and emerging concepts. Pharm Res 2004; 21 (5): 719-735.
    • (2004) Pharm Res , vol.21 , Issue.5 , pp. 719-735
    • Chandra, P.1    Brouwer, K.2
  • 44
    • 33644843888 scopus 로고    scopus 로고
    • Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor
    • Chen J, Raymond K. Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Ann Clin Microbiol Antimicrob 2006; 5.
    • (2006) Ann Clin Microbiol Antimicrob , pp. 5
    • Chen, J.1    Raymond, K.2
  • 45
    • 23944510035 scopus 로고    scopus 로고
    • The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter
    • Chen Y, et al. The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter. J Pharmacol Exp Ther 2005; 314 (3): 1125-1133.
    • (2005) J Pharmacol Exp Ther , vol.314 , Issue.3 , pp. 1125-1133
    • Chen, Y.1
  • 46
    • 33846059783 scopus 로고    scopus 로고
    • Analytical tools and approaches for metabolite identification in early drug discovery
    • Chen Y, Monshouwer M, Fitch W. Analytical tools and approaches for metabolite identification in early drug discovery. Pharm Res 2007; 24 (2): 248-257.
    • (2007) Pharm Res , vol.24 , Issue.2 , pp. 248-257
    • Chen, Y.1    Monshouwer, M.2    Fitch, W.3
  • 47
    • 54349128898 scopus 로고    scopus 로고
    • Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment
    • Cheung C, Gonzalez F. Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment. J Pharmacol Exp Ther 2008; 327 (2): 288-299.
    • (2008) J Pharmacol Exp Ther , vol.327 , Issue.2 , pp. 288-299
    • Cheung, C.1    Gonzalez, F.2
  • 48
    • 0035152161 scopus 로고    scopus 로고
    • P450 interaction with HIV protease inhibitors: relationship between metabolic stability, inhibitory potency, and P450 binding spec
    • Chiba M, et al. P450 interaction with HIV protease inhibitors: relationship between metabolic stability, inhibitory potency, and P450 binding spec. Drug Metab Dispos 2001; 29 (1): 1-3.
    • (2001) Drug Metab Dispos , vol.29 , Issue.1 , pp. 1-3
    • Chiba, M.1
  • 49
    • 33745281869 scopus 로고    scopus 로고
    • Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole
    • Chien J, et al. Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole. Drug Metab Dispos 2006; 34 (7): 1208-1219.
    • (2006) Drug Metab Dispos , vol.34 , Issue.7 , pp. 1208-1219
    • Chien, J.1
  • 50
    • 33846206082 scopus 로고    scopus 로고
    • Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data
    • Christensen H, et al. Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data. J Pharm Sci 2006; 95 (12): 2778-2787.
    • (2006) J Pharm Sci , vol.95 , Issue.12 , pp. 2778-2787
    • Christensen, H.1
  • 51
    • 41949108590 scopus 로고    scopus 로고
    • Metabolic profiling as a tool for understanding mechanisms of toxicity
    • Clarke C, Haselden J. Metabolic profiling as a tool for understanding mechanisms of toxicity. Toxicol Pathol 2008; 36: 140-147.
    • (2008) Toxicol Pathol , vol.36 , pp. 140-147
    • Clarke, C.1    Haselden, J.2
  • 52
    • 32944464498 scopus 로고    scopus 로고
    • Cysteine S-conjugate beta-lyases
    • Cooper A, Pinto J. Cysteine S-conjugate beta-lyases. Amino Acids 2006; 30 (1): 1-15.
    • (2006) Amino Acids , vol.30 , Issue.1 , pp. 1-15
    • Cooper, A.1    Pinto, J.2
  • 53
    • 0037103561 scopus 로고    scopus 로고
    • Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism
    • Cooper A, Bruschi S, Anders M. Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism. Biochem Pharmacol 2002; 64 (4): 553-564.
    • (2002) Biochem Pharmacol , vol.64 , Issue.4 , pp. 553-564
    • Cooper, A.1    Bruschi, S.2    Anders, M.3
  • 54
    • 11944274532 scopus 로고    scopus 로고
    • The influence of age and sex on the clearance of cytochrome P450 3A substrates
    • Cotreau M, Von Moltke LL, Greenblatt DJ. The influence of age and sex on the clearance of cytochrome P450 3A substrates. Clin Pharmacokinet 2005; 44 (1): 33-60.
    • (2005) Clin Pharmacokinet , vol.44 , Issue.1 , pp. 33-60
    • Cotreau, M.1    Von Moltke, L.L.2    Greenblatt, D.J.3
  • 55
    • 0036201599 scopus 로고    scopus 로고
    • Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship
    • Cresteil T, et al. Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship. Drug Metab Dispos 2002; 30 (4): 438-445.
    • (2002) Drug Metab Dispos , vol.30 , Issue.4 , pp. 438-445
    • Cresteil, T.1
  • 56
    • 0026787192 scopus 로고
    • The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes
    • Crewe H, et al. The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. Br J Clin Pharmacol 1992; 34 (3): 262-265.
    • (1992) Br J Clin Pharmacol , vol.34 , Issue.3 , pp. 262-265
    • Crewe, H.1
  • 57
    • 33645518818 scopus 로고    scopus 로고
    • Role of polymorphic human cytochrome P450 enzymes in estrone oxidation
    • Cribb AE, et al. Role of polymorphic human cytochrome P450 enzymes in estrone oxidation. Cancer Epidemiol Biomarkers Prev 2006; 15 (3): 551-558.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , Issue.3 , pp. 551-558
    • Cribb, A.E.1
  • 58
    • 0037251643 scopus 로고    scopus 로고
    • Lopinavir/ritonavir: a review of its use in the management of HIV infection
    • Cvetkovic R, Goa K. Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs 2003; 63 (8): 769-802.
    • (2003) Drugs , vol.63 , Issue.8 , pp. 769-802
    • Cvetkovic, R.1    Goa, K.2
  • 59
    • 0034791777 scopus 로고    scopus 로고
    • Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid
    • Dai D, et al. Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid. Pharmacogenetics 2001; 11 (7): 597-607.
    • (2001) Pharmacogenetics , vol.11 , Issue.7 , pp. 597-607
    • Dai, D.1
  • 60
    • 0036127307 scopus 로고    scopus 로고
    • Biotransformation reactions of five-membered aromatic heterocyclic rings
    • Dalvie D, et al. Biotransformation reactions of five-membered aromatic heterocyclic rings. Chem Res Toxicol 2002; 15 (3): 269-299.
    • (2002) Chem Res Toxicol , vol.15 , Issue.3 , pp. 269-299
    • Dalvie, D.1
  • 61
    • 33845734598 scopus 로고    scopus 로고
    • A regulatory perspective on issues and approaches in characterizing human metabolites
    • Davis-Bruno K, Atrakchi A. A regulatory perspective on issues and approaches in characterizing human metabolites. Chem Biol Interact 2006; 19: 1561-1563.
    • (2006) Chem Biol Interact , vol.19 , pp. 1561-1563
    • Davis-Bruno, K.1    Atrakchi, A.2
  • 62
    • 34047157087 scopus 로고    scopus 로고
    • The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools
    • De Buck S, et al. The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools. Drug Metab Dispos 2007; 35 (4): 649-659.
    • (2007) Drug Metab Dispos , vol.35 , Issue.4 , pp. 649-659
    • De Buck, S.1
  • 63
    • 26444498631 scopus 로고    scopus 로고
    • The role of P-glycoprotein and organic anion-transporting polypeptides in drug interactions
    • DeBuske L. The role of P-glycoprotein and organic anion-transporting polypeptides in drug interactions. Drug Safety 2005; 28 (9): 789-801.
    • (2005) Drug Safety , vol.28 , Issue.9 , pp. 789-801
    • DeBuske, L.1
  • 64
    • 0036784476 scopus 로고    scopus 로고
    • Comparison of in vitro preparations for semi-quantitative prediction of in vivo drug metabolism
    • De Graaf I, et al. Comparison of in vitro preparations for semi-quantitative prediction of in vivo drug metabolism. Drug Metab Dispos 2002; 30 (10): 1129-1136.
    • (2002) Drug Metab Dispos , vol.30 , Issue.10 , pp. 1129-1136
    • De Graaf, I.1
  • 65
    • 0042661009 scopus 로고    scopus 로고
    • Biosynthesis of toxic glutathione conjugates from halogenated alkenes
    • Dekant W. Biosynthesis of toxic glutathione conjugates from halogenated alkenes. Toxicol Lett 2003; 144 (1): 49-54.
    • (2003) Toxicol Lett , vol.144 , Issue.1 , pp. 49-54
    • Dekant, W.1
  • 66
    • 0028190695 scopus 로고
    • Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate beta-lyase pathway
    • Dekant W, Vamvakas S, Anders M. Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate beta-lyase pathway. Adv Pharmacol 1994; 27: 115-162.
    • (1994) Adv Pharmacol , vol.27 , pp. 115-162
    • Dekant, W.1    Vamvakas, S.2    Anders, M.3
  • 67
    • 0025057574 scopus 로고
    • On the formation of carbamate glucuronides
    • Delbressine L, et al. On the formation of carbamate glucuronides. Xenobiotica 1990; 20 (1): 133-134.
    • (1990) Xenobiotica , vol.20 , Issue.1 , pp. 133-134
    • Delbressine, L.1
  • 68
    • 0034913661 scopus 로고    scopus 로고
    • Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role of CYP3A
    • Desta Z, et al. Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role of CYP3A. J Pharmacol Exp Ther 2001; 298 (2): 508-520.
    • (2001) J Pharmacol Exp Ther , vol.298 , Issue.2 , pp. 508-520
    • Desta, Z.1
  • 69
    • 84965185865 scopus 로고    scopus 로고
    • Clinical significance of drug binding, protein binding, and binding displacement drug interactions
    • DeVane C. Clinical significance of drug binding, protein binding, and binding displacement drug interactions. Psychopharmacol Bull 2002; 36 (3): 5-21.
    • (2002) Psychopharmacol Bull , vol.36 , Issue.3 , pp. 5-21
    • DeVane, C.1
  • 70
    • 0031963129 scopus 로고    scopus 로고
    • Route dependent pulmonary first-pass metabolism of a series of biphenylacetic acid esters in rats
    • Dickinson P, Taylor G. Route dependent pulmonary first-pass metabolism of a series of biphenylacetic acid esters in rats. Eur J Pharm Sci 1998; 6 (1): 11-18.
    • (1998) Eur J Pharm Sci , vol.6 , Issue.1 , pp. 11-18
    • Dickinson, P.1    Taylor, G.2
  • 71
    • 0033927921 scopus 로고    scopus 로고
    • A mechanistic approach to understanding species differences in felbamate bioactivation: relevance to drug-induced idiosyncratic reactions
    • Dieckhaus C, et al. A mechanistic approach to understanding species differences in felbamate bioactivation: relevance to drug-induced idiosyncratic reactions. Drug Metab Dispos 2000; 28 (7): 814-822.
    • (2000) Drug Metab Dispos , vol.28 , Issue.7 , pp. 814-822
    • Dieckhaus, C.1
  • 72
    • 40749143959 scopus 로고    scopus 로고
    • 4-Aminopyrimidine tetrahydronaphthols: a series of novel vanilloid receptor-1 antagonists with improved solubility properties
    • Doherty E, et al. 4-Aminopyrimidine tetrahydronaphthols: a series of novel vanilloid receptor-1 antagonists with improved solubility properties. Bioorg Med Chem Lett 2008; 18: 1830-1834.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 1830-1834
    • Doherty, E.1
  • 73
    • 0030658987 scopus 로고    scopus 로고
    • Level A in vivo-in vitro correlation: nonlinear models and statistical methodology
    • Dunne A, O'Hara T, Devane J. Level A in vivo-in vitro correlation: nonlinear models and statistical methodology. J Pharm Sci 1997; 86 (11): 1245-1249.
    • (1997) J Pharm Sci , vol.86 , Issue.11 , pp. 1245-1249
    • Dunne, A.1    O'Hara, T.2    Devane, J.3
  • 74
    • 33745253791 scopus 로고    scopus 로고
    • Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor
    • Duret C, et al. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol Pharmacol 2006; 70 (1): 329-339.
    • (2006) Mol Pharmacol , vol.70 , Issue.1 , pp. 329-339
    • Duret, C.1
  • 75
    • 0037561538 scopus 로고    scopus 로고
    • Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation
    • Dvorak Z, et al. Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Mol Pharmacol 2003; 64 (1): 160-169.
    • (2003) Mol Pharmacol , vol.64 , Issue.1 , pp. 160-169
    • Dvorak, Z.1
  • 76
    • 0028360826 scopus 로고
    • Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human
    • Edwards R, et al. Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human. Carcinogenesis 1994; 15 (5): 829-836.
    • (1994) Carcinogenesis , vol.15 , Issue.5 , pp. 829-836
    • Edwards, R.1
  • 77
    • 33644835354 scopus 로고    scopus 로고
    • The role of transporters in drug interactions
    • Enders C, et al. The role of transporters in drug interactions. Eur J Pharm Sci 2006; 27: 501-517.
    • (2006) Eur J Pharm Sci , vol.27 , pp. 501-517
    • Enders, C.1
  • 78
    • 33845491064 scopus 로고    scopus 로고
    • Chemical toxicology: reactive intermediates and their role in pharmacology and toxicology
    • Erve J. Chemical toxicology: reactive intermediates and their role in pharmacology and toxicology. Expert Opin Drug Metab Toxicol 2006; 2 (6): 923-946.
    • (2006) Expert Opin Drug Metab Toxicol , vol.2 , Issue.6 , pp. 923-946
    • Erve, J.1
  • 79
    • 1642281756 scopus 로고    scopus 로고
    • Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development
    • Evans D, et al. Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development. Chem Res Toxicol 2004; 17: 3-16.
    • (2004) Chem Res Toxicol , vol.17 , pp. 3-16
    • Evans, D.1
  • 80
    • 34447312263 scopus 로고    scopus 로고
    • Prediction of human pharmacokinetics -evaluation of methods for prediction of hepatic metabolic clearance
    • Fagerholm U. Prediction of human pharmacokinetics -evaluation of methods for prediction of hepatic metabolic clearance. J Pharm Pharmacol 2007a; 59: 803-828.
    • (2007) J Pharm Pharmacol , vol.59 , pp. 803-828
    • Fagerholm, U.1
  • 81
    • 35349020575 scopus 로고    scopus 로고
    • Prediction of human pharmacokinetics -improving microsome-based predictions of hepatic metabolic clearance
    • Fagerholm U. Prediction of human pharmacokinetics -improving microsome-based predictions of hepatic metabolic clearance. J Pharm Pharmacol 2007b; 59: 1427-1431.
    • (2007) J Pharm Pharmacol , vol.59 , pp. 1427-1431
    • Fagerholm, U.1
  • 82
    • 50049091411 scopus 로고    scopus 로고
    • Prediction of drug-drug interactions from in vitro induction data: application of the relative induction score approach using cryopreserved human hepatocytes
    • Fahmi OBS, et al. Prediction of drug-drug interactions from in vitro induction data: application of the relative induction score approach using cryopreserved human hepatocytes. Drug Metab Dispos 2008; 36 (9): 1971-1974.
    • (2008) Drug Metab Dispos , vol.36 , Issue.9 , pp. 1971-1974
    • Fahmi, O.B.S.1
  • 83
    • 35548997887 scopus 로고    scopus 로고
    • Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor
    • Fang H-L, et al. Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor. J Pharmacol Exp Ther 2007; 323 (2): 586-598.
    • (2007) J Pharmacol Exp Ther , vol.323 , Issue.2 , pp. 586-598
    • Fang, H.-L.1
  • 84
    • 38749088304 scopus 로고    scopus 로고
    • Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice
    • Felmlee M, et al. Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice. Drug Metab Dispos 2008; 36 (2): 435-441.
    • (2008) Drug Metab Dispos , vol.36 , Issue.2 , pp. 435-441
    • Felmlee, M.1
  • 85
    • 0034120946 scopus 로고    scopus 로고
    • Allometric pharmacokinetic scaling: towards the prediction of human oral pharmacokinetics
    • Feng M, et al. Allometric pharmacokinetic scaling: towards the prediction of human oral pharmacokinetics. Pharm Res 2000; 17 (4): 410-418.
    • (2000) Pharm Res , vol.17 , Issue.4 , pp. 410-418
    • Feng, M.1
  • 86
    • 0036784485 scopus 로고    scopus 로고
    • Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance
    • Fisher M, et al. Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance. Drug Metab Dispos 2002; 30 (10): 1087-1093.
    • (2002) Drug Metab Dispos , vol.30 , Issue.10 , pp. 1087-1093
    • Fisher, M.1
  • 87
    • 0026521187 scopus 로고
    • Benzazepinone calcium channel blockers 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones
    • Floyd D, et al. Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones. J Med Chem 1992; 35 (4): 756-772.
    • (1992) J Med Chem , vol.35 , Issue.4 , pp. 756-772
    • Floyd, D.1
  • 88
    • 24944510505 scopus 로고    scopus 로고
    • Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity
    • Fontana E, Dansette P, Poli S. Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab 2005; 6: 413-454.
    • (2005) Curr Drug Metab , vol.6 , pp. 413-454
    • Fontana, E.1    Dansette, P.2    Poli, S.3
  • 89
    • 53849084442 scopus 로고    scopus 로고
    • In vitro evaluation of reversible and irreversible cytochrome P450 inhibition: current status on methodologies and their utility for predicting drug-drug interactions
    • Fowler S, Zhang H. In vitro evaluation of reversible and irreversible cytochrome P450 inhibition: current status on methodologies and their utility for predicting drug-drug interactions. AAPS J 2008; 10 (2): 410-424.
    • (2008) AAPS J , vol.10 , Issue.2 , pp. 410-424
    • Fowler, S.1    Zhang, H.2
  • 90
    • 33846642215 scopus 로고    scopus 로고
    • Gender differences in drug responses
    • Franconi F, et al. Gender differences in drug responses. Pharmacol Res 2007; 55: 81-95.
    • (2007) Pharmacol Res , vol.55 , pp. 81-95
    • Franconi, F.1
  • 91
    • 57349181460 scopus 로고    scopus 로고
    • 2-Diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) revisited: comparative cytochrome P450 inhibition in human liver microsomes by SKF525A, its metabolites, and SKF-acid and SKF-alcohol
    • Franklin M, Hathaway L. 2-Diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) revisited: comparative cytochrome P450 inhibition in human liver microsomes by SKF525A, its metabolites, and SKF-acid and SKF-alcohol. Drug Metab Dispos 2008; 36 (12): 2539-2546.
    • (2008) Drug Metab Dispos , vol.36 , Issue.12 , pp. 2539-2546
    • Franklin, M.1    Hathaway, L.2
  • 92
    • 0028860187 scopus 로고
    • Dose-response studies of MeIQx in rat liver and liver DNA at low doses
    • Frantz C, et al. Dose-response studies of MeIQx in rat liver and liver DNA at low doses. Carcinogenesis 1995; 16 (2): 367-373.
    • (1995) Carcinogenesis , vol.16 , Issue.2 , pp. 367-373
    • Frantz, C.1
  • 93
    • 0034042711 scopus 로고    scopus 로고
    • Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans
    • Fuhr U. Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans. Clin Pharmacokinet 2000; 38 (6): 493-504.
    • (2000) Clin Pharmacokinet , vol.38 , Issue.6 , pp. 493-504
    • Fuhr, U.1
  • 94
    • 44349148749 scopus 로고    scopus 로고
    • The role of hepatic transporters in drug elimination
    • Funk C. The role of hepatic transporters in drug elimination. Expert Opin Drug Metab Toxicol 2008; 4 (4): 363-379.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , Issue.4 , pp. 363-379
    • Funk, C.1
  • 95
    • 33644859466 scopus 로고    scopus 로고
    • Role of pharmacologically active metabolites in drug discovery and development
    • Fura A. Role of pharmacologically active metabolites in drug discovery and development. Drug Discovery Tech 2006; 11 (3/4): 133-142.
    • (2006) Drug Discovery Tech , vol.11 , Issue.3-4 , pp. 133-142
    • Fura, A.1
  • 96
    • 35348813095 scopus 로고    scopus 로고
    • Intestinal first-pass metabolism: bridging the gap between in vitro and in vivo
    • Galetin A. Intestinal first-pass metabolism: bridging the gap between in vitro and in vivo. Curr Drug Metab 2007; 8 (7): 643-644.
    • (2007) Curr Drug Metab , vol.8 , Issue.7 , pp. 643-644
    • Galetin, A.1
  • 97
    • 29944446485 scopus 로고    scopus 로고
    • Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition
    • Galetin A, et al. Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition. Drug Metab Dispos 2006; 34 (1): 166-175.
    • (2006) Drug Metab Dispos , vol.34 , Issue.1 , pp. 166-175
    • Galetin, A.1
  • 98
    • 36248956546 scopus 로고    scopus 로고
    • Method for rapid metabolite profiling of drug candidates in fresh hepatocytes using liquid chromatography coupled with a hybrid quadrupole linear ion trap
    • Gao H, et al. Method for rapid metabolite profiling of drug candidates in fresh hepatocytes using liquid chromatography coupled with a hybrid quadrupole linear ion trap. Rapid Commun in Mass Spec 2007; 21: 3683-3693.
    • (2007) Rapid Commun in Mass Spec , vol.21 , pp. 3683-3693
    • Gao, H.1
  • 99
    • 0028927525 scopus 로고
    • Comparison of the disposition of two novel combined thromboxane synthase inhibitors/thromboxane A2 receptor antagonists in the isolated perfused rat liver
    • Gardner I, et al. Comparison of the disposition of two novel combined thromboxane synthase inhibitors/thromboxane A2 receptor antagonists in the isolated perfused rat liver. Xenobiotica 1995; 25 (2): 185-197.
    • (1995) Xenobiotica , vol.25 , Issue.2 , pp. 185-197
    • Gardner, I.1
  • 100
    • 2942596319 scopus 로고    scopus 로고
    • The use of a cyclosporin-ketoconazole combination: making renal transplantation affordable in developing countries
    • Gerntholtz T, et al. The use of a cyclosporin-ketoconazole combination: making renal transplantation affordable in developing countries. Eur J Clin Pharmacol 2004; 60 (3): 143-148.
    • (2004) Eur J Clin Pharmacol , vol.60 , Issue.3 , pp. 143-148
    • Gerntholtz, T.1
  • 101
    • 34247510665 scopus 로고    scopus 로고
    • Hepatocytes -the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo
    • Gomez-Lechon M, Castell J, Donato M. Hepatocytes -the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo. Chemico-Biol Interactions 2007; 168: 30-50.
    • (2007) Chemico-Biol Interactions , vol.168 , pp. 30-50
    • Gomez-Lechon, M.1    Castell, J.2    Donato, M.3
  • 102
    • 36048953756 scopus 로고    scopus 로고
    • CYP3A4 and pregnane X receptor humanized mice
    • Gonzalez F. CYP3A4 and pregnane X receptor humanized mice. J Biochem Mol Toxicol 2007; 21 (4): 158-162.
    • (2007) J Biochem Mol Toxicol , vol.21 , Issue.4 , pp. 158-162
    • Gonzalez, F.1
  • 103
    • 33144459032 scopus 로고    scopus 로고
    • Cytochrome P450 expression and regulation in CYP3A4/ CYP2D6 double transgenic humanized mice
    • Gonzalez F, Yu A-M. Cytochrome P450 expression and regulation in CYP3A4/ CYP2D6 double transgenic humanized mice. Annu Rev Pharmacol Toxicol 2006; 46: 41-64.
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 41-64
    • Gonzalez, F.1    Yu, A.-M.2
  • 105
    • 8244234465 scopus 로고    scopus 로고
    • Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial
    • Graham M, et al. Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial. Cancer Chemother Pharmacol 1997; 40 (1): 1-10.
    • (1997) Cancer Chemother Pharmacol , vol.40 , Issue.1 , pp. 1-10
    • Graham, M.1
  • 106
    • 0034056369 scopus 로고    scopus 로고
    • Alprazolam-ritonavir interaction: implications for product labeling
    • Greenblatt D, et al. Alprazolam-ritonavir interaction: implications for product labeling. Clin Pharmacol Ther 2000; 67 (4): 335-341.
    • (2000) Clin Pharmacol Ther , vol.67 , Issue.4 , pp. 335-341
    • Greenblatt, D.1
  • 107
    • 33645961595 scopus 로고    scopus 로고
    • The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions
    • Grime K, Riley R. The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions. Curr Drug Metab 2006; 7: 251-264.
    • (2006) Curr Drug Metab , vol.7 , pp. 251-264
    • Grime, K.1    Riley, R.2
  • 108
    • 67649389519 scopus 로고    scopus 로고
    • The conduct of in vitro studies to address time-dependent inhibition of drug metabolising enzymes: a perspective of the Pharmaceutical Research and Manufacturers of America (PhRMA)
    • Grimm SW, et al. The conduct of in vitro studies to address time-dependent inhibition of drug metabolising enzymes: a perspective of the Pharmaceutical Research and Manufacturers of America (PhRMA). Drug Metab Dispos 2009; 37(7): 1355-1370.
    • (2009) Drug Metab Dispos , vol.37 , Issue.7 , pp. 1355-1370
    • Grimm, S.W.1
  • 109
    • 0034970549 scopus 로고    scopus 로고
    • Uncommon P450-catalyzed reactions
    • Guengerich F. Uncommon P450-catalyzed reactions. Curr Drug Metab 2001; 2: 93-115.
    • (2001) Curr Drug Metab , vol.2 , pp. 93-115
    • Guengerich, F.1
  • 110
    • 33645050104 scopus 로고    scopus 로고
    • Cytochrome P450s and other enzymes in drug metabolism and toxicity
    • Guengerich F. Cytochrome P450s and other enzymes in drug metabolism and toxicity. AAPS J 2006a; 8 (1): E101-E111.
    • (2006) AAPS J , vol.8 , Issue.1
    • Guengerich, F.1
  • 111
    • 33845792941 scopus 로고    scopus 로고
    • Safety assessment of stable drug metabolites
    • Guengerich F. Safety assessment of stable drug metabolites. Chem Res Toxicol 2006b; 19 (12): 1559-1560.
    • (2006) Chem Res Toxicol , vol.19 , Issue.12 , pp. 1559-1560
    • Guengerich, F.1
  • 112
    • 34047266790 scopus 로고    scopus 로고
    • Applying mechanisms of chemical toxicity to predict drug safety
    • Guengerich F, MacDonald J. Applying mechanisms of chemical toxicity to predict drug safety. Chem Res Toxicol 2007; 20: 344-369.
    • (2007) Chem Res Toxicol , vol.20 , pp. 344-369
    • Guengerich, F.1    MacDonald, J.2
  • 113
    • 0027298442 scopus 로고
    • Age-and gender-related variations in the activities of drug-metabolizing and antioxidant enzymes in the white-footed mouse (Peromyscus leucopus
    • Guo Z, et al. Age-and gender-related variations in the activities of drug-metabolizing and antioxidant enzymes in the white-footed mouse (Peromyscus leucopus. Growth Dev Aging 1993; 57 (2): 85-100.
    • (1993) Growth Dev Aging , vol.57 , Issue.2 , pp. 85-100
    • Guo, Z.1
  • 114
    • 33644893086 scopus 로고    scopus 로고
    • Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance
    • Hakooz N, et al. Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance. Pharm Res 2006; 23 (3): 533-539.
    • (2006) Pharm Res , vol.23 , Issue.3 , pp. 533-539
    • Hakooz, N.1
  • 115
    • 33751100417 scopus 로고    scopus 로고
    • Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance
    • Hallifax D, Houston J. Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance. Drug Metab Dispos 2006; 34: 1829-1836.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1829-1836
    • Hallifax, D.1    Houston, J.2
  • 116
    • 34547163963 scopus 로고    scopus 로고
    • Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction
    • Hallifax D, Houston J. Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction. Drug Metab Dispos 2007; 35 (8): 1325-1332.
    • (2007) Drug Metab Dispos , vol.35 , Issue.8 , pp. 1325-1332
    • Hallifax, D.1    Houston, J.2
  • 117
    • 33947387173 scopus 로고    scopus 로고
    • A PK-PD model for predicting the impact of age, CYP2C9, and VKORC1 genotype on individualization of warfarin therapy
    • Hamberg A, et al. A PK-PD model for predicting the impact of age, CYP2C9, and VKORC1 genotype on individualization of warfarin therapy. Clin Pharmacol Ther 2007; 81 (4): 529-616.
    • (2007) Clin Pharmacol Ther , vol.81 , Issue.4 , pp. 529-616
    • Hamberg, A.1
  • 118
    • 51249114512 scopus 로고    scopus 로고
    • Reaction phenotyping: current industry efforts to identify enzymes responsible for metabolizing drug candidates
    • Harper T, Brassil P. Reaction phenotyping: current industry efforts to identify enzymes responsible for metabolizing drug candidates. AAPS J 2008; 10 (1): 200-207.
    • (2008) AAPS J , vol.10 , Issue.1 , pp. 200-207
    • Harper, T.1    Brassil, P.2
  • 119
    • 33645240574 scopus 로고    scopus 로고
    • Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a) pyrene
    • Harrigan J, et al. Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a) pyrene. Toxicol In Vitro 2006; 20: 426-438.
    • (2006) Toxicol In Vitro , vol.20 , pp. 426-438
    • Harrigan, J.1
  • 120
    • 0029128720 scopus 로고
    • Gender effects in pharmacokinetics and pharmacodynamics
    • Harris R, Benet L, Schwartz J. Gender effects in pharmacokinetics and pharmacodynamics. Drugs 1995; 50 (2): 222-239.
    • (1995) Drugs , vol.50 , Issue.2 , pp. 222-239
    • Harris, R.1    Benet, L.2    Schwartz, J.3
  • 121
    • 0033960051 scopus 로고    scopus 로고
    • Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms
    • Hein D, et al. Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer Epidemiol Biomarkers Prev 2000; 9: 29-42.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 29-42
    • Hein, D.1
  • 122
    • 33646006090 scopus 로고    scopus 로고
    • Evaluation of microsomal incubation conditions on CYP3A4-mediated metabolism of cyclosporine A by a statistical experimental design
    • Hermann M, et al. Evaluation of microsomal incubation conditions on CYP3A4-mediated metabolism of cyclosporine A by a statistical experimental design. Curr Drug Metab 2006; 7: 265-271.
    • (2006) Curr Drug Metab , vol.7 , pp. 265-271
    • Hermann, M.1
  • 123
    • 34848925477 scopus 로고    scopus 로고
    • Tissue-specific induction of the carcinogen-inducible cytochrome P450 isoforms in the gastrointestinal tract
    • Hernandez-Martinez N, et al. Tissue-specific induction of the carcinogen-inducible cytochrome P450 isoforms in the gastrointestinal tract. Environ Toxicol Pharmacol 2007; 24 (3): 297-303.
    • (2007) Environ Toxicol Pharmacol , vol.24 , Issue.3 , pp. 297-303
    • Hernandez-Martinez, N.1
  • 124
    • 33847018050 scopus 로고    scopus 로고
    • Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies
    • Hewitt N, et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev 2007a; 39: 159-234.
    • (2007) Drug Metab Rev , vol.39 , pp. 159-234
    • Hewitt, N.1
  • 125
    • 34247505094 scopus 로고    scopus 로고
    • Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry -do they comply with FDA recommendations?
    • Hewitt N, de Kanter R, LeCluyse E. Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry -do they comply with FDA recommendations ? Chemico-Biol Interactions 2007b; 168: 51-65.
    • (2007) Chemico-Biol Interactions , vol.168 , pp. 51-65
    • Hewitt, N.1    de Kanter, R.2    LeCluyse, E.3
  • 126
    • 35648976075 scopus 로고    scopus 로고
    • Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations
    • 10/11
    • Hewitt N, LeCluyse E, Ferguson S. Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations. Xenobiotica 2007c; 37 (10/11): 1196-1224.
    • (2007) Xenobiotica , vol.37 , pp. 1196-1224
    • Hewitt, N.1    LeCluyse, E.2    Ferguson, S.3
  • 127
    • 0032977985 scopus 로고    scopus 로고
    • Dose-dependent intestinal and hepatic first-pass metabolism of midazolam, a cytochrome P450 3A substrate with differently modulated enzyme activity in rats
    • Higashikawa F, et al. Dose-dependent intestinal and hepatic first-pass metabolism of midazolam, a cytochrome P450 3A substrate with differently modulated enzyme activity in rats. J Pharm Pharmacol 1999; 51: 67-72.
    • (1999) J Pharm Pharmacol , vol.51 , pp. 67-72
    • Higashikawa, F.1
  • 128
    • 0020644892 scopus 로고
    • Reactive metabolites of phenacetin and acetaminophen: a review
    • Hinson J. Reactive metabolites of phenacetin and acetaminophen: a review. Environ Health Persp 1983; 49: 71-79.
    • (1983) Environ Health Persp , vol.49 , pp. 71-79
    • Hinson, J.1
  • 129
    • 38949099990 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications
    • Hollenberg P, Kent U, Bumpus N. Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications. Chem Res Toxicol 2008; 21: 189-205.
    • (2008) Chem Res Toxicol , vol.21 , pp. 189-205
    • Hollenberg, P.1    Kent, U.2    Bumpus, N.3
  • 130
    • 27544478275 scopus 로고    scopus 로고
    • Uniformity of ionization response of structurally diverse analytes using a chip-based nanoelectrospray ionization source
    • Hop C, Chen Y, Yu L. Uniformity of ionization response of structurally diverse analytes using a chip-based nanoelectrospray ionization source. Rapid Commun Mass Spectrom 2005; 19 (21): 3139-3142.
    • (2005) Rapid Commun Mass Spectrom , vol.19 , Issue.21 , pp. 3139-3142
    • Hop, C.1    Chen, Y.2    Yu, L.3
  • 131
    • 0346992330 scopus 로고    scopus 로고
    • Progress towards prediction of human pharmacokinetic parameters from in vitro technologies
    • Houston J, Galetin A. Progress towards prediction of human pharmacokinetic parameters from in vitro technologies. Drug Metab Rev 2003; 35 (4): 393-415.
    • (2003) Drug Metab Rev , vol.35 , Issue.4 , pp. 393-415
    • Houston, J.1    Galetin, A.2
  • 132
    • 0034105896 scopus 로고    scopus 로고
    • In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model
    • Houston J, Kenworthy K. In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model. Drug Metab Dispos 2000; 28 (3): 246-254.
    • (2000) Drug Metab Dispos , vol.28 , Issue.3 , pp. 246-254
    • Houston, J.1    Kenworthy, K.2
  • 133
    • 33845769325 scopus 로고    scopus 로고
    • Safety assessment of drug metabolites: characterization of chemically stable metabolites
    • Humphreys W, Unger S. Safety assessment of drug metabolites: characterization of chemically stable metabolites. Chem Res Toxicol 2006; 19: 1564-1569.
    • (2006) Chem Res Toxicol , vol.19 , pp. 1564-1569
    • Humphreys, W.1    Unger, S.2
  • 134
    • 0021245919 scopus 로고
    • Hepatic elimination of drugs with concentration-dependent serum protein binding
    • Huang J, Oie S. Hepatic elimination of drugs with concentration-dependent serum protein binding. J Pharmacokinet Biopharm 1984; 12 (1): 67-81.
    • (1984) J Pharmacokinet Biopharm , vol.12 , Issue.1 , pp. 67-81
    • Huang, J.1    Oie, S.2
  • 135
    • 43349093221 scopus 로고    scopus 로고
    • Projection of exposure and efficacious dose prior to first-in-human studies: How successful have we been?
    • Huang C, et al. Projection of exposure and efficacious dose prior to first-in-human studies: How successful have we been? Pharm Res 2008; 25 (4): 713-726.
    • (2008) Pharm Res , vol.25 , Issue.4 , pp. 713-726
    • Huang, C.1
  • 136
    • 0026708362 scopus 로고
    • Effect of age and gender on the activity of human hepatic CYP3A
    • Hunt C, Westerkam W, Stave G. Effect of age and gender on the activity of human hepatic CYP3A. Biochem Pharmacol 1992; 44 (2): 275-283.
    • (1992) Biochem Pharmacol , vol.44 , Issue.2 , pp. 275-283
    • Hunt, C.1    Westerkam, W.2    Stave, G.3
  • 138
    • 33745253947 scopus 로고    scopus 로고
    • Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans
    • Ishiguro N, et al. Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans. Drug Metab Dispos 2006; 34 (7): 1109-1115.
    • (2006) Drug Metab Dispos , vol.34 , Issue.7 , pp. 1109-1115
    • Ishiguro, N.1
  • 139
    • 33846483860 scopus 로고    scopus 로고
    • Complex reactions catalyzed by cytochrome P450 enzymes
    • Isin E, Guengerich F. Complex reactions catalyzed by cytochrome P450 enzymes. Biochim Biophys Acta 2006a; 1770: 314-329.
    • (2006) Biochim Biophys Acta , vol.1770 , pp. 314-329
    • Isin, E.1    Guengerich, F.2
  • 140
    • 33646942269 scopus 로고    scopus 로고
    • Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4
    • Isin E, Guengerich F. Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4. J Biol Chem 2006b; 281 (14): 9127-9136.
    • (2006) J Biol Chem , vol.281 , Issue.14 , pp. 9127-9136
    • Isin, E.1    Guengerich, F.2
  • 141
    • 4644321613 scopus 로고    scopus 로고
    • Role of itraconazole metabolites in CYP3A4 inhibition
    • Isoherranen N, et al. Role of itraconazole metabolites in CYP3A4 inhibition. Drug Metab Dispos 2004; 32 (10): 1121-1131.
    • (2004) Drug Metab Dispos , vol.32 , Issue.10 , pp. 1121-1131
    • Isoherranen, N.1
  • 142
    • 17644381224 scopus 로고    scopus 로고
    • Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches
    • Ito K, Houston J. Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches. Pharm Res 2005; 22 (1): 103-112.
    • (2005) Pharm Res , vol.22 , Issue.1 , pp. 103-112
    • Ito, K.1    Houston, J.2
  • 143
    • 0031777718 scopus 로고    scopus 로고
    • Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver
    • Ito K, et al. Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver. Annu Rev Pharmacol Toxicol 1998a; 38: 461-499.
    • (1998) Annu Rev Pharmacol Toxicol , vol.38 , pp. 461-499
    • Ito, K.1
  • 144
    • 0031723235 scopus 로고    scopus 로고
    • Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver
    • Ito K, et al. Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver. Pharmacol Rev 1998b; 50 (3): 387-411.
    • (1998) Pharmacol Rev , vol.50 , Issue.3 , pp. 387-411
    • Ito, K.1
  • 145
    • 0030937636 scopus 로고    scopus 로고
    • Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data
    • Iwatsubo T, et al. Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data. Pharmacol Ther 1997; 73 (2): 147-171.
    • (1997) Pharmacol Ther , vol.73 , Issue.2 , pp. 147-171
    • Iwatsubo, T.1
  • 147
    • 0344412840 scopus 로고    scopus 로고
    • Acetaminophen-induced hepatotoxicity
    • James L, Mayeux P, Hinson J. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 2003; 31 (12): 1499-1506.
    • (2003) Drug Metab Dispos , vol.31 , Issue.12 , pp. 1499-1506
    • James, L.1    Mayeux, P.2    Hinson, J.3
  • 148
    • 0033022766 scopus 로고    scopus 로고
    • Comparison of human and rat metabolism of molinate in liver microsomes and slices
    • Jewell WT, Miller MG. Comparison of human and rat metabolism of molinate in liver microsomes and slices. Drug Metab Dispos 1999; 27 (7): 842-847.
    • (1999) Drug Metab Dispos , vol.27 , Issue.7 , pp. 842-847
    • Jewell, W.T.1    Miller, M.G.2
  • 149
    • 10644242554 scopus 로고    scopus 로고
    • Gender-related differences in metabolism of the enantiomers of trans tramadol and trans O-demethyltramadol in rat liver microsomes
    • Jin S, Liu H. Gender-related differences in metabolism of the enantiomers of trans tramadol and trans O-demethyltramadol in rat liver microsomes. Yao Xue Xue Bao 2004; 39 (8): 581-585.
    • (2004) Yao Xue Xue Bao , vol.39 , Issue.8 , pp. 581-585
    • Jin, S.1    Liu, H.2
  • 150
    • 33845640084 scopus 로고    scopus 로고
    • Methods for predicting human drug metabolism
    • Jolivette L, Ekins S. Methods for predicting human drug metabolism. Adv Clin Chem 2007; 43: 131-176.
    • (2007) Adv Clin Chem , vol.43 , pp. 131-176
    • Jolivette, L.1    Ekins, S.2
  • 151
    • 46749096466 scopus 로고    scopus 로고
    • Morphine-6-glucuronide, an active morphine metabolite for the potential treatment of post-operative pain
    • Joshi G. Morphine-6-glucuronide, an active morphine metabolite for the potential treatment of post-operative pain. Curr Opin Investig Drugs 2008; 9 (7): 786-799.
    • (2008) Curr Opin Investig Drugs , vol.9 , Issue.7 , pp. 786-799
    • Joshi, G.1
  • 152
    • 0035996570 scopus 로고    scopus 로고
    • Mechanism of idiosyncratic drug reactions: reactive metabolite formation, protein binding and the regulation of the immune system
    • Ju C, Uetrecht J. Mechanism of idiosyncratic drug reactions: reactive metabolite formation, protein binding and the regulation of the immune system. Curr Drug Metab 2002; 3: 367-377.
    • (2002) Curr Drug Metab , vol.3 , pp. 367-377
    • Ju, C.1    Uetrecht, J.2
  • 153
    • 25644432842 scopus 로고    scopus 로고
    • Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid (TA-1801A)
    • Kaji H, Kume T. Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid (TA-1801A). Drug Metab Pharmacokinet 2005; 20 (3): 212-218.
    • (2005) Drug Metab Pharmacokinet , vol.20 , Issue.3 , pp. 212-218
    • Kaji, H.1    Kume, T.2
  • 154
    • 33344462585 scopus 로고    scopus 로고
    • Minimising the potential for metabolic activation in drug discovery
    • Kalgutkar A, Soglia J. Minimising the potential for metabolic activation in drug discovery. Expert Opin Drug Metab Toxicol 2005; 1 (1): 91-142.
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , Issue.1 , pp. 91-142
    • Kalgutkar, A.1    Soglia, J.2
  • 155
    • 19944399431 scopus 로고    scopus 로고
    • A comprehensive listing of bioactivation pathways of organic functional grou
    • Kalgutkar A, et al. A comprehensive listing of bioactivation pathways of organic functional grou. Curr Drug Metab 2005a; 6: 161-225.
    • (2005) Curr Drug Metab , vol.6 , pp. 161-225
    • Kalgutkar, A.1
  • 156
    • 20844454730 scopus 로고    scopus 로고
    • Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4
    • Kalgutkar A, et al. Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4. Drug Metab Dispos 2005b; 33 (2): 243-253.
    • (2005) Drug Metab Dispos , vol.33 , Issue.2 , pp. 243-253
    • Kalgutkar, A.1
  • 157
    • 34548805504 scopus 로고    scopus 로고
    • Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions
    • Kalgutkar A, Obach R, Maurer T. Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions. Curr Drug Metab 2007; 8 (5): 407-447.
    • (2007) Curr Drug Metab , vol.8 , Issue.5 , pp. 407-447
    • Kalgutkar, A.1    Obach, R.2    Maurer, T.3
  • 158
    • 0034827302 scopus 로고    scopus 로고
    • Influence of microsomal concentration on apparent intrinsic clearance: implications for scaling in vitro
    • Kalvaas J, et al. Influence of microsomal concentration on apparent intrinsic clearance: implications for scaling in vitro. Data Drug Metab Dispos 2001; 29 (10): 1332-1336.
    • (2001) Data Drug Metab Dispos , vol.29 , Issue.10 , pp. 1332-1336
    • Kalvaas, J.1
  • 159
    • 0031015345 scopus 로고    scopus 로고
    • Human P450 metabolism of warfarin
    • Kaminsky LS, Zhang Z-Y. Human P450 metabolism of warfarin. Pharmacol Ther 1997; 73 (1): 67-74.
    • (1997) Pharmacol Ther , vol.73 , Issue.1 , pp. 67-74
    • Kaminsky, L.S.1    Zhang, Z.-Y.2
  • 160
    • 0028913587 scopus 로고
    • Sulfation and glucuronidation of acetaminophen by human hepatocytes cultured on Matrigel and type 1 collagen reproduces conjugation in vivo
    • Kane RE, Li AP, Kaminski DR. Sulfation and glucuronidation of acetaminophen by human hepatocytes cultured on Matrigel and type 1 collagen reproduces conjugation in vivo. Drug Metab Dispos 1995; 23 (3): 303-307.
    • (1995) Drug Metab Dispos , vol.23 , Issue.3 , pp. 303-307
    • Kane, R.E.1    Li, A.P.2    Kaminski, D.R.3
  • 161
    • 0031769801 scopus 로고    scopus 로고
    • Potentially reactive cyclic carbamate metabolite of the antiepileptic drug felbamate produced by human liver tissue in vitro
    • Kapetanovic I, et al. Potentially reactive cyclic carbamate metabolite of the antiepileptic drug felbamate produced by human liver tissue in vitro. Drug Metab Dispos 1998; 26 (11): 1089-1095.
    • (1998) Drug Metab Dispos , vol.26 , Issue.11 , pp. 1089-1095
    • Kapetanovic, I.1
  • 162
    • 33847034231 scopus 로고    scopus 로고
    • In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver
    • Katoh M, et al. In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver. J Pharm Sci 2006; 96 (2): 428-437.
    • (2006) J Pharm Sci , vol.96 , Issue.2 , pp. 428-437
    • Katoh, M.1
  • 163
    • 40049104670 scopus 로고    scopus 로고
    • Chimeric mice with humanized liver
    • Katoh M, et al. Chimeric mice with humanized liver. Toxicology 2008; 245: 9-17.
    • (2008) Toxicology , vol.245 , pp. 9-17
    • Katoh, M.1
  • 164
    • 0034869034 scopus 로고    scopus 로고
    • Mechanism-based inactivators as probes of cytochrome P450 structure and function
    • Kent UM, Jushchhyshyn M, Hollenberg P. Mechanism-based inactivators as probes of cytochrome P450 structure and function. Curr Drug Metab 2001; 2 (3): 215-243.
    • (2001) Curr Drug Metab , vol.2 , Issue.3 , pp. 215-243
    • Kent, U.M.1    Jushchhyshyn, M.2    Hollenberg, P.3
  • 165
    • 33644536707 scopus 로고    scopus 로고
    • Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6
    • Kent U, et al. Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6. Chem Res Toxicol 2006; 19 (2): 279-287.
    • (2006) Chem Res Toxicol , vol.19 , Issue.2 , pp. 279-287
    • Kent, U.1
  • 166
    • 0034525426 scopus 로고    scopus 로고
    • Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and cerebrospinal fluid from patients infected with human immunodefi-ciency virus
    • Khaliq Y, et al. Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and cerebrospinal fluid from patients infected with human immunodefi-ciency virus. Clin Pharm Ther 2000; 68: 637-646.
    • (2000) Clin Pharm Ther , vol.68 , pp. 637-646
    • Khaliq, Y.1
  • 167
    • 0033214849 scopus 로고    scopus 로고
    • Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats
    • Kharasch ED, et al. Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats. Toxicol Appl Pharmacol 1999; 160: 49-59.
    • (1999) Toxicol Appl Pharmacol , vol.160 , pp. 49-59
    • Kharasch, E.D.1
  • 168
    • 0035059510 scopus 로고    scopus 로고
    • Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4
    • Kilicarslan T, et al. Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4. Drug Metab Dispos 2001; 29 (4): 460-465.
    • (2001) Drug Metab Dispos , vol.29 , Issue.4 , pp. 460-465
    • Kilicarslan, T.1
  • 169
    • 29644445409 scopus 로고    scopus 로고
    • P450 2C18 catalyzes the metabolic bioactivation of phenytoin
    • Kinobe RT, et al. P450 2C18 catalyzes the metabolic bioactivation of phenytoin. Chem Res Toxicol 2005; 18 (12): 1868-1875.
    • (2005) Chem Res Toxicol , vol.18 , Issue.12 , pp. 1868-1875
    • Kinobe, R.T.1
  • 170
    • 42449095963 scopus 로고    scopus 로고
    • Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans
    • Klieber S, et al. Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans. Drug Metab Dispos 2008; 36 (5): 851-862.
    • (2008) Drug Metab Dispos , vol.36 , Issue.5 , pp. 851-862
    • Klieber, S.1
  • 171
    • 43749091716 scopus 로고    scopus 로고
    • Prescribers'knowledge of and sources of information for potential drug-drug interactions: a postal survey of US prescribers
    • Ko Y, et al. Prescribers'knowledge of and sources of information for potential drug-drug interactions: a postal survey of US prescribers. Drug Safety 2008; 31 (6): 525-536.
    • (2008) Drug Safety , vol.31 , Issue.6 , pp. 525-536
    • Ko, Y.1
  • 172
    • 0033596707 scopus 로고    scopus 로고
    • Electrospray ionization mass spectrometric analysis of intact cytochrome P450: identification of tienilic acid adducts to P450 2C9
    • Koenigs L, et al. Electrospray ionization mass spectrometric analysis of intact cytochrome P450: identification of tienilic acid adducts to P450 2C9. Biochemistry 1999; 38 (8): 2312-2319.
    • (1999) Biochemistry , vol.38 , Issue.8 , pp. 2312-2319
    • Koenigs, L.1
  • 173
    • 0031790709 scopus 로고    scopus 로고
    • Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: mechanism-based inactivation of cytochrome P4503A by ritonavir
    • Koudriakova T, et al. Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: mechanism-based inactivation of cytochrome P4503A by ritonavir. Drug Metab Dispos 1998; 26 (6): 552-561.
    • (1998) Drug Metab Dispos , vol.26 , Issue.6 , pp. 552-561
    • Koudriakova, T.1
  • 174
    • 45949107646 scopus 로고    scopus 로고
    • Studying cytochrome P450 kinetics in drug metabolism
    • Kramer M, Tracy T. Studying cytochrome P450 kinetics in drug metabolism. Expert Opin Drug Metab Toxicol 2008; 4 (5): 591-603.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , Issue.5 , pp. 591-603
    • Kramer, M.1    Tracy, T.2
  • 175
    • 37849042912 scopus 로고    scopus 로고
    • Minimizing metabolic activation during pharmaceutical lead optimization: progress, knowledge gaps and future directions
    • Kumar S, et al. Minimizing metabolic activation during pharmaceutical lead optimization: progress, knowledge gaps and future directions. Curr Opin Drug Discovery Dev 2008; 11 (1): 43-52.
    • (2008) Curr Opin Drug Discovery Dev , vol.11 , Issue.1 , pp. 43-52
    • Kumar, S.1
  • 176
    • 33645103422 scopus 로고    scopus 로고
    • Stereochemical aspects of itraconazole metabolism in vitro and in vivo
    • Kunze KL, et al. Stereochemical aspects of itraconazole metabolism in vitro and in vivo. Drug Metab Dispos 2006; 34 (4): 583-590.
    • (2006) Drug Metab Dispos , vol.34 , Issue.4 , pp. 583-590
    • Kunze, K.L.1
  • 177
    • 0034776646 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue
    • Kuperman A, et al. Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue. Drug Metab Dispos 2001; 29 (11): 1403-1409.
    • (2001) Drug Metab Dispos , vol.29 , Issue.11 , pp. 1403-1409
    • Kuperman, A.1
  • 178
    • 33646183072 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites
    • Lalovic B, et al. Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clin Pharmacol Ther 2006; 79 (5): 461-479.
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.5 , pp. 461-479
    • Lalovic, B.1
  • 179
    • 6944219986 scopus 로고    scopus 로고
    • Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes
    • Lam J, Benet L. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes. Drug Metab Dispos 2004; 32 (11): 1311-1316.
    • (2004) Drug Metab Dispos , vol.32 , Issue.11 , pp. 1311-1316
    • Lam, J.1    Benet, L.2
  • 180
    • 1342302110 scopus 로고    scopus 로고
    • Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay
    • Lau Y, et al. Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. J Pharmacol Exp Ther 2004; 308 (3): 1045-1050.
    • (2004) J Pharmacol Exp Ther , vol.308 , Issue.3 , pp. 1045-1050
    • Lau, Y.1
  • 181
    • 31144438802 scopus 로고    scopus 로고
    • Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems
    • Lau Y, et al. Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. J Pharmacol Exp Ther 2006; 316 (2): 762-771.
    • (2006) J Pharmacol Exp Ther , vol.316 , Issue.2 , pp. 762-771
    • Lau, Y.1
  • 182
    • 37849050900 scopus 로고    scopus 로고
    • Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic-pharmacodynamic modelling approach
    • Lehr T, et al. Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic-pharmacodynamic modelling approach. Br J Pharmacol 2008; 153 (1): 164-174.
    • (2008) Br J Pharmacol , vol.153 , Issue.1 , pp. 164-174
    • Lehr, T.1
  • 183
    • 0242383181 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of atorvastatin
    • Lennernas H. Clinical pharmacokinetics of atorvastatin. Clin Pharmacokinet 2003; 42: 1141-1160.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 1141-1160
    • Lennernas, H.1
  • 184
    • 0004135420 scopus 로고    scopus 로고
    • Baltimore: Lipincott Williams & Wilkins
    • Levy R, et al., editors. Metabolic Drug Interaction. Baltimore: Lipincott Williams & Wilkins, 2000.
    • (2000) Metabolic Drug Interaction
    • Levy, R.1
  • 185
    • 42649118458 scopus 로고    scopus 로고
    • A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry
    • Lim H-K, et al. A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry. Rapid Commun Mass Spec 2008; 22: 1295-1311.
    • (2008) Rapid Commun Mass Spec , vol.22 , pp. 1295-1311
    • Lim, H.-K.1
  • 186
    • 42249102806 scopus 로고    scopus 로고
    • Interplay of pregnane X receptor with other nuclear receptors on gene regulation
    • Lim Y-P, Huang J-D. Interplay of pregnane X receptor with other nuclear receptors on gene regulation. Drug Metab Pharmacokinet 2008; 23 (1): 14-21.
    • (2008) Drug Metab Pharmacokinet , vol.23 , Issue.1 , pp. 14-21
    • Lim, Y.-P.1    Huang, J.-D.2
  • 187
    • 33745395225 scopus 로고    scopus 로고
    • CYP induction-mediated drug interactions: in vitro assessment and clinical implications
    • Lin H. CYP induction-mediated drug interactions: in vitro assessment and clinical implications. Pharm Res 2006; 23 (6): 1089-1116.
    • (2006) Pharm Res , vol.23 , Issue.6 , pp. 1089-1116
    • Lin, H.1
  • 188
    • 0032428485 scopus 로고    scopus 로고
    • Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics
    • Lin J. Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics. Drug Metab Dispos 1998; 26 (12): 1202-1212.
    • (1998) Drug Metab Dispos , vol.26 , Issue.12 , pp. 1202-1212
    • Lin, J.1
  • 189
    • 47749137002 scopus 로고    scopus 로고
    • Applications and limitations of genetically modified mouse models in drug discovery and development
    • Lin J. Applications and limitations of genetically modified mouse models in drug discovery and development. Curr Drug Metab 2008; 9 (5): 419-438.
    • (2008) Curr Drug Metab , vol.9 , Issue.5 , pp. 419-438
    • Lin, J.1
  • 190
    • 0031472588 scopus 로고    scopus 로고
    • Role of pharmacokinetics and metabolism in drug discovery and development
    • Lin J, Lu A. Role of pharmacokinetics and metabolism in drug discovery and development. Pharmacol Rev 1997; 49 (4): 403-449.
    • (1997) Pharmacol Rev , vol.49 , Issue.4 , pp. 403-449
    • Lin, J.1    Lu, A.2
  • 191
    • 0038282311 scopus 로고    scopus 로고
    • The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery
    • Lin J, et al. The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery. Curr Topics Med Chem 2003; 3: 1125-1154.
    • (2003) Curr Topics Med Chem , vol.3 , pp. 1125-1154
    • Lin, J.1
  • 192
    • 12344263826 scopus 로고    scopus 로고
    • Strategies for characterization of drug metabolites using liquid chromatography-tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches
    • Liu D, Hop C. Strategies for characterization of drug metabolites using liquid chromatography-tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches. J Pharm Biomed Analysis 2005; 37: 1-18.
    • (2005) J Pharm Biomed Analysis , vol.37 , pp. 1-18
    • Liu, D.1    Hop, C.2
  • 193
    • 4444303063 scopus 로고    scopus 로고
    • Stereoselectivity in absorption of trans tramadol in rat intestine
    • Liu H, et al. Stereoselectivity in absorption of trans tramadol in rat intestine. Yao Xue Xue Bao 2003; 38 (12): 893-896.
    • (2003) Yao Xue Xue Bao , vol.38 , Issue.12 , pp. 893-896
    • Liu, H.1
  • 194
    • 0025327018 scopus 로고
    • The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities
    • Lock E, Schnellmann R. The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities. Toxicol Appl Pharmacol 1990; 104 (1): 180-190.
    • (1990) Toxicol Appl Pharmacol , vol.104 , Issue.1 , pp. 180-190
    • Lock, E.1    Schnellmann, R.2
  • 195
    • 0037379318 scopus 로고    scopus 로고
    • Cytochrome P450 in vitro reaction phenotyping: a re-evaluation of approaches used for P450 isoform identification
    • Lu A, Wang R, Lin J. Cytochrome P450 in vitro reaction phenotyping: a re-evaluation of approaches used for P450 isoform identification. Drug Metab Dispos 2003; 31 (4): 345-350.
    • (2003) Drug Metab Dispos , vol.31 , Issue.4 , pp. 345-350
    • Lu, A.1    Wang, R.2    Lin, J.3
  • 196
    • 33747833384 scopus 로고    scopus 로고
    • Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes
    • Lu C, et al. Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes. Drug Metab Dispos 2006a; 34 (9): 1600-1605.
    • (2006) Drug Metab Dispos , vol.34 , Issue.9 , pp. 1600-1605
    • Lu, C.1
  • 197
    • 33845978421 scopus 로고    scopus 로고
    • A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data
    • Lu C, et al. A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data. Drug Metab Dispos 2006b; 35 (1): 79-85.
    • (2006) Drug Metab Dispos , vol.35 , Issue.1 , pp. 79-85
    • Lu, C.1
  • 198
    • 46449134481 scopus 로고    scopus 로고
    • Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data II. In vitro-in vivo correlation with ketoconazole
    • Lu C, et al. Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. II. In vitro-in vivo correlation with ketoconazole. Drug Metab Dispos 2008a; 36 (7): 1255-1260.
    • (2008) Drug Metab Dispos , vol.36 , Issue.7 , pp. 1255-1260
    • Lu, C.1
  • 199
    • 46449093909 scopus 로고    scopus 로고
    • Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data III. In vitro-in vivo correlation with fluconazole
    • Lu C, et al. Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. III. In vitro-in vivo correlation with fluconazole. Drug Metab Dispos 2008b; 36 (7): 1261-1267.
    • (2008) Drug Metab Dispos , vol.36 , Issue.7 , pp. 1261-1267
    • Lu, C.1
  • 200
    • 0035987895 scopus 로고    scopus 로고
    • CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes
    • Luo G, et al. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab Dispos 2002; 30 (7): 795-804.
    • (2002) Drug Metab Dispos , vol.30 , Issue.7 , pp. 795-804
    • Luo, G.1
  • 201
    • 8844286879 scopus 로고    scopus 로고
    • CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development
    • Luo G, et al. CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development. Curr Drug Metab 2004; 5: 483-505.
    • (2004) Curr Drug Metab , vol.5 , pp. 483-505
    • Luo, G.1
  • 202
    • 34547663626 scopus 로고    scopus 로고
    • The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects
    • Lynch T, Price A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am Fam Phys 2007; 76: 391-396.
    • (2007) Am Fam Phys , vol.76 , pp. 391-396
    • Lynch, T.1    Price, A.2
  • 203
    • 47749105317 scopus 로고    scopus 로고
    • The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters
    • Ma Q, Lu A. The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters. Curr Drug Metab 2008; 9: 374-383.
    • (2008) Curr Drug Metab , vol.9 , pp. 374-383
    • Ma, Q.1    Lu, A.2
  • 204
    • 33846461683 scopus 로고    scopus 로고
    • The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A
    • Ma X, et al. The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. Drug Metab Dispos 2007; 35 (2): 194-200.
    • (2007) Drug Metab Dispos , vol.35 , Issue.2 , pp. 194-200
    • Ma, X.1
  • 205
    • 57349179929 scopus 로고    scopus 로고
    • A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4
    • Ma X, et al. A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. Drug Metab Dispos 2008; 36 (12): 2506-2512.
    • (2008) Drug Metab Dispos , vol.36 , Issue.12 , pp. 2506-2512
    • Ma, X.1
  • 206
    • 0021354248 scopus 로고
    • Pharmacokinetic consequences of drug displacement from blood and tissue proteins
    • MacKichan J. Pharmacokinetic consequences of drug displacement from blood and tissue proteins. Clin Pharmacokinet 1984; 9: 32-41.
    • (1984) Clin Pharmacokinet , vol.9 , pp. 32-41
    • MacKichan, J.1
  • 207
    • 0024513791 scopus 로고
    • Protein binding drug displacement interactions fact or fiction?
    • MacKichan J. Protein binding drug displacement interactions fact or fiction? Clin Pharmacokinet 1989; 16 (2): 65-73.
    • (1989) Clin Pharmacokinet , vol.16 , Issue.2 , pp. 65-73
    • MacKichan, J.1
  • 208
    • 0033731283 scopus 로고    scopus 로고
    • Interspecies scaling: role of protein binding in the prediction of clearance from animals to humans
    • Mahmood I. Interspecies scaling: role of protein binding in the prediction of clearance from animals to humans. J Clin Pharmacol 2000; 40: 1439-1446.
    • (2000) J Clin Pharmacol , vol.40 , pp. 1439-1446
    • Mahmood, I.1
  • 210
    • 33747154776 scopus 로고    scopus 로고
    • Prediction of human drug clearance from animal data: application of the rule of exponents and " fu Corrected Intercept Method " (FCIM)
    • Mahmood I. Prediction of human drug clearance from animal data: application of the rule of exponents and " fu Corrected Intercept Method " (FCIM). J Pharm Sci 2006; 95 (8): 1810-1821.
    • (2006) J Pharm Sci , vol.95 , Issue.8 , pp. 1810-1821
    • Mahmood, I.1
  • 211
    • 0037974213 scopus 로고    scopus 로고
    • Selection of the first-time dose in humans: comparison of different approaches based on interspecies scaling of clearance
    • Mahmood I, Green M, Fisher J. Selection of the first-time dose in humans: comparison of different approaches based on interspecies scaling of clearance. J Clin Pharmacol 2003; 43: 692-697.
    • (2003) J Clin Pharmacol , vol.43 , pp. 692-697
    • Mahmood, I.1    Green, M.2    Fisher, J.3
  • 212
    • 4544235407 scopus 로고    scopus 로고
    • Drug interactions with St John's wort: mechanisms and clinical implications
    • Mannel M. Drug interactions with St John's wort: mechanisms and clinical implications. Drug Safety 2004; 27 (11): 773-797.
    • (2004) Drug Safety , vol.27 , Issue.11 , pp. 773-797
    • Mannel, M.1
  • 213
    • 33749443439 scopus 로고    scopus 로고
    • In vivo animal models for investigating potential CYP3A-and Pgp-mediated drug-drug interactions
    • Marathe P, Rodrigues AD. In vivo animal models for investigating potential CYP3A-and Pgp-mediated drug-drug interactions. Curr Drug Metab 2006; 7 (7): 687-704.
    • (2006) Curr Drug Metab , vol.7 , Issue.7 , pp. 687-704
    • Marathe, P.1    Rodrigues, A.D.2
  • 214
    • 53349149747 scopus 로고    scopus 로고
    • Clinical relevance: drug-drug interaction, pharmacokinetics, pharmacodynamics, and toxicology
    • You G, Morris M, editors., John Wiley & Sons
    • Marchetti S, et al. Clinical relevance: drug-drug interaction, pharmacokinetics, pharmacodynamics, and toxicology. In: You G, Morris M, editors. Drug Transporters: Molecular Characterization and Role in Drug Disposition, John Wiley & Sons, 2007a, pp. 747-880.
    • (2007) Drug Transporters: Molecular Characterization and Role in Drug Disposition , pp. 747-880
    • Marchetti, S.1
  • 215
    • 34548378642 scopus 로고    scopus 로고
    • Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein)
    • Marchetti S, et al. Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein). The Oncologist 2007b; 12: 927-941.
    • (2007) The Oncologist , vol.12 , pp. 927-941
    • Marchetti, S.1
  • 216
    • 0037707638 scopus 로고    scopus 로고
    • Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges
    • Masimirembwa C, Bredberg U, Andersson T. Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges. Clin Pharmacokinet 2003; 42 (6): 515-528.
    • (2003) Clin Pharmacokinet , vol.42 , Issue.6 , pp. 515-528
    • Masimirembwa, C.1    Bredberg, U.2    Andersson, T.3
  • 217
    • 34047275727 scopus 로고    scopus 로고
    • Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans
    • Masubuchi N, Makino C, Murayama N. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans. Chem Res Toxicol 2007; 20: 455-464.
    • (2007) Chem Res Toxicol , vol.20 , pp. 455-464
    • Masubuchi, N.1    Makino, C.2    Murayama, N.3
  • 218
    • 4143153180 scopus 로고    scopus 로고
    • Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissue
    • Matheny C, et al. Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissue. Drug Metab Dispos 2004; 32 (9): 1008-1014.
    • (2004) Drug Metab Dispos , vol.32 , Issue.9 , pp. 1008-1014
    • Matheny, C.1
  • 219
    • 0033743402 scopus 로고    scopus 로고
    • Impact of mechanism-based enzyme inactivation on inhibitor potency: implications for rational drug discovery
    • Maurer T, Tabrizi-Fard M, Fung H-L. Impact of mechanism-based enzyme inactivation on inhibitor potency: implications for rational drug discovery. J Pharm Sci 2000; 89 (11): 1404-1414.
    • (2000) J Pharm Sci , vol.89 , Issue.11 , pp. 1404-1414
    • Maurer, T.1    Tabrizi-Fard, M.2    Fung, H.-L.3
  • 220
    • 1942421316 scopus 로고    scopus 로고
    • Integrating in vitro kinetic data from compounds exhibiting induction, reversible inhibition and mechanism-based inactivation: in vitro study design
    • McConn D, Zhao Z. Integrating in vitro kinetic data from compounds exhibiting induction, reversible inhibition and mechanism-based inactivation: in vitro study design. Curr Drug Metab 2004; 5: 141-146.
    • (2004) Curr Drug Metab , vol.5 , pp. 141-146
    • McConn, D.1    Zhao, Z.2
  • 221
    • 0020580646 scopus 로고
    • Protein binding displacement interactions and their clinical importance
    • McElnay J, D'Arcy P. Protein binding displacement interactions and their clinical importance. Drugs 1983; 25: 495-513.
    • (1983) Drugs , vol.25 , pp. 495-513
    • McElnay, J.1    D'Arcy, P.2
  • 222
    • 0034010664 scopus 로고    scopus 로고
    • Nonspecific binding of drugs to human liver microso
    • McLure J, Miners J, Birkett DJ. Nonspecific binding of drugs to human liver microso. Br J Clin Pharmacol 2000; 49: 453-461.
    • (2000) Br J Clin Pharmacol , vol.49 , pp. 453-461
    • McLure, J.1    Miners, J.2    Birkett, D.J.3
  • 223
    • 33746604494 scopus 로고    scopus 로고
    • Herb-drug interactions in oncology: focus on mechanisms of induction
    • Meijerman I, Beijnen J, Schellens J. Herb-drug interactions in oncology: focus on mechanisms of induction. The Oncologist 2006; 11: 742-752.
    • (2006) The Oncologist , vol.11 , pp. 742-752
    • Meijerman, I.1    Beijnen, J.2    Schellens, J.3
  • 224
    • 0031975185 scopus 로고    scopus 로고
    • Update: clinically significant cytochrome P-450 drug interactions
    • Michalets E. Update: clinically significant cytochrome P-450 drug interactions. Pharmacotherapy 1998; 18 (1): 84-112.
    • (1998) Pharmacotherapy , vol.18 , Issue.1 , pp. 84-112
    • Michalets, E.1
  • 225
    • 36248969713 scopus 로고    scopus 로고
    • Codeine and 6-acetylcodeine analgesia in mice
    • 4-6
    • Milo S, et al. Codeine and 6-acetylcodeine analgesia in mice. Cell Mol Neurobiol 2006; 26 (4-6): 1011-1019.
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 1011-1019
    • Milo, S.1
  • 226
    • 0043027096 scopus 로고    scopus 로고
    • Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes
    • Miyazawa M, Sugie A, Shimada T. Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes. Drug Metab Dispos 2003; 31 (8): 1049-1053.
    • (2003) Drug Metab Dispos , vol.31 , Issue.8 , pp. 1049-1053
    • Miyazawa, M.1    Sugie, A.2    Shimada, T.3
  • 227
    • 33646421123 scopus 로고    scopus 로고
    • Predictions of the in vivo clearance of drugs from rate of loss using human liver microsomes for phase I and phase II biotransformations
    • Mohutsky M, et al. Predictions of the in vivo clearance of drugs from rate of loss using human liver microsomes for phase I and phase II biotransformations. Pharm Res 2006; 23 (4): 654-662.
    • (2006) Pharm Res , vol.23 , Issue.4 , pp. 654-662
    • Mohutsky, M.1
  • 228
    • 0036335573 scopus 로고    scopus 로고
    • Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humans
    • Mouly S, et al. Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humans. Clin Pharmacol Ther 2002; 72 (1): 1-9.
    • (2002) Clin Pharmacol Ther , vol.72 , Issue.1 , pp. 1-9
    • Mouly, S.1
  • 229
    • 0030869281 scopus 로고    scopus 로고
    • Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation
    • Munns A, et al. Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation. Chem Res Toxicol 1997; 10 (9): 1049-1058.
    • (1997) Chem Res Toxicol , vol.10 , Issue.9 , pp. 1049-1058
    • Munns, A.1
  • 230
    • 49649120671 scopus 로고    scopus 로고
    • Intestinal efflux transporters and drug absorption
    • Murakami T, Takano M. Intestinal efflux transporters and drug absorption. Expert Opin Drug Metab Toxicol 2008; 4 (7): 923-939.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , Issue.7 , pp. 923-939
    • Murakami, T.1    Takano, M.2
  • 231
    • 43949122957 scopus 로고    scopus 로고
    • Mice as clinically relevant models for the study of cytochrome P450-dependent metabolism
    • Muruganandan S, Sinal C. Mice as clinically relevant models for the study of cytochrome P450-dependent metabolism. Nature 2008; 83 (6): 818-828.
    • (2008) Nature , vol.83 , Issue.6 , pp. 818-828
    • Muruganandan, S.1    Sinal, C.2
  • 232
    • 0032589627 scopus 로고    scopus 로고
    • Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz
    • Mutlib A, et al. Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz. Drug Metab Dispos 1999; 27 (11): 1319-1333.
    • (1999) Drug Metab Dispos , vol.27 , Issue.11 , pp. 1319-1333
    • Mutlib, A.1
  • 233
    • 0033914344 scopus 로고    scopus 로고
    • Disposition of glutathione conjugates in rats by a novel glutamic acid pathway: characterization of unique peptide conjugates by liquid chromatography/ mass spectrometry and liquid chromatography/NMR
    • Mutlib A, et al. Disposition of glutathione conjugates in rats by a novel glutamic acid pathway: characterization of unique peptide conjugates by liquid chromatography/ mass spectrometry and liquid chromatography/NMR. J Pharmacol Exp Ther 2000; 294 (2): 735-745.
    • (2000) J Pharmacol Exp Ther , vol.294 , Issue.2 , pp. 735-745
    • Mutlib, A.1
  • 234
    • 33644546039 scopus 로고    scopus 로고
    • Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance
    • Nagilla R, et al. Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance. J Pharmacol Toxicol Methods 2006; 53: 106-116.
    • (2006) J Pharmacol Toxicol Methods , vol.53 , pp. 106-116
    • Nagilla, R.1
  • 235
    • 35648982920 scopus 로고    scopus 로고
    • Current opinion: safety evaluation of drug metabolites in development of pharmaceuticals
    • Naito S, et al. Current opinion: safety evaluation of drug metabolites in development of pharmaceuticals. J Toxicol Sci 2007; 32 (4): 329-341.
    • (2007) J Toxicol Sci , vol.32 , Issue.4 , pp. 329-341
    • Naito, S.1
  • 236
    • 0034835463 scopus 로고    scopus 로고
    • Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans
    • Naritomi Y, et al. Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans. Drug Metab Dispos 2001; 29 (10): 1316-1324.
    • (2001) Drug Metab Dispos , vol.29 , Issue.10 , pp. 1316-1324
    • Naritomi, Y.1
  • 237
    • 2942593914 scopus 로고    scopus 로고
    • Strategies for dealing with reactive intermediates in drug discovery and development
    • Nassar A-EF, Lopez-Anaya A. Strategies for dealing with reactive intermediates in drug discovery and development. Curr Opin Drug Discovery 2004; 7 (1): 126-136.
    • (2004) Curr Opin Drug Discovery , vol.7 , Issue.1 , pp. 126-136
    • Nassar, A.-E.F.1    Lopez-Anaya, A.2
  • 238
    • 9644278194 scopus 로고    scopus 로고
    • Improving the decision-making process in the structural modification of drug candidates: enhancing metabolic stability
    • Nassar A-EF, Kamel A, Clairmont C. Improving the decision-making process in the structural modification of drug candidates: enhancing metabolic stability. Drug Discovery Tech 2004; 9 (23): 1020-1028.
    • (2004) Drug Discovery Tech , vol.9 , Issue.23 , pp. 1020-1028
    • Nassar, A.-E.F.1    Kamel, A.2    Clairmont, C.3
  • 239
    • 33947160983 scopus 로고    scopus 로고
    • Novel approach to performing metabolite identification in drug metabolism
    • Nassar A-EF, Lee D. Novel approach to performing metabolite identification in drug metabolism. J Chromatogr Sci 2007; 45: 113-119.
    • (2007) J Chromatogr Sci , vol.45 , pp. 113-119
    • Nassar, A.-E.F.1    Lee, D.2
  • 240
    • 0024523867 scopus 로고
    • Immune mechanisms in tienilic acid associated hepatotoxicity
    • Neuberger J, Williams R. Immune mechanisms in tienilic acid associated hepatotoxicity. Gut 1989; 30 (4): 515-519.
    • (1989) Gut , vol.30 , Issue.4 , pp. 515-519
    • Neuberger, J.1    Williams, R.2
  • 241
    • 0030425332 scopus 로고    scopus 로고
    • The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways
    • Nielsen K, et al. The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways. J Pharmacol Exp Ther 1996; 277 (3): 1659-1664.
    • (1996) J Pharmacol Exp Ther , vol.277 , Issue.3 , pp. 1659-1664
    • Nielsen, K.1
  • 242
    • 0034053811 scopus 로고    scopus 로고
    • Inhibition of drug-metabolizing enzyme activity in human hepatic cytochrome P450s by bisphenol A
    • Niwa T, et al. Inhibition of drug-metabolizing enzyme activity in human hepatic cytochrome P450s by bisphenol A. Biol Pharm Bull 2000; 23 (4): 498-501.
    • (2000) Biol Pharm Bull , vol.23 , Issue.4 , pp. 498-501
    • Niwa, T.1
  • 243
    • 34547178337 scopus 로고    scopus 로고
    • Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3
    • Noe J, et al. Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab Dispos 2007; 35 (8): 1308-1314.
    • (2007) Drug Metab Dispos , vol.35 , Issue.8 , pp. 1308-1314
    • Noe, J.1
  • 244
    • 33744497091 scopus 로고    scopus 로고
    • The science of drug therapy
    • Brunton L, Lazo J, Parker K, editors. New York: McGraw-Hill
    • Oates J. The science of drug therapy. In: Brunton L, Lazo J, Parker K, editors. Goodman & Gilman's The Pharmacological Basis of Therapeutics. New York: McGraw-Hill, 2006, pp. 117-136.
    • (2006) Goodman & Gilman's The Pharmacological Basis of Therapeutics , pp. 117-136
    • Oates, J.1
  • 245
    • 0029908277 scopus 로고    scopus 로고
    • The importance of nonspecific binding in in vitro matrices, its impact on enzyme kinetic studies of drug metabolism reactions, and implications for in vitro-in vivo correlations
    • Obach R. The importance of nonspecific binding in in vitro matrices, its impact on enzyme kinetic studies of drug metabolism reactions, and implications for in vitro-in vivo correlations. Drug Metab Dispos 1996; 24 (10): 1047-1049.
    • (1996) Drug Metab Dispos , vol.24 , Issue.10 , pp. 1047-1049
    • Obach, R.1
  • 246
    • 0031466149 scopus 로고    scopus 로고
    • Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol
    • Obach R. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol. Drug Metab Dispos 1997; 25 (12): 1359-1369.
    • (1997) Drug Metab Dispos , vol.25 , Issue.12 , pp. 1359-1369
    • Obach, R.1
  • 247
    • 0032733974 scopus 로고    scopus 로고
    • Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes
    • Obach R. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metab Dispos 1999; 27 (11): 1350-1359.
    • (1999) Drug Metab Dispos , vol.27 , Issue.11 , pp. 1350-1359
    • Obach, R.1
  • 248
    • 0033840074 scopus 로고    scopus 로고
    • Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correl
    • Obach R. Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correl. Drug Metab Dispos 2000a; 28 (9): 1069-1076.
    • (2000) Drug Metab Dispos , vol.28 , Issue.9 , pp. 1069-1076
    • Obach, R.1
  • 250
    • 0035147471 scopus 로고    scopus 로고
    • The prediction of human clearance from hepatic microsomal metabolism data
    • Obach R. The prediction of human clearance from hepatic microsomal metabolism data. Curr Opin Drug Discovery Dev 2001; 4 (1): 36-44.
    • (2001) Curr Opin Drug Discovery Dev , vol.4 , Issue.1 , pp. 36-44
    • Obach, R.1
  • 251
    • 0030799001 scopus 로고    scopus 로고
    • The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data
    • Obach R, et al. The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data. J Pharmacol Exp Ther 1997; 283 (1): 46-58.
    • (1997) J Pharmacol Exp Ther , vol.283 , Issue.1 , pp. 46-58
    • Obach, R.1
  • 252
    • 28844476587 scopus 로고    scopus 로고
    • In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach
    • Obach R, et al. In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach. Clin Pharmacol Ther 2005; 78: 582-592.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 582-592
    • Obach, R.1
  • 253
    • 29244447987 scopus 로고    scopus 로고
    • The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions
    • Obach R, et al. The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions. J Pharmacol Exp Ther 2006; 316 (1): 336-348.
    • (2006) J Pharmacol Exp Ther , vol.316 , Issue.1 , pp. 336-348
    • Obach, R.1
  • 254
    • 33846449874 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions
    • Obach R, Walsky R, Venkatakrishnan K. Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions. Drug Metab Dispos 2007; 35 (2): 246-255.
    • (2007) Drug Metab Dispos , vol.35 , Issue.2 , pp. 246-255
    • Obach, R.1    Walsky, R.2    Venkatakrishnan, K.3
  • 255
    • 53549107196 scopus 로고    scopus 로고
    • In vitro metabolism and covalent binding of enol-carboxamide derivatives and anti-inflammatory agents sudoxicam and meloxicam: insights into the hepatotoxicity of sudoxicam
    • Obach R, et al. In vitro metabolism and covalent binding of enol-carboxamide derivatives and anti-inflammatory agents sudoxicam and meloxicam: insights into the hepatotoxicity of sudoxicam. Chem Res Toxicol 2008b; 21 (9): 1890-1896.
    • (2008) Chem Res Toxicol , vol.21 , Issue.9 , pp. 1890-1896
    • Obach, R.1
  • 256
    • 53549100467 scopus 로고    scopus 로고
    • Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose
    • Obach R, et al. Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose. Chem Res Toxicol 2008a; 21: 1814-1822.
    • (2008) Chem Res Toxicol , vol.21 , pp. 1814-1822
    • Obach, R.1
  • 257
    • 0027244905 scopus 로고
    • Studies on cytochrome P450 responsible for oxidative metabolism of imipramine in human liver microsomes
    • Ohmori S, et al. Studies on cytochrome P450 responsible for oxidative metabolism of imipramine in human liver microsomes. Biol Pharm Bull 1993; 16 (6): 517-575.
    • (1993) Biol Pharm Bull , vol.16 , Issue.6 , pp. 517-575
    • Ohmori, S.1
  • 258
    • 34547641389 scopus 로고    scopus 로고
    • General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs
    • Ohno Y, Hisaka A, Suzuki H. General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs. Clin Pharmacokinet 2007; 46 (8): 681-696.
    • (2007) Clin Pharmacokinet , vol.46 , Issue.8 , pp. 681-696
    • Ohno, Y.1    Hisaka, A.2    Suzuki, H.3
  • 259
    • 0030903835 scopus 로고    scopus 로고
    • Genotyping of N-acetylation polymorphism and correlation with procainamide metabolism
    • Okumura K, et al. Genotyping of N-acetylation polymorphism and correlation with procainamide metabolism. Clin Pharmacol Ther 1997; 61 (5): 509-517.
    • (1997) Clin Pharmacol Ther , vol.61 , Issue.5 , pp. 509-517
    • Okumura, K.1
  • 260
    • 0037313425 scopus 로고    scopus 로고
    • A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole
    • Olbe L, Carlsson E, Lindberg P. A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole. Nat Rev Drug Discovery 2003; 2 (2): 132-139.
    • (2003) Nat Rev Drug Discovery , vol.2 , Issue.2 , pp. 132-139
    • Olbe, L.1    Carlsson, E.2    Lindberg, P.3
  • 261
    • 0027456438 scopus 로고
    • Inhibition by fluoxetine of cytochrome P450 2D6 activity
    • Otton S, et al. Inhibition by fluoxetine of cytochrome P450 2D6 activity. Clin Pharmacol Ther 1993; 53 (4): 401-409.
    • (1993) Clin Pharmacol Ther , vol.53 , Issue.4 , pp. 401-409
    • Otton, S.1
  • 262
    • 33747352798 scopus 로고    scopus 로고
    • MDR-and CYP3A4-mediated drug-drug interactions
    • Pal D, Mitra A. MDR-and CYP3A4-mediated drug-drug interactions. J Neuroimmune Pharmacol 2006; 1: 323-339.
    • (2006) J Neuroimmune Pharmacol , vol.1 , pp. 323-339
    • Pal, D.1    Mitra, A.2
  • 263
    • 59649103035 scopus 로고    scopus 로고
    • Safety testing of metabolites: expectations and outcomes
    • Pang S. Safety testing of metabolites: expectations and outcomes. Chemico-Biol Interactions 2009; 179 (1): 45-59.
    • (2009) Chemico-Biol Interactions , vol.179 , Issue.1 , pp. 45-59
    • Pang, S.1
  • 264
    • 84889336635 scopus 로고    scopus 로고
    • Interplay of drug transporters and enzymes on hepatic drug disposition
    • You G, Morris M, editors. Hoboken, NJ: John Wiley & Sons
    • Pang S, Sun H, Liu S. Interplay of drug transporters and enzymes on hepatic drug disposition. In: You G, Morris M, editors. Drug Transporters: Molecular Characterization and Role in Drug Disposition. Hoboken, NJ: John Wiley & Sons, 2007, pp. 709-745.
    • (2007) Drug Transporters: Molecular Characterization and Role in Drug Disposition , pp. 709-745
    • Pang, S.1    Sun, H.2    Liu, S.3
  • 265
    • 33748969837 scopus 로고    scopus 로고
    • Selection of new chemical entities with decreased potential for adverse drug reactions
    • Park K, et al. Selection of new chemical entities with decreased potential for adverse drug reactions. Eur J Pharmacol 2006; 549: 1-8.
    • (2006) Eur J Pharmacol , vol.549 , pp. 1-8
    • Park, K.1
  • 266
    • 46449096570 scopus 로고    scopus 로고
    • Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir
    • Parker A, Houston J. Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir. Drug Metab Dispos 2008; 36 (7): 1375-1384.
    • (2008) Drug Metab Dispos , vol.36 , Issue.7 , pp. 1375-1384
    • Parker, A.1    Houston, J.2
  • 267
    • 0000889408 scopus 로고    scopus 로고
    • Biotransformation of Xenobiotics
    • Klaassen CD, editor. McGraw-Hill
    • Parkinson A. Biotransformation of Xenobiotics. In: Klaassen CD, editor. Casarett and Doull's Toxicology. McGraw-Hill, 2001, pp. 134-224.
    • (2001) Casarett and Doull's Toxicology , pp. 134-224
    • Parkinson, A.1
  • 268
    • 0028069734 scopus 로고
    • Glutathione-dependent biosynthesis and bioactivation of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-l-cysteine, the glutathione and cysteine S-conjugates of dichloroacetylene, in rat tissues and subcellular fractions
    • Patel N, et al. Glutathione-dependent biosynthesis and bioactivation of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-l-cysteine, the glutathione and cysteine S-conjugates of dichloroacetylene, in rat tissues and subcellular fractions. Drug Metab Dispos 1994; 22 (1): 143-147.
    • (1994) Drug Metab Dispos , vol.22 , Issue.1 , pp. 143-147
    • Patel, N.1
  • 269
    • 0030430339 scopus 로고    scopus 로고
    • Identification of the human P450 enzymes involved in lansoprazole metabolism
    • Pearce RE, Rodrigues AD, Goldstein JA. Identification of the human P450 enzymes involved in lansoprazole metabolism. J Pharmacol Exp Ther 1996; 277: 805-816.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 805-816
    • Pearce, R.E.1    Rodrigues, A.D.2    Goldstein, J.A.3
  • 270
    • 55049100842 scopus 로고    scopus 로고
    • Inhibition and induction of human cytochrome P450 enzymes: current status
    • Pelkonen O, et al. Inhibition and induction of human cytochrome P450 enzymes: current status. Arch Toxicol 2008; 82 (10): 667-715.
    • (2008) Arch Toxicol , vol.82 , Issue.10 , pp. 667-715
    • Pelkonen, O.1
  • 271
    • 13444266910 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib)
    • Penning T, et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J Med Chem 1997; 40 (9): 1347-1365.
    • (1997) J Med Chem , vol.40 , Issue.9 , pp. 1347-1365
    • Penning, T.1
  • 272
    • 0026503611 scopus 로고
    • An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro
    • Pirmohamed M, et al. An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro. Biochem Pharmacol 1992; 43 (8): 1675-1682.
    • (1992) Biochem Pharmacol , vol.43 , Issue.8 , pp. 1675-1682
    • Pirmohamed, M.1
  • 273
    • 34548283499 scopus 로고    scopus 로고
    • In vitro approaches to investigate mechanism-based inactivation of CYP enzymes
    • Polasek T, Miners JO. In vitro approaches to investigate mechanism-based inactivation of CYP enzymes. Expert Opin Drug Metab Toxicol 2007; 3 (3): 321-329.
    • (2007) Expert Opin Drug Metab Toxicol , vol.3 , Issue.3 , pp. 321-329
    • Polasek, T.1    Miners, J.O.2
  • 274
    • 3342955644 scopus 로고    scopus 로고
    • Drug metabolism by cultured human hepatocytes: how far are we from the in vivo reality?
    • Ponsoda X, et al. Drug metabolism by cultured human hepatocytes: how far are we from the in vivo reality? Altern Lab Animals 2004; 32: 101-110.
    • (2004) Altern Lab Animals , vol.32 , pp. 101-110
    • Ponsoda, X.1
  • 275
    • 0034102209 scopus 로고    scopus 로고
    • The relative bioavailability and metabolism of bisphenol A in rats is dependent upon the route of administration
    • Pottenger L, et al. The relative bioavailability and metabolism of bisphenol A in rats is dependent upon the route of administration. Toxicol Sci 2000; 54 (1): 3-18.
    • (2000) Toxicol Sci , vol.54 , Issue.1 , pp. 3-18
    • Pottenger, L.1
  • 276
    • 0020919604 scopus 로고
    • Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man
    • Powis G. Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man. Drug Metab Rev 1983; 14 (6): 1145-1163.
    • (1983) Drug Metab Rev , vol.14 , Issue.6 , pp. 1145-1163
    • Powis, G.1
  • 277
    • 34248582576 scopus 로고    scopus 로고
    • Analytical strategies for identifying drug metabolites
    • Prakash C, Shaffer C, Nedderman A. Analytical strategies for identifying drug metabolites. Mass Spec Rev 2007; 26: 340-369.
    • (2007) Mass Spec Rev , vol.26 , pp. 340-369
    • Prakash, C.1    Shaffer, C.2    Nedderman, A.3
  • 278
    • 1542344547 scopus 로고    scopus 로고
    • Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors
    • Proctor N, Tucker G, Rostami-Hodjegan A. Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors. Proctor NJ, Tucker. Xenobiotica 2004; 34 (2): 151-178.
    • (2004) Proctor NJ, Tucker. Xenobiotica , vol.34 , Issue.2 , pp. 151-178
    • Proctor, N.1    Tucker, G.2    Rostami-Hodjegan, A.3
  • 279
    • 33751249069 scopus 로고    scopus 로고
    • Complicating factors in safety testing of drug metabolites: kinetic differences between generated and preformed metabolites
    • Prueksaritanont T, Lin J, Ballie T. Complicating factors in safety testing of drug metabolites: kinetic differences between generated and preformed metabolites. Toxicol Appl Pharmacol 2006; 217: 143-152.
    • (2006) Toxicol Appl Pharmacol , vol.217 , pp. 143-152
    • Prueksaritanont, T.1    Lin, J.2    Ballie, T.3
  • 280
    • 59149097969 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways
    • Puga A, Ma C, Marlowe J. The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochem Pharmacol 2009; 77 (4): 713-722.
    • (2009) Biochem Pharmacol , vol.77 , Issue.4 , pp. 713-722
    • Puga, A.1    Ma, C.2    Marlowe, J.3
  • 281
    • 0035102353 scopus 로고    scopus 로고
    • Chemoprevention of benzene-induced bone marrow and pulmonary genotoxicity
    • Raj H, et al. Chemoprevention of benzene-induced bone marrow and pulmonary genotoxicity. Teratogenesis Carcinogenesis and Mutagenesis 2001; 21 (2): 181-187.
    • (2001) Teratogenesis Carcinogenesis and Mutagenesis , vol.21 , Issue.2 , pp. 181-187
    • Raj, H.1
  • 282
    • 34548787427 scopus 로고    scopus 로고
    • Species differences in the selective inhibition of monoamine oxidase (1-methyl-2-phenylethyl)hydrazine and its potentiation by cyanide
    • Ramadan Z, Wrang M, Tipton K. Species differences in the selective inhibition of monoamine oxidase (1-methyl-2-phenylethyl)hydrazine and its potentiation by cyanide. Neurochem Res 2007; 32 (10): 1783-1790.
    • (2007) Neurochem Res , vol.32 , Issue.10 , pp. 1783-1790
    • Ramadan, Z.1    Wrang, M.2    Tipton, K.3
  • 283
    • 0024381948 scopus 로고
    • Investigations of the N-hydroxylation of 3 '-hydroxyacetanilide, a non-hepatotoxic positional isomer of acetaminophen
    • Rashed M, Streeter A, Nelson S. Investigations of the N-hydroxylation of 3 '-hydroxyacetanilide, a non-hepatotoxic positional isomer of acetaminophen. Drug Metab Dispos 1989; 17 (4): 355-359.
    • (1989) Drug Metab Dispos , vol.17 , Issue.4 , pp. 355-359
    • Rashed, M.1    Streeter, A.2    Nelson, S.3
  • 284
    • 13544275671 scopus 로고    scopus 로고
    • Validation of a semi-automated human hepatocyte assay for the determination and prediction of intrinsic clearance in discovery
    • Reddy A, et al. Validation of a semi-automated human hepatocyte assay for the determination and prediction of intrinsic clearance in discovery. J Pharm Biomed Anal 2005; 37: 319-326.
    • (2005) J Pharm Biomed Anal , vol.37 , pp. 319-326
    • Reddy, A.1
  • 285
    • 0030834058 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors
    • Rendic S, Di Carlo F. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 1997; 29 (1/2): 413-580.
    • (1997) Drug Metab Rev , vol.29 , Issue.1-2 , pp. 413-580
    • Rendic, S.1    Di Carlo, F.2
  • 286
    • 0036783410 scopus 로고    scopus 로고
    • The influence of DMPK as an integrated partner in modern drug discovery
    • Riley R, Martin I, Cooper A. The influence of DMPK as an integrated partner in modern drug discovery. Curr Drug Metab 2002; 3: 527-550.
    • (2002) Curr Drug Metab , vol.3 , pp. 527-550
    • Riley, R.1    Martin, I.2    Cooper, A.3
  • 287
    • 23944451585 scopus 로고    scopus 로고
    • A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes
    • Riley R, McGinnity D, Austin R. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes. Drug Metab Dispos 2005; 33 (9): 1304-1311.
    • (2005) Drug Metab Dispos , vol.33 , Issue.9 , pp. 1304-1311
    • Riley, R.1    McGinnity, D.2    Austin, R.3
  • 289
    • 0027244836 scopus 로고
    • Elucidation of the structural requirements for the bioactivation of mianserin in vitro
    • Roberts P, Kitteringham N, Park B. Elucidation of the structural requirements for the bioactivation of mianserin in vitro. J Pharm Pharmacol 1993; 45 (7): 663-675.
    • (1993) J Pharm Pharmacol , vol.45 , Issue.7 , pp. 663-675
    • Roberts, P.1    Kitteringham, N.2    Park, B.3
  • 290
    • 0033105118 scopus 로고    scopus 로고
    • Integrated cytochrome P450 reaction phenotyping: attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes
    • Rodrigues AD, Integrated cytochrome P450 reaction phenotyping: attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes. Biochem Pharmacol 1999; 57: 465-480.
    • (1999) Biochem Pharmacol , vol.57 , pp. 465-480
    • Rodrigues, A.D.1
  • 291
    • 84859501771 scopus 로고    scopus 로고
    • Drug-Drug Interactions
    • 2nd edition. New York: Informa Healthcare
    • Rodrigues AD, editor. Drug-Drug Interactions, 2nd edition. Drugs and Pharmaceutical Sciences, Vol. 179. New York: Informa Healthcare, 2008.
    • (2008) Drugs and Pharmaceutical Sciences , vol.179
    • Rodrigues, A.D.1
  • 292
    • 0035987212 scopus 로고    scopus 로고
    • Cytochrome P450 pharmacogenetics in drug development: in vitro studies and clinical consequences
    • Rodrigues AD, Rushmore T. Cytochrome P450 pharmacogenetics in drug development: in vitro studies and clinical consequences. Curr Drug Metab 2002; 3: 289-309.
    • (2002) Curr Drug Metab , vol.3 , pp. 289-309
    • Rodrigues, A.D.1    Rushmore, T.2
  • 293
    • 0028303820 scopus 로고
    • Plasma protein binding displacement interactions -why are they still regarded as clinically important?
    • Rolan P. Plasma protein binding displacement interactions -why are they still regarded as clinically important? Br J Clin Pharmacol 1994; 37 (2): 125-128.
    • (1994) Br J Clin Pharmacol , vol.37 , Issue.2 , pp. 125-128
    • Rolan, P.1
  • 294
    • 0032510318 scopus 로고    scopus 로고
    • Discovery of 1-(4-fluorophenyl)-(3 R)-[3-(4-fluorophenyl)-(3 S)-hydroxypropyl]-(4 S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption
    • Rosenblum S, et al. Discovery of 1-(4-fluorophenyl)-(3 R)-[3-(4-fluorophenyl)-(3 S)-hydroxypropyl]-(4 S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption. J Med Chem 1998; 41 (6): 973-980.
    • (1998) J Med Chem , vol.41 , Issue.6 , pp. 973-980
    • Rosenblum, S.1
  • 295
    • 33947587274 scopus 로고    scopus 로고
    • Simulation and prediction of in vivo drug metabolism in human populations from in vitro
    • Rostami-Hodjegan A, Tucker G. Simulation and prediction of in vivo drug metabolism in human populations from in vitro. Nature Rev Drug Discov 2007; 6 (2): 140-148.
    • (2007) Nature Rev Drug Discov , vol.6 , Issue.2 , pp. 140-148
    • Rostami-Hodjegan, A.1    Tucker, G.2
  • 296
    • 0030947756 scopus 로고    scopus 로고
    • Concentration-effect relations of glibenclamide and its active metabolites in man: modelling of pharmacokinetics and pharmacodynamics
    • Rydberg T, et al. Concentration-effect relations of glibenclamide and its active metabolites in man: modelling of pharmacokinetics and pharmacodynamics. Br J Clin Pharmacol 1997; 43 (4): 373-381.
    • (1997) Br J Clin Pharmacol , vol.43 , Issue.4 , pp. 373-381
    • Rydberg, T.1
  • 297
    • 84884426874 scopus 로고    scopus 로고
    • Safety Testing of Drug Metabolites, FDA, editor
    • Safety Testing of Drug Metabolites, FDA, editor. http://www.fda.gov/CDER/GUIDANCE/6897fnl.pdf.2008.
  • 298
    • 29944438253 scopus 로고    scopus 로고
    • Metabolism and transporter-mediated drug-drug interactions of the endothelin -A receptor antagonist CI-1034
    • Sahi J, et al. Metabolism and transporter-mediated drug-drug interactions of the endothelin -A receptor antagonist CI-1034. Chemico-Biol Interactions 2006; 159 (2): 156-168.
    • (2006) Chemico-Biol Interactions , vol.159 , Issue.2 , pp. 156-168
    • Sahi, J.1
  • 299
    • 1642504441 scopus 로고    scopus 로고
    • Glucuronidation of carboxylic acid containing compounds by UDP-glucuronosyltransferase isoforms
    • Sakaguchi K, et al. Glucuronidation of carboxylic acid containing compounds by UDP-glucuronosyltransferase isoforms. Arch Biochem Biophys 2004; 424: 219-225.
    • (2004) Arch Biochem Biophys , vol.424 , pp. 219-225
    • Sakaguchi, K.1
  • 300
    • 84865340586 scopus 로고    scopus 로고
    • Genetic polymorphism in drug metabolism and toxicity: linking animal research and risk assessment in man
    • Satoh T. Genetic polymorphism in drug metabolism and toxicity: linking animal research and risk assessment in man. AATEX 2007; 14: 443-445.
    • (2007) AATEX , vol.14 , pp. 443-445
    • Satoh, T.1
  • 301
    • 33845312611 scopus 로고    scopus 로고
    • Reaction of primary and secondary amines to form carbamic acid glucuronides
    • Schaefer W. Reaction of primary and secondary amines to form carbamic acid glucuronides. Curr Drug Metab 2006; 7/8: 873-881.
    • (2006) Curr Drug Metab , vol.7-8 , pp. 873-881
    • Schaefer, W.1
  • 302
    • 27844579198 scopus 로고    scopus 로고
    • Rapid detection and identification of N-acetyl-l-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced production scans on a linear ion trap mass spectrometer
    • Scholz K, et al. Rapid detection and identification of N-acetyl-l-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced production scans on a linear ion trap mass spectrometer. J Am Soc Mass Spectrom 2005; 16: 1976-1984.
    • (2005) J Am Soc Mass Spectrom , vol.16 , pp. 1976-1984
    • Scholz, K.1
  • 303
    • 0018363645 scopus 로고
    • Plasma protein displacement interactions are rarely of clinical significance
    • Sellers E. Plasma protein displacement interactions are rarely of clinical significance. Pharmacology 1979; 18: 225-227.
    • (1979) Pharmacology , vol.18 , pp. 225-227
    • Sellers, E.1
  • 304
    • 0030725274 scopus 로고    scopus 로고
    • Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2
    • Shet M, et al. Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2. Drug Metab Dispos 1997; 25 (11): 1298-1303.
    • (1997) Drug Metab Dispos , vol.25 , Issue.11 , pp. 1298-1303
    • Shet, M.1
  • 305
    • 33746829030 scopus 로고    scopus 로고
    • Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling
    • Shiran M, et al. Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling. Xenobiotica 2006; 36 (7): 567-580.
    • (2006) Xenobiotica , vol.36 , Issue.7 , pp. 567-580
    • Shiran, M.1
  • 306
    • 12244295474 scopus 로고    scopus 로고
    • Prediction of pharmacokinetics and drug-drug interactions from in vitro metabolism data
    • Shou M. Prediction of pharmacokinetics and drug-drug interactions from in vitro metabolism data. Curr Opin Drug Discovery Dev 2005; 8 (1): 66-77.
    • (2005) Curr Opin Drug Discovery Dev , vol.8 , Issue.1 , pp. 66-77
    • Shou, M.1
  • 307
    • 0345866811 scopus 로고    scopus 로고
    • Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs
    • Siebert G, et al. Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs. J Pharmacol Exp Ther 2004; 308 (1): 228-235.
    • (2004) J Pharmacol Exp Ther , vol.308 , Issue.1 , pp. 228-235
    • Siebert, G.1
  • 309
    • 37149008003 scopus 로고    scopus 로고
    • Predicting oral clearance in humans: how close can we get with allometry?
    • Sinha V, et al. Predicting oral clearance in humans: how close can we get with allometry? Clin Pharmacokin 2008; 47 (1): 35-45.
    • (2008) Clin Pharmacokin , vol.47 , Issue.1 , pp. 35-45
    • Sinha V.et, al.1
  • 310
    • 53849093733 scopus 로고    scopus 로고
    • Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical
    • Sinz M, Wallace G, Sahi J. Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical. AAPS J 2008; 10 (2): 391-400.
    • (2008) AAPS J , vol.10 , Issue.2 , pp. 391-400
    • Sinz, M.1    Wallace, G.2    Sahi, J.3
  • 311
    • 24944563781 scopus 로고    scopus 로고
    • Seeing through the mist: abundance versus percentage Commentary on metabolites in safety testing
    • Smith D, Obach R. Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing. Drug Metab Dispos 2005; 33 (10): 1409-1417.
    • (2005) Drug Metab Dispos , vol.33 , Issue.10 , pp. 1409-1417
    • Smith, D.1    Obach, R.2
  • 312
    • 33845748169 scopus 로고    scopus 로고
    • Metabolites and safety: What are the concerns, and how should we address them?
    • Smith D, Obach R. Metabolites and safety: What are the concerns, and how should we address them? Chem Res Toxicol 2006; 19: 1570-1579.
    • (2006) Chem Res Toxicol , vol.19 , pp. 1570-1579
    • Smith, D.1    Obach, R.2
  • 313
    • 0033178249 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism in early drug discovery
    • Smith D, van de Waterbeemd H. Pharmacokinetics and metabolism in early drug discovery. Curr Opin in Chem Biol 1999; 3: 373-378.
    • (1999) Curr Opin in Chem Biol , vol.3 , pp. 373-378
    • Smith, D.1    van de Waterbeemd, H.2
  • 314
    • 0029865450 scopus 로고    scopus 로고
    • Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
    • Smith D, Jones B, Walker D. Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics. Med Res Rev 1996; 16 (3): 243-246.
    • (1996) Med Res Rev , vol.16 , Issue.3 , pp. 243-246
    • Smith, D.1    Jones, B.2    Walker, D.3
  • 315
    • 59649084532 scopus 로고    scopus 로고
    • Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity
    • Smith D, et al. Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity. Chemico-Biol Interactions 2009; 179 (1): 60-67.
    • (2009) Chemico-Biol Interactions , vol.179 , Issue.1 , pp. 60-67
    • Smith, D.1
  • 316
    • 0037325276 scopus 로고    scopus 로고
    • In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity
    • Smith K, et al. In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity. Chem Res Toxicol 2003; 16 (2): 123-128.
    • (2003) Chem Res Toxicol , vol.16 , Issue.2 , pp. 123-128
    • Smith, K.1
  • 317
    • 34247492532 scopus 로고    scopus 로고
    • The pivotal role of hepatocytes in drug discovery
    • Soars M, et al. The pivotal role of hepatocytes in drug discovery. Chemico-Biol Interactions 2007a; 168: 2-15.
    • (2007) Chemico-Biol Interactions , vol.168 , pp. 2-15
    • Soars, M.1
  • 318
    • 34249006024 scopus 로고    scopus 로고
    • Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo
    • Soars M, et al. Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo. Drug Metab Dispos 2007b; 35 (6): 859-865.
    • (2007) Drug Metab Dispos , vol.35 , Issue.6 , pp. 859-865
    • Soars, M.1
  • 319
    • 4444361038 scopus 로고    scopus 로고
    • The development of a higher throughput reactive intermediate screening assay incorporating micro-bore liquid chromatography-micro-electrospray ionization-tandem mass spectrometry and glutathione ethyl ester as an in vitro conjugating agent
    • Soglia J, et al. The development of a higher throughput reactive intermediate screening assay incorporating micro-bore liquid chromatography-micro-electrospray ionization-tandem mass spectrometry and glutathione ethyl ester as an in vitro conjugating agent. J Pharm Biomed Anal 2004; 36: 105-116.
    • (2004) J Pharm Biomed Anal , vol.36 , pp. 105-116
    • Soglia, J.1
  • 320
    • 33645469797 scopus 로고    scopus 로고
    • A semiquantitative method for the determination of reactive metabolite conjugate levels in vitro utilizing liquid chromatography-tandem mass spectrometry and novel quaternary ammonium glutathione analogues
    • Soglia J, et al. A semiquantitative method for the determination of reactive metabolite conjugate levels in vitro utilizing liquid chromatography-tandem mass spectrometry and novel quaternary ammonium glutathione analogues. Chem Res Toxicol 2006; 19: 480-490.
    • (2006) Chem Res Toxicol , vol.19 , pp. 480-490
    • Soglia, J.1
  • 321
    • 34547344360 scopus 로고    scopus 로고
    • New analytical strategies in studying drug metabolism
    • Staack R, Hopfgartner G. New analytical strategies in studying drug metabolism. Anal Bioanal Chem 2007; 388: 1365-1380.
    • (2007) Anal Bioanal Chem , vol.388 , pp. 1365-1380
    • Staack, R.1    Hopfgartner, G.2
  • 324
    • 0346787821 scopus 로고    scopus 로고
    • Integrated oral bioavailability projection using in vitro screening data as a selection tool in drug discovery
    • Stoner C, et al. Integrated oral bioavailability projection using in vitro screening data as a selection tool in drug discovery. Int J Pharmaceutics 2004; 269: 241-249.
    • (2004) Int J Pharmaceutics , vol.269 , pp. 241-249
    • Stoner, C.1
  • 325
    • 0345465945 scopus 로고    scopus 로고
    • Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication
    • Stratford RJ, et al. Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication. J Pharm Sci 1999; 88 (8): 747-753.
    • (1999) J Pharm Sci , vol.88 , Issue.8 , pp. 747-753
    • Stratford, R.J.1
  • 326
    • 34548016818 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of an alpha,beta-blocker, amosulalol hydrochloride, in mice: biliary excretion of carbamoyl glucuronide
    • Suzuki K, Kamimura H. Pharmacokinetics and metabolism of an alpha,beta-blocker, amosulalol hydrochloride, in mice: biliary excretion of carbamoyl glucuronide. Biol Pharm Bull 2007; 30 (8): 1580-1585.
    • (2007) Biol Pharm Bull , vol.30 , Issue.8 , pp. 1580-1585
    • Suzuki, K.1    Kamimura, H.2
  • 327
    • 43149118341 scopus 로고    scopus 로고
    • The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox)
    • 9/10
    • Szakacs G, et al. The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox). Drug Discovery Today 2008; 13 (9/10): 379-393.
    • (2008) Drug Discovery Today , vol.13 , pp. 379-393
    • Szakacs, G.1
  • 328
    • 25644452793 scopus 로고    scopus 로고
    • A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters
    • Tahara H, et al. A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther 2005; 315 (1): 337-345.
    • (2005) J Pharmacol Exp Ther , vol.315 , Issue.1 , pp. 337-345
    • Tahara, H.1
  • 329
    • 33644749355 scopus 로고    scopus 로고
    • Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists
    • Tahara H, et al. Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists. J Pharmacol Exp Ther 2006; 316 (3): 1187-1194.
    • (2006) J Pharmacol Exp Ther , vol.316 , Issue.3 , pp. 1187-1194
    • Tahara, H.1
  • 330
    • 50049084336 scopus 로고    scopus 로고
    • Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity
    • Takakusa H, et al. Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity. Drug Metab Dispos 2008; 36 (9): 1770-1779.
    • (2008) Drug Metab Dispos , vol.36 , Issue.9 , pp. 1770-1779
    • Takakusa, H.1
  • 331
    • 28444484982 scopus 로고    scopus 로고
    • Expression and function of efflux drug transporters in the intestine
    • 1-2
    • Takano M, Yumoto R, Murakami T. Expression and function of efflux drug transporters in the intestine. Pharmacol Ther 2006; 109 (1-2): 137-161.
    • (2006) Pharmacol Ther , vol.109 , pp. 137-161
    • Takano, M.1    Yumoto, R.2    Murakami, T.3
  • 332
    • 33746046061 scopus 로고    scopus 로고
    • Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode
    • Takeda S, et al. Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode. Drug Metab Dispos 2006; 34 (8): 1277-1282.
    • (2006) Drug Metab Dispos , vol.34 , Issue.8 , pp. 1277-1282
    • Takeda, S.1
  • 333
    • 34548214599 scopus 로고    scopus 로고
    • Drug metabolite profiling and elucidation of drug-induced hepatotoxicity
    • Tang W. Drug metabolite profiling and elucidation of drug-induced hepatotoxicity. Expert Opin Drug Metab Toxicol 2007; 3 (3): 407-420.
    • (2007) Expert Opin Drug Metab Toxicol , vol.3 , Issue.3 , pp. 407-420
    • Tang, W.1
  • 334
    • 0031017391 scopus 로고    scopus 로고
    • A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics
    • Tang W, Abbott F. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics. Drug Metab Dispos 1997; 25 (2): 219-227.
    • (1997) Drug Metab Dispos , vol.25 , Issue.2 , pp. 219-227
    • Tang, W.1    Abbott, F.2
  • 335
    • 0028241592 scopus 로고
    • Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms
    • Tassaneeyakul W, et al. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem Pharmacol 1994; 47 (10): 1767-1776.
    • (1994) Biochem Pharmacol , vol.47 , Issue.10 , pp. 1767-1776
    • Tassaneeyakul, W.1
  • 336
    • 0029849184 scopus 로고    scopus 로고
    • Synthesis and in vitro reactivity of 3-carbamoyl-2-phenylpropionaldehyde and 2-phenylpropenal: putative reactive metabolites of felbamate
    • Thompson C, Kinter M, Macdonald T. Synthesis and in vitro reactivity of 3-carbamoyl-2-phenylpropionaldehyde and 2-phenylpropenal: putative reactive metabolites of felbamate. Chem Res Toxicol 1996; 9 (8): 1225-1229.
    • (1996) Chem Res Toxicol , vol.9 , Issue.8 , pp. 1225-1229
    • Thompson, C.1    Kinter, M.2    Macdonald, T.3
  • 337
    • 0034890106 scopus 로고    scopus 로고
    • Optimization of metabolic stability as a goal of modern drug design
    • Thompson T, Optimization of metabolic stability as a goal of modern drug design. Med Res Rev 2001; 21 (5): 412-449.
    • (2001) Med Res Rev , vol.21 , Issue.5 , pp. 412-449
    • Thompson, T.1
  • 338
    • 0029875880 scopus 로고    scopus 로고
    • Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding
    • Thornton-Manning J, et al. Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding. J Pharmacol Exp Ther 1996; 276 (1): 21-29.
    • (1996) J Pharmacol Exp Ther , vol.276 , Issue.1 , pp. 21-29
    • Thornton-Manning, J.1
  • 339
    • 85146102681 scopus 로고    scopus 로고
    • Role of the gut mucosa in metabolically based drug-drug interactions
    • Rodrigues AD, editor
    • Thummel KE, Shen D, Isoherranen N. Role of the gut mucosa in metabolically based drug-drug interactions. In: Rodrigues AD, editor. Drug-Drug Interactions, Informa Healthcare, 2008, pp. 471-513.
    • (2008) Drug-Drug Interactions, Informa Healthcare , pp. 471-513
    • Thummel, K.E.1    Shen, D.2    Isoherranen, N.3
  • 341
    • 0028296071 scopus 로고
    • Route-dependent comparative metabolism of [14C] toluene 2,4-diisocyanate and [14C]toluene 2,4-diamine in Fischer 344 rats
    • Timchalk C, Smith F, Bartels M. Route-dependent comparative metabolism of [14C] toluene 2,4-diisocyanate and [14C]toluene 2,4-diamine in Fischer 344 rats. Toxicol Appl Pharmacol 1994; 124: 181-190.
    • (1994) Toxicol Appl Pharmacol , vol.124 , pp. 181-190
    • Timchalk, C.1    Smith, F.2    Bartels, M.3
  • 342
    • 0037327003 scopus 로고    scopus 로고
    • The orphan nuclear receptor HNF4alpha determines PXR-and CAR-mediated xenobiotic induction of CYP3A4
    • Tirona R, et al. The orphan nuclear receptor HNF4alpha determines PXR-and CAR-mediated xenobiotic induction of CYP3A4. Nat Med 2003; 9 (2): 220-224.
    • (2003) Nat Med , vol.9 , Issue.2 , pp. 220-224
    • Tirona, R.1
  • 343
    • 0030785065 scopus 로고    scopus 로고
    • Dexamethasone metabolism in vitro: species differences
    • Tomlinson E, et al. Dexamethasone metabolism in vitro: species differences. J Steroid Biochem Mol Biol 1997; 62 (4): 345-352.
    • (1997) J Steroid Biochem Mol Biol , vol.62 , Issue.4 , pp. 345-352
    • Tomlinson, E.1
  • 344
    • 0037518294 scopus 로고    scopus 로고
    • High pressure liquid chromatography and mass spectrometry characterization of the nephrotoxic biotransformation products of Cisplatin
    • Townsend D, et al. High pressure liquid chromatography and mass spectrometry characterization of the nephrotoxic biotransformation products of Cisplatin. Drug Metab Dispos 2003; 31 (6): 705-713.
    • (2003) Drug Metab Dispos , vol.31 , Issue.6 , pp. 705-713
    • Townsend, D.1
  • 345
    • 33750535207 scopus 로고    scopus 로고
    • Atypical cytochrome p450 kinetics: implications for drug discovery
    • Tracy T, Atypical cytochrome p450 kinetics: implications for drug discovery. Drugs R D 2006; 7 (6): 349-363.
    • (2006) Drugs R D , vol.7 , Issue.6 , pp. 349-363
    • Tracy, T.1
  • 346
    • 3042608648 scopus 로고    scopus 로고
    • Modeling kinetic data from in vitro drug metabolism enzyme experiments
    • Tracy T, Hummel M. Modeling kinetic data from in vitro drug metabolism enzyme experiments. Drug Metab Rev 2004; 36 (2): 231-242.
    • (2004) Drug Metab Rev , vol.36 , Issue.2 , pp. 231-242
    • Tracy, T.1    Hummel, M.2
  • 347
    • 0035147506 scopus 로고    scopus 로고
    • Prediction of a new drug's potential to cause idiosyncratic reactions
    • Uetrecht J. Prediction of a new drug's potential to cause idiosyncratic reactions. Curr Opin Drug Discovery Dev 2001; 4 (1): 55-59.
    • (2001) Curr Opin Drug Discovery Dev , vol.4 , Issue.1 , pp. 55-59
    • Uetrecht, J.1
  • 348
    • 0042831348 scopus 로고    scopus 로고
    • Screening for the potential of a drug candidate to cause idiosyncratic drug reactions
    • Uetrecht J. Screening for the potential of a drug candidate to cause idiosyncratic drug reactions. Drug Discovery Tech 2003; 8 (18): 832-837.
    • (2003) Drug Discovery Tech , vol.8 , Issue.18 , pp. 832-837
    • Uetrecht, J.1
  • 349
    • 33845409838 scopus 로고    scopus 로고
    • Evaluation of which reactive metabolite, if any, is responsible for a specific idiosyncratic reaction
    • Uetrecht J. Evaluation of which reactive metabolite, if any, is responsible for a specific idiosyncratic reaction. Drug Metab Rev 2006; 38: 745-753.
    • (2006) Drug Metab Rev , vol.38 , pp. 745-753
    • Uetrecht, J.1
  • 350
    • 0028911862 scopus 로고
    • Oxidation of aminopyrine by hypochlorite to a reactive dication: possible implications for aminopyrine-induced agranulocytosis
    • Uetrecht J, et al. Oxidation of aminopyrine by hypochlorite to a reactive dication: possible implications for aminopyrine-induced agranulocytosis. Chem Res Toxicol 1995; 8 (2): 226-233.
    • (1995) Chem Res Toxicol , vol.8 , Issue.2 , pp. 226-233
    • Uetrecht, J.1
  • 351
    • 34247349605 scopus 로고    scopus 로고
    • Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs
    • Urquhart B, Tirona R, Kim R. Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs. J Clin Pharmacol 2007; 47 (5): 566-578.
    • (2007) J Clin Pharmacol , vol.47 , Issue.5 , pp. 566-578
    • Urquhart, B.1    Tirona, R.2    Kim, R.3
  • 352
    • 27544462180 scopus 로고    scopus 로고
    • Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib
    • Uttamsingh V, et al. Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib. Drug Metab Dispos 2005; 33 (11): 1723-1728.
    • (2005) Drug Metab Dispos , vol.33 , Issue.11 , pp. 1723-1728
    • Uttamsingh, V.1
  • 353
    • 59849125083 scopus 로고    scopus 로고
    • Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism
    • Van L, et al. Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism. J Pharm Sci 2009; 98 (2): 763-771.
    • (2009) J Pharm Sci , vol.98 , Issue.2 , pp. 763-771
    • Van, L.1
  • 354
    • 59649117206 scopus 로고    scopus 로고
    • Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human OATP1B1 (SLCO1B1)
    • van de Steeg E, et al. Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human OATP1B1 (SLCO1B1). Drug Metab Dispos 2009; 37 (2): 277-281.
    • (2009) Drug Metab Dispos , vol.37 , Issue.2 , pp. 277-281
    • van de Steeg, E.1
  • 355
    • 34948910649 scopus 로고    scopus 로고
    • Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase
    • van Voorhis W, et al. Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrob Agents Chemother 2007; 51 (10): 3659-3671.
    • (2007) Antimicrob Agents Chemother , vol.51 , Issue.10 , pp. 3659-3671
    • van Voorhis, W.1
  • 356
    • 18844426008 scopus 로고    scopus 로고
    • In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: prediction of nonstationary pharmacokinetics and drug interaction magnitude
    • Venkatakrishnan K, Obach R. In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: prediction of nonstationary pharmacokinetics and drug interaction magnitude. Drug Metab Dispos 2005; 33 (6): 845-854.
    • (2005) Drug Metab Dispos , vol.33 , Issue.6 , pp. 845-854
    • Venkatakrishnan, K.1    Obach, R.2
  • 357
    • 34548738229 scopus 로고    scopus 로고
    • Drug-drug interactions via mechanism-based cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation
    • Venkatakrishnan K, Obach R. Drug-drug interactions via mechanism-based cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation. Curr Drug Metab 2007; 8: 449-462.
    • (2007) Curr Drug Metab , vol.8 , pp. 449-462
    • Venkatakrishnan, K.1    Obach, R.2
  • 358
    • 0033674502 scopus 로고    scopus 로고
    • Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches
    • Venkatakrishnan K, et al. Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches. Drug Metab Dispos 2000; 28 (12): 1493-1504.
    • (2000) Drug Metab Dispos , vol.28 , Issue.12 , pp. 1493-1504
    • Venkatakrishnan, K.1
  • 359
    • 0034770465 scopus 로고    scopus 로고
    • Human drug metabolism and the cytochromes P450: application and relevance of in vitro models
    • Venkatakrishnan K, Von Moltke LL, Greenblatt DJ. Human drug metabolism and the cytochromes P450: application and relevance of in vitro models. J Clin Pharmacol 2001; 41: 1149-1179.
    • (2001) J Clin Pharmacol , vol.41 , pp. 1149-1179
    • Venkatakrishnan, K.1    Von Moltke, L.L.2    Greenblatt, D.J.3
  • 360
    • 0142010701 scopus 로고    scopus 로고
    • Drug metabolism and drug interactions: application and clinical value of in vitro models
    • Venkatakrishnan K, et al. Drug metabolism and drug interactions: application and clinical value of in vitro models. Curr Drug Metab 2003; 4: 423-459.
    • (2003) Curr Drug Metab , vol.4 , pp. 423-459
    • Venkatakrishnan, K.1
  • 361
    • 0038637264 scopus 로고    scopus 로고
    • Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice
    • Veronese M, et al. Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice. J Clin Pharmacol 2003; 43 (8): 831-839.
    • (2003) J Clin Pharmacol , vol.43 , Issue.8 , pp. 831-839
    • Veronese, M.1
  • 362
    • 0030920759 scopus 로고    scopus 로고
    • Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime
    • Victor F, et al. Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime. J Med Chem 1997; 40 (10): 1511-1518.
    • (1997) J Med Chem , vol.40 , Issue.10 , pp. 1511-1518
    • Victor, F.1
  • 363
    • 0032454713 scopus 로고    scopus 로고
    • Microsomal metabolism of delavirdine: evidence for mechanism-based inactivation of human cytochrome P450 3A
    • Voorman R, et al. Microsomal metabolism of delavirdine: evidence for mechanism-based inactivation of human cytochrome P450 3A. J Pharmacol Exp Ther 1998; 287 (1): 381-388.
    • (1998) J Pharmacol Exp Ther , vol.287 , Issue.1 , pp. 381-388
    • Voorman, R.1
  • 364
    • 0032986686 scopus 로고    scopus 로고
    • Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations
    • Von Moltke LL, et al. Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations. Br J Clin Pharmacol 1999; 48: 89-97.
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 89-97
    • Von Moltke, L.L.1
  • 365
    • 0033948964 scopus 로고    scopus 로고
    • Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: comparison with ketoconazole
    • Von Moltke LL, et al. Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: comparison with ketoconazole. Eur J Clin Pharmacol 2000; 56: 259-261.
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 259-261
    • Von Moltke, L.L.1
  • 366
    • 18844373318 scopus 로고    scopus 로고
    • Role of metabolism in drug-induced idiosyncratic hepatotoxicity
    • Walgren J, Mitchell M, Thompson D. Role of metabolism in drug-induced idiosyncratic hepatotoxicity. Critical Rev Toxicol 2005; 35: 325-361.
    • (2005) Critical Rev Toxicol , vol.35 , pp. 325-361
    • Walgren, J.1    Mitchell, M.2    Thompson, D.3
  • 367
    • 34548267589 scopus 로고    scopus 로고
    • Improving metabolic stability of cancer chemoprotective polyphenols
    • Walle T, Wen X, Walle U. Improving metabolic stability of cancer chemoprotective polyphenols. Expert Opin Drug Metab Toxicol 2007; 3 (3): 379-388.
    • (2007) Expert Opin Drug Metab Toxicol , vol.3 , Issue.3 , pp. 379-388
    • Walle, T.1    Wen, X.2    Walle, U.3
  • 368
    • 0346099111 scopus 로고    scopus 로고
    • Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes
    • Wang H, LeCluyse E. Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clin Pharmacokinet 2003; 42 (15): 1331-1357.
    • (2003) Clin Pharmacokinet , vol.42 , Issue.15 , pp. 1331-1357
    • Wang, H.1    LeCluyse, E.2
  • 369
    • 0037855831 scopus 로고    scopus 로고
    • Induction of hepatic phase II drug-metabolizing enzymes by 1,7-phenanthroline in rats is accompanied by induction of MRP3
    • Wang S, et al. Induction of hepatic phase II drug-metabolizing enzymes by 1,7-phenanthroline in rats is accompanied by induction of MRP3. Drug Metab Dispos 2003; 31 (6): 773-775.
    • (2003) Drug Metab Dispos , vol.31 , Issue.6 , pp. 773-775
    • Wang, S.1
  • 370
  • 371
    • 0034837148 scopus 로고    scopus 로고
    • Assessment of drug-drug interactions: concepts and approaches
    • 8/9
    • Weaver R. Assessment of drug-drug interactions: concepts and approaches. Xenobiotica 2001; 31 (8/9): 499-538.
    • (2001) Xenobiotica , vol.31 , pp. 499-538
    • Weaver, R.1
  • 372
    • 33947611171 scopus 로고    scopus 로고
    • The effect of ageing on cytochrome p450 enzymes: consequences for drug biotransformation in the elderly
    • Wauthier V, Verbeek R, Calderon P. The effect of ageing on cytochrome p450 enzymes: consequences for drug biotransformation in the elderly. Curr Med Chem 2007; 14: 745-757.
    • (2007) Curr Med Chem , vol.14 , pp. 745-757
    • Wauthier, V.1    Verbeek, R.2    Calderon, P.3
  • 373
    • 27644596457 scopus 로고    scopus 로고
    • Predicting in vivo drug interactions from in vitro drug discovery data
    • Weinkers L, Heath T. Predicting in vivo drug interactions from in vitro drug discovery data. Nature Rev 2005; 4: 825-833.
    • (2005) Nature Rev , vol.4 , pp. 825-833
    • Weinkers, L.1    Heath, T.2
  • 374
    • 0020511430 scopus 로고
    • Plasma and tissue binding considerations in drug disposition
    • Wilkinson G. Plasma and tissue binding considerations in drug disposition. Drug Metab Rev 1983; 14 (3): 427-465.
    • (1983) Drug Metab Rev , vol.14 , Issue.3 , pp. 427-465
    • Wilkinson, G.1
  • 375
    • 0023132476 scopus 로고
    • Clearance approaches in pharmacology
    • Wilkinson G. Clearance approaches in pharmacology. Pharmacol Rev 1987; 39 (1): 1-47.
    • (1987) Pharmacol Rev , vol.39 , Issue.1 , pp. 1-47
    • Wilkinson, G.1
  • 376
    • 0016566218 scopus 로고
    • Commentary: a physiological approach to hepatic drug clearance
    • Wilkinson G, Shand D. Commentary: a physiological approach to hepatic drug clearance. Clin Pharmacokinet Ther 1975; 18 (4): 377-390.
    • (1975) Clin Pharmacokinet Ther , vol.18 , Issue.4 , pp. 377-390
    • Wilkinson, G.1    Shand, D.2
  • 377
    • 0033938971 scopus 로고    scopus 로고
    • Induction of metabolism-dependent and-independent neutrophil apoptosis by clozapine
    • Williams D, et al. Induction of metabolism-dependent and-independent neutrophil apoptosis by clozapine. Mol Pharmacol 2000; 58 (1): 207-216.
    • (2000) Mol Pharmacol , vol.58 , Issue.1 , pp. 207-216
    • Williams, D.1
  • 378
    • 0036843701 scopus 로고    scopus 로고
    • Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes
    • Williams J, et al. Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes. Drug Metab Dispos 2002; 30 (11): 1266-1273.
    • (2002) Drug Metab Dispos , vol.30 , Issue.11 , pp. 1266-1273
    • Williams, J.1
  • 379
    • 19944428787 scopus 로고    scopus 로고
    • In vitro ADME phenotyping in drug discovery: current challenges and future solutions
    • Williams J, et al. In vitro ADME phenotyping in drug discovery: current challenges and future solutions. Curr Opin in Drug Discovery Dev 2005; 8 (1): 78-88.
    • (2005) Curr Opin in Drug Discovery Dev , vol.8 , Issue.1 , pp. 78-88
    • Williams, J.1
  • 380
    • 45749146622 scopus 로고    scopus 로고
    • PhRMA white paper on ADME pharmacogenomics
    • Williams J, et al. PhRMA white paper on ADME pharmacogenomics. J Clin Pharmacol 2008; 48: 849-889.
    • (2008) J Clin Pharmacol , vol.48 , pp. 849-889
    • Williams, J.1
  • 381
    • 23344450788 scopus 로고    scopus 로고
    • Induction of phase I, II and III drug metabolism/transport by xenobiotics
    • Xu C, Li Y-T, Kong A-N. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharm Res 2005; 28 (3): 249-268.
    • (2005) Arch Pharm Res , vol.28 , Issue.3 , pp. 249-268
    • Xu, C.1    Li, Y.-T.2    Kong, A.-N.3
  • 382
    • 11144285534 scopus 로고    scopus 로고
    • Metabolic activation of fluoropyrrolidine dipeptidyl peptidase-IV inhibitors by rat liver microsomes
    • Xu S, et al. Metabolic activation of fluoropyrrolidine dipeptidyl peptidase-IV inhibitors by rat liver microsomes. Drug Metab Dispos 2005; 33 (1): 121-130.
    • (2005) Drug Metab Dispos , vol.33 , Issue.1 , pp. 121-130
    • Xu, S.1
  • 383
    • 33745231761 scopus 로고    scopus 로고
    • Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans
    • Yamashiro W, et al. Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans. Drug Metab Dispos 2006; 34 (7): 1247-1254.
    • (2006) Drug Metab Dispos , vol.34 , Issue.7 , pp. 1247-1254
    • Yamashiro, W.1
  • 385
    • 34249274907 scopus 로고    scopus 로고
    • Theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism (time)-based enzyme inhibition
    • Yang J, et al. Theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism (time)-based enzyme inhibition. Eur J Pharm Sci 2007; 31: 232-241.
    • (2007) Eur J Pharm Sci , vol.31 , pp. 232-241
    • Yang, J.1
  • 386
    • 50049128215 scopus 로고    scopus 로고
    • Unbiased high-throughput screening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered data-dependent acquisition
    • Yan Z, Caldwell C, Maher N. Unbiased high-throughput screening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered data-dependent acquisition. Anal Chem 2008; 80: 6410-6422.
    • (2008) Anal Chem , vol.80 , pp. 6410-6422
    • Yan, Z.1    Caldwell, C.2    Maher, N.3
  • 387
    • 0036771085 scopus 로고    scopus 로고
    • Inhibition-based metabolic drug-drug interactions: predictions from in vitro data
    • Yao C, Levy R. Inhibition-based metabolic drug-drug interactions: predictions from in vitro data. J Pharm Sci 2002; 91 (9): 1923-1935.
    • (2002) J Pharm Sci , vol.91 , Issue.9 , pp. 1923-1935
    • Yao, C.1    Levy, R.2
  • 388
    • 0027377294 scopus 로고
    • Species differences in stereoselective metabolism of mephenytoin by cytochrome P450 (CYP2C and CYP3A)
    • Yasumori T, et al. Species differences in stereoselective metabolism of mephenytoin by cytochrome P450 (CYP2C and CYP3A). J Pharmacol Exp Ther 1993; 264 (1): 89-94.
    • (1993) J Pharmacol Exp Ther , vol.264 , Issue.1 , pp. 89-94
    • Yasumori, T.1
  • 389
    • 0024804838 scopus 로고
    • Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies
    • Yeh K, et al. Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies. Neurology 1989; 39 (11 (2)): 25-38.
    • (1989) Neurology , vol.39 , Issue.2-11 , pp. 25-38
    • Yeh, K.1
  • 390
    • 34247631742 scopus 로고    scopus 로고
    • The evolving role of drug metabolism in drug discovery and development
    • Yengi L, Leung L, Kao J. The evolving role of drug metabolism in drug discovery and development. Pharm Res 2007; 24 (5): 842-858.
    • (2007) Pharm Res , vol.24 , Issue.5 , pp. 842-858
    • Yengi, L.1    Leung, L.2    Kao, J.3
  • 391
    • 0034104232 scopus 로고    scopus 로고
    • Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in perfused rat liver: involvement of hepatic aldehyde oxidase as a detoxification enzyme
    • Yoshihara S, Harada K, Ohta S. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in perfused rat liver: involvement of hepatic aldehyde oxidase as a detoxification enzyme. Drug Metab Dispos 2000; 28 (5): 538-543.
    • (2000) Drug Metab Dispos , vol.28 , Issue.5 , pp. 538-543
    • Yoshihara, S.1    Harada, K.2    Ohta, S.3
  • 393
    • 42149153187 scopus 로고    scopus 로고
    • Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction
    • Youdim K, et al. Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction. Br J Clin Pharmacol 2008; 65 (5): 680-692.
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.5 , pp. 680-692
    • Youdim, K.1
  • 394
    • 34247391128 scopus 로고    scopus 로고
    • Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys
    • Zhang H, et al. Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys. Drug Metab Dispos 2007a; 35 (5): 795-805.
    • (2007) Drug Metab Dispos , vol.35 , Issue.5 , pp. 795-805
    • Zhang, H.1
  • 395
    • 85047686583 scopus 로고    scopus 로고
    • Cytochrome P450 reaction-phenotyping: an industrial perspective
    • Zhang H, et al. Cytochrome P450 reaction-phenotyping: an industrial perspective. Expert Opin Drug Metab Toxicol 2007b; 3 (5): 667-687.
    • (2007) Expert Opin Drug Metab Toxicol , vol.3 , Issue.5 , pp. 667-687
    • Zhang, H.1
  • 396
    • 0034080254 scopus 로고    scopus 로고
    • Metabolism of A dopamine D(4)-selective antagonist in rat, monkey, and humans: formation of A novel mercapturic acid adduct
    • Zhang K, et al. Metabolism of A dopamine D(4)-selective antagonist in rat, monkey, and humans: formation of A novel mercapturic acid adduct. Drug Metab Dispos 2000; 28 (6): 633-642.
    • (2000) Drug Metab Dispos , vol.28 , Issue.6 , pp. 633-642
    • Zhang, K.1
  • 397
    • 48749084803 scopus 로고    scopus 로고
    • A regulatory viewpoint on transporter-based drug interactions
    • Zhang L, et al. A regulatory viewpoint on transporter-based drug interactions. Xenobiotica 2008; 38 (7/8): 709-724.
    • (2008) Xenobiotica , vol.38 , Issue.7-8 , pp. 709-724
    • Zhang, L.1
  • 399
    • 39749143423 scopus 로고    scopus 로고
    • The use of hepatocytes in evaluating time-dependent inactivation of P450 in vivo
    • Zhao P, The use of hepatocytes in evaluating time-dependent inactivation of P450 in vivo. Expert Opin Drug Metab Toxicol 2008; 4 (2): 151-164.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , Issue.2 , pp. 151-164
    • Zhao, P.1
  • 400
    • 4644361194 scopus 로고    scopus 로고
    • Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes
    • Zhou C, et al. Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. Drug Metab Dispos 2004a; 32 (10): 1075-1082.
    • (2004) Drug Metab Dispos , vol.32 , Issue.10 , pp. 1075-1082
    • Zhou, C.1
  • 401
    • 3242709450 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of drugs with St John's wort
    • Zhou S, et al. Pharmacokinetic interactions of drugs with St John's wort. J Psychopharmacol 2004b; 18 (2): 262-276.
    • (2004) J Psychopharmacol , vol.18 , Issue.2 , pp. 262-276
    • Zhou, S.1
  • 402
    • 53349117254 scopus 로고    scopus 로고
    • Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development
    • Zhou S, et al. Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development. Curr Med Chem 2008; 15 (20): 1981-2039.
    • (2008) Curr Med Chem , vol.15 , Issue.20 , pp. 1981-2039
    • Zhou, S.1
  • 403
    • 45249121177 scopus 로고    scopus 로고
    • Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
    • Zhou S-F. Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr Drug Metab 2008; 9 (4): 310-322.
    • (2008) Curr Drug Metab , vol.9 , Issue.4 , pp. 310-322
    • Zhou, S.-F.1
  • 404
    • 4644308675 scopus 로고    scopus 로고
    • Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4
    • Zhou S-F, et al. Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4. Curr Drug Metab 2004c; 5: 415-442.
    • (2004) Curr Drug Metab , vol.5 , pp. 415-442
    • Zhou S-F et, al.1


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