Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

Pharmaceutical Research

Volumn 22, Issue 1, 2005, Pages 103-112

  Ito, Kiyomi ^a   Houston, J Brian ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Allometry; Clearance prediction; Hepatic clearance; Intrinsic clearance, in vitro scaling

Indexed keywords

ALPRAZOLAM; CAFFEINE; DIAZEPAM; DICLOFENAC; DILTIAZEM; DOFETILIDE; FABESETRON; FELODIPINE; FLUNITRAZEPAM; HEXOBARBITAL; IBUPROFEN; IMIPRAMINE; INDINAVIR; LIDOCAINE; METOPROLOL; MIDAZOLAM; N [1 (2 FLUOROPHENYL) 3,4,6,7 TETRAHYDRO 4 OXOPYRROLO[3,2,1 JK][1,4]BENZODIAZEPIN 3 YL] 1H INDOLE 2 CARBOXAMIDE; NICARDIPINE; NILVADIPINE; OMEPRAZOLE; ONDANSETRON; PHENACETIN; PHENAZONE; PHENYTOIN; PROPRANOLOL; TOLBUTAMIDE; TRIAZOLAM; UNINDEXED DRUG; WARFARIN; ZOLPIDEM;

ACCURACY; ALLOMETRY; ARTICLE; COMPARATIVE STUDY; DRUG CLEARANCE; DRUG SPECIFICITY; EMPIRICISM; HUMAN; IN VITRO STUDY; LIVER CLEARANCE; LIVER MICROSOME; MATHEMATICAL MODEL; PREDICTION; PRIORITY JOURNAL; RATING SCALE;

ANIMALS; DRUG EVALUATION, PRECLINICAL; EMPIRICAL RESEARCH; HUMANS; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS; PROTEIN BINDING; RATS;

EID: 17644381224     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-004-9015-1     Document Type: Article

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