Metabolism of a dopamine D4-selective antagonist in rat, monkey, and humans: Formation of a novel mercapturic acid adduct

Drug Metabolism and Disposition

Volumn 28, Issue 6, 2000, Pages 633-642

  Zhang, Kanyin E ^a   Kari, Prasad H ^d   Davis, Margaret R ^b   Doss, George ^d   Baillie, Thomas A ^d   Vyas, Kamlesh P ^c  

^a AGOURON PHARMACEUTICALS INC   (United States)

^b Cerep Inc   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; ACETYLCYSTEINE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DRUG METABOLITE; INDOLE DERIVATIVE; PIPERAZINE; SKATOLE;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CLINICAL TRIAL; DOPAMINERGIC SYSTEM; DRUG MECHANISM; DRUG METABOLISM; DRUG TRANSFORMATION; EXTRAPYRAMIDAL SYMPTOM; HUMAN; LIQUID CHROMATOGRAPHY; MALE; NEGATIVE SYNDROME; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RAT; RHESUS MONKEY; SCHIZOPHRENIA; TANDEM MASS SPECTROMETRY;

ACETYLCYSTEINE; ANIMALS; DOPAMINE ANTAGONISTS; HUMANS; MACACA MULATTA; MALE; PYRIDINES; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4;

ANIMALIA; MACACA MULATTA;

EID: 0034080254     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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