The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters

Current Drug Metabolism

Volumn 9, Issue 5, 2008, Pages 374-383

  Ma, Qiang ^a   Lu, Anthony Y H ^b  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Crystal structure; Drug interaction; Drug metabolism; Drug transporter; Drug metabolizing enzymes; P450; Promiscuity; Receptor

Indexed keywords

AMFEBUTAMONE; AROMATIC HYDROCARBON RECEPTOR; BROMOCRIPTINE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYCLOSPORIN; CYTOCHROME P450; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; EFAVIRENZ; ENVIRONMENTAL CHEMICAL; EPOXIDE HYDROLASE; ERYTHROMYCIN; FLURBIPROFEN; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN P; INDINAVIR; MACROLIDE; METYRAPONE; NIFEDIPINE; PARACETAMOL; PHENYTOIN; PREGNANE X RECEPTOR; SULFOTRANSFERASE; TESTOSTERONE; UNINDEXED DRUG; WARFARIN;

COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG CLEARANCE; DRUG METABOLISM; DRUG SAFETY; DRUG TRANSPORT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HETEROTROPHY; HUMAN; LIGAND BINDING; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW;

ANIMALS; BINDING SITES; CARRIER PROTEINS; ENZYMES; HUMANS; KINETICS; LIGANDS; PHARMACEUTICAL PREPARATIONS; PROTEIN CONFORMATION; RECEPTORS, DRUG; SUBSTRATE SPECIFICITY;

EID: 47749105317     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008784746337     Document Type: Review

References (67)

1. Ma, Q.; Lu, A.Y. (2003) Chem. Res. Toxicol., 16, 249-60.
2. Conney, A.H. (2003) Annu. Rev. Pharmacol. Toxico., 43, 1-30.
3. Coon, M.J. (2005) Annu. Rev. Pharmacol. Toxicol., 45, 1-25.
4. Lu, A.Y. (1998) Drug Melab. Dispos., 26, 1217-22.
5. Guengerich, F.P. (2004) Drug Metab. Rev., 36, 159-97.
6. Evans, R.M. (2005) Mol. Endocrinol., 19, 1429-38.
7. Ma, Q. (2007) Mol. Interv., 7, 133-7.
8. Ma, Q. (2001) Curr. Drug Metab., 2, 149-64.
9. Lu, A.Y. (1998) Drug Metab. Dispos., 26, 1168-73.
10. Zhao, Y.; Halpert, J.R. (2007) Biochim. Biophys. Acta, 1770, 402-12.
11. Guengerich, F.P. (2006) Proc. Natl. Acad. Sci. USA, 103, 13565-6.
12. Tang, C.; Lin, J.H. and Lu, A.Y. (2005) Drug Metab Dispos, 33, 603-13.
13. Guengerich, F.P. (1995) in Cytochrome P450, (Ortiz de Montellano, P.R. Ed.), Plenum Press, New York, pp. 473-535.
14. Wrighton, S.A.; Stevens, J.C. (1992) Crit. Rev. Toxicol., 22, 1-21.
15. Sansen, S.; Yano, J.K.; Reynald, R.L.; Schoch, G.A.; Griffin, K.J.; Stout, C.D. and Johnson, E.F. (2007) J. Biol. Chem., 282, 14348-55.
16. Kim, D.; Guengerich, F.P. (2005) Annu. Rev. Pharmacol. Toxicol., 45, 27-49.
17. Rowland, P.; Blaney, F.E.; Smyth, M.G.; Jones, J.J.; Leydon, V.R.; Oxbrow, A.K.; Lewis, C.J.; Tennant, M.G.; Modi, S.; Eggleston, D.S.; Chenery, R.J. and Bridges, A.M. (2006) J. Biol. Chem., 281, 7614-22.
18. Ambudkar, S.V.; Dey, S.; Hrycyna, C.A.; Ramachandra, M.; Pastan, I, and Gottesman, M.M. (1999) Annu. Rev. Pharmacol. Toxicol., 39, 361-98.
19. Seelig, A. (1998) Eur. J. Biochem., 251, 252-61.
20. Carnahan, V.E.; Redinbo, M.R. (2005) Curr. Drug Metab., 6, 357-67.
21. Poulos, T.L.; Finzel, B.C.; Gunsalus, I.C.; Wagner, G.C. and Kraut, J. (1985) J. Biol. Chem., 260, 16122-30.
22. Johnson, E.F. (2003) Drug Metab. Dispos., 31, 1532-40.
23. Johnson, E.F.; Stout, C.D. (2005) Biochem. Biophys. Res. Commun., 338, 331-6.
24. Gamage, N.U.; Tsvetanov, S.; Duggleby, R.G.; McManus, M.E. and Martin, J.L. (2005) J. Biol. Chem., 280, 41482-6.
25. Yano, J.K.; Wester, M.R.; Schoch, G.A.; Griffin, K.J.; Stout, C.D. and Johnson, E.F. (2004) J. Biol. Chem., 279, 38091-4.
26. Ekroos, M.; Sjogren, T. (2006) Proc. Natl. Acad. Sci. USA, 103, 13682-7.
27. Williams, P.A.; Cosine, J.; Ward, A.; Angove, H.C.; Matak Vinkovic, D. and Jhoti, H. (2003) Nature, 424, 464-8.
28. Wester, M.R.; Yano, J.K.; Schoch, G.A.; Yang, C.; Griffin, K.J.; Stout, C.D. and Johnson, E.F. (2004) J. Biol. Chem., 279, 35630-7.
29. Schoch, G.A.; Yano, J.K.; Wester, M.R.; Griffin, K.J.; Stout C.D. and Johnson, E.F. (2004) J. Biol. Chem., 279, 9497-503.
30. Wester, M.R.; Johnson, E.F.; Marques-Soares, C.; Dansette, P.M.; Mansuy, D. and Stout C.D. (2003) Biochemistry, 42, 6370-9.
31. Yano, J.K.; Hsu, M.H.; Griffin, K.J.; Stout, C.D. and Johnson, E.F. (2005) Nat. Struct. Mol. Biol., 12, 822-3.
32. Ma, Q.; Lu, A.Y. (2007) Drug Metab. Dispos., 35, 1009-16.
33. Strott, C.A. (2002) Endocr. Rev., 23, 703-32.
34. Gamage, N. U.; Duggleby, R.G.; Barnett, A.C.; Tresillian, M.; Latham, C.F.; Liyou, N.E.; McManus, M.E. and Marfin, J.L. J. Biol. Chem., 278, 7655-62.
35. Germain, P.; Staels, B.; Dacquet, C.; Spedding, M. and Laudet, V. (2006) Pharmacol. Rev., 58, 685-704.
36. Chrencik, J.E.; Orans, J.; Moore, L.B.; Xue, Y.; Peng, L.; Collins, J.L,; Wisely, G.B.; Lambert, M.H.; Kliewer, S.A. and Redinbo, M.R. (2005) Mol. Endocrinol., 19, 1125-34.
37. Shan, L.; Vincent, J.; Brunzelle, J.S.; Dussault, I.; Lin, M.; Ianculescu, I.; Sherman, M.A.; Forman, B.M. and Fernandez, E.J. (2004) Mol. Cell, 16, 907-17.
38. Suino, K.; Peng, L.; Reynolds, R.; Li, Y.; Cha, J.Y.; Repa, J.J.; Kliewer, S.A.; Xu, H.E. (2004) Mol. Cell, 16, 893-905.
39. Xu, R.X.; Lambert, M.H.; Wisely, B.B.; Warren, E.N.; Weinert, E.E.; Waitt, G.M.; Williams, J.D.; Collins, J.L.; Moore, L.B.; Willson, T.M. and Moore, J.T. (2004) Mol. Cell, 16, 919-28.
40. Whitlock, J.P., Jr. (1999) Annu. Rev. Pharmacol. Toxicol., 39, 103-25.
41. Poland, A.; Knutson, J.C. (1982) Annu. Rev. Pharmacol. Toxicol., 22, 517-54.
42. Denison, M.S.; Nagy, S.R. (2003) Annu. Rev. Pharmacol. Toxicol., 43, 309-34.
43. Williams, P.A.; Cosme, J.; Vinkovic, D.M.; Ward, A.; Angove, H.C.; Day, P.J.; Vonrhein, C.; Tickle, I.J. and Jhoti, H. (2004) Science, 305, 683-6.
44. Scott, E.E.; He, Y.A.; Wester, M.R.; White, M.A.; Chin, C.C.; Halpert, J.R.; Johnson, E.F. and Stout, C.D. (2003) Proc. Natl. Acad. Sci. USA, 100, 13196-201.
45. Scott, E.E.; White, MA.; He, Y.A.; Johnson, E.F.; Stout, C.D. and Halpert, J.R. (2004) J. Mol. Chem., 279, 27294-301.
46. Zhao, Y.; White, M.A.; Muralidhara, B.K.; Sun, L.; Halpert, J.R. and Stout, C.D. (2006) J. Biol. Chem., 281, 5973-81.
47. Muralidhara, B.K.; Negi, S.; Chin, C.C.; Braun, W. and Halpert, J.R. (2006) J. Biol. Chem., 281, 8051-61.
48. Zhao, Y.; Sun, L.; Muralidhara, B.K.; Kumar, S.; White, M.A.; Stout, C.D. and Halpert, J.R. (2007) Biochemistry, 46, 11559-67.
49. Poulos, T.L. (2003) Proc. Natl. Acad. Sci. USA, 100, 13121-2.
50. Loo, T.W.; Bartlett, M.C. and Clarke, D.M. (2003) J. Biol. Chem., 278, 13603-6.
51. Chiba, M.; Hensleigh, M.; Nishime, J.A.; Balani, S.K. and Lin, J.H. (1996) Drug Metab. Dispos., 24, 307-14.
52. Peters, W.H.; Jansen, P.L. (1986) J. Hepatol., 2, 182-94.
53. Ueng, Y.F.; Kuwabara, T.; Chun, Y.J. and Guengerich, F.P. (1997) Biochemistry, 36, 370-81.
54. Harlow, G.R.; Halpert, J.R. (1998) Proc. Natl. Acad. Sci. USA, 95, 6636-41.
55. He, Y.A.; Roussel, F. and Halpert J.R. (2003) Arch. Biochem. Biophys., 409, 92-101.
56. Baas, B.J.; Denisov, I.G. and Sligar, S.G. (2004) Arch. Biochem. Biophys., 430, 218-28.
57. Shou, M.; Lin, Y.; Lu, P.; Tang, C.; Mei, Q.; Cui, D.; Tang, W.; Ngui, J.S.; Lin, C.C.; Singh, R.; Wong, B.K.; Yergey, J.A.; Lin, J.H.; Pearson, P.G.; Baillie, T.A.; Rodrigues, A.D. and Rushmore, T.H. (2001) Curr. Drug Metab., 2, 17-36.
58. Shou, M.; Grogan, J.; Mancewicz, J.A.; Krausz, K.W.; Gonzalez, F.J.; Gelboin, H.V. and Korzekwa, K.R. (1994) Biochemistry, 33, 6450-5.
59. Kenworthy, K.E.; Clarke, S.E.; Andrews, J. and Houston, J.B. (2001) Drug Metab. Dispos., 29, 1644-51.
60. Hosea, N.A.; Miller, G.P. and Guengerich, F.P. (2000) Biochemistry, 39, 5929-39.
61. Wang, R.W.; Newton, D.J.; Liu, N.; Atkins, W.M.; Lu, A.Y. (2000) Drug Metab. Dispos., 28, 360-6.
62. Levin, W.; Thomas, P.E,; Korzeniowski, D.; Seifried, H.; Jerina, D.M. and Lu, A.Y. (1978) Mol. Pharmacol., 14, 1107-20.
63. Zimmermann, C.; van de Wetering, K.; van de Steeg, E.; Wagenaar, E.; Vens, C. and Schinkel, A.H. (2008) Drug Metab. Dispos., 36, 631-40.
64. Atkins, W.M. (2006) Expert Opin. Drug Metab. Toxicol., 2, 573-9.
65. Ekins, S.; Andreyev, S.; Ryabov, A.; Kirillov, E.; Rakhmatulin, E.A.; Bugrim, A. and Nikolskaya, T. (2005) Expert Opin. Drug Metab. Toxicol., 1, 303-24.
66. Madden, J.C.; Cronin, M.T. (2006) Expert Opin. Drug Metab. Toxicol., 2, 545-57.
67. van de Waterbeemd, H.; Gifford, E. (2003) Nat. Rev. Drug Discov., 2, 192-204.