The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

Nature Medicine

Volumn 9, Issue 2, 2003, Pages 220-224

  Tirona, Rommel G ^a   Lee, Wooin ^a   Leake, Brenda F ^a   Lan, Lu Bin ^d   Brimer Cline, Cynthia ^d   Lamba, Vishal ^d   Parviz, Fereshteh ^b   Duncan, Stephen A ^b   Inoue, Yusuke ^c   Gonzalez, Frank J ^c   Schuetz, Erin G ^d   Kim, Richard B ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANE RECEPTOR; CELL NUCLEUS RECEPTOR; CIS ACTING ELEMENT; CYTOCHROME P450 3A4; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ADOLESCENT; ARTICLE; CONTROLLED STUDY; DRUG RESPONSE; DRUG TOXICITY; ENHANCER REGION; ENZYME ACTIVITY; ENZYME INDUCTION; FETUS; GENE ACTIVATION; GENE DELETION; HUMAN; HUMAN CELL; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENHANCER ELEMENTS (GENETICS); ENZYME INDUCTION; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; MALE; MICE; MICE, INBRED C57BL; PHOSPHOPROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; XENOBIOTICS;

EUKARYOTA;

EID: 0037327003     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm815     Document Type: Article

References (23)

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