Drug-drug interactions via mechanism-based cytochrome P450 inactivation: Points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation

Current Drug Metabolism

Volumn 8, Issue 5, 2007, Pages 449-462

  Venkatakrishnan, Karthik ^a   Obach, R Scott ^a  

^a PFIZER INC   (United States)

Author keywords

DDI risk assessment; Drug drug interactions; In vitro in vivo extrapolation; Mechanism based inactivation

Indexed keywords

ALPRAZOLAM; AMFEBUTAMONE; AZITHROMYCIN; BUSPIRONE; CLARITHROMYCIN; CYTOCHROME P450; CYTOCHROME P450 3A; DICLOFENAC; DILTIAZEM; ERYTHROMYCIN; ETHINYLESTRADIOL; FLUOXETINE; KETOCONAZOLE; MACROLIDE; METHADONE; MIBEFRADIL; MIDAZOLAM; OLTIPRAZ; OMEPRAZOLE; PARAXANTHINE; PAROXETINE; QUINIDINE; RIFAMPICIN; RITONAVIR; THEOPHYLLINE; TICLOPIDINE; TRIAZOLAM; UNINDEXED DRUG; VERAPAMIL; ZILEUTON; XENOBIOTIC AGENT;

AREA UNDER THE CURVE; COMPETITIVE INHIBITION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENTIATION; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME METABOLISM; HUMAN; IN VITRO STUDY; MATHEMATICAL ANALYSIS; MICROSOME; NONHUMAN; PREDICTION; PROTEIN METABOLISM; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; SENSITIVITY ANALYSIS; STEADY STATE; ARTICLE; BIOLOGICAL MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; ENZYME SPECIFICITY; ENZYMOLOGY; IC 50; LIVER MICROSOME; PREDICTION AND FORECASTING;

CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; HUMANS; INHIBITORY CONCENTRATION 50; MICROSOMES, LIVER; MODELS, BIOLOGICAL; PREDICTIVE VALUE OF TESTS; RISK ASSESSMENT; SUBSTRATE SPECIFICITY; XENOBIOTICS;

EID: 34548738229     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920007780866861     Document Type: Review

References (120)

1. FDA Draft Guidance (2006) Drug Interaction Studies - Study Design, Data Analysis, and Implications for Dosing and Labeling.
2. Huang, S.M. and Lesko, L.J. (2004) J. Clin. Pharmacol. 44(6), 559-569.
3. FDA Talk Paper (1998) Roche Laboratories announces withdrawal of Posicor from the market.
4. Granneman, G.R., Braeckman, R.A., Locke, C.S., Cavanaugh, J.H., Dube, L.M. and Awni, W.M. (1995) Clin. Pharmacokinet. 29(Suppl 2), 77-83.
5. Lu, P., Schrag, M.L., Slaughter, D.E., Raab, C.E., Shou, M. and Rodrigues, A.D. (2003) Drug Metab. Dispos. 31(11), 1352-60.
6. Richter, T., Murdter, T.E., Heinkele, G., Pleiss, J., Tatzel, S., Schwab, M., Eichelbaum, M. and Zanger, U.M. (2004) J. Pharmacol. Exp. Ther. 308(1), 189-197.
7. Turpeinen, M., Tolonen, A., Uusitalo, J., Jalonen, J., Pelkonen, O. and Laine, K. Clin. Pharmacol. Ther. 77(6), 553-539.
8. Ha-Duong, N.T., Dijols, S., Macherey, A.C., Goldstein, J.A., Dansette, P.M. and Mansuy, D. (2001) Biochemistry 40(40), 12112-12122.
9. Ieiri, I., Kimura, M., Irie, S., Urae, A., Otsubo, K. and Ishizaki, T. (2005) Pharmacogenet. Genom. 15(12), 851-859.
10. Granfors, M.T., Backman, J.T., Neuvonen, M., Ahonen, J. and Neuvonen, P.J. (2004) Clin. Pharmacol. Ther. 75(4), 331-341.
11. Granfors, M.T., Backman, J.T., Neuvonen, M. and Neuvonen, P.J. (2004) Clin. Pharmacol. Ther. 76(6), 598-606.
12. Granfors, M.T., Backman, J.T., Laitila, J. and Neuvonen, P.J. (2004) Br. J. Clin. Pharmacol. 57(3), 349-353.
13. Obach, R.S., Walsky, R.L., Venkatakrishnan, K., Houston, J.B. and Tremaine, L.M. (2005) Clin. Pharmacol. Ther. 78(6), 582-592.
14. Obach, R.S., Walsky, R.L., Venkatakrishnan, K., Gaman, E.A., Houston, J.B. and Tremaine, L.M. (2006) J. Pharmacol. Exp. Ther. 316(1), 336-348.
15. Bertelsen, K.M., Venkatakrishnan, K., Von Moltke, L.L., Obach, R.S. and Greenblatt, D.J. (2003) Drug Metab. Dispos. 31(3), 289-293.
16. von Moltke, L.L., Greenblatt, D.J., Duan, S.X., Schmider, J., Kudchadker, L., Fogelman, S.M., Harmatz, J.S. and Shader, R.I. (1996) Psychopharmacology 128(4), 398-407.
17. Silverman, R.B. (1995) Methods Enzymol. 249, 240-283.
18. Mayhew, B.S., Jones, D.R. and Hall, S.D. (2000) Drug Metab. Dispos. 28(9), 1031-1037.
19. Ghanbari, F., Rowland-Yeo, K., Bloomer, J.C., Clarke, S.E., Lennard, M.S., Tucker, G.T. and Rostami-Hodjegan, A. (2006) Curr. Drug Metab. 7(3), 315-334.
20. Ernest II, C.S., Hall, S.D. and Jones, D.R. (2005) J. Pharmacol. Exp. Ther. 312(2), 583-591.
21. Tucker, G.T., Houston, J.B. and Huang, S.M. (2001) Br. J. Clin. Pharmacol. 52(1), 107-117.
22. Bjornsson, T.D., Callaghan, J.T., Einolf, H.J., Fischer, V., Gan, L., Grimm, S., Kao, J., King, S.P., Miwa, G., Ni, L., Kumar, G., McLeod, J., Obach, R.S., Roberts, S., Roe, A., Shah, A., Snikeris, F., Sullivan, J.T., Tweedie, D., Vega, J.M., Walsh, J., Wrighton, S.A. (2003) Drug Metab. Dispos. 31(7), 815-832.
23. Sofowora, G.G., Choo, E.F., Mayo, G., Shyr, Y. and Wilkinson, G.A. (2001) Cancer Chemother. Pharmacol. 47(6), 505-510.
24. Venkatakrishnan, K. and Obach, R.S. (2005) Drug Metab. Dispos. 33(6), 845-852.
25. Belle, D.J., Callaghan, J.T., Gorski, J.C., Maya, J.F., Mousa, O., Wrighton, S.A. and Hall, S.D. (2002) Br. J. Clin. Pharmacol. 53(1), 67-74.
26. Damkier, P., Hansen, L.L. and Brosen, K. (1999) Br. J. Clin. Pharmacol. 48(6), 829-838.
27. Backman, J.T., Olkkola, K.T. and Neuvonen, P.J. (1995) Int. J. Clin. Pharmacol. Ther. 33(6), 356-359.
28. Lam, Y.W., Alfaro, C.L., Ereshefsky, L. and Miller, M. (2003). J. Clin. Pharmacol. 43(11), 1274-1282.
29. Greenblatt, D.J., Preskorn, S.H., Cotreau, M.M., Horst, W.D. and Harmatz, J.S. (1992) Clin. Pharmacol. Ther. 52(5), 479-486.
30. Hall, J., Naranjo, C.A., Sproule, B.A. and Herrmann, N. (2003) J. Clin. Psychopharmacol. 23(4), 349-357.
31. DeVane, C.L., Donovan, J.L., Liston, H.L., Markowitz, J.S., Cheng, K.T., Risch, S.C. and Willard, L. (2004) J. Clin. Psychopharmacol. 24(1), 4-10.
32. Olkkola, K.T., Aranko, K., Luurila, H., Hiller, A., Saarnivaara, L., Himberg, J.J. and Neuvonen, P.J. (1993) Clin. Pharmacol. Ther. 53(3), 298-305.
33. Zimmermann, T., Yeates, R.A., Laufen, H., Scharpf, F., Leitold, M. and Wildfeuer, A. (1996) Arzneimittelforschung 46(2), 213-217.
34. Phillips, J.P., Antal, E.J. and Smith, R.B. (1986) J. Clin. Psychopharmacol. 6(5), 297-299.
35. Greenblatt, D.J., von Moltke, L.L., Harmatz, J.S., Counihan, M., Graf, J.A., Durol, A.L., Mertzanis, P., Duan, S.X., Wright, C.E. and Shader, R.I. (1998) Clin. Pharmacol. Ther. 64(3), 278-285.
36. Kivisto, K.T., Lamberg, T.S., Kantola, T. and Neuvonen, P.J. (1997) Clin. Pharmacol. Ther. 62(3), 348-354.
37. Backman, J.T., Olkkola, K.T., Aranko, K., Himberg, J.J. and Neuvonen, P.J. (1994) Br. J. Clin. Pharmacol. 37(3), 221-225.
38. Varhe, A., Olkkola, K.T. and Neuvonen, P.J. (1996) Clin. Pharmacol. Ther. 59(4), 369-375.
39. Kosuge, K., Nishimoto, M., Kimura, M., Umemura, K., Nakashima, M. and Ohashi, K. (1997) Br. J. Clin. Pharmacol. 43(4), 367-372.
40. Lamberg, T.S., Kivisto, K.T. and Neuvonen, P.J. (1998) Clin. Pharmacol. Ther. 63(6), 640-645.
41. Gorski, J.C., Jones, D.R., Haehner-Daniels, B.D., Hamman, M.A., O'Mara, E.M., Jr. and Hall, S.D. (1998) Clin. Pharmacol. Ther. 64(2), 133-143.
42. Gurley, B., Hubbard, M.A., Williams, D.K., Thaden, J., Tong, Y., Gentry, W.B., Breen, P., Carrier, D.J. and Cheboyina, S. (2006) J. Clin. Pharmacol. 46(2), 201-213.
43. Greenblatt, D.J., von Moltke, L.L., Harmatz, J.S., Durol, A.L., Daily, J.P., Graf, J.A., Mertzanis, P., Hoffman, J.L. and Shader, R.I. (2000) J. Acquir. Immune. Defic. Syndr. 24(2), 129-136.
44. Culm-Merdek, K.E., von Moltke, L.L., Gan, L., Horan, K.A., Reynolds, R., Harmatz, J.S., Court, M.H. and Greenblatt, D.J. (2006) Clin. Pharmacol. Ther. 79(3), 243-254.
45. Langouet, S., Furge, L.L., Kerriguy, N., Nakamura, K., Guillouzo, A. and Guengerich, F.P. (2000) Chem. Res. Toxicol. 13(4), 245-252.
46. Lin, H.L., Kent, U.M. and Hollenberg, P.F. (2002) J. Pharmacol. Exp. Ther. 301(1), 160-167.
47. Masubuchi, Y., Ose, A. and Horie, T. (2002) Drug Metab. Dispos. 30(10), 1143-1148.
48. Ito, K., Ogihara, K., Kanamitsu, S. and Itoh, T. (2003) Drug Metab. Dispos. 31(7), 945-954.
49. Polasek, T.M. and Miners, J.O. (2006) Eur. J. Clin. Pharmacol. 62(3), 203-208.
50. Polasek, T.M., Elliot, D.J., Lewis, B.C. and Miners, J.O. (2004). J. Pharmacol. Exp. Ther. 311(3), 996-1007.
51. McGinnity, D.F., Berry, A.J., Kenny, J.R., Grime, K. and Riley, R.J. (2006) Drug Metab. Dispos. 34(8), 1291-1300.
52. Kanamitsu, S., Ito, K., Green, C.E., Tyson, C.A., Shimada, N. and Sugiyama, Y. (2000) Pharm. Res. 17(4), 419-426.
53. McConn, D.J., 2nd, Lin, Y.S., Allen, K., Kunze, K.L. and Thummel, K.E. (2004) Drug Metab. Dispos. 32(10), 1083-1091.
54. Zhao, P., Kunze, K.L. and Lee, C.A. (2005) Drug Metab. Dispos. 33(6), 853-861.
55. Ma, B., Prueksaritanont, T. and Lin, J.H. (2000) Drug Metab. Dispos. 28(2), 125-130.
56. Yeo, K.R. and Yeo, W.W. (2001) Br. J. Clin. Pharmacol. 51(5), 461-470.
57. Luo, G., Lin, J., Fiske, W.D., Dai, R., Yang, T.J., Kim, S., Sinz, M., LeCluyse, E., Solon, E., Brennan, J.M., Benedek, I.H., Jolley, S., Gilbert, D., Wang, L., Lee, F.W. and Gan, L.S. (2003) Drug Metab. Dispos. 31(9), 1170-1175.
58. Obach, R.S. (1999) Drug Metab. Dispos. 27(11), 1350-1359.
59. Hemeryck, A., De Vriendt, C.A. and Belpaire, F.M. (2001) Drug Metab. Dispos. 29(5), 656-663.
60. Tran, T.H., von Moltke, L.L., Venkatakrishnan, K., Granda, B.W., Gibbs, M.A., Obach, R.S., Harmatz, J.S. and Greenblatt, D.J. (2002) Drug Metab. Dispos. 30(12), 1441-1445.
61. Margolis, J.M. and Obach, R.S. (2003) Drug Metab. Dispos. 31(5), 606-611.
62. Hallifax, D. and Houston, J.B. (2006) Drug Metab. Dispos. 34(4), 724-726.
63. Faber, M.S. and Fuhr, U. (2004) Clin. Pharmacol. Ther. 76(2), 178-184.
64. Liston, H.L., DeVane, C.L., Boulton, D.W., Risch, S.C., Markowitz, J.S. and Goldman, J. (2002) J. Clin. Psychopharmacol. 22(2), 169-173.
65. Fromm, M.F., Busse, D., Kroemer, H.K. and Eichelbaum, M. (1996) Hepatology 24(4), 796-801.
66. Thummel, K.E., Kunze, K.L. and Shen, D.D. in Metabolic. Drug Interactions, (Levy, R.H., Thummel, K.E., Trager, W.F., Hansten, P.D. and Eichelbaum, M. Eds.) 2000, Lippincott Williams and Wilkins, Philadelphia, pp. 3-19.
67. Renwick, A.B., Watts, P.S., Edwards, R.J., Barton, P.T., Guyonnet, I., Price, R.J., Tredger, J.M., Pelkonen, O., Boobis, A.R. and Lake, B.G. (2000) Drug Metab. Dispos. 28(10), 1202-1209.
68. Galetin, A., Burt, H., Gibbons, L. and Houston, J.B. (2006) Drug Metab. Dispos. 34(1), 166-175.
69. Obach, R.S., Walsky, R.L. and Venkatakrishnan, K. (2007) Drug Metab. Dispos. 35(2), 246-255.
70. Colli, A., Buccino, G., Cocciolo, M., Parravicini, R., Elli, G.M. and Scaltrini, G. (1987) Clin. Pharmacol. Ther. 41(3), 358-362.
71. Tateishi, T., Kumai, T., Watanabe, M., Nakura, H., Tanaka, M. and Kobayashi, S. (1999) Br. J. Clin. Pharmacol. 47(4), 454-457.
72. Ito, K., Hallifax, D., Obach, R.S. and Houston, J.B. (2005) Drug Metab. Dispos. 33(6), 837-844.
73. Gibbs, J.P., Hyland, R. and Youdim, K. (2006) Drug Metab. Dispos. 34(9), 1516-1522.
74. Rodrigues, A.D. (1999) Biochem. Pharmacol. 57(5), 465-480.
75. Venkatakrishnan, K., von Mottke, L.L. and Greenblatt, D.J. (2001) J. Clin. Pharmacol. 41(11), 1149-1179.
76. Alderman, J., Preskorn, S.H., Greenblatt, D.J., Harrison, W., Penenberg, D., Allison, J. and Chung, M. (1997) J. Clin. Psychopharmacol. 17(4), 284-291.
77. Brøsen, K., Hansen, J.G., Nielsen, K.K., Sindrup, S.H. and Gram, L.F. (1993) Eur J. Clin. Pharmacol. 44(4), 349-355.
78. Albers, L.J., Reist, C., Helmeste, D., Vu, R. and Tang, S.W. (1996) Psychiatry Res. 59(3), 189-196.
79. Wang, Y.H., Jones, D.R. and Hall, S.D. (2004) Drug Metab. Dispos. 32(2), 259-266.
80. Yasui, N., Otani, K., Kaneko, S., Ohkubo, T., Osanai, T., Sugawara, K., Chiba, K. and Ishizaki, T. (1996) Clin. Pharmacol. Ther. 59(5), 514-519.
81. Yasui, N., Kondo, T., Furukori, H., Kaneko, S., Ohkubo, T., Uno, T., Osanai, T., Sugawara, K. and Otani, K. (2000) Psychopharmacology 150(2), 185-190.
82. Greenblatt, D.J., von Moltke, L.L., Harmatz, J.S., Durol, A.L., Daily, J.P., Graf, J.A., Mertzanis, P., Hoffman, J.L. and Shader, R.I. (2000) Clin. Pharmacol. Ther. 67(4), 335-341.
83. Greenblatt, D.J., von Moltke, L.L., Harmatz, J.S., Chen, G., Weemhoff, J.L., Jen, C., Kelley, C.J., LeDuc, B.W. and Zinny, M.A. (2003) Clin. Pharmacol. Ther. 74(2), 121-129. ,
84. Veronese, M.L., Gillen, L.P., Burke, J.P., Dorval, E.P., Hauck, W.W., Pequignot, E., Waldman, S.A. and Greenberg, H.E. (2003) J. Clin. Pharmacol. 43(8), 831-839.
85. Kharasch, E.D., Walker, A., Hoffer, C. and Sheffels, P. (2004) Clin. Pharmacol. Ther. 76(5), 452-466.
86. Kupferschmidt, H.H., Ha, H.R., Ziegler, W.H., Meier, P.J. and Krahenbuhl, S. (1995) Clin. Pharmacol. Ther. 58(1), 20-28.
87. Barbhaiya, R.H., Shukla, U.A., Kroboth, P.D. and Greene, D.S. (1995) J. Clin. Psychopharmacol. 15(5), 320-326.
88. Lilja, J.J., Kivisto, K.T., Backman, J.T. and Neuvonen, P.J. (2000) Eur. J. Clin. Pharmacol. 56(5), 411-415.
89. Hukkinen, S.K., Varhe, A. Olkkola, K.T. and Neuvonen, P.J. (1995) Clin. Pharmacol. Ther. 58(2), 127-131.
90. Sugimoto, K., Araki, N., Ohmori, M., Harada, K., Cui, Y., Tsuruoka, S., Kawaguchi, A. and Fujimura, A. (2006) Eur. J. Clin. Pharmacol. 62(3), 209-215.
91. Lilja, J.J., Kivisto, K.T., Backman, J.T., Lamberg, T.S. and Neuvonen, P.J. (1998) Clin. Pharmacol. Ther. 64(6), 655-660.
92. Rostami-Hodjegan, A. and Tucker, G. (2004) Drug, Discov. Today Technol. 1(4), 441-448.
93. Pinto, A.G., Wang, Y.H., Chalasani, N., Skaar, T., Kolwankar, D., Gorski, J.C.; Liangpunsakul, S., Hamman, M.A., Arefayene, M. and Hall, S.D. (2005) Clin. Pharmacol. Ther. 77(3), 178-188.
94. Yang, J., Jamei, M., Yeo, K.R., Tucker, T. and Rostami-Hodjegan, A. (2005) Eur. J. Pharm. Sci. 26(3-4), 334-340.
95. Walsky, R.L. and Obach, R.S. (2004) Drug Metab. Dispos. 32(6), 647-660.
96. Austin, R.P., Barton, P., Cockroft, S.L., Wenlock, M.C. and Riley, R.J. (2002) Drug Metab. Dispos. 30(12), 1497-1503.
97. Watkins, P.B., Wrighton, S.A., Schuetz, E.G., Maurel, P. and Guzelian, P. S. (1986) J. Biol. Chem. 261(14), 6264-6271.
98. Correia, M.A. (1991) Methods Enzymol. 206, 315-325.
99. Roberts, B.J., Song, B.J., Soh, Y., Park, S.S. and Shoaf, S.E. (1995) J. Biol. Chem. 270(50), 29632-29635.
100. Lucas, D., Menez, C. Girre, C., Bodenez, P., Hispard, E. and Menez, J.F. (1995) Alcohol Clin. Exp. Res. 19(2), 362-366.
101. Emery, M.G., Jubert, C., Thummel, K.E. and Kharasch, E.D. (1999) J. Pharmacol. Exp. Ther. 291(1), 213-219.
102. Hsu, A., Granneman, G.R., Witt, G., Locke, C., Denissen, J., Molla, A., Valdes, J., Smith, J., Erdman, K., Lyons, N., Niu, P., Decourt, J.P., Fourtillan, J.B., Girault, J. and Leonard, J.M. (1997) Antimicrob. Agents Chemother. 41(5), 898-905.
103. Rostami-Hodjegan, A., Wolff, K., Hay, A. W., Raistrick, D., Calvert, R. and Tucker, G.T. (1999) Br. J. Clin. Pharmacol. 48(1), 43-52.
104. Lin, J.H. (2006) Pharm. Res. 23(6), 1089-1116.
105. Pichard, L., Fabre, I., Daujat, M., Domergue, J., Joyeux, H. and Maurel, P. (1992) Mol. Pharmacol. 41(6), 1047-1055.
106. Yang, J., Jamei, M., Heydari, A., Yeo, K., De La Torre, R., Farre, M., Tucker, G.T. and Rostami-Hodjegan, A. (2006) J. Psychopharmacol. 20(6), 842-849.
107. Luo, G., Cunningham, M., Kim, S., Burn, T., Lin, J., Sinz, M., Hamilton, G., Rizzo, C., Jolley, S., Gilbert, D., Downey, A., Mudra, D., Graham, R., Carroll, K., Xie, J., Madan, A., Parkinson, A., Christ, D., Selling, B., LeCluyse, E. and Gan, L.S. (2002) Drug Metab. Dispos. 30(7), 795-804.
108. Wandel, C., Kim, R.B., Guengerich, F.P. and Wood, A.J. (2000) Drug Metab. Dispos. 28(8), 895-898.
109. Wang, Y.H., Jones, D.R. and Hall, S.D. (2005) Drug Metab. Dispos. 33(5), 664-671.
110. von Moltke, L.L., Greenblatt, D.J., Granda, B.W., Grassi, J.M., Schmider, J., Harmatz, J.S. and Shader, R.I. (1999) Psychopharmacology 145(1), 113-122.
111. Kalgutkar, A.S., Vaz, A.D., Lame. M.E., Henne, K.R., Soglia, J., Zhao, S.X., Abramov, Y.A., Lombardo, F., Collin, C., Hendsch, Z.S. and Hop, C.E. (2005) Drug Metab. Dispos. 33(2), 243-53.
112. Kaul, S., Shukla, U.A. and Barbhaiya, R.H. (1995) J. Clin. Pharmacol. 35(8), 830-839.
113. Sindrup, S.H., Brosen, K., Gram, L.F., Hallas, J., Skjelbo, E., Allen, A., Allen, G.D., Cooper, S.M., Mellows, G. and Tasker, T.C. (1992) Clin. Pharmacol. Ther. 51(3), 278-287.
114. Colburn, W.A., Di Santo, A.R. and Gibaldi, M. (1977) J. Clin. Pharmacol. 17(10 Pt 1), 592-600.
115. Chu, S., Wilson, D.S., Deaton, R.L., Mackenthun, A.V., Eason, C.N. and Cavanaugh, J.H. (1993) J. Clin. Pharmacol. 33(8), 719-726.
116. Montamat, S.C. and Abernethy, D.R. (1989) Clin. Pharmacol. Ther. 45(6), 682-691.
117. Anderson, P., Bondesson, U. and de Faire, U. (1986) Eur. J. Clin. Pharmacol. 31(2), 155-163.
118. Knudsen, J.B., Bastain, W., Sefton, C.M., Allen, J.G. and Dickinson, J.P. (1992) Xenobiotica 22(5), 579-589.
119. Awni, W.M., Braeckman, R.A., Granneman, G.R., Witt, G. and Dube, L.M. (1995) Clin. Pharmacokinet. 29(Suppl 2), 22-33.
120. Sweeny, D.J. and Nellans, H.N. (1995). Drug Metab. Dispos. 23(1), 149-153.