Regioselective metabolism of taxoids by human CYP3A4 and 2C8: Structure-activity relationship

Drug Metabolism and Disposition

Volumn 30, Issue 4, 2002, Pages 438-445

  Cresteil, Thierry ^a   Monsarrat, Bernard ^b   Dubois, Joelle ^a   Sonnier, Michelle ^a   Alvinerie, Paul ^b   Gueritte, Françoise ^a  

^a CNRS   (France)

^b INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

10 DEACETYLBACCATIN III; 10 DEACETYLPACLITAXEL; BACCATIN III; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DOCETAXEL; DRUG METABOLITE; PACLITAXEL; RECOMBINANT ENZYME; TAXANE DERIVATIVE; TAXOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; LIVER MICROSOME; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; COS CELLS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROXYLATION; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; PACLITAXEL; RECOMBINANT PROTEINS; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TAXOIDS; TRITERPENES;

ANIMALIA;

EID: 0036201599     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.4.438     Document Type: Article

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