The pregnane X receptor gene-humanized mouse: A model for investigating drug-drug interactions mediated by cytochromes P450 3A

Drug Metabolism and Disposition

Volumn 35, Issue 2, 2007, Pages 194-200

  Ma, Xiaochao ^a   Shah, Yatrik ^a   Cheung, Connie ^a   Guo, Grace L ^b   Feigenbaum, Lionel ^c   Krausz, Kristopher W ^a   Idle, Jeffrey R ^d   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c SAIC FREDERICK INC   (United States)

^d CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CYTOCHROME P450 1A1; CYTOCHROME P450 2C; CYTOCHROME P450 2D; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; MIDAZOLAM; PREGNANE X RECEPTOR; RIFAMPICIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; DNA FLANKING REGION; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INDUCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; TISSUE DISTRIBUTION; TRANSGENICS;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDAZOLAM; MODELS, ANIMAL; RECEPTORS, STEROID;

BACTERIA (MICROORGANISMS); MUS; RODENTIA;

EID: 33846461683     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.012831     Document Type: Article

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