Determining the best animal model for human cytochrome P450 activities: A comparison of mouse, rat, rabbit, dog, micropig, monkey and man

Xenobiotica

Volumn 30, Issue 12, 2000, Pages 1131-1152

  Bogaards, J J P ^a   Bertrand, M ^b   Jackson, P ^b   Oudshoorn, M J ^a   Weaver, R J ^c   Van Bladeren, P J ^a   Walther, B ^b  

^a TNO   (Netherlands)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c Servier Research and Development   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; FEMALE; HUMAN; LIVER MICROSOME; MALE; METABOLISM; MOUSE; NONHUMAN; RAT; SPECIES DIFFERENCE;

ALKANE 1-MONOOXYGENASE; ANIMALS; ANTIBODIES, MONOCLONAL; ARYL HYDROCARBON HYDROXYLASES; BENZOFLAVONES; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; ENZYME INHIBITORS; FEMALE; HUMANS; ISOENZYMES; MACACA FASCICULARIS; MALE; MICE; MICE, INBRED STRAINS; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES, N-DEMETHYLATING; RABBITS; RATS; RATS, WISTAR; SPECIES SPECIFICITY; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES;

ANIMALIA; CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS;

EID: 0034454016     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250010021684     Document Type: Article

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