Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver

Current Drug Metabolism

Volumn 8, Issue 1, 2007, Pages 33-45

  Barter, Zoe E ^a,b   Bayliss, Martin K ^c   Beaune, Philip H ^d   Boobis, Alan R ^e   Carlile, David J ^f   Edwards, Robert J ^e   Houston, J Brian ^g   Lake, Brian G ^h,i   Lipscomb, John C ^j   Pelkonen, Olavi R ^k   Tucker, Geoffrey T ^a,b   Rostami Hodjegan, Amin ^a,b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b CERTARA UK LIMITED   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

^d INSERM   (France)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

^f ROCHE PRODUCTS LTD   (United Kingdom)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

^h BIBRA INTERNATIONAL   (United Kingdom)

ⁱ UNIVERSITY OF SURREY   (United Kingdom)

^j U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^k UNIVERSITY OF OULU   (Finland)

more..

Author keywords

Alprazolam clearance; CYP isoforms; Homogenate protein per gram of liver (HomPGGL); Microsomal protein per gram of liver (MPPGL); NAPDH cytochrome P450 reductase (NCR)

Indexed keywords

ALPRAZOLAM; BUFURALOL; CAFFEINE; CHLORZOXAZONE; CLOZAPINE; CYCLOSPORIN; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DEXTROMETHORPHAN; DICLOFENAC; LIVER ENZYME; MEPHENYTOIN; METOPROLOL; MICROSOME ENZYME; MIDAZOLAM; OMEPRAZOLE; PHENACETIN; SILDENAFIL; SIMVASTATIN; THEOPHYLLINE; TOLBUTAMIDE; TOLTERODINE; TRIAZOLAM; WARFARIN; ZOLPIDEM;

ACCURACY; AGE; CONFIDENCE INTERVAL; CORRELATION COEFFICIENT; DRUG CLEARANCE; DRUG METABOLISM; ENZYME ACTIVITY; ETHNIC DIFFERENCE; GENETIC VARIABILITY; HUMAN; LIVER CELL; LIVER CLEARANCE; LIVER HISTOLOGY; LIVER SIZE; LIVER WEIGHT; METABOLIC CLEARANCE RATE; MULTIPLE LINEAR REGRESSION ANALYSIS; NONHUMAN; PREDICTION; REFERENCE VALUE; REVIEW;

ANIMALS; DRUG EVALUATION, PRECLINICAL; HEPATOCYTES; HUMANS; LIVER; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; PROTEINS;

EID: 33845996187     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920007779315053     Document Type: Review

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