-
1
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola I., and Landis J. Can the pharmaceutical industry reduce attrition rates?. Nat. Rev. Drug Discov. 3 (2004) 711-715
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
2
-
-
0037277751
-
Metabolite identification in drug discovery
-
Watt A.P., et al. Metabolite identification in drug discovery. Curr. Opin. Drug Discov. Dev. 6 (2003) 57-65
-
(2003)
Curr. Opin. Drug Discov. Dev.
, vol.6
, pp. 57-65
-
-
Watt, A.P.1
-
3
-
-
33745784133
-
Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560
-
Bateman K.P., et al. Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560. J. Mass Spectrom. 41 (2006) 771-780
-
(2006)
J. Mass Spectrom.
, vol.41
, pp. 771-780
-
-
Bateman, K.P.1
-
4
-
-
0035416421
-
Systematic LCMS metabolite identification in drug discovery
-
Clarke N.J., et al. Systematic LCMS metabolite identification in drug discovery. Anal. Chem. 73 (2001) 430A-439A
-
(2001)
Anal. Chem.
, vol.73
-
-
Clarke, N.J.1
-
5
-
-
0036100354
-
Advances in MS-based approaches for drug and metabolism studies
-
Castro-Perez J., et al. Advances in MS-based approaches for drug and metabolism studies. Chromatographia 55 (2002) S59-S63
-
(2002)
Chromatographia
, vol.55
-
-
Castro-Perez, J.1
-
6
-
-
0027205012
-
Mass spectrometry in the analysis of glutathione conjugates
-
Baillie T.A., and Davis M.R. Mass spectrometry in the analysis of glutathione conjugates. Biol. Mass Spectrom. 22 (1993) 319-325
-
(1993)
Biol. Mass Spectrom.
, vol.22
, pp. 319-325
-
-
Baillie, T.A.1
Davis, M.R.2
-
7
-
-
18644385994
-
Contemporary issues in toxicology: drug metabolites in safety testing
-
Baillie T.A., et al. Contemporary issues in toxicology: drug metabolites in safety testing. Toxicol. Appl. Pharmacol. 181 (2002) 188-196
-
(2002)
Toxicol. Appl. Pharmacol.
, vol.181
, pp. 188-196
-
-
Baillie, T.A.1
-
8
-
-
3042855893
-
Profiling of sulfoconjugates in urine using precursor ion and neutral loss scans in tandem mass spectrometry. Application to the investigation of heavy metal toxicity in rats
-
Lafaye A., et al. Profiling of sulfoconjugates in urine using precursor ion and neutral loss scans in tandem mass spectrometry. Application to the investigation of heavy metal toxicity in rats. J. Mass Spectrom. 39 (2004) 364-655
-
(2004)
J. Mass Spectrom.
, vol.39
, pp. 364-655
-
-
Lafaye, A.1
-
9
-
-
19444365324
-
Application of LCMS, LCMMR, NMR and stable isotopes in identifying and characterizing metabolites
-
Le J.S., Obatch R.S., and Fisher M.B. (Eds), FontisMedia S.A. and Marcel DeMcer
-
Mutlib A.E., and Shockcor J.P. Application of LCMS, LCMMR, NMR and stable isotopes in identifying and characterizing metabolites. In: Le J.S., Obatch R.S., and Fisher M.B. (Eds). Drug Metabolizing Enzymes Cytochrome P450 and Other Enzymes in Drug Discovery and Development (2003), FontisMedia S.A. and Marcel DeMcer 33-83
-
(2003)
Drug Metabolizing Enzymes Cytochrome P450 and Other Enzymes in Drug Discovery and Development
, pp. 33-83
-
-
Mutlib, A.E.1
Shockcor, J.P.2
-
10
-
-
0026823365
-
Studies on the metabolism of omeprazole in rat using liquid chromatography/ionspray mass spectrometry and isotope cluster technique with omeprazole
-
WeidoIf L., and Covey T.R. Studies on the metabolism of omeprazole in rat using liquid chromatography/ionspray mass spectrometry and isotope cluster technique with omeprazole. Rapid Commun. Mass Spectrom. 6 (1992) 192-196
-
(1992)
Rapid Commun. Mass Spectrom.
, vol.6
, pp. 192-196
-
-
WeidoIf, L.1
Covey, T.R.2
-
11
-
-
0034532968
-
Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: application to diclofenac using chlorine and sulfur detection
-
Corcoran O., et al. Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: application to diclofenac using chlorine and sulfur detection. Rapid Commun. Mass Spectrom. 14 (2000) 2377-2384
-
(2000)
Rapid Commun. Mass Spectrom.
, vol.14
, pp. 2377-2384
-
-
Corcoran, O.1
-
12
-
-
0028944553
-
Use of electrospray ionization and neutral loss liquid chromatography/tandem mass spectrometry in drug metabolism studies
-
Jackson P.J., et al. Use of electrospray ionization and neutral loss liquid chromatography/tandem mass spectrometry in drug metabolism studies. J. Mass Spectrom. 30 (1995) 446-451
-
(1995)
J. Mass Spectrom.
, vol.30
, pp. 446-451
-
-
Jackson, P.J.1
-
13
-
-
0348050555
-
A strategy for metabolite identification using triple quadrupole mass spectrometry with enhanced resolution and accurate mass capability
-
Jemal M., et al. A strategy for metabolite identification using triple quadrupole mass spectrometry with enhanced resolution and accurate mass capability. Rapid Commun. Mass Spectrom. 17 (2003) 2732-2740
-
(2003)
Rapid Commun. Mass Spectrom.
, vol.17
, pp. 2732-2740
-
-
Jemal, M.1
-
14
-
-
0037649064
-
Liquid chromatogtaphy/atmosphetic pressure ionization-mass spectrometry in drug metabolism studies
-
Kostiainen R., et al. Liquid chromatogtaphy/atmosphetic pressure ionization-mass spectrometry in drug metabolism studies. J. Mass Spectrom. 38 (2003) 357-372
-
(2003)
J. Mass Spectrom.
, vol.38
, pp. 357-372
-
-
Kostiainen, R.1
-
15
-
-
26444533998
-
Narrow-bore sample trapping and chromatography combined with quadrupole/time-of-flight mass spectrometry for ultra-sensitive identification of in vivo and in vitro metabolites
-
Foltz D.J., et al. Narrow-bore sample trapping and chromatography combined with quadrupole/time-of-flight mass spectrometry for ultra-sensitive identification of in vivo and in vitro metabolites. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 825 (2005) 144-151
-
(2005)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
, vol.825
, pp. 144-151
-
-
Foltz, D.J.1
-
16
-
-
14844316005
-
A high-throughput liquid chromatography/tandem mass spectrometry method for screening glutathione conjugates using exact mass neutral loss acquisition
-
Castro-Perez J., et al. A high-throughput liquid chromatography/tandem mass spectrometry method for screening glutathione conjugates using exact mass neutral loss acquisition. Rapid Commun. Mass Spectrom. 19 (2005) 798-804
-
(2005)
Rapid Commun. Mass Spectrom.
, vol.19
, pp. 798-804
-
-
Castro-Perez, J.1
-
17
-
-
0036232049
-
Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry
-
Sundstrom I., et al. Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry. J. Mass Spectrom. 37 (2002) 414-420
-
(2002)
J. Mass Spectrom.
, vol.37
, pp. 414-420
-
-
Sundstrom, I.1
-
18
-
-
13444311842
-
Assigning product ions from complex MSMS spectra: The importance of mass uncertainty and resolving power
-
Sleno L., et al. Assigning product ions from complex MSMS spectra: The importance of mass uncertainty and resolving power. J. Am. Soc. Mass Spectrom. 16 (2005) 183-198
-
(2005)
J. Am. Soc. Mass Spectrom.
, vol.16
, pp. 183-198
-
-
Sleno, L.1
-
19
-
-
0345095459
-
Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids
-
Plumb R.S., et al. Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids. Rapid Commun. Mass Spectrom. 17 (2003) 2632-2638
-
(2003)
Rapid Commun. Mass Spectrom.
, vol.17
, pp. 2632-2638
-
-
Plumb, R.S.1
-
20
-
-
0038361179
-
Use of a quadrupole linear ion trap mass spectrometer in metabolite identification and bioanalysis
-
Xia Y.-Q., et al. Use of a quadrupole linear ion trap mass spectrometer in metabolite identification and bioanalysis. Rapid Commun. Mass Spectrom. 17 (2003) 1137-1145
-
(2003)
Rapid Commun. Mass Spectrom.
, vol.17
, pp. 1137-1145
-
-
Xia, Y.-Q.1
-
21
-
-
33750259677
-
Generation of ultrahigh peak capacity LC separations via elevated temperatures and high linear mobile-phase velocities
-
Plumb R.S., et al. Generation of ultrahigh peak capacity LC separations via elevated temperatures and high linear mobile-phase velocities. Anal. Chem. 78 (2006) 7278-7283
-
(2006)
Anal. Chem.
, vol.78
, pp. 7278-7283
-
-
Plumb, R.S.1
-
22
-
-
21144435518
-
A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice
-
Plumb R.S., et al. A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice. Analyst 30 (2005) 844-849
-
(2005)
Analyst
, vol.30
, pp. 844-849
-
-
Plumb, R.S.1
-
23
-
-
17444404226
-
High resolution 'ultra performance' liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies
-
Wilson I.D., et al. High resolution 'ultra performance' liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J. Proteome Res. 4 (2005) 591-598
-
(2005)
J. Proteome Res.
, vol.4
, pp. 591-598
-
-
Wilson, I.D.1
-
24
-
-
14844293921
-
Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer
-
Castro-Perez J., et al. Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 19 (2005) 843-848
-
(2005)
Rapid Commun. Mass Spectrom.
, vol.19
, pp. 843-848
-
-
Castro-Perez, J.1
-
25
-
-
4644265806
-
Ultra-performance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry
-
Plumb R., et al. Ultra-performance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 18 (2004) 2331-2337
-
(2004)
Rapid Commun. Mass Spectrom.
, vol.18
, pp. 2331-2337
-
-
Plumb, R.1
-
26
-
-
26444507780
-
Improving LC-MS sensitivity through increases in chromatographic performance: comparisons of UPLC-ES/MS/MS to HPLC-ES/MS/MS
-
Churchwell M.I., et al. Improving LC-MS sensitivity through increases in chromatographic performance: comparisons of UPLC-ES/MS/MS to HPLC-ES/MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 825 (2005) 134-143
-
(2005)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
, vol.825
, pp. 134-143
-
-
Churchwell, M.I.1
-
27
-
-
15344344076
-
Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes
-
Zhu M., et al. Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab. Dispos. 33 (2005) 500-507
-
(2005)
Drug Metab. Dispos.
, vol.33
, pp. 500-507
-
-
Zhu, M.1
-
28
-
-
12344263826
-
Strategies for characterization of drug metabolites using liquid chromatography-tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches
-
Liu D.Q., and Hop C.E. Strategies for characterization of drug metabolites using liquid chromatography-tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches. J. Pharm. Biomed. Anal. 37 (2005) 1-18
-
(2005)
J. Pharm. Biomed. Anal.
, vol.37
, pp. 1-18
-
-
Liu, D.Q.1
Hop, C.E.2
-
29
-
-
0033374014
-
Identification of in vitro metabolites of indinavir by 'intelligent automated LC-MS/MS' (INTAMS) utilizing triple quadrupole tandem mass spectrometry
-
Yu X., et al. Identification of in vitro metabolites of indinavir by 'intelligent automated LC-MS/MS' (INTAMS) utilizing triple quadrupole tandem mass spectrometry. J. Am. Soc. Mass Spectrom. 10 (1999) 175-183
-
(1999)
J. Am. Soc. Mass Spectrom.
, vol.10
, pp. 175-183
-
-
Yu, X.1
-
30
-
-
25144438177
-
Kirby Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis
-
Mortishire-Smith R.J., et al. Kirby Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis. Rapid Commun. Mass Spectrom. 19 (2005) 2659-2670
-
(2005)
Rapid Commun. Mass Spectrom.
, vol.19
, pp. 2659-2670
-
-
Mortishire-Smith, R.J.1
-
31
-
-
0242521617
-
A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses
-
Zhang H., et al. A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses. J. Mass Spectrom. 38 (2003) 1110-1112
-
(2003)
J. Mass Spectrom.
, vol.38
, pp. 1110-1112
-
-
Zhang, H.1
-
32
-
-
33748902567
-
Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data
-
Zhu M., et al. Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data. Drug Metab. Dispos. 34 (2006) 1722-1733
-
(2006)
Drug Metab. Dispos.
, vol.34
, pp. 1722-1733
-
-
Zhu, M.1
-
33
-
-
33751208003
-
Spectral interpretation, part ii: tools of the trade, MS- the practical art
-
Balogh M.P. Spectral interpretation, part ii: tools of the trade, MS- the practical art. LC GC 24 (2006) 762-769
-
(2006)
LC GC
, vol.24
, pp. 762-769
-
-
Balogh, M.P.1
-
34
-
-
0842327199
-
Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir
-
Anari M.R., et al. Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir. Anal. Chem. 76 (2004) 823-832
-
(2004)
Anal. Chem.
, vol.76
, pp. 823-832
-
-
Anari, M.R.1
-
35
-
-
25144468977
-
'All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching
-
Wrona M., et al. 'All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching. Rapid Commun. Mass Spectrom. 19 (2005) 2597-2602
-
(2005)
Rapid Commun. Mass Spectrom.
, vol.19
, pp. 2597-2602
-
-
Wrona, M.1
-
36
-
-
33846811132
-
An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/traveling wave IMS/oa-ToF instrument
-
10.1016/ijms.2006.07.021
-
Giles K., et al. An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/traveling wave IMS/oa-ToF instrument. Int. J. Mass Spectrom. (2006) 10.1016/ijms.2006.07.021
-
(2006)
Int. J. Mass Spectrom.
-
-
Giles, K.1
-
37
-
-
28844474910
-
Evidence for macromolecular protein rings in the absence of bulk water
-
Ruotolo B.T., et al. Evidence for macromolecular protein rings in the absence of bulk water. Science 310 (2005) 1658-1661
-
(2005)
Science
, vol.310
, pp. 1658-1661
-
-
Ruotolo, B.T.1
-
38
-
-
33750604754
-
A novel histology-directed strategy for MALDI-MS tissue profiling that improves throughput and cellular specificity in human breast cancer
-
Cornett D.S., et al. A novel histology-directed strategy for MALDI-MS tissue profiling that improves throughput and cellular specificity in human breast cancer. Mol. Cell. Proteomics 5 (2006) 1975-1983
-
(2006)
Mol. Cell. Proteomics
, vol.5
, pp. 1975-1983
-
-
Cornett, D.S.1
-
39
-
-
33748865022
-
Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry
-
Khatib-Shahidi S., et al. Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry. Anal. Chem. 78 (2006) 6448-6456
-
(2006)
Anal. Chem.
, vol.78
, pp. 6448-6456
-
-
Khatib-Shahidi, S.1
-
40
-
-
33746672483
-
Molecular imaging of thin mammalian tissue sections by mass spectrometry
-
Chaurand P., et al. Molecular imaging of thin mammalian tissue sections by mass spectrometry. Curr Opin Biotechnol. 4 (2006) 431-436
-
(2006)
Curr Opin Biotechnol.
, vol.4
, pp. 431-436
-
-
Chaurand, P.1
|