-
1
-
-
0037377144
-
Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2
-
Alam, J., Killeen, E., Gong, P., Naquin, R., Hu, B., Stewart, D., Ingelfinger, J. R., and Nath, K. A., Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2. Am. J. Physiol. Renal. Physiol., 284, F743-752 (2003).
-
(2003)
Am. J. Physiol. Renal. Physiol.
, vol.284
-
-
Alam, J.1
Killeen, E.2
Gong, P.3
Naquin, R.4
Hu, B.5
Stewart, D.6
Ingelfinger, J.R.7
Nath, K.A.8
-
2
-
-
7044237266
-
CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11
-
Anakk, S., Kalsotra, A., Kikuta, Y., Huang, W., Zhang, J., Staudinger, J. L., Moore, D. D., and Strobel, H. W., CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11. Pharmacogenomics J., 4, 91-101 (2004).
-
(2004)
Pharmacogenomics J.
, vol.4
, pp. 91-101
-
-
Anakk, S.1
Kalsotra, A.2
Kikuta, Y.3
Huang, W.4
Zhang, J.5
Staudinger, J.L.6
Moore, D.D.7
Strobel, H.W.8
-
3
-
-
1242337303
-
Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP)
-
Bae, Y., Kemper, J. K., and Kemper, B., Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP). DNA Cell Biol., 23, 81-91 (2004).
-
(2004)
DNA Cell Biol.
, vol.23
, pp. 81-91
-
-
Bae, Y.1
Kemper, J.K.2
Kemper, B.3
-
4
-
-
0028210426
-
A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements
-
Baes, M., Gulick, T., Choi, H. S., Martinoli, M. G., Simha, D., and Moore, D. D., A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol. Cell Biol., 14, 1544-1552 (1994).
-
(1994)
Mol. Cell Biol.
, vol.14
, pp. 1544-1552
-
-
Baes, M.1
Gulick, T.2
Choi, H.S.3
Martinoli, M.G.4
Simha, D.5
Moore, D.D.6
-
5
-
-
0034232475
-
Current status of the cytosolic sulfotransferases in the metabolic activation of promutagens and procarcinogens
-
Banoglu, E., Current status of the cytosolic sulfotransferases in the metabolic activation of promutagens and procarcinogens. Curr. Drug Metab., 1, 1-30 (2000).
-
(2000)
Curr. Drug Metab.
, vol.1
, pp. 1-30
-
-
Banoglu, E.1
-
6
-
-
0036296149
-
Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response
-
Beigneux, A. P., Moser, A. H., Shigenaga, J. K., Grunfeld, C., and Feingold, K. R., Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochem. Biophys. Res. Commun., 293, 145-149 (2002).
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.293
, pp. 145-149
-
-
Beigneux, A.P.1
Moser, A.H.2
Shigenaga, J.K.3
Grunfeld, C.4
Feingold, K.R.5
-
7
-
-
0031873379
-
AH receptor-controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms
-
Bock, K. W., Gschaidmeier, H., Heel, H., Lehmkoster, T., Munzel, P. A., Raschko, F., and Bock-Hennig, B., AH receptor-controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms. Adv. Enzyme Regul., 38, 207-222 (1998).
-
(1998)
Adv. Enzyme Regul.
, vol.38
, pp. 207-222
-
-
Bock, K.W.1
Gschaidmeier, H.2
Heel, H.3
Lehmkoster, T.4
Munzel, P.A.5
Raschko, F.6
Bock-Hennig, B.7
-
8
-
-
0035703537
-
Quinoids as reactive intermediates in estrogen carcinogenesis
-
Bolton, J. L. and Chang, M., Quinoids as reactive intermediates in estrogen carcinogenesis. Adv. Exp. Med. Biol., 500, 497-507 (2001).
-
(2001)
Adv. Exp. Med. Biol.
, vol.500
, pp. 497-507
-
-
Bolton, J.L.1
Chang, M.2
-
9
-
-
0034068228
-
Role of quinones in toxicology
-
Bolton, J. L., Trush, M. A., Penning, T. M., Dryhurst, G., and Monks, T. J., Role of quinones in toxicology. Chem. Res. Toxicol., 13, 135-160 (2000).
-
(2000)
Chem. Res. Toxicol.
, vol.13
, pp. 135-160
-
-
Bolton, J.L.1
Trush, M.A.2
Penning, T.M.3
Dryhurst, G.4
Monks, T.J.5
-
10
-
-
0035749772
-
Polymorphisms in the ABC drug transporter gene MDR1
-
Brinkmann, U. and Eichelbaum, M., Polymorphisms in the ABC drug transporter gene MDR1. Pharmacogenomics J., 1, 59-64 (2001).
-
(2001)
Pharmacogenomics J.
, vol.1
, pp. 59-64
-
-
Brinkmann, U.1
Eichelbaum, M.2
-
11
-
-
13044304201
-
Nrf2 is essential for protection against acute pulmonary injury in mice
-
Chan, K. and Kan, Y. W., Nrf2 is essential for protection against acute pulmonary injury in mice. Proc. Natl. Acad. Sci. U.S.A., 96, 12731-12736 (1999).
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 12731-12736
-
-
Chan, K.1
Kan, Y.W.2
-
12
-
-
0346728729
-
The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability
-
Chan, L. M., Lowes, S., and Hirst, B. H., The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. Eur. J. Pharm. Sci., 21, 25-51 (2004).
-
(2004)
Eur. J. Pharm. Sci.
, vol.21
, pp. 25-51
-
-
Chan, L.M.1
Lowes, S.2
Hirst, B.H.3
-
13
-
-
3542995726
-
The complexities of hepatic drug transport: Current knowledge and emerging concepts
-
Chandra, P. and Brouwer, K. L., The complexities of hepatic drug transport: current knowledge and emerging concepts. Pharm. Res., 21, 719-735 (2004).
-
(2004)
Pharm. Res.
, vol.21
, pp. 719-735
-
-
Chandra, P.1
Brouwer, K.L.2
-
14
-
-
0034573074
-
Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death
-
Chen, C., Yu, R., Owuor, E. D., and Kong, A. N., Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. Arch. Pharm. Res., 23, 605-612 (2000).
-
(2000)
Arch. Pharm. Res.
, vol.23
, pp. 605-612
-
-
Chen, C.1
Yu, R.2
Owuor, E.D.3
Kong, A.N.4
-
15
-
-
0036137072
-
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats
-
Cherrington, N. J., Hartley, D. P., Li, N., Johnson, D. R., and Klaassen, C. D., Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J. Pharmacol. Exp. Ther., 300, 97-104 (2002).
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.300
, pp. 97-104
-
-
Cherrington, N.J.1
Hartley, D.P.2
Li, N.3
Johnson, D.R.4
Klaassen, C.D.5
-
16
-
-
0037099541
-
Interindividual variation and organ-specific patterns of glutathione S-transferase alpha, mu, and pi expression in gastrointestinal tract mucosa of normal individuals
-
Coles, B. F., Chen, G., Kadlubar, F. F., and Radominska-Pandya, A., Interindividual variation and organ-specific patterns of glutathione S-transferase alpha, mu, and pi expression in gastrointestinal tract mucosa of normal individuals. Arch. Biochem. Biophys., 403, 270-276 (2002).
-
(2002)
Arch. Biochem. Biophys.
, vol.403
, pp. 270-276
-
-
Coles, B.F.1
Chen, G.2
Kadlubar, F.F.3
Radominska-Pandya, A.4
-
17
-
-
0037112315
-
PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides
-
Coumoul, X., Diry, M., and Barouki, R., PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. Biochem. Pharmacol., 64, 1513-1519 (2002).
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 1513-1519
-
-
Coumoul, X.1
Diry, M.2
Barouki, R.3
-
18
-
-
2442542312
-
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress
-
Cullinan, S. B. and Diehl, J. A., PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J. Biol. Chem., 279, 20108-20117 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 20108-20117
-
-
Cullinan, S.B.1
Diehl, J.A.2
-
19
-
-
0141752795
-
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
-
Cullinan, S. B., Zhang, D., Hannink, M., Arvisais, E., Kaufman, R. J., and Diehl, J. A., Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell Biol., 23, 7198-7209 (2003).
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 7198-7209
-
-
Cullinan, S.B.1
Zhang, D.2
Hannink, M.3
Arvisais, E.4
Kaufman, R.J.5
Diehl, J.A.6
-
20
-
-
0034953105
-
The human ATP-binding cassette (ABC) transporter superfamily
-
Dean, M., Hamon, Y., and Chimini, G., The human ATP-binding cassette (ABC) transporter superfamily. J. Lipid Res., 42, 1007-1017 (2001).
-
(2001)
J. Lipid Res.
, vol.42
, pp. 1007-1017
-
-
Dean, M.1
Hamon, Y.2
Chimini, G.3
-
21
-
-
0034666027
-
Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase transcription
-
del Castillo-Olivares, A. and Gil, G., Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase transcription. Nucleic Acids Res., 28, 3587-3593 (2000).
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 3587-3593
-
-
Del Castillo-Olivares, A.1
Gil, G.2
-
22
-
-
0034950514
-
The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp
-
Denson, L. A., Sturm, E., Echevarria, W., Zimmerman, T. L., Makishima, M., Mangelsdorf, D. J., and Karpen, S. J., The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology., 121, 140-147 (2001).
-
(2001)
Gastroenterology
, vol.121
, pp. 140-147
-
-
Denson, L.A.1
Sturm, E.2
Echevarria, W.3
Zimmerman, T.L.4
Makishima, M.5
Mangelsdorf, D.J.6
Karpen, S.J.7
-
23
-
-
0011985195
-
Protection against cancer by plant phenylpropenoids: Induction of mammalian anticarcinogenic enzymes
-
Dinkova-Kostova, A. T., Protection against cancer by plant phenylpropenoids: induction of mammalian anticarcinogenic enzymes. Mini Rev. Med. Chem., 2, 595-610 (2002a).
-
(2002)
Mini Rev. Med. Chem.
, vol.2
, pp. 595-610
-
-
Dinkova-Kostova, A.T.1
-
24
-
-
0037015035
-
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., and Talalay, P., Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl. Acad. Sci. U.S.A., 99, 11908-11913 (2002b).
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
Holtzclaw, W.D.2
Cole, R.N.3
Itoh, K.4
Wakabayashi, N.5
Katoh, Y.6
Yamamoto, M.7
Talalay, P.8
-
25
-
-
0035853101
-
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
-
Dinkova-Kostova, A. T., Massiah, M. A., Bozak, R. E., Hicks, R. J., and Talalay, P., Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc. Natl. Acad. Sci. U.S.A., 98, 3404-3409 (2001).
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 3404-3409
-
-
Dinkova-Kostova, A.T.1
Massiah, M.A.2
Bozak, R.E.3
Hicks, R.J.4
Talalay, P.5
-
26
-
-
0036592202
-
The nuclear receptor PXR: A master regulator of "homeland" defense
-
Dussault, I. and Forman, B. M., The nuclear receptor PXR: a master regulator of "homeland" defense. Crit. Rev. Eukaryot. Gene Expr., 12, 53-64 (2002).
-
(2002)
Crit. Rev. Eukaryot. Gene Expr.
, vol.12
, pp. 53-64
-
-
Dussault, I.1
Forman, B.M.2
-
27
-
-
0642286536
-
Aryl hydrocarbon receptor-mediated cell cycle control
-
Elferink, C. J., Aryl hydrocarbon receptor-mediated cell cycle control. Prog. Cell Cycle Res., 5, 261-267 (2003).
-
(2003)
Prog. Cell Cycle Res.
, vol.5
, pp. 261-267
-
-
Elferink, C.J.1
-
28
-
-
0030051562
-
P-glycoprotein induction in rat liver epithelial cells in response to acute 3-methylcholanthrene treatment
-
Fardel, O., Lecureur, V., Corlu, A., and Guillouzo, A., P-glycoprotein induction in rat liver epithelial cells in response to acute 3-methylcholanthrene treatment. Biochem. Pharmacol., 51, 1427-1436 (1996).
-
(1996)
Biochem. Pharmacol.
, vol.51
, pp. 1427-1436
-
-
Fardel, O.1
Lecureur, V.2
Corlu, A.3
Guillouzo, A.4
-
29
-
-
0036765751
-
Regulation of human CYP2C9 by the constitutive androstane receptor: Discovery of a new distal binding site
-
Ferguson, S. S., LeCluyse, E. L., Negishi, M., and Goldstein, J. A., Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Mol. Pharmacol., 62, 737-746 (2002).
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 737-746
-
-
Ferguson, S.S.1
LeCluyse, E.L.2
Negishi, M.3
Goldstein, J.A.4
-
30
-
-
0141925798
-
Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene
-
Fraser, D. J., Zumsteg, A., and Meyer, U. A., Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. J. Biol. Chem., 278, 39392-39401 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 39392-39401
-
-
Fraser, D.J.1
Zumsteg, A.2
Meyer, U.A.3
-
31
-
-
0036154356
-
Localization of organic anion transport protein 2 in the apical region of rat retinal pigment epithelium
-
Gao, B., Wenzel, A., Grimm, C., Vavricka, S. R., Benke, D., Meier, P. J., and Reme, C. E., Localization of organic anion transport protein 2 in the apical region of rat retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci., 43, 510-514 (2002).
-
(2002)
Invest. Ophthalmol. Vis. Sci.
, vol.43
, pp. 510-514
-
-
Gao, B.1
Wenzel, A.2
Grimm, C.3
Vavricka, S.R.4
Benke, D.5
Meier, P.J.6
Reme, C.E.7
-
32
-
-
0035805536
-
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
-
Geick, A., Eichelbaum, M., and Burk, O., Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem., 276, 14581-14587 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 14581-14587
-
-
Geick, A.1
Eichelbaum, M.2
Burk, O.3
-
33
-
-
0034106942
-
Regulation of lipid and lipoprotein metabolism by PPAR activators
-
Gervois, P., Torra, I. P., Fruchart, J. C., and Staels, B., Regulation of lipid and lipoprotein metabolism by PPAR activators. Clin. Chem. Lab. Med., 38, 3-11 (2000).
-
(2000)
Clin. Chem. Lab. Med.
, vol.38
, pp. 3-11
-
-
Gervois, P.1
Torra, I.P.2
Fruchart, J.C.3
Staels, B.4
-
34
-
-
0037459358
-
Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism
-
Gilde, A. J., van der Lee, K. A., Willemsen, P. H., Chinetti, G., van der Leij, F. R., van der Vusse, G. J., Staels, B., and van Bilsen, M., Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism. Circ. Res., 92, 518-524 (2003).
-
(2003)
Circ. Res.
, vol.92
, pp. 518-524
-
-
Gilde, A.J.1
Van Der Lee, K.A.2
Willemsen, P.H.3
Chinetti, G.4
Van Der Leij, F.R.5
Van Der Vusse, G.J.6
Staels, B.7
Van Bilsen, M.8
-
35
-
-
0032447116
-
The aryl hydrocarbon receptor: Studies using the AHR-null mice
-
Gonzalez, F. J. and Fernandez-Salguero, P., The aryl hydrocarbon receptor: studies using the AHR-null mice. Drug Metab. Dispos., 26, 1194-1198 (1998).
-
(1998)
Drug Metab. Dispos.
, vol.26
, pp. 1194-1198
-
-
Gonzalez, F.J.1
Fernandez-Salguero, P.2
-
36
-
-
0025333289
-
Evolution of the P450 gene superfamily: Animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation
-
Gonzalez, F. J. and Nebert, D. W., Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. Trends Genet., 6, 182-186 (1990).
-
(1990)
Trends Genet.
, vol.6
, pp. 182-186
-
-
Gonzalez, F.J.1
Nebert, D.W.2
-
37
-
-
0036070955
-
Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor
-
Goodwin, B., Hodgson, E., D'Costa, D. J., Robertson, G. R., and Liddle, C., Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol. Pharmacol., 62, 359-365 (2002).
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 359-365
-
-
Goodwin, B.1
Hodgson, E.2
D'Costa, D.J.3
Robertson, G.R.4
Liddle, C.5
-
38
-
-
1942497956
-
Cytochromes p450, drugs, and diseases
-
Guengerich, F. P., Cytochromes p450, drugs, and diseases. Mol. Intervent., 3, 194-204 (2003).
-
(2003)
Mol. Intervent.
, vol.3
, pp. 194-204
-
-
Guengerich, F.P.1
-
39
-
-
0024459069
-
Similarities between catalase and cytosolic epoxide hydrolase
-
Guenthner, T. M., Qato, M., Whalen, R., and Glomb, S., Similarities between catalase and cytosolic epoxide hydrolase. Drug Metab. Rev., 20, 733-748 (1989).
-
(1989)
Drug Metab. Rev.
, vol.20
, pp. 733-748
-
-
Guenthner, T.M.1
Qato, M.2
Whalen, R.3
Glomb, S.4
-
40
-
-
0036138199
-
Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways
-
Guo, G. L., Choudhuri, S., and Klaassen, C. D., Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. J. Pharmacol. Exp. Ther., 300, 206-212 (2002a).
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.300
, pp. 206-212
-
-
Guo, G.L.1
Choudhuri, S.2
Klaassen, C.D.3
-
41
-
-
0036205380
-
Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor
-
Guo, G. L., Staudinger, J., Ogura, K., and Klaassen, C. D., Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha- carbonitrile is via interaction with pregnane X receptor. Mol. Pharmacol., 61, 832-839 (2002b).
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 832-839
-
-
Guo, G.L.1
Staudinger, J.2
Ogura, K.3
Klaassen, C.D.4
-
42
-
-
0037145023
-
Aryl hydrocarbon receptors: Diversity and evolution
-
Hahn, M. E., Aryl hydrocarbon receptors: diversity and evolution. Chem. Biol. Interact., 141, 131-160 (2002).
-
(2002)
Chem. Biol. Interact.
, vol.141
, pp. 131-160
-
-
Hahn, M.E.1
-
43
-
-
0033970688
-
Role of heat shock protein 90 dissociation in mediating agonist-induced activation of the aryl hydrocarbon receptor
-
Heid, S. E., Pollenz, R. S., and Swanson, H. I., Role of heat shock protein 90 dissociation in mediating agonist-induced activation of the aryl hydrocarbon receptor. Mol. Pharmacol., 57, 82-92 (2000).
-
(2000)
Mol. Pharmacol.
, vol.57
, pp. 82-92
-
-
Heid, S.E.1
Pollenz, R.S.2
Swanson, H.I.3
-
45
-
-
0031866357
-
Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats
-
Hirohashi, T., Suzuki, H., Ito, K., Ogawa, K., Kume, K., Shimizu, T., and Sugiyama, Y., Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. Mol. Pharmacol., 53, 1068-1075 (1998).
-
(1998)
Mol. Pharmacol.
, vol.53
, pp. 1068-1075
-
-
Hirohashi, T.1
Suzuki, H.2
Ito, K.3
Ogawa, K.4
Kume, K.5
Shimizu, T.6
Sugiyama, Y.7
-
46
-
-
0031968936
-
Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene
-
Honkakoski, P., Moore, R., Washburn, K. A., and Negishi, M., Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene. Mol. Pharmacol., 53, 597-601 (1998a).
-
(1998)
Mol. Pharmacol.
, vol.53
, pp. 597-601
-
-
Honkakoski, P.1
Moore, R.2
Washburn, K.A.3
Negishi, M.4
-
47
-
-
0030908295
-
Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene
-
Honkakoski, P. and Negishi, M., Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene. J. Biol. Chem., 272, 14943-14949 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14943-14949
-
-
Honkakoski, P.1
Negishi, M.2
-
48
-
-
0038798874
-
Drug-activated nuclear receptors CAR and PXR
-
Honkakoski, P., Sueyoshi, T., and Negishi, M., Drug-activated nuclear receptors CAR and PXR. Ann. Med., 35, 172-182 (2003).
-
(2003)
Ann. Med.
, vol.35
, pp. 172-182
-
-
Honkakoski, P.1
Sueyoshi, T.2
Negishi, M.3
-
49
-
-
0031682988
-
The nuclear orphan receptor CAR-retinoid X receptor heterodimeractivates the phenobarbital-responsive enhancer module of the CYP2B gene
-
Honkakoski, P., Zelko, I., Sueyoshi, T., and Negishi, M., The nuclear orphan receptor CAR-retinoid X receptor heterodimeractivates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol. Cell Biol., 18, 5652-5658 (1998b).
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 5652-5658
-
-
Honkakoski, P.1
Zelko, I.2
Sueyoshi, T.3
Negishi, M.4
-
50
-
-
3042688047
-
In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat
-
Hu, R., Hebbar, V., Kim, B. R., Chen, C., Winnik, B., Buckley, B., Soteropoulos, P., Tolias, P., Hart, R. P., and Kong, A. N., In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J. Pharmacol. Exp. Ther. ,(2004).
-
(2004)
J. Pharmacol. Exp. Ther.
-
-
Hu, R.1
Hebbar, V.2
Kim, B.R.3
Chen, C.4
Winnik, B.5
Buckley, B.6
Soteropoulos, P.7
Tolias, P.8
Hart, R.P.9
Kong, A.N.10
-
51
-
-
0033731182
-
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2
-
Huang, H. C., Nguyen, T., and Pickett, C. B., Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc. Natl. Acad. Sci. U.S.A., 97, 12475-12480 (2000).
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 12475-12480
-
-
Huang, H.C.1
Nguyen, T.2
Pickett, C.B.3
-
52
-
-
0037044791
-
Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
-
Huang, H. C., Nguyen, T., and Pickett, C. B., Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J. Biol. Chem., 277, 42769-42774 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42769-42774
-
-
Huang, H.C.1
Nguyen, T.2
Pickett, C.B.3
-
53
-
-
1342263523
-
The AHR-1 aryl hydrocarbon receptor and its co-factor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans
-
Huang, X., Powell-Coffman, J. A., and Jin, Y., The AHR-1 aryl hydrocarbon receptor and its co-factor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans. Development, 131, 819-828 (2004).
-
(2004)
Development
, vol.131
, pp. 819-828
-
-
Huang, X.1
Powell-Coffman, J.A.2
Jin, Y.3
-
54
-
-
12244271026
-
Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups
-
Innocenti, F., Grimsley, C., Das, S., Ramirez, J., Cheng, C., Kuttab-Boulos, H., Ratain, M. J., and Di Rienzo, A., Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups. Pharmacogenetics, 12, 725-733 (2002).
-
(2002)
Pharmacogenetics
, vol.12
, pp. 725-733
-
-
Innocenti, F.1
Grimsley, C.2
Das, S.3
Ramirez, J.4
Cheng, C.5
Kuttab-Boulos, H.6
Ratain, M.J.7
Di Rienzo, A.8
-
55
-
-
0035861581
-
Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter
-
Inokuchi, A., Hinoshita, E., Iwamoto, Y., Kohno, K., Kuwano, M., and Uchiumi, T., Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter. J. Biol. Chem., 276, 46822-46829 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 46822-46829
-
-
Inokuchi, A.1
Hinoshita, E.2
Iwamoto, Y.3
Kohno, K.4
Kuwano, M.5
Uchiumi, T.6
-
56
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
Issemann, I. and Green, S., Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 347, 645-650 (1990).
-
(1990)
Nature
, vol.347
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
57
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., Yamamoto, M., and Nabeshima, Y., An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun., 236, 313-322 (1997).
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
Oyake, T.7
Hayashi, N.8
Satoh, K.9
Hatayama, I.10
Yamamoto, M.11
Nabeshima, Y.12
-
58
-
-
0028299545
-
Jun and Fos regulation of NAD(P)H: Quinone oxidoreductase gene expression
-
Jaiswal, A. K., Jun and Fos regulation of NAD(P)H: quinone oxidoreductase gene expression. Pharmacogenetics, 4, 1-10 (1994).
-
(1994)
Pharmacogenetics
, vol.4
, pp. 1-10
-
-
Jaiswal, A.K.1
-
59
-
-
0025269939
-
Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis
-
Jelinek, D. F., Andersson, S., Slaughter, C. A., and Russell, D. W., Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J. Biol. Chem., 265, 8190-8197 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 8190-8197
-
-
Jelinek, D.F.1
Andersson, S.2
Slaughter, C.A.3
Russell, D.W.4
-
60
-
-
0025050504
-
Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase
-
Jelinek, D. F. and Russell, D. W., Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase. Biochemistry, 29, 7781-7785 (1990).
-
(1990)
Biochemistry
, vol.29
, pp. 7781-7785
-
-
Jelinek, D.F.1
Russell, D.W.2
-
61
-
-
0041856526
-
Application of compartmental modeling to an examination of in vitro intestinal permeability data: Assessing the impact of tissue uptake, P-glycoprotein, and CYP3A
-
Johnson, B. M., Charman, W. N., and Porter, C. J., Application of compartmental modeling to an examination of in vitro intestinal permeability data: assessing the impact of tissue uptake, P-glycoprotein, and CYP3A. Drug Metab. Dispos., 31, 1151-1160 (2003).
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 1151-1160
-
-
Johnson, B.M.1
Charman, W.N.2
Porter, C.J.3
-
62
-
-
17744375160
-
The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
-
Jones, S. A., Moore, L. B., Shenk, J. L., Wisely, G. B., Hamilton, G. A., McKee, D. D., Tomkinson, N. C., LeCluyse, E. L., Lambert, M.H ., Willson, T. M., Kliewer, S. A., and Moore, J. T., The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol. Endocrinol., 14, 27-39 (2000).
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 27-39
-
-
Jones, S.A.1
Moore, L.B.2
Shenk, J.L.3
Wisely, G.B.4
Hamilton, G.A.5
McKee, D.D.6
Tomkinson, N.C.7
LeCluyse, E.L.8
Lambert, M.H.9
Willson, T.M.10
Kliewer, S.A.11
Moore, J.T.12
-
63
-
-
0036840585
-
Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress
-
Kang, K. W., Lee, S. J., Park, J. W., and Kim, S. G., Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress. Mol. Pharmacol., 62, 1001-1010 (2002).
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 1001-1010
-
-
Kang, K.W.1
Lee, S.J.2
Park, J.W.3
Kim, S.G.4
-
64
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
-
Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M., and Edwards, P. A., Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J. Biol. Chem., 277, 2908-2915 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stoltz, C.M.6
Tontonoz, P.7
Kliewer, S.8
Willson, T.M.9
Edwards, P.A.10
-
65
-
-
0032766430
-
Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
-
Kawamoto, T., Sueyoshi, T., Zelko, I., Moore, R., Washburn, K., and Negishi, M., Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol. Cell Biol., 19, 6318-6322 (1999).
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 6318-6322
-
-
Kawamoto, T.1
Sueyoshi, T.2
Zelko, I.3
Moore, R.4
Washburn, K.5
Negishi, M.6
-
66
-
-
0034936354
-
ABC drug transporters: Hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2
-
Kerb, R., Hoffmeyer, S., and Brinkmann, U., ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2. Pharmacogenomics, 2, 51-64 (2001).
-
(2001)
Pharmacogenomics
, vol.2
, pp. 51-64
-
-
Kerb, R.1
Hoffmeyer, S.2
Brinkmann, U.3
-
67
-
-
0141567455
-
Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC)
-
Keum, Y. S., Owuor, E. D., Kim, B. R., Hu, R., and Kong, A. N., Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC). Pharm. Res., 20, 1351-1356 (2003).
-
(2003)
Pharm. Res.
, vol.20
, pp. 1351-1356
-
-
Keum, Y.S.1
Owuor, E.D.2
Kim, B.R.3
Hu, R.4
Kong, A.N.5
-
68
-
-
0141992044
-
Role of nuclear receptors in the regulation of gene expression by dietary fatty acids
-
(review)
-
Khan, S. A. and Vanden Heuvel, J. P., Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review). J. Nutr. Biochem., 14, 554-567 (2003).
-
(2003)
J. Nutr. Biochem.
, vol.14
, pp. 554-567
-
-
Khan, S.A.1
Vanden Heuvel, J.P.2
-
69
-
-
0042821648
-
Heterodimers of bHLH-PAS protein fragments derived from AhR, AhRR, and Arnt prepared by co-expression in Escherichia coli: Characterization of their DNA binding activity and preparation of a DNA complex
-
Kikuchi, Y., Ohsawa, S., Mimura, J., Ema, M., Takasaki, C., Sogawa, K., and Fujii-Kuriyama, Y., Heterodimers of bHLH-PAS protein fragments derived from AhR, AhRR, and Arnt prepared by co-expression in Escherichia coli: characterization of their DNA binding activity and preparation of a DNA complex. J. Biochem. (Tokyo), 134, 83-90 (2003).
-
(2003)
J. Biochem. (Tokyo)
, vol.134
, pp. 83-90
-
-
Kikuchi, Y.1
Ohsawa, S.2
Mimura, J.3
Ema, M.4
Takasaki, C.5
Sogawa, K.6
Fujii-Kuriyama, Y.7
-
70
-
-
0242469240
-
Organic anion-transporting polypeptide (OATP) transporter family and drug disposition
-
Kim, R. B., Organic anion-transporting polypeptide (OATP) transporter family and drug disposition. Eur. J. Clin. Invest., 33 Suppl 2, 1-5 (2003).
-
(2003)
Eur. J. Clin. Invest.
, vol.33
, Issue.SUPPL. 2
, pp. 1-5
-
-
Kim, R.B.1
-
71
-
-
0034278984
-
UDP-glucuronosyltransferases
-
King, C. D., Rios, G. R., Green, M. D., and Tephly, T. R., UDP-glucuronosyltransferases. Curr. Drug Metab., 1, 143-161 (2000).
-
(2000)
Curr. Drug Metab.
, vol.1
, pp. 143-161
-
-
King, C.D.1
Rios, G.R.2
Green, M.D.3
Tephly, T.R.4
-
72
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterstrom, R. H., Perlmann, T., and Lehmann, J. M., An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell, 92, 73-82 (1998).
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
Perlmann, T.11
Lehmann, J.M.12
-
73
-
-
0035212419
-
Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE)
-
Kong, A. N. T., Owuor, E., Yu, R., Hebbar, V., Chen, C., Hu, R., and Mandlekar, S., Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab. Rev., 33, 255-271 (2001a).
-
(2001)
Drug Metab. Rev.
, vol.33
, pp. 255-271
-
-
Kong, A.N.T.1
Owuor, E.2
Yu, R.3
Hebbar, V.4
Chen, C.5
Hu, R.6
Mandlekar, S.7
-
74
-
-
0034137655
-
Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis
-
Kong, A. N. T., Yu, R., Chen, C., Mandlekar, S., and Primiano, T., Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch. Pharm. Res., 23, 1-16 (2000).
-
(2000)
Arch. Pharm. Res.
, vol.23
, pp. 1-16
-
-
Kong, A.N.T.1
Yu, R.2
Chen, C.3
Mandlekar, S.4
Primiano, T.5
-
75
-
-
0001497590
-
Signal transduction events elicited by cancer prevention compounds
-
Kong, A. N. T., Yu, R., Hebbar, V., Chen, C., Owuor, E., Hu, R., Ee, R., and Mandlekar, S., Signal transduction events elicited by cancer prevention compounds. Mutat. Res., 480-481, 231-241 (2001b).
-
(2001)
Mutat. Res.
, vol.480-481
, pp. 231-241
-
-
Kong, A.N.T.1
Yu, R.2
Hebbar, V.3
Chen, C.4
Owuor, E.5
Hu, R.6
Ee, R.7
Mandlekar, S.8
-
76
-
-
0344927562
-
Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
-
Konig, J., Nies, A.T., Cui, Y., Leier, I., and Keppler, D., Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim. Biophys. Acta, 1461, 377-394 (1999a).
-
(1999)
Biochim. Biophys. Acta
, vol.1461
, pp. 377-394
-
-
Konig, J.1
Nies, A.T.2
Cui, Y.3
Leier, I.4
Keppler, D.5
-
77
-
-
0032926354
-
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
-
Konig, J., Rost, D., Cui, Y., and Keppler, D., Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology., 29, 1156-1163 (1999b).
-
(1999)
Hepatology
, vol.29
, pp. 1156-1163
-
-
Konig, J.1
Rost, D.2
Cui, Y.3
Keppler, D.4
-
78
-
-
0345731376
-
Regulation of drug and bile salt transporters in liver and intestine
-
Kullak-Ublick, G. A. and Becker, M. B., Regulation of drug and bile salt transporters in liver and intestine. Drug Metab. Rev., 35, 305-317 (2003).
-
(2003)
Drug Metab. Rev.
, vol.35
, pp. 305-317
-
-
Kullak-Ublick, G.A.1
Becker, M.B.2
-
79
-
-
0346100571
-
Enterohepatic bile salt transporters in normal physiology and liver disease
-
Kullak-Ublick, G. A., Stieger, B., and Meier, P. J., Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology, 126, 322-342 (2004).
-
(2004)
Gastroenterology
, vol.126
, pp. 322-342
-
-
Kullak-Ublick, G.A.1
Stieger, B.2
Meier, P.J.3
-
80
-
-
0033054115
-
The structure of the nuclear hormone receptors
-
Kumar, R. and Thompson, E. B., The structure of the nuclear hormone receptors. Steroids, 64, 310-319 (1999).
-
(1999)
Steroids
, vol.64
, pp. 310-319
-
-
Kumar, R.1
Thompson, E.B.2
-
81
-
-
0036240610
-
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: Role of antioxidant response element-like sequences in the nrf2 promoter
-
Kwak, M. K., Itoh, K., Yamamoto, M., and Kensler, T. W., Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol. Cell Biol., 22, 2883-2892 (2002).
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 2883-2892
-
-
Kwak, M.K.1
Itoh, K.2
Yamamoto, M.3
Kensler, T.W.4
-
82
-
-
0035260034
-
Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione
-
Kwak, M. K., Itoh, K., Yamamoto, M., Sutter, T. R., and Kensler, T. W., Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione. Mol. Med., 7, 135-145 (2001).
-
(2001)
Mol. Med.
, vol.7
, pp. 135-145
-
-
Kwak, M.K.1
Itoh, K.2
Yamamoto, M.3
Sutter, T.R.4
Kensler, T.W.5
-
83
-
-
0029977518
-
A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs
-
Lambe, K. G. and Tugwood, J. D., A human peroxisome-proliferator- activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs. Eur. J. Biochem., 239, 1-7 (1996).
-
(1996)
Eur. J. Biochem.
, vol.239
, pp. 1-7
-
-
Lambe, K.G.1
Tugwood, J.D.2
-
84
-
-
0035827505
-
Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells
-
Lee, J. M., Hanson, J. M., Chu, W. A., and Johnson, J. A., Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells. J. Biol. Chem., 276, 20011-20016 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20011-20016
-
-
Lee, J.M.1
Hanson, J.M.2
Chu, W.A.3
Johnson, J.A.4
-
85
-
-
14444285707
-
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
-
Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J. L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., and Willson, T. M., Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem., 272, 3137-3140 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3137-3140
-
-
Lehmann, J.M.1
Kliewer, S.A.2
Moore, L.B.3
Smith-Oliver, T.A.4
Oliver, B.B.5
Su, J.L.6
Sundseth, S.S.7
Winegar, D.A.8
Blanchard, D.E.9
Spencer, T.A.10
Willson, T.M.11
-
86
-
-
0032169485
-
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
-
Lehmann, J. M., McKee, D. D., Watson, M. A., Willson, T. M., Moore, J. T., and Kliewer, S. A., The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest., 102, 1016-1023 (1998).
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1016-1023
-
-
Lehmann, J.M.1
McKee, D.D.2
Watson, M.A.3
Willson, T.M.4
Moore, J.T.5
Kliewer, S.A.6
-
87
-
-
0035126508
-
Aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) activity is unaltered by phosphorylation of a periodicity/ARNT/single-minded (PAS)-region serine residue
-
Levine, S. L. and Perdew, G. H., Aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) activity is unaltered by phosphorylation of a periodicity/ARNT/single-minded (PAS)-region serine residue. Mol. Pharmacol., 59, 557-566 (2001).
-
(2001)
Mol. Pharmacol.
, vol.59
, pp. 557-566
-
-
Levine, S.L.1
Perdew, G.H.2
-
88
-
-
0038106668
-
P450 structures and oxidative metabolism of xenobiotics
-
Lewis, D. F., P450 structures and oxidative metabolism of xenobiotics. Pharmacogenomics, 4, 387-395 (2003).
-
(2003)
Pharmacogenomics
, vol.4
, pp. 387-395
-
-
Lewis, D.F.1
-
89
-
-
0032169826
-
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene
-
Li, W., Harper, P. A., Tang, B. K., and Okey, A. B., Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene. Biochem. Pharmacol., 56, 599-612 (1998).
-
(1998)
Biochem. Pharmacol.
, vol.56
, pp. 599-612
-
-
Li, W.1
Harper, P.A.2
Tang, B.K.3
Okey, A.B.4
-
90
-
-
8544224973
-
The UDP glycosyltransferasegene superfamily: Recommended nomenclature update based on evolutionary divergence
-
Mackenzie, P. I., Owens, I. S., Burchell, B., Bock, K. W., Bairoch, A., Belanger, A., Fournel-Gigleux, S., Green, M., Hum, D. W., Iyanagi, T., Lancet, D., Louisot, P., Magdalou, J., Chowdhury, J. R., Ritter, J. K., Schachter, H., Tephly, T. R., Tipton, K. F., and Nebert, D. W., The UDP glycosyltransferasegene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics, 7, 255-269 (1997).
-
(1997)
Pharmacogenetics
, vol.7
, pp. 255-269
-
-
Mackenzie, P.I.1
Owens, I.S.2
Burchell, B.3
Bock, K.W.4
Bairoch, A.5
Belanger, A.6
Fournel-Gigleux, S.7
Green, M.8
Hum, D.W.9
Iyanagi, T.10
Lancet, D.11
Louisot, P.12
Magdalou, J.13
Chowdhury, J.R.14
Ritter, J.K.15
Schachter, H.16
Tephly, T.R.17
Tipton, K.F.18
Nebert, D.W.19
-
91
-
-
0036765785
-
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification
-
Maglich, J. M., Stoltz, C. M., Goodwin, B., Hawkins-Brown, D., Moore, J. T., and Kliewer, S. A., Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol. Pharmacol., 62, 638-646 (2002).
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 638-646
-
-
Maglich, J.M.1
Stoltz, C.M.2
Goodwin, B.3
Hawkins-Brown, D.4
Moore, J.T.5
Kliewer, S.A.6
-
92
-
-
0030974473
-
Modulation of glutathione S-transferase subunits A2, M1, and P1 expression by interleukin-1beta in rat hepatocytes in primary culture
-
Maheo, K., Antras-Ferry, J., Morel, F., Langouet, S., and Guillouzo, A., Modulation of glutathione S-transferase subunits A2, M1, and P1 expression by interleukin-1beta in rat hepatocytes in primary culture. J. Biol. Chem., 272, 16125-16132 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16125-16132
-
-
Maheo, K.1
Antras-Ferry, J.2
Morel, F.3
Langouet, S.4
Guillouzo, A.5
-
93
-
-
0033591297
-
Identification of a nuclear receptor for bile acids
-
Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., and Shan, B., Identification of a nuclear receptor for bile acids. Science, 284, 1362-1365 (1999).
-
(1999)
Science
, vol.284
, pp. 1362-1365
-
-
Makishima, M.1
Okamoto, A.Y.2
Repa, J.J.3
Tu, H.4
Learned, R.M.5
Luk, A.6
Hull, M.V.7
Lustig, K.D.8
Mangelsdorf, D.J.9
Shan, B.10
-
94
-
-
0026597950
-
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid
-
Mangelsdorf, D. J., Borgmeyer, U., Heyman, R. A., Zhou, J. Y., Ong, E. S., Oro, A. E., Kakizuka, A., and Evans, R. M., Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev., 6, 329-344 (1992).
-
(1992)
Genes Dev.
, vol.6
, pp. 329-344
-
-
Mangelsdorf, D.J.1
Borgmeyer, U.2
Heyman, R.A.3
Zhou, J.Y.4
Ong, E.S.5
Oro, A.E.6
Kakizuka, A.7
Evans, R.M.8
-
95
-
-
0029562554
-
The RXR heterodimers and orphan receptors
-
Mangelsdorf, D. J. and Evans, R. M., The RXR heterodimers and orphan receptors. Cell, 83, 841-850 (1995).
-
(1995)
Cell
, vol.83
, pp. 841-850
-
-
Mangelsdorf, D.J.1
Evans, R.M.2
-
96
-
-
18144440415
-
A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a)
-
Menke, J. G., Macnaul, K. L., Hayes, N. S., Baffic, J., Chao, Y. S., Elbrecht, A., Kelly, L. J., Lam, M. H., Schmidt, A., Sahoo, S., Wang, J., Wright, S. D., Xin, P., Zhou, G., Moller, D. E., and Sparrow, C. P., A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology, 143, 2548-2558 (2002).
-
(2002)
Endocrinology
, vol.143
, pp. 2548-2558
-
-
Menke, J.G.1
Macnaul, K.L.2
Hayes, N.S.3
Baffic, J.4
Chao, Y.S.5
Elbrecht, A.6
Kelly, L.J.7
Lam, M.H.8
Schmidt, A.9
Sahoo, S.10
Wang, J.11
Wright, S.D.12
Xin, P.13
Zhou, G.14
Moller, D.E.15
Sparrow, C.P.16
-
97
-
-
0030426570
-
Overview of enzymes of drug metabolism
-
Meyer, U. A., Overview of enzymes of drug metabolism. J. Pharmacokinet. Biopharm., 24, 449-459 (1996).
-
(1996)
J. Pharmacokinet. Biopharm.
, vol.24
, pp. 449-459
-
-
Meyer, U.A.1
-
98
-
-
0042468096
-
Impact of drug transporter studies on drug discovery and development
-
Mizuno, N., Niwa, T., Yotsumoto, Y., and Sugiyama, Y., Impact of drug transporter studies on drug discovery and development. Pharmacol. Rev., 55, 425-461 (2003).
-
(2003)
Pharmacol. Rev.
, vol.55
, pp. 425-461
-
-
Mizuno, N.1
Niwa, T.2
Yotsumoto, Y.3
Sugiyama, Y.4
-
99
-
-
0034685779
-
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
-
Moore, L. B., Parks, D. J., Jones, S. A., Bledsoe, R. K., Consler, T. G., Stimmel, J. B., Goodwin, B., Liddle, C., Blanchard, S. G., Willson, T. M., Collins, J. L., and Kliewer, S. A., Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J. Biol. Chem., 275, 15122-15127 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15122-15127
-
-
Moore, L.B.1
Parks, D.J.2
Jones, S.A.3
Bledsoe, R.K.4
Consler, T.G.5
Stimmel, J.B.6
Goodwin, B.7
Liddle, C.8
Blanchard, S.G.9
Willson, T.M.10
Collins, J.L.11
Kliewer, S.A.12
-
100
-
-
0027754356
-
Glutathione-related enzymes, glutathione and multidrug resistance
-
Moscow, J. A. and Dixon, K. H., Glutathione-related enzymes, glutathione and multidrug resistance. Cytotechnology, 12, 155-170 (1993).
-
(1993)
Cytotechnology
, vol.12
, pp. 155-170
-
-
Moscow, J.A.1
Dixon, K.H.2
-
101
-
-
0041631065
-
Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells
-
Nakajima, M., Iwanari, M., and Yokoi, T., Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells. Toxicol. Lett., 144, 247-256 (2003).
-
(2003)
Toxicol. Lett.
, vol.144
, pp. 247-256
-
-
Nakajima, M.1
Iwanari, M.2
Yokoi, T.3
-
102
-
-
0025765126
-
The P450 superfamily: Update on new sequences, gene mapping, and recommended nomenclature
-
Nebert, D. W., Nelson, D. R., Coon, M. J., Estabrook, R. W., Feyereisen, R., Fujii-Kuriyama, Y., Gonzalez, F. J., Guengerich, F. P., Gunsalus, I. C., Johnson, E. F., et al., The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol., 10, 1-14 (1991).
-
(1991)
DNA Cell Biol.
, vol.10
, pp. 1-14
-
-
Nebert, D.W.1
Nelson, D.R.2
Coon, M.J.3
Estabrook, R.W.4
Feyereisen, R.5
Fujii-Kuriyama, Y.6
Gonzalez, F.J.7
Guengerich, F.P.8
Gunsalus, I.C.9
Johnson, E.F.10
-
103
-
-
9044254525
-
P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
-
Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., Gunsalus, I. C., and Nebert, D. W., P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1-42 (1996).
-
(1996)
Pharmacogenetics
, vol.6
, pp. 1-42
-
-
Nelson, D.R.1
Koymans, L.2
Kamataki, T.3
Stegeman, J.J.4
Feyereisen, R.5
Waxman, D.J.6
Waterman, M.R.7
Gotoh, O.8
Coon, M.J.9
Estabrook, R.W.10
Gunsalus, I.C.11
Nebert, D.W.12
-
104
-
-
0013282861
-
Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome
-
Nguyen, T., Sherratt, P. J., Huang, H. C., Yang, C. S., and Pickett, C. B., Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome. J. Biol. Chem., 278, 4536-4541 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 4536-4541
-
-
Nguyen, T.1
Sherratt, P.J.2
Huang, H.C.3
Yang, C.S.4
Pickett, C.B.5
-
105
-
-
0036708902
-
Antioxidants and oxidants regulated signal transduction pathways
-
Owuor, E. D. and Kong, A. N., Antioxidants and oxidants regulated signal transduction pathways. Biochem. Pharmacol.,64, 765-770 (2002).
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 765-770
-
-
Owuor, E.D.1
Kong, A.N.2
-
106
-
-
0034623998
-
Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of the constitutive androstane receptor on phenobarbital responsiveness
-
Paquet, Y., Trottier, E., Beaudet, M. J., and Anderson, A., Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of the constitutive androstane receptor on phenobarbital responsiveness. J. Biol. Chem., 275, 38427-38436 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 38427-38436
-
-
Paquet, Y.1
Trottier, E.2
Beaudet, M.J.3
Anderson, A.4
-
107
-
-
0346992329
-
Pathophysiological factors affecting CAR gene expression
-
Pascussi, J. M., Dvorak, Z., Gerbal-Chaloin, S., Assenat, E., Maurel, P., and Vilarem, M. J., Pathophysiological factors affecting CAR gene expression. Drug Metab. Rev., 35, 255-268 (2003a).
-
(2003)
Drug Metab. Rev.
, vol.35
, pp. 255-268
-
-
Pascussi, J.M.1
Dvorak, Z.2
Gerbal-Chaloin, S.3
Assenat, E.4
Maurel, P.5
Vilarem, M.J.6
-
108
-
-
0037450436
-
The expression of CYP2B6, CYP2C9 and CYP3A4 genes: A tangle of networks of nuclear and steroid receptors
-
Pascussi, J. M., Gerbal-Chaloin, S., Drocourt, L., Maurel, P., and Vilarem, M. J., The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochim. Biophys. Acta, 1619, 243-253 (2003b).
-
(2003)
Biochim. Biophys. Acta
, vol.1619
, pp. 243-253
-
-
Pascussi, J.M.1
Gerbal-Chaloin, S.2
Drocourt, L.3
Maurel, P.4
Vilarem, M.J.5
-
109
-
-
0013199471
-
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
-
Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. M., Hammer, R. E., and Mangelsdorf, D. J., Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell, 93, 693-704 (1998).
-
(1998)
Cell
, vol.93
, pp. 693-704
-
-
Peet, D.J.1
Turley, S.D.2
Ma, W.3
Janowski, B.A.4
Lobaccaro, J.M.5
Hammer, R.E.6
Mangelsdorf, D.J.7
-
110
-
-
1542314451
-
Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats
-
Perloff, M. D., von Moltke, L. L., and Greenblatt, D. J., Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats. Xenobiotica, 34, 133-150 (2004).
-
(2004)
Xenobiotica
, vol.34
, pp. 133-150
-
-
Perloff, M.D.1
Von Moltke, L.L.2
Greenblatt, D.J.3
-
111
-
-
0033522186
-
Phenobarbital responsiveness conferred by the 5′-flanking region of the rat CYP2B2 gene in transgenic mice
-
Ramsden, R., Beck, N. B., Sommer, K. M., and Omiecinski, C. J., Phenobarbital responsiveness conferred by the 5′-flanking region of the rat CYP2B2 gene in transgenic mice. Gene, 228, 169-179 (1999).
-
(1999)
Gene
, vol.228
, pp. 169-179
-
-
Ramsden, R.1
Beck, N.B.2
Sommer, K.M.3
Omiecinski, C.J.4
-
112
-
-
0032819955
-
Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver
-
Reichel, C., Gao, B., Van Montfoort, J., Cattori, V., Rahner, C., Hagenbuch, B., Stieger, B., Kamisako, T., and Meier, P. J., Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver. Gastroenterology, 117, 688-695 (1999).
-
(1999)
Gastroenterology
, vol.117
, pp. 688-695
-
-
Reichel, C.1
Gao, B.2
Van Montfoort, J.3
Cattori, V.4
Rahner, C.5
Hagenbuch, B.6
Stieger, B.7
Kamisako, T.8
Meier, P.J.9
-
113
-
-
0032791711
-
Expression and inducibility of the human bilirubin UDP- glucuronosyltransferase UGT1A1in liver and cultured primary hepatocytes: Evidence for both genetic and environmental influences
-
Ritter, J. K., Kessler, F. K., Thompson, M. T., Grove, A. D., Auyeung, D. J., and Fisher, R. A., Expression and inducibility of the human bilirubin UDP-glucuronosyltransferase UGT1A1in liver and cultured primary hepatocytes: evidence for both genetic and environmental influences. Hepatology, 30, 476-484 (1999).
-
(1999)
Hepatology
, vol.30
, pp. 476-484
-
-
Ritter, J.K.1
Kessler, F.K.2
Thompson, M.T.3
Grove, A.D.4
Auyeung, D.J.5
Fisher, R.A.6
-
114
-
-
0030888748
-
Aryl hydrocarbon receptor-mediated signal transduction
-
Rowlands, J. C. and Gustafsson, J. A., Aryl hydrocarbon receptor-mediated signal transduction. Crit. Rev. Toxicol., 27, 109-134 (1997).
-
(1997)
Crit. Rev. Toxicol.
, vol.27
, pp. 109-134
-
-
Rowlands, J.C.1
Gustafsson, J.A.2
-
115
-
-
0025368036
-
Regulation of glutathione S-transferase Ya subunit gene expression: Identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds
-
Rushmore, T. H., King, R. G., Paulson, K. E., and Pickett, C. B., Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds. Proc. Natl. Acad. Sci. U.S.A., 87, 3826-3830 (1990).
-
(1990)
Proc. Natl. Acad. Sci. U.S.A.
, vol.87
, pp. 3826-3830
-
-
Rushmore, T.H.1
King, R.G.2
Paulson, K.E.3
Pickett, C.B.4
-
116
-
-
0036783335
-
Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes
-
Rushmore, T. H. and Kong, A. N., Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr. Drug Metab., 3, 481-490 (2002).
-
(2002)
Curr. Drug Metab.
, vol.3
, pp. 481-490
-
-
Rushmore, T.H.1
Kong, A.N.2
-
117
-
-
0027477384
-
Phase I and phase II xenobiotic reactions and metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in aggregating liver cell cultures
-
Schilter, B., Turesky, R. J., Juillerat, M., Honegger, P., and Guigoz, Y., Phase I and phase II xenobiotic reactions and metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in aggregating liver cell cultures. Biochem. Pharmacol., 45, 1087-1096 (1993).
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 1087-1096
-
-
Schilter, B.1
Turesky, R.J.2
Juillerat, M.3
Honegger, P.4
Guigoz, Y.5
-
118
-
-
0029994543
-
Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
-
Schoonjans, K., Staels, B., and Auwerx, J., Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res., 37, 907-925 (1996).
-
(1996)
J. Lipid Res.
, vol.37
, pp. 907-925
-
-
Schoonjans, K.1
Staels, B.2
Auwerx, J.3
-
119
-
-
2542418930
-
Regulation of Nrf2 transactivation domain activity: The differential effects of mitogen-activated protein kinase cascades and synergistic stimulation effect of Raf and CREB binding protein
-
Shen, G., Hebbar, V., Nair, S. S., Xu, C., Li, W., Lin, W., Keum, Y. S., Han, J., Gallo, M. A., and Kong, A. N., Regulation of Nrf2 transactivation domain activity: The differential effects of mitogen-activated protein kinase cascades and synergistic stimulation effect of Raf and CREB binding protein. J. Biol. Chem., 279, 23052-23060 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 23052-23060
-
-
Shen, G.1
Hebbar, V.2
Nair, S.S.3
Xu, C.4
Li, W.5
Lin, W.6
Keum, Y.S.7
Han, J.8
Gallo, M.A.9
Kong, A.N.10
-
120
-
-
0034681182
-
Benzo[a] pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor
-
Shimizu, Y., Nakatsuru, Y., Ichinose, M., Takahashi, Y., Kume, H., Mimura, J., Fujii-Kuriyama, Y., and Ishikawa, T., Benzo[a] pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc. Natl. Acad. Sci. U.S.A., 97, 779-782 (2000).
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 779-782
-
-
Shimizu, Y.1
Nakatsuru, Y.2
Ichinose, M.3
Takahashi, Y.4
Kume, H.5
Mimura, J.6
Fujii-Kuriyama, Y.7
Ishikawa, T.8
-
121
-
-
0036175452
-
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport
-
Shitara, Y., Sugiyama, D., Kusuhara, H., Kato, Y., Abe, T., Meier, P. J., Itoh, T., and Sugiyama, Y., Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm. Res., 19, 147-153 (2002).
-
(2002)
Pharm. Res.
, vol.19
, pp. 147-153
-
-
Shitara, Y.1
Sugiyama, D.2
Kusuhara, H.3
Kato, Y.4
Abe, T.5
Meier, P.J.6
Itoh, T.7
Sugiyama, Y.8
-
122
-
-
0031049745
-
The cytochrome P450 4 (CYP4) family
-
Simpson, A. E., The cytochrome P450 4 (CYP4) family. Gen. Pharmacol., 28, 351-359 (1997).
-
(1997)
Gen. Pharmacol.
, vol.28
, pp. 351-359
-
-
Simpson, A.E.1
-
123
-
-
1642579696
-
The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes
-
Song, X., Xie, M., Zhang, H., Li, Y., Sachdeva, K., and Yan, B., The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes. Drug Metab. Dispos., 32, 35-42 (2004).
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 35-42
-
-
Song, X.1
Xie, M.2
Zhang, H.3
Li, Y.4
Sachdeva, K.5
Yan, B.6
-
124
-
-
0034782509
-
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor
-
Staudinger, J., Liu, Y., Madan, A., Habeebu, S., and Klaassen, C. D., Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Drug Metab. Dispos., 29, 1467-1472 (2001a).
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 1467-1472
-
-
Staudinger, J.1
Liu, Y.2
Madan, A.3
Habeebu, S.4
Klaassen, C.D.5
-
125
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
Staudinger, J. L., Goodwin, B., Jones, S. A., Hawkins-Brown, D., MacKenzie, K. I., LaTour, A., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J., Willson, T. M., Koller, B.H., and Kliewer, S. A., The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc. Natl. Acad. Sci. U.S.A., 98, 3369-3374 (2001b).
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
Hawkins-Brown, D.4
MacKenzie, K.I.5
LaTour, A.6
Liu, Y.7
Klaassen, C.D.8
Brown, K.K.9
Reinhard, J.10
Willson, T.M.11
Koller, B.H.12
Kliewer, S.A.13
-
126
-
-
0037403746
-
Regulation of drug transporter gene expression by nuclear receptors
-
Staudinger, J. L., Madan, A., Carol, K. M., and Parkinson, A., Regulation of drug transporter gene expression by nuclear receptors. Drug Metab. Dispos., 31, 523-527 (2003).
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 523-527
-
-
Staudinger, J.L.1
Madan, A.2
Carol, K.M.3
Parkinson, A.4
-
127
-
-
0037462651
-
Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
-
Stewart, D., Killeen, E., Naquin, R., Alam, S., and Alam, J., Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J. Biol. Chem., 278, 2396-2402 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2396-2402
-
-
Stewart, D.1
Killeen, E.2
Naquin, R.3
Alam, S.4
Alam, J.5
-
128
-
-
0033525886
-
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
-
Sueyoshi, T., Kawamoto, T., Zelko, I., Honkakoski, P., and Negishi, M., The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J. Biol. Chem., 274, 6043-6046 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6043-6046
-
-
Sueyoshi, T.1
Kawamoto, T.2
Zelko, I.3
Honkakoski, P.4
Negishi, M.5
-
129
-
-
0035038008
-
Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
-
Sueyoshi, T. and Negishi, M., Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu. Rev. Pharmacol. Toxicol., 41, 123-143 (2001).
-
(2001)
Annu. Rev. Pharmacol. Toxicol.
, vol.41
, pp. 123-143
-
-
Sueyoshi, T.1
Negishi, M.2
-
130
-
-
0035029401
-
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR
-
Sugatani, J., Kojima, H., Ueda, A., Kakizaki, S., Yoshinari, K., Gong, Q. H., Owens, I. S., Negishi, M., and Sueyoshi, T., The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology, 33, 1232-1238 (2001).
-
(2001)
Hepatology
, vol.33
, pp. 1232-1238
-
-
Sugatani, J.1
Kojima, H.2
Ueda, A.3
Kakizaki, S.4
Yoshinari, K.5
Gong, Q.H.6
Owens, I.S.7
Negishi, M.8
Sueyoshi, T.9
-
131
-
-
0142150021
-
Induction of ABCC3 (MRP3) by pregnane X receptor activators
-
Teng, S., Jekerle, V., and Piquette-Miller, M., Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab. Dispos., 31, 1296-1299 (2003).
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 1296-1299
-
-
Teng, S.1
Jekerle, V.2
Piquette-Miller, M.3
-
132
-
-
0033150522
-
GST function in drug and stress response
-
Tew, K. D. and Ronai, Z., GST function in drug and stress response. Drug Resist. Updat., 2, 143-147 (1999).
-
(1999)
Drug Resist. Updat.
, vol.2
, pp. 143-147
-
-
Tew, K.D.1
Ronai, Z.2
-
133
-
-
0037131885
-
Pharmacogenomics of organic anion-transporting polypeptides (OATP)
-
Tirona, R. G. and Kim, R. B., Pharmacogenomics of organic anion-transporting polypeptides (OATP). Adv. Drug Deliv. Rev., 54, 1343-1352 (2002).
-
(2002)
Adv. Drug Deliv. Rev.
, vol.54
, pp. 1343-1352
-
-
Tirona, R.G.1
Kim, R.B.2
-
134
-
-
0030454445
-
Peroxisome proliferator-activated receptors: Structures and function
-
Tugwood, J. D., Aldridge, T. C., Lambe, K. G., Macdonald, N., and Woodyatt, N. J., Peroxisome proliferator-activated receptors: structures and function. Ann. N. Y. Acad. Sci., 804, 252-265 (1996).
-
(1996)
Ann. N. Y. Acad. Sci.
, vol.804
, pp. 252-265
-
-
Tugwood, J.D.1
Aldridge, T.C.2
Lambe, K.G.3
Macdonald, N.4
Woodyatt, N.J.5
-
135
-
-
0026541591
-
The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene
-
Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., and Green, S., The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO. J., 11, 433-439 (1992).
-
(1992)
EMBO. J.
, vol.11
, pp. 433-439
-
-
Tugwood, J.D.1
Issemann, I.2
Anderson, R.G.3
Bundell, K.R.4
McPheat, W.L.5
Green, S.6
-
136
-
-
0034128936
-
Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
-
Tukey, R. H. and Strassburg, C. P., Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu. Rev. Pharmacol. Toxicol., 40, 581-616 (2000).
-
(2000)
Annu. Rev. Pharmacol. Toxicol.
, vol.40
, pp. 581-616
-
-
Tukey, R.H.1
Strassburg, C.P.2
-
137
-
-
0035103197
-
Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members
-
Turgeon, D., Carrier, J. S., Levesque, E., Hum, D. W., and Belanger, A., Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members. Endocrinology., 142, 778-787 (2001).
-
(2001)
Endocrinology
, vol.142
, pp. 778-787
-
-
Turgeon, D.1
Carrier, J.S.2
Levesque, E.3
Hum, D.W.4
Belanger, A.5
-
138
-
-
0036299114
-
Transcriptional regulation of the rat Mrp3 promoter in intestine cells
-
Tzeng, S. J. and Huang, J. D., Transcriptional regulation of the rat Mrp3 promoter in intestine cells. Biochem. Biophys. Res. Commun., 291, 270-277 (2002).
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.291
, pp. 270-277
-
-
Tzeng, S.J.1
Huang, J.D.2
-
139
-
-
0028831941
-
Nomenclature for N-acetyltransferases
-
Vatsis, K. P., Weber, W. W., Bell, D. A., Dupret, J. M., Evans, D. A., Grant, D. M., Hein, D. W., Lin, H. J., Meyer, U. A., Relling, M. V. et al., Nomenclature for N-acetyltransferases. Pharmacogenetics., 5, 1-17 (1995).
-
(1995)
Pharmacogenetics
, vol.5
, pp. 1-17
-
-
Vatsis, K.P.1
Weber, W.W.2
Bell, D.A.3
Dupret, J.M.4
Evans, D.A.5
Grant, D.M.6
Hein, D.W.7
Lin, H.J.8
Meyer, U.A.9
Relling, M.V.10
-
140
-
-
0034710965
-
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha
-
Venkateswaran, A., Laffitte, B. A., Joseph, S. B., Mak, P. A., Wilpitz, D. C., Edwards, P. A., and Tontonoz, P., Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc. Natl. Acad. Sci. U.S.A., 97, 12097-12102 (2000).
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 12097-12102
-
-
Venkateswaran, A.1
Laffitte, B.A.2
Joseph, S.B.3
Mak, P.A.4
Wilpitz, D.C.5
Edwards, P.A.6
Tontonoz, P.7
-
141
-
-
1242296811
-
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
-
Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M. I., Kobayashi, A., Yamamoto, M., Kensler, T. W., and Talalay, P., Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc. Natl. Acad. Sci. U.S.A., 101, 2040-2045 (2004).
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 2040-2045
-
-
Wakabayashi, N.1
Dinkova-Kostova, A.T.2
Holtzclaw, W.D.3
Kang, M.I.4
Kobayashi, A.5
Yamamoto, M.6
Kensler, T.W.7
Talalay, P.8
-
142
-
-
0033026760
-
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
-
Wang, H., Chen, J., Hollister, K., Sowers, L. C., and Forman, B. M., Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell, 3, 543-553 (1999).
-
(1999)
Mol. Cell
, vol.3
, pp. 543-553
-
-
Wang, H.1
Chen, J.2
Hollister, K.3
Sowers, L.C.4
Forman, B.M.5
-
143
-
-
0037515661
-
A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression
-
Wang, H., Faucette, S., Sueyoshi, T., Moore, R., Ferguson, S., Negishi, M., and LeCluyse, E. L., A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. J. Biol. Chem., 278, 14146-14152 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14146-14152
-
-
Wang, H.1
Faucette, S.2
Sueyoshi, T.3
Moore, R.4
Ferguson, S.5
Negishi, M.6
LeCluyse, E.L.7
-
144
-
-
0346099111
-
Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes
-
Wang, H. and LeCluyse, E. L., Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clin. Pharmacokinet., 42, 1331-1357 (2003).
-
(2003)
Clin. Pharmacokinet.
, vol.42
, pp. 1331-1357
-
-
Wang, H.1
LeCluyse, E.L.2
-
145
-
-
0033199499
-
P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
-
Waxman, D. J., P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch. Biochem. Biophys., 369, 11-23 (1999).
-
(1999)
Arch. Biochem. Biophys.
, vol.369
, pp. 11-23
-
-
Waxman, D.J.1
-
146
-
-
0036367792
-
Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response
-
Wei, P., Zhang, J., Dowhan, D. H., Han, Y., and Moore, D. D., Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response. Pharmacogenomics J., 2, 117-126 (2002).
-
(2002)
Pharmacogenomics J.
, vol.2
, pp. 117-126
-
-
Wei, P.1
Zhang, J.2
Dowhan, D.H.3
Han, Y.4
Moore, D.D.5
-
147
-
-
0031039057
-
Sulfation and sulfotransferases1: Sulfotransferase molecular biology: cDNAs and genes
-
Weinshilboum, R. M., Otterness, D. M., Aksoy, I. A., Wood, T. C., Her, C., and Raftogianis, R. B., Sulfation and sulfotransferases1: Sulfotransferase molecular biology: cDNAs and genes. FASEB J., 11, 3-14 (1997).
-
(1997)
FASEB J.
, vol.11
, pp. 3-14
-
-
Weinshilboum, R.M.1
Otterness, D.M.2
Aksoy, I.A.3
Wood, T.C.4
Her, C.5
Raftogianis, R.B.6
-
148
-
-
0036528233
-
PXR, CAR and drug metabolism
-
Willson, T. M. and Kliewer, S. A., PXR, CAR and drug metabolism. Nat. Rev. Drug Discov., 1, 259-266 (2002).
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 259-266
-
-
Willson, T.M.1
Kliewer, S.A.2
-
149
-
-
0036847090
-
Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice
-
Wolters, H., Elzinga, B. M., Baller, J. F., Boverhof, R., Schwarz, M., Stieger, B., Verkade, H. J., and Kuipers, F., Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice. J. Hepatol., 37, 556-563 (2002).
-
(2002)
J. Hepatol.
, vol.37
, pp. 556-563
-
-
Wolters, H.1
Elzinga, B.M.2
Baller, J.F.3
Boverhof, R.4
Schwarz, M.5
Stieger, B.6
Verkade, H.J.7
Kuipers, F.8
-
150
-
-
0034721159
-
Humanized xenobiotic response in mice expressing nuclear receptor SXR
-
Xie, W., Barwick, J. L., Downes, M., Blumberg, B., Simon, C. M., Nelson, M. C., Neuschwander-Tetri, B. A., Brunt, E. M., Guzelian, P. S., and Evans, R. M., Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature, 406, 435-439 (2000a).
-
(2000)
Nature
, vol.406
, pp. 435-439
-
-
Xie, W.1
Barwick, J.L.2
Downes, M.3
Blumberg, B.4
Simon, C.M.5
Nelson, M.C.6
Neuschwander-Tetri, B.A.7
Brunt, E.M.8
Guzelian, P.S.9
Evans, R.M.10
-
151
-
-
0033638960
-
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
-
Xie, W., Barwick, J. L., Simon, C. M., Pierce, A. M., Safe, S., Blumberg, B., Guzelian, P. S., and Evans, R. M., Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev., 14, 3014-3023 (2000b).
-
(2000)
Genes Dev.
, vol.14
, pp. 3014-3023
-
-
Xie, W.1
Barwick, J.L.2
Simon, C.M.3
Pierce, A.M.4
Safe, S.5
Blumberg, B.6
Guzelian, P.S.7
Evans, R.M.8
-
152
-
-
0035853057
-
An essential role for nuclear receptors SXR/PXR in detoxificationof cholestatic bile acids
-
Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C. M., Nelson, M. C., Ong, E. S., Waxman, D. J., and Evans, R. M., An essential role for nuclear receptors SXR/PXR in detoxificationof cholestatic bile acids. Proc. Natl. Acad. Sci. U.S.A., 98, 3375-3380 (2001).
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 3375-3380
-
-
Xie, W.1
Radominska-Pandya, A.2
Shi, Y.3
Simon, C.M.4
Nelson, M.C.5
Ong, E.S.6
Waxman, D.J.7
Evans, R.M.8
-
153
-
-
0036328387
-
Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital
-
Xiong, H., Yoshinari, K., Brouwer, K. L., and Negishi, M., Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital. Drug Metab. Dispos., 30, 918-923 (2002).
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 918-923
-
-
Xiong, H.1
Yoshinari, K.2
Brouwer, K.L.3
Negishi, M.4
-
154
-
-
0034704079
-
Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism
-
Yu, R., Chen, C., Mo, Y. Y., Hebbar, V., Owuor, E. D., Tan, T. H., and Kong, A. N. T., Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J. Biol. Chem., 275, 39907-39913 (2000a).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39907-39913
-
-
Yu, R.1
Chen, C.2
Mo, Y.Y.3
Hebbar, V.4
Owuor, E.D.5
Tan, T.H.6
Kong, A.N.T.7
-
155
-
-
0033600914
-
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals
-
Yu, R., Lei, W., Mandlekar, S., Weber, M. J., Der, C. J., Wu, J., and Kong, A. N. T., Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals. J. Biol. Chem., 274, 27545-27552 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 27545-27552
-
-
Yu, R.1
Lei, W.2
Mandlekar, S.3
Weber, M.J.4
Der, C.J.5
Wu, J.6
Kong, A.N.T.7
-
156
-
-
0034723357
-
p38 mitogen-activated protein kinase negatively regulates the induction of phase II drug-metabolizing enzymes that detoxify carcinogens
-
Yu, R., Mandlekar, S., Lei, W., Fahl, W. E., Tan, T. H., and Kong, A. N. T., p38 mitogen-activated protein kinase negatively regulates the induction of phase II drug-metabolizing enzymes that detoxify carcinogens. J. Biol. Chem., 275, 2322-2327 (2000b).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2322-2327
-
-
Yu, R.1
Mandlekar, S.2
Lei, W.3
Fahl, W.E.4
Tan, T.H.5
Kong, A.N.T.6
-
157
-
-
0141828972
-
Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis
-
Yu, S., Rao, S., and Reddy, J. K., Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis. Curr. Mol. Med., 3, 561-572 (2003).
-
(2003)
Curr. Mol. Med.
, vol.3
, pp. 561-572
-
-
Yu, S.1
Rao, S.2
Reddy, J.K.3
-
158
-
-
0029857001
-
Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1
-
Zetterstrom, R. H., Solomin, L., Mitsiadis, T., Olson, L., and Perlmann, T., Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1. Mol. Endocrinol., 10, 1656-1666 (1996).
-
(1996)
Mol. Endocrinol.
, vol.10
, pp. 1656-1666
-
-
Zetterstrom, R.H.1
Solomin, L.2
Mitsiadis, T.3
Olson, L.4
Perlmann, T.5
-
159
-
-
0036073480
-
Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: Cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways
-
Zhou, Y. C., Davey, H. W., McLachlan, M. J., Xie, T., and Waxman, D. J., Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways. Toxicol. Appl. Pharmacol., 182, 1-10 (2002).
-
(2002)
Toxicol. Appl. Pharmacol.
, vol.182
, pp. 1-10
-
-
Zhou, Y.C.1
Davey, H.W.2
McLachlan, M.J.3
Xie, T.4
Waxman, D.J.5
|