Route dependent pulmonary first-pass metabolism of a series of biphenylacetic acid esters in rats

European Journal of Pharmaceutical Sciences

Volumn 6, Issue 1, 1998, Pages 11-18

  Dickinson, Paul A ^a   Taylor, Glyn ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

4 Biphenylacetic acid; Enzyme kinetics; Ester; Extra hepatic metabolism; First pass metabolism; Lung

Indexed keywords

BIPHENYLACETIC ACID ESTER DERIVATIVE; DODECYL BIPHENYLACETATE; FELBINAC; HEXYL BIPHENYLACETATE; OCTYL BIPHENYLACETATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; ENZYME KINETICS; FIRST PASS EFFECT; INTRAARTERIAL DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG PARENCHYMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; EMULSIONS; ESTERS; HALF-LIFE; INJECTIONS, INTRA-ARTERIAL; INJECTIONS, INTRAVENOUS; INTUBATION, INTRATRACHEAL; LUNG; MALE; METABOLIC CLEARANCE RATE; PHENYLACETATES; RATS; RATS, WISTAR; SOLUTIONS; SUSPENSIONS;

EID: 0031963129     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(97)00062-6     Document Type: Article

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