Integrating in vitro kinetic data from compounds exhibiting induction, reversible inhibition and mechanism-based inactivation: In vitro study design

Current Drug Metabolism

Volumn 5, Issue 2, 2004, Pages 141-146

  McConn, Donavon J ^a   Zhao, Zhiyang ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Drug:drug interaction; Enzyme kinetics; In vitro; Induction; Inhibition; Mechanism based inactivation; Ritonavir

Indexed keywords

ANTIBIOTIC AGENT; CELL NUCLEUS RECEPTOR; CISAPRIDE; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C9; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; DILTIAZEM; DRUG METABOLIZING ENZYME; MACROLIDE; MIBEFRADIL; MIDAZOLAM; PREGNANE X RECEPTOR; RITONAVIR; TERFENADINE; TROLEANDOMYCIN;

DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG INTERACTION; DRUG METABOLISM; ENZYME INACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME METABOLISM; ENZYME REGULATION; ENZYME SUBSTRATE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MICHAELIS MENTEN KINETICS; MONOTHERAPY; PLASMA PROTEIN BINDING; PROTEIN EXPRESSION; REVIEW;

DATA INTERPRETATION, STATISTICAL; DRUG INTERACTIONS; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RESEARCH DESIGN;

EID: 1942421316     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200043489063     Document Type: Review

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