-
1
-
-
0016566218
-
Commentary: A physiological approach to hepatic drug clearance
-
Wilkinson GR, Shand DG. Commentary: a physiological approach to hepatic drug clearance. Clin Pharmacol Ther 1975; 18 (4): 377-90
-
(1975)
Clin Pharmacol Ther
, vol.18
, Issue.4
, pp. 377-390
-
-
Wilkinson, G.R.1
Shand, D.G.2
-
2
-
-
0017603437
-
Hepatic clearance of drugs: I. Theoretical considerations of a 'well-stirred' model and a 'parallel tube' model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance
-
Pang KS, Rowland M. Hepatic clearance of drugs: I. Theoretical considerations of a 'well-stirred' model and a 'parallel tube' model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance. J Pharmacokinet Biopharm 1977; 5 (6): 625-53
-
(1977)
J Pharmacokinet Biopharm
, vol.5
, Issue.6
, pp. 625-653
-
-
Pang, K.S.1
Rowland, M.2
-
3
-
-
0028342648
-
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
-
Houston JB. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem Pharmacol 1994; 47 (9): 1469-79
-
(1994)
Biochem Pharmacol
, vol.47
, Issue.9
, pp. 1469-1479
-
-
Houston, J.B.1
-
4
-
-
0344333422
-
Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices
-
Houston JB, Carlile DJ. Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices. Drug Metab Rev 1997; 29 (4): 891-922
-
(1997)
Drug Metab Rev
, vol.29
, Issue.4
, pp. 891-922
-
-
Houston, J.B.1
Carlile, D.J.2
-
5
-
-
0036206152
-
Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: Effect on atypical kinetic metabolism profiles
-
Tracy TS, Hutzler JM, Haining RL, et al. Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles. Drug Metab Dispos 2002; 30 (4): 385-90
-
(2002)
Drug Metab Dispos
, vol.30
, Issue.4
, pp. 385-390
-
-
Tracy, T.S.1
Hutzler, J.M.2
Haining, R.L.3
-
6
-
-
0000574406
-
Evaluation of atypical cytochrome P450 kinetics with two-substrate models: Evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites
-
Korzekwa KR, Krishnamachary N, Shou M, et al. Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites. Biochemistry 1998; 37 (12): 4137-47
-
(1998)
Biochemistry
, vol.37
, Issue.12
, pp. 4137-4147
-
-
Korzekwa, K.R.1
Krishnamachary, N.2
Shou, M.3
-
7
-
-
0033564235
-
Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: An example of the metabolism of diazepam and its derivatives
-
Shou M, Mei Q, Ettore Jr MW, et al. Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. Biochem J 1999; 340 (Pt 3): 845-53
-
(1999)
Biochem J
, vol.340
, Issue.PART 3
, pp. 845-853
-
-
Shou, M.1
Mei, Q.2
Ettore Jr., M.W.3
-
8
-
-
0035910579
-
A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4
-
Shou M, Dai R, Cui D, et al. A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4. J Biol Chem 2001; 276 (3): 2256-62
-
(2001)
J Biol Chem
, vol.276
, Issue.3
, pp. 2256-2262
-
-
Shou, M.1
Dai, R.2
Cui, D.3
-
9
-
-
1842866515
-
Quinidine and haloperidol as modifiers of CYP3A4 activity: Multisite kinetic model approach
-
Galetin A, Clarke SE, Houston JB. Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos 2002; 30 (12): 1512-22
-
(2002)
Drug Metab Dispos
, vol.30
, Issue.12
, pp. 1512-1522
-
-
Galetin, A.1
Clarke, S.E.2
Houston, J.B.3
-
10
-
-
0042357511
-
Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: Midazolam, testosterone, and nifedipine
-
Galetin A, Clarke SE, Houston JB. Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine. Drug Metab Dispos 2003; 31 (9): 1108-16
-
(2003)
Drug Metab Dispos
, vol.31
, Issue.9
, pp. 1108-1116
-
-
Galetin, A.1
Clarke, S.E.2
Houston, J.B.3
-
11
-
-
0035193493
-
Multisite kinetic models for CYP3A4: Simultaneous activation and inhibition of diazepam and testosterone metabolism
-
Kenworthy KE, Clarke SE, Andrews J, et al. Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism. Drug Metab Dispos 2001; 29 (12): 1644-51
-
(2001)
Drug Metab Dispos
, vol.29
, Issue.12
, pp. 1644-1651
-
-
Kenworthy, K.E.1
Clarke, S.E.2
Andrews, J.3
-
12
-
-
0032968065
-
Sigmoidal kinetics of CYP3A substrates: An approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat
-
Witherow LE, Houston JB. Sigmoidal kinetics of CYP3A substrates: an approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat. J Pharmacol Exp Ther 1999; 290 (1): 58-65
-
(1999)
J Pharmacol Exp Ther
, vol.290
, Issue.1
, pp. 58-65
-
-
Witherow, L.E.1
Houston, J.B.2
-
13
-
-
0028307539
-
Activation of CYP3A4: Evidence for the simultaneous binding of two substrates in a cytochrome P450 active site
-
Shou M, Grogan J, Mancewicz JA, et al. Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site. Biochemistry 1994; 33 (21): 6450-5
-
(1994)
Biochemistry
, vol.33
, Issue.21
, pp. 6450-6455
-
-
Shou, M.1
Grogan, J.2
Mancewicz, J.A.3
-
14
-
-
0034009448
-
In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin
-
Fisher MB, Campanale K, Ackermann BL, et al. In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin. Drug Metab Dispos 2000; 28 (5): 560-6
-
(2000)
Drug Metab Dispos
, vol.28
, Issue.5
, pp. 560-566
-
-
Fisher, M.B.1
Campanale, K.2
Ackermann, B.L.3
-
15
-
-
26444551640
-
S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): Role of UGT2B7 in the elimination of naproxen
-
Bowalgaha K, Elliot DJ, Mackenzie PI, et al. S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol 2005; 60 (4): 423-33
-
(2005)
Br J Clin Pharmacol
, vol.60
, Issue.4
, pp. 423-433
-
-
Bowalgaha, K.1
Elliot, D.J.2
Mackenzie, P.I.3
-
16
-
-
33646784394
-
In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction
-
Rowland A, Elliot DJ, Williams JA, et al. In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction. Drug Metab Dispos 2006; 34 (6): 1055-62
-
(2006)
Drug Metab Dispos
, vol.34
, Issue.6
, pp. 1055-1062
-
-
Rowland, A.1
Elliot, D.J.2
Williams, J.A.3
-
17
-
-
0042679455
-
Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human UDP-glucuronosyltransferases: Evidence for atypical glucuronidation kinetics by UGT2B7
-
Stone AN, Mackenzie PI, Galetin A, et al. Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human UDP- glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7. Drug Metab Dispos 2003; 31 (9): 1086-9
-
(2003)
Drug Metab Dispos
, vol.31
, Issue.9
, pp. 1086-1089
-
-
Stone, A.N.1
Mackenzie, P.I.2
Galetin, A.3
-
18
-
-
1842536833
-
Human UDP-glucuronosyltransferases: Isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid
-
Uchaipichat V, Mackenzie PI, Guo XH, et al. Human UDP- glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid. Drug Metab Dispos 2004; 32 (4): 413-23
-
(2004)
Drug Metab Dispos
, vol.32
, Issue.4
, pp. 413-423
-
-
Uchaipichat, V.1
Mackenzie, P.I.2
Guo, X.H.3
-
19
-
-
0345549371
-
Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): Kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7
-
Tsoutsikos P, Miners JO, Stapleton A, et al. Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7. Biochem Pharmacol 2004; 67 (1): 191-9
-
(2004)
Biochem Pharmacol
, vol.67
, Issue.1
, pp. 191-199
-
-
Tsoutsikos, P.1
Miners, J.O.2
Stapleton, A.3
-
20
-
-
33645816779
-
N-glucuronidation of the platelet-derived growth factor receptor tyrosine kinase inhibitor 6,7-(dimethoxy-2,4-dihydroindeno[1,2-C]pyrazol-3 -yl)-(3-fluoro-phenyl)-amine by human UDP-glucuronosyltransferases
-
Yan Z, Caldwell GW, Gauthier D, et al. N-glucuronidation of the platelet-derived growth factor receptor tyrosine kinase inhibitor 6,7-(dimethoxy-2,4-dihydroindeno[1,2-C]pyrazol-3 -yl)-(3-fluoro-phenyl)-amine by human UDP-glucuronosyltransferases. Drug Metab Dispos 2006; 34 (5): 748-55
-
(2006)
Drug Metab Dispos
, vol.34
, Issue.5
, pp. 748-755
-
-
Yan, Z.1
Caldwell, G.W.2
Gauthier, D.3
-
21
-
-
3042683736
-
Human UDP-glucuronosyl-transferases show atypical metabolism of mycophenolic acid and inhibition by curcumin
-
Basu NK, Kole L, Kubota S, et al. Human UDP-glucuronosyl-transferases show atypical metabolism of mycophenolic acid and inhibition by curcumin. Drug Metab Dispos 2004; 32 (7): 768-73
-
(2004)
Drug Metab Dispos
, vol.32
, Issue.7
, pp. 768-773
-
-
Basu, N.K.1
Kole, L.2
Kubota, S.3
-
22
-
-
0036843701
-
Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes
-
Williams JA, Ring BJ, Cantrell VE, et al. Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes. Drug Metab Dispos 2002; 30 (11): 1266-73
-
(2002)
Drug Metab Dispos
, vol.30
, Issue.11
, pp. 1266-1273
-
-
Williams, J.A.1
Ring, B.J.2
Cantrell, V.E.3
-
23
-
-
27944483765
-
Isoflavones modulate the glucuronidation of estradiol in human liver microsomes
-
Pfeiffer E, Treiling CR, Hoehle SI, et al. Isoflavones modulate the glucuronidation of estradiol in human liver microsomes. Carcinogenesis 2005; 26 (12): 2172-8
-
(2005)
Carcinogenesis
, vol.26
, Issue.12
, pp. 2172-2178
-
-
Pfeiffer, E.1
Treiling, C.R.2
Hoehle, S.I.3
-
24
-
-
2642555502
-
Effector-mediated alteration of substrate orientation in cytochrome P450 2C9
-
Hummel MA, Gannett PM, Aguilar JS, et al. Effector-mediated alteration of substrate orientation in cytochrome P450 2C9. Biochemistry 2004; 43 (22): 7207-14
-
(2004)
Biochemistry
, vol.43
, Issue.22
, pp. 7207-7214
-
-
Hummel, M.A.1
Gannett, P.M.2
Aguilar, J.S.3
-
25
-
-
0038691508
-
A method for determining two substrates binding in the same active site of cytochrome P450BM3: An explanation of high energy omega product formation
-
Rock DA, Perkins BN, Wahlstrom J, et al. A method for determining two substrates binding in the same active site of cytochrome P450BM3: an explanation of high energy omega product formation. Arch Biochem Biophys 2003; 416 (1): 9-16
-
(2003)
Arch Biochem Biophys
, vol.416
, Issue.1
, pp. 9-16
-
-
Rock, D.A.1
Perkins, B.N.2
Wahlstrom, J.3
-
26
-
-
0037048522
-
Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: Evidence for a multiple substrate binding site
-
Dabrowski MJ, Schrag ML, Wienkers LC, et al. Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site. J Am Chem Soc 2002; 124 (40): 11866-7
-
(2002)
J Am Chem Soc
, vol.124
, Issue.40
, pp. 11866-11867
-
-
Dabrowski, M.J.1
Schrag, M.L.2
Wienkers, L.C.3
-
27
-
-
0031022331
-
Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone
-
Koley AP, Buters JT, Robinson RC, et al. Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone. J Biol Chem 1997; 272 (6): 3149-52
-
(1997)
J Biol Chem
, vol.272
, Issue.6
, pp. 3149-3152
-
-
Koley, A.P.1
Buters, J.T.2
Robinson, R.C.3
-
28
-
-
0031581857
-
Drug-drug interactions: Effect of quinidine on nifedipine binding to human cytochrome P450 3A4
-
Koley AP, Robinson RC, Markowitz A, et al. Drug-drug interactions: effect of quinidine on nifedipine binding to human cytochrome P450 3A4. Biochem Pharmacol 1997; 53 (4): 455-60
-
(1997)
Biochem Pharmacol
, vol.53
, Issue.4
, pp. 455-460
-
-
Koley, A.P.1
Robinson, R.C.2
Markowitz, A.3
-
29
-
-
0028986596
-
CO binding kinetics of human cytochrome P450 3A4. Specific interaction of substrates with kinetically distinguishable conformers
-
Koley AP, Buters JT, Robinson RC, et al. CO binding kinetics of human cytochrome P450 3A4. Specific interaction of substrates with kinetically distinguishable conformers. J Biol Chem 1995; 270 (10): 5014-8
-
(1995)
J Biol Chem
, vol.270
, Issue.10
, pp. 5014-5018
-
-
Koley, A.P.1
Buters, J.T.2
Robinson, R.C.3
-
30
-
-
0035059352
-
Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions: A prospective based on conformational dynamics
-
Atkins WM, Wang RW, Lu AY. Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions: a prospective based on conformational dynamics. Chem Res Toxicol 2001; 14 (4): 338-47
-
(2001)
Chem Res Toxicol
, vol.14
, Issue.4
, pp. 338-347
-
-
Atkins, W.M.1
Wang, R.W.2
Lu, A.Y.3
-
31
-
-
3442896773
-
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
-
Williams PA, Cosme J, Vinkovic DM, et al. Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone. Science 2004; 305 (5684): 683-6
-
(2004)
Science
, vol.305
, Issue.5684
, pp. 683-686
-
-
Williams, P.A.1
Cosme, J.2
Vinkovic, D.M.3
-
32
-
-
1542364450
-
Structure of human microsomal cytochrome P450 2C8: Evidence for a peripheral fatty acid binding site
-
Schoch GA, Yano JK, Wester MR, et al. Structure of human microsomal cytochrome P450 2C8: evidence for a peripheral fatty acid binding site. J Biol Chem 2004; 279 (10): 9497-503
-
(2004)
J Biol Chem
, vol.279
, Issue.10
, pp. 9497-9503
-
-
Schoch, G.A.1
Yano, J.K.2
Wester, M.R.3
-
33
-
-
0003043542
-
The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves
-
Hill AV. The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 1910; 40: iv-vii
-
(1910)
J Physiol
, vol.40
-
-
Hill, A.V.1
-
34
-
-
0034105896
-
In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model
-
Houston JB, Kenworthy KE. In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model. Drug Metab Dispos 2000; 28 (3): 246-54
-
(2000)
Drug Metab Dispos
, vol.28
, Issue.3
, pp. 246-254
-
-
Houston, J.B.1
Kenworthy, K.E.2
-
35
-
-
0346992330
-
Progress towards prediction of human pharmacokinetic parameters from in vitro technologies
-
Houston JB, Galetin A. Progress towards prediction of human pharmacokinetic parameters from in vitro technologies. Drug Metab Rev 2003; 35 (4): 393-415
-
(2003)
Drug Metab Rev
, vol.35
, Issue.4
, pp. 393-415
-
-
Houston, J.B.1
Galetin, A.2
-
36
-
-
0035004408
-
Enzyme kinetics of cytochrome P450-mediated reactions
-
Shou M, Lin Y, Lu P, et al. Enzyme kinetics of cytochrome P450-mediated reactions. Curr Drug Metab 2001; 2 (1): 17-36
-
(2001)
Curr Drug Metab
, vol.2
, Issue.1
, pp. 17-36
-
-
Shou, M.1
Lin, Y.2
Lu, P.3
-
37
-
-
0037325958
-
Activation of cytochrome P450 2C9-mediated metabolism: Mechanistic evidence in support of kinetic observations
-
Hutzler JM, Wienkers LC, Wahlstrom JL, et al. Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations. Arch Biochem Biophys 2003; 410: 16-24
-
(2003)
Arch Biochem Biophys
, vol.410
, pp. 16-24
-
-
Hutzler, J.M.1
Wienkers, L.C.2
Wahlstrom, J.L.3
-
38
-
-
0034956877
-
Dapsone activation of CYP2C9-mediated metabolism: Evidence for activation of multiple substrates and a two-site model
-
Hutzler JM, Hauer MJ, Tracy TS. Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model. Drug Metab Dispos 2001; 29 (7): 1029-34
-
(2001)
Drug Metab Dispos
, vol.29
, Issue.7
, pp. 1029-1034
-
-
Hutzler, J.M.1
Hauer, M.J.2
Tracy, T.S.3
-
39
-
-
0037229515
-
Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling
-
He YA, Roussel F, Halpert JR. Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling. Arch Biochem Biophys 2003; 409 (1): 92-101
-
(2003)
Arch Biochem Biophys
, vol.409
, Issue.1
, pp. 92-101
-
-
He, Y.A.1
Roussel, F.2
Halpert, J.R.3
-
40
-
-
33750547308
-
CYP2C9 inhibition: Impact of probe selection and pharmacogenetics on in vitro inhibition profiles
-
Epub
-
Kumar V, Wahlstrom JL, Rock DA, et al.. CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. Drug Metab Dispos. Epub 2006
-
(2006)
Drug Metab Dispos
-
-
Kumar, V.1
Wahlstrom, J.L.2
Rock, D.A.3
Al, E.4
-
41
-
-
23044500208
-
CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions
-
Galetin A, Ito K, Hallifax D, et al. CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions. J Pharmacol Exp Ther 2005; 314 (1): 180-90
-
(2005)
J Pharmacol Exp Ther
, vol.314
, Issue.1
, pp. 180-190
-
-
Galetin, A.1
Ito, K.2
Hallifax, D.3
-
42
-
-
0032735988
-
CYP3A4 drug interactions: Correlation of 10 in vitro probe substrates
-
Kenworthy KE, Bloomer JC, Clarke SE, et al. CYP3A4 drug interactions: correlation of 10 in vitro probe substrates. Br J Clin Pharmacol 1999; 48 (5): 716-27
-
(1999)
Br J Clin Pharmacol
, vol.48
, Issue.5
, pp. 716-727
-
-
Kenworthy, K.E.1
Bloomer, J.C.2
Clarke, S.E.3
-
43
-
-
0036118686
-
Factors confounding the successful extrapolation of in vitro CYP3A inhibition information to the in vivo condition
-
Wienkers LC. Factors confounding the successful extrapolation of in vitro CYP3A inhibition information to the in vivo condition. Eur J Pharm Sci 2002; 15: 239-42
-
(2002)
Eur J Pharm Sci
, vol.15
, pp. 239-242
-
-
Wienkers, L.C.1
-
44
-
-
0034109883
-
Microsomal binding of amitriptyline: Effect on estimation of enzyme kinetic parameters in vitro
-
Venkatakrishnan K, von Moltke LL, Obach RS, et al. Microsomal binding of amitriptyline: effect on estimation of enzyme kinetic parameters in vitro. J Pharmacol Exp Ther 2000; 293 (2): 343-50
-
(2000)
J Pharmacol Exp Ther
, vol.293
, Issue.2
, pp. 343-350
-
-
Venkatakrishnan, K.1
Von Moltke, L.L.2
Obach, R.S.3
-
45
-
-
0031466149
-
Nonspecific binding to microsomes: Impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol
-
Obach RS. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol. Drug Metab Dispos 1997; 25 (12): 1359-69
-
(1997)
Drug Metab Dispos
, vol.25
, Issue.12
, pp. 1359-1369
-
-
Obach, R.S.1
-
46
-
-
0042664035
-
Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: The potential role of multiple oxygenating species
-
Hutzler JM, Powers FJ, Wynalda MA, et al. Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: the potential role of multiple oxygenating species. Arch Biochem Biophys 2003; 417 (2): 165-75
-
(2003)
Arch Biochem Biophys
, vol.417
, Issue.2
, pp. 165-175
-
-
Hutzler, J.M.1
Powers, F.J.2
Wynalda, M.A.3
-
47
-
-
0031921010
-
Evaluation of the selectivity of in vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities
-
Hickman D, Wang JP, Wang Y, et al. Evaluation of the selectivity of in vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities. Drug Metab Dispos 1998; 26 (3): 207-15
-
(1998)
Drug Metab Dispos
, vol.26
, Issue.3
, pp. 207-215
-
-
Hickman, D.1
Wang, J.P.2
Wang, Y.3
-
48
-
-
0034007499
-
Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity
-
Tang C, Shou M, Rodrigues AD. Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity. Drug Metab Dispos 2000; 28 (5): 567-72
-
(2000)
Drug Metab Dispos
, vol.28
, Issue.5
, pp. 567-572
-
-
Tang, C.1
Shou, M.2
Rodrigues, A.D.3
-
49
-
-
19444375135
-
Catalytic turnover of pyrene by CYP3A4: Evidence that cytochrome b5 directly induces positive cooperativity
-
Jushchyshyn MI, Hutzler JM, Schrag ML, et al. Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity. Arch Biochem Biophys 2005; 438 (1): 21-8
-
(2005)
Arch Biochem Biophys
, vol.438
, Issue.1
, pp. 21-28
-
-
Jushchyshyn, M.I.1
Hutzler, J.M.2
Schrag, M.L.3
-
50
-
-
0032732349
-
Interaction of diclofenac and quinidine in monkeys: Stimulation of diclofenac metabolism
-
Tang W, Stearns RA, Kwei GY, et al. Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism. J Pharmacol Exp Ther 1999; 291 (3): 1068-74
-
(1999)
J Pharmacol Exp Ther
, vol.291
, Issue.3
, pp. 1068-1074
-
-
Tang, W.1
Stearns, R.A.2
Kwei, G.Y.3
-
51
-
-
0034934070
-
Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone
-
Hutzler JM, Frye RF, Korzekwa KR, et al. Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone. Eur J Pharm Sci 2001; 14 (1): 47-52
-
(2001)
Eur J Pharm Sci
, vol.14
, Issue.1
, pp. 47-52
-
-
Hutzler, J.M.1
Frye, R.F.2
Korzekwa, K.R.3
-
52
-
-
0037799740
-
In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine
-
Egnell AC, Houston B, Boyer S. In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine. J Pharmacol Exp Ther 2003 Jun; 305 (3): 1251-62
-
(2003)
J Pharmacol Exp Ther
, vol.305
, Issue.3
, pp. 1251-1262
-
-
Egnell, A.C.1
Houston, B.2
Boyer, S.3
-
53
-
-
0032724140
-
Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam
-
Backman JT, Wang JS, Wen X, et al. Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam. Clin Pharmacol Ther 1999; 66 (4): 401-7
-
(1999)
Clin Pharmacol Ther
, vol.66
, Issue.4
, pp. 401-407
-
-
Backman, J.T.1
Wang, J.S.2
Wen, X.3
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