The effect of ageing on cytochrome P450 enzymes: Consequences for drug biotransformation in the elderly

Current Medicinal Chemistry

Volumn 14, Issue 7, 2007, Pages 745-757

  Wauthier, V ^a   Verbeeck, R K ^a   Calderon, P Buc ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Ageing; Cytochrome P450; Drug metabolism; Growth hormone

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR 1; CHLORZOXAZONE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME B5 REDUCTASE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C11; CYTOCHROME P450 2C12; CYTOCHROME P450 2C18; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A2; CYTOCHROME P450 3A4; DICLOFENAC; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MIDAZOLAM; MIXED FUNCTION OXIDASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHENACETIN; PHENAZONE; PREGNANE X RECEPTOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; RETINOID X RECEPTOR; TRIAZOLAM;

AGING; CLINICAL TRIAL; DRUG CLEARANCE; DRUG EFFICACY; DRUG ELIMINATION; DRUG METABOLISM; DRUG OXIDATION; DRUG SAFETY; DRUG TRANSFORMATION; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME REGULATION; GROWTH HORMONE RELEASE; HUMAN; LIVER CLEARANCE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; REVIEW; SEX DIFFERENCE; TRANSLATION INITIATION;

AGE FACTORS; AGED; ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; ISOENZYMES; LIVER; PHARMACEUTICAL PREPARATIONS; SEX FACTORS;

EID: 33947611171     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986707780090981     Document Type: Review

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