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Volumn 4, Issue 2, 2008, Pages 151-164
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The use of hepatocytes in evaluating time-dependent inactivation of P450 in vivo
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Author keywords
Hepatocytes; In vitro in vivo correlation; Time dependent inactivation
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Indexed keywords
AMPRENAVIR;
AZITHROMYCIN;
CLARITHROMYCIN;
CP 100356;
CYTOCHROME P450;
DELAVIRDINE;
DIGOXIN;
DILTIAZEM;
DPC 681;
ERYTHROMYCIN;
FLUOXETINE;
GLYCOPROTEIN P INHIBITOR;
ITRACONAZOLE;
MIBEFRADIL;
MIDAZOLAM;
N NORDILTIAZEM;
PAROXETINE;
PROTEINASE INHIBITOR;
RALOXIFENE;
TERFENADINE;
TROLEANDOMYCIN;
UNCLASSIFIED DRUG;
AREA UNDER THE CURVE;
CATALYSIS;
CORRELATIONAL STUDY;
CRYOPRESERVATION;
DISEASE MARKER;
DRUG ABSORPTION;
DRUG CLEARANCE;
DRUG ELIMINATION;
DRUG HALF LIFE;
DRUG INHIBITION;
DRUG INTERACTION;
DRUG MECHANISM;
DRUG METABOLISM;
DRUG POTENCY;
DRUG POTENTIATION;
DRUG WITHDRAWAL;
ENZYME ACTIVITY;
ENZYME BLOOD LEVEL;
ENZYME DEGRADATION;
ENZYME INHIBITION;
GENE INACTIVATION;
HOMEOSTASIS;
HUMAN;
IC 50;
IN VITRO STUDY;
IN VIVO STUDY;
LIVER CELL;
LIVER FUNCTION;
LIVER MICROSOME;
PREDICTION;
PROTEIN BINDING;
PROTEIN BLOOD LEVEL;
REVIEW;
SHIFT TO THE LEFT;
SHIFT TO THE RIGHT;
TIME DEPENDENT INACTIVATION;
UNSPECIFIED SIDE EFFECT;
CYTOCHROME P-450 ENZYME SYSTEM;
DRUG INTERACTIONS;
ENZYME ACTIVATION;
ENZYME INHIBITORS;
FORECASTING;
HEPATOCYTES;
HUMANS;
MICROSOMES, LIVER;
MODELS, BIOLOGICAL;
PHARMACEUTICAL PREPARATIONS;
TIME FACTORS;
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EID: 39749143423
PISSN: 17425255
EISSN: None
Source Type: Journal
DOI: 10.1517/17425255.4.2.151 Document Type: Review |
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Times cited : (23)
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References (76)
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