Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation

Molecular Pharmacology

Volumn 64, Issue 1, 2003, Pages 160-169

  Dvořák, Zdeňek ^a,b   Modrianský, Martin ^a   Pichard Garcia, Lydiane ^b   Balaguer, Patrick ^c   Vilarem, Marie Jose ^b   Ulrichova, Jitka ^a   Maurel, Patrick ^b   Pascussi, Jean Marc ^b  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b CNRS   (France)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B6; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; LUCIFERASE; MESSENGER RNA; PHENOBARBITAL; PREGNANE X RECEPTOR; RIFAMPICIN; STEROID RECEPTOR; TUBULIN; TYROSINE AMINOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; EMBRYO CELL; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; LIGAND BINDING; LIVER CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION;

EID: 0037561538     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.1.160     Document Type: Article

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