Electrospray ionization mass spectrometric analysis of intact cytochrome P450: Identification of tienilic acid adducts to P450 2C9

Biochemistry

Volumn 38, Issue 8, 1999, Pages 2312-2319

  Koenigs, Luke L ^a,d   Peter, Raimund M ^a,e   Hunter, Ann P ^a,f   Haining, Robert L ^a   Rettie, Allan E ^a   Friedberg, Thomas ^b   Pritchard, Michael P ^b   Shou, Magang ^c   Rushmore, Thomas H ^c   Trager, William F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NOVARTIS PHARMA AG   (Switzerland)

^f SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; CYTOCHROME P450 REDUCTASE; GLUTATHIONE; TIENILIC ACID;

ACCURACY; ANALYTIC METHOD; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME MODIFICATION; ENZYME PURIFICATION; ENZYME STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BACULOVIRIDAE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRONS; ENZYME ACTIVATION; GENETIC VECTORS; HUMANS; RATS; RECOMBINANT PROTEINS; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; TICRYNAFEN;

INSECTA; UNIDENTIFIED BACULOVIRUS;

EID: 0033596707     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9823030     Document Type: Article

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