Acetaminophen-induced hepatotoxicity

Drug Metabolism and Disposition

Volumn 31, Issue 12, 2003, Pages 1499-1506

  James, Laura P ^a,b   Mayeux, Philip R ^a   Hinson, Jack A ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ACETYLCYSTEINE; ANALGESIC AGENT; BENZOQUINONE DERIVATIVE; CHEMOKINE; CYCLOOXYGENASE 2; CYTOCHROME P450; CYTOKINE; GLUTATHIONE; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MACROPHAGE MIGRATION INHIBITION FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; PARACETAMOL; PEROXYNITRITE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; TRANSFORMING GROWTH FACTOR ALPHA; TYROSINE DERIVATIVE;

BLOOD LEVEL; CORRELATION ANALYSIS; COVALENT BOND; CYTOKINE PRODUCTION; DRUG DETOXIFICATION; DRUG METABOLISM; ENZYME INDUCTION; INFLAMMATION; KNOCKOUT MOUSE; KUPFFER CELL; LIPID PEROXIDATION; LIVER TOXICITY; METABOLITE; MITOCHONDRIAL MYOPATHY; NITRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; STATISTICAL SIGNIFICANCE; TOXICOKINETICS; WILD TYPE;

ACETAMINOPHEN; ACETYLCYSTEINE; ANALGESICS, NON-NARCOTIC; ANTIDOTES; CYTOKINES; HUMANS; KUPFFER CELLS; LIVER DISEASES; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; TYROSINE;

EID: 0344412840     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.12.1499     Document Type: Review

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