Flunitrazepam metabolism by cytochrome P450s 2C19 and 3A4

Drug Metabolism and Disposition

Volumn 29, Issue 4 I, 2001, Pages 460-465

  Kilicarslan, Tansel ^a,b   Haining, Robert L ^c   Rettie, Allan E ^c   Busto, Usanda ^a,b   Tyndale, Rachel F ^a,b   Sellers, Edward M ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF WASHINGTON   (United States)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; FLUNITRAZEPAM; KETOCONAZOLE; MEPHENYTOIN; NORFLUNITRAZEPAM;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DEMETHYLATION; DRUG EFFICACY; DRUG SAFETY; HUMAN; HUMAN TISSUE; LIPID SOLUBILITY; LIPOPHILICITY; PRIORITY JOURNAL;

ANTI-ANXIETY AGENTS; ANTIBODIES; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; ENZYME INHIBITORS; FLUNITRAZEPAM; HUMANS; KINETICS; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES;

EID: 0035059510     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism
2. Delayed recovery from a sedative: Correlation of the plasma levels of diazepam with clinical effects after oral and intravenous administration
3. Pharmacokinetics of flunitrazepam following single- and multiple-dose oral administration to healthy human subjects
4. Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes
5. Abuse of flunitrazepam (Rohypnol) and other benzodiazepines in Austin and south Texas
6. Comparative pharmacokinetics of diazepam and flunitrazepam
7. Genetic polymorphism of S-mephenytoin 4′-hydroxylation
8. Biochemistry and molecular biology of the human CYP2C subfamily
9. Allelic variants of human cytochrome P450 2C9: Baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and 1359L mutant forms
10. Role of phospholipids in reconstituted cytochrome P450 3A form and mechanism of their activation of catalytic activity
11. High rates of substrate hydroxylation by human cytochrome P450 3A4 in reconstituted membranous vesicles: Influence of membrane charge
12. M diazepam N-demethylases
13. Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: The effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone
14. Flunitrazepam: A review of its pharmacological properties and therapeutic use
15. Flunitrazepam consumption among heroin addicts admitted for in-patient detoxification
16. Rohypnol misuse in the United States
17. Long-term sleep laboratory evaluation of flunitrazepam
18. Rohypnol, the date rape drug
19. Pharmacokinetics of flunitrazepam
20. Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens, and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
21. Evidence in humans for variant allozymes of the nondeficient sparteine/debrisoquine monooxygenase (P450IID1) in vitro
22. Pharmacokinetic and clinical observations on prolonged administration of flunitrazepam