Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: Enzyme kinetics, cytochrome p450 isoform identity, and in vitro-in vivo correlation

Drug Metabolism and Disposition

Volumn 28, Issue 9, 2000, Pages 1069-1076

  Obach, R Scott ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CJ 12458; CJ 12764; CYTOCHROME P450; DRUG METABOLITE; EZLOPITANT; SUBSTANCE P ANTAGONIST; SUBSTANCE P RECEPTOR; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER METABOLISM; LIVER MICROSOME; MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BENZYLAMINES; BICYCLO COMPOUNDS, HETEROCYCLIC; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; ENZYME INHIBITORS; GUINEA PIGS; HAPLORHINI; HUMANS; ISOENZYMES; KETOCONAZOLE; KINETICS; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; QUINIDINE; RATS; RECEPTORS, NEUROKININ-1; SPECIES SPECIFICITY; SULFAPHENAZOLE; TRITIUM; TROLEANDOMYCIN;

EID: 0033840074     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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