Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: Major role of CYP3A

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 2, 2001, Pages 508-520

  Desta, Zeruesenay ^a   Soukhova, Nadia ^a   Morocho, Alan M ^a   Flockhart, David A ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 FLUORO 4 HYDROXYCISAPRIDE; 4 FLUORO 2 HYDROXYCISAPRIDE; CISAPRIDE; CYTOCHROME P450; CYTOCHROME P450 3A; NORCISAPRIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHIRALITY; CONTROLLED STUDY; DEALKYLATION; DRUG ACTIVITY; DRUG DISPOSITION; DRUG EFFICACY; DRUG METABOLISM; DRUG SAFETY; ENANTIOMER; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOMERISM; KINETICS; LIVER MICROSOME; MICHAELIS CONSTANT; PRIORITY JOURNAL; STEREOCHEMISTRY;

ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CISAPRIDE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; KINETICS; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 0034913661     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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