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Volumn 63, Issue 8, 2003, Pages 769-802

Lopinavir/ritonavir: A review of its use in the management of HIV infection

Author keywords

Adults; AIDS; Children; Coformulation; HIV 1; Lopinavir ritonavir; Pharmacodynamics; Pharmacokinetics; Therapeutic use

Indexed keywords

AMPRENAVIR; ANTIARRHYTHMIC AGENT; ANTIHISTAMINIC AGENT; ASTEMIZOLE; CHOLESTEROL; CISAPRIDE; CYCLOSPORIN; DIHYDROERGOTAMINE; DISULFIRAM; EFAVIRENZ; ERGOMETRINE; ERGOT DERIVATIVE; ERGOTAMINE; FLECAINIDE; IMMUNOSUPPRESSIVE AGENT; INDINAVIR; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; METHYLERGOMETRINE; METRONIDAZOLE; MIDAZOLAM; NELFINAVIR; PIMOZIDE; PROPAFENONE; RAPAMYCIN; RITONAVIR; TACROLIMUS; TERFENADINE; TRIAZOLAM; UNINDEXED DRUG;

EID: 0037251643     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-200363080-00004     Document Type: Review
Times cited : (368)

References (150)
  • 2
    • 0031788930 scopus 로고    scopus 로고
    • ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease
    • Sham HL, Kempf DJ, Molla A, et al. ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob Agents Chemother 1998; 42 (12): 3218-24
    • (1998) Antimicrob Agents Chemother , vol.42 , Issue.12 , pp. 3218-3224
    • Sham, H.L.1    Kempf, D.J.2    Molla, A.3
  • 3
    • 17044457875 scopus 로고    scopus 로고
    • ABT-378/ritonavir plus stavudine and lamivudine for the treatment of antiretroviral-naive adults with HIV-1 infection: 48-Week results
    • Jan 5
    • Murphy RL, Brun S, Hicks C, et al. ABT-378/ritonavir plus stavudine and lamivudine for the treatment of antiretroviral-naive adults with HIV-1 infection: 48-week results. AIDS 2001 Jan 5; 15 (1): F1-9
    • (2001) AIDS , vol.15 , Issue.1
    • Murphy, R.L.1    Brun, S.2    Hicks, C.3
  • 4
    • 0003241359 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics (PK) of ABT-378/ritonavir (ABT/r) in HIV+ subjects [abstract plus poster no. 0327]; Sep 26-29: San Francisco (CA)
    • Bertz R, Lam W, Brun S, et al. Multiple-dose pharmacokinetics (PK) of ABT-378/ritonavir (ABT/r) in HIV+ subjects [abstract plus poster no. 0327]. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1999 Sep 26-29: San Francisco (CA), 16
    • (1999) 39th Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 16
    • Bertz, R.1    Lam, W.2    Brun, S.3
  • 5
    • 0034519616 scopus 로고    scopus 로고
    • Lopinavir
    • Dec
    • Hurst M, Faulds D. Lopinavir. Drugs 2000 Dec; 60 (6): 1371-9
    • (2000) Drugs , vol.60 , Issue.6 , pp. 1371-1379
    • Hurst, M.1    Faulds, D.2
  • 6
    • 0026579208 scopus 로고
    • The HIV-1 protease as a therapeutic target for AIDS
    • Debouck C. The HIV-1 protease as a therapeutic target for AIDS. AIDS Res Hum Retroviruses 1992; 8 (2): 153-64
    • (1992) AIDS Res Hum Retroviruses , vol.8 , Issue.2 , pp. 153-164
    • Debouck, C.1
  • 7
    • 0037130296 scopus 로고    scopus 로고
    • New developments in anti-HIV chemotherapy
    • Jul 18
    • De Clercq E. New developments in anti-HIV chemotherapy. Biochim Biophys Acta 2002 Jul 18; 1587 (2-3): 258-75
    • (2002) Biochim Biophys Acta , vol.1587 , Issue.2-3 , pp. 258-275
    • De Clercq, E.1
  • 8
    • 0026515142 scopus 로고
    • Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: Posttranslational modifications, proteolytic processing, and complete amino acid sequences
    • Apr
    • Henderson LE, Bowers MA, Sowder RC, et al. Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: posttranslational modifications, proteolytic processing, and complete amino acid sequences. J Virol 1992 Apr; 66 (4): 1856-65
    • (1992) J Virol , vol.66 , Issue.4 , pp. 1856-1865
    • Henderson, L.E.1    Bowers, M.A.2    Sowder, R.C.3
  • 9
    • 0005241362 scopus 로고
    • Active human immunodeficiency virus protease is required for viral infectivity
    • Jul
    • Kohl NE, Emini EA, Schleif WA, et al. Active human immunodeficiency virus protease is required for viral infectivity. Proc Natl Acad Sci USA 1988 Jul; 85: 4686-90
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4686-4690
    • Kohl, N.E.1    Emini, E.A.2    Schleif, W.A.3
  • 10
    • 0025268321 scopus 로고
    • Rational design of peptide-based HIV proteinase inhibitors
    • Apr 20
    • Roberts NA, Martin JA, Kinchington D, et al. Rational design of peptide-based HIV proteinase inhibitors. Science 1990 Apr 20; 248: 358-61
    • (1990) Science , vol.248 , pp. 358-361
    • Roberts, N.A.1    Martin, J.A.2    Kinchington, D.3
  • 11
    • 0025005794 scopus 로고
    • Effect of two novel inhibitors of the human immunodeficiency virus protease on the maturation of the HIV gag and gag-pol polyproteins
    • Nov
    • Overton HA, McMillan DJ, Gridley SJ, et al. Effect of two novel inhibitors of the human immunodeficiency virus protease on the maturation of the HIV gag and gag-pol polyproteins. Virology 1990 Nov; 179: 508-11
    • (1990) Virology , vol.179 , pp. 508-511
    • Overton, H.A.1    McMillan, D.J.2    Gridley, S.J.3
  • 12
    • 0032566902 scopus 로고    scopus 로고
    • Human serum attenuates the activity of protease inhibitors toward wild-type and mutant human immunodeficiency virus
    • Oct 25
    • Molla A, Vasavanonda S, Kumar G, et al. Human serum attenuates the activity of protease inhibitors toward wild-type and mutant human immunodeficiency virus. Virology 1998 Oct 25; 250: 255-62
    • (1998) Virology , vol.250 , pp. 255-262
    • Molla, A.1    Vasavanonda, S.2    Kumar, G.3
  • 13
    • 0001059094 scopus 로고    scopus 로고
    • Effect of human serum proteins on the antiretroviral activity of ritonavir and ABT-378, potent inhibitors of HIV protease
    • Jan 22-26; Washington, DC
    • Molla A, Vasavanonda S, Denissen J, et al. Effect of human serum proteins on the antiretroviral activity of ritonavir and ABT-378, potent inhibitors of HIV protease [abstract]. 4th Conference on Retroviruses and Opportunistic Infections; 1997 Jan 22-26; Washington, DC.
    • (1997) 4th Conference on Retroviruses and Opportunistic Infections
    • Molla, A.1    Vasavanonda, S.2    Denissen, J.3
  • 14
    • 12444293554 scopus 로고    scopus 로고
    • Assessment of the bioequivalence and food effects for liquid and soft elastic capsule coformulations of ABT-378/ritonavir (ABT-378/r) in healthy subjects [poster]; Sep 17-20; Toronto
    • Gustavson L, Lam W, Bertz R, et al. Assessment of the bioequivalence and food effects for liquid and soft elastic capsule coformulations of ABT-378/ritonavir (ABT-378/r) in healthy subjects [poster]. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2000 Sep 17-20; Toronto
    • (2000) 40th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Gustavson, L.1    Lam, W.2    Bertz, R.3
  • 17
    • 0011703408 scopus 로고    scopus 로고
    • Lopinavir/ritonavir (Kaletra) in antiretroviral-naïve HIV+ patients: 4-year follow-up [abstract plus poster no. H-165]; Sep 27; San Diego (CA)
    • Murphy R, Brun S, King M, et al. Lopinavir/ritonavir (Kaletra) in antiretroviral-naïve HIV+ patients: 4-year follow-up [abstract plus poster no. H-165]. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy; 2002 Sep 27; San Diego (CA), 261
    • (2002) 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 261
    • Murphy, R.1    Brun, S.2    King, M.3
  • 18
    • 12444342825 scopus 로고    scopus 로고
    • Comparison of the emergence of resistance in a blinded phase III study with Kaletra™ (lopinavir/ritonavir) or nelfinavir plus d4T/3TC from week 24 through 96 [abstract no. 1-1768 plus poster]; Sep 22-25; Chicago (IL)
    • Bernstein B, Kempf D, King M, et al. Comparison of the emergence of resistance in a blinded phase III study with Kaletra™ (lopinavir/ritonavir) or nelfinavir plus d4T/3TC from week 24 through 96 [abstract no. 1-1768 plus poster]. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; 2001 Sep 22-25; Chicago (IL), 338
    • (2001) 41st Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 338
    • Bernstein, B.1    Kempf, D.2    King, M.3
  • 19
    • 0003276454 scopus 로고    scopus 로고
    • Kaletra (ABT-378/r) and efavirenz: One-year safety/efficacy evaluation and phenotypic breakpoints in multiple-PI-experienced patients
    • abstract no. 525; Feb 4; Chicago (IL)
    • Clumeck N, Brun S, Sylte J, et al. Kaletra (ABT-378/r) and efavirenz: one-year safety/efficacy evaluation and phenotypic breakpoints in multiple-PI-experienced patients [abstract no. 525]. 8th Conference on Retroviruses and Opportunistic Infections; 2001 Feb 4; Chicago (IL)
    • (2001) 8th Conference on Retroviruses and Opportunistic Infections
    • Clumeck, N.1    Brun, S.2    Sylte, J.3
  • 20
    • 12444333316 scopus 로고    scopus 로고
    • Kaletra (lopinavir/ritonavir) and efavirenz: 72-week safety and efficacy evaluation in multiple PI-experienced patients [poster no. 1925]; Dec; Chicago (IL)
    • Danner S, Brun S, Richards B, et al. Kaletra (lopinavir/ritonavir) and efavirenz: 72-week safety and efficacy evaluation in multiple PI-experienced patients [poster no. 1925]. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; 2001 Dec; Chicago (IL)
    • (2001) 41st Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Danner, S.1    Brun, S.2    Richards, B.3
  • 21
    • 0036768328 scopus 로고    scopus 로고
    • Analysis of the virologic response with respect to baseline viral phenotype and genotype in protease inhibitor-experienced HIV-1-infected patients receiving lopinavir/ritonavir
    • Sep
    • Kempf DJ, Isaacson JD, King MS, et al. Analysis of the virologic response with respect to baseline viral phenotype and genotype in protease inhibitor-experienced HIV-1-infected patients receiving lopinavir/ritonavir. Antiviral Ther 2002 Sep; 7 (3): 165-74
    • (2002) Antiviral Ther , vol.7 , Issue.3 , pp. 165-174
    • Kempf, D.J.1    Isaacson, J.D.2    King, M.S.3
  • 22
    • 0034909925 scopus 로고    scopus 로고
    • Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients
    • Aug
    • Kempf DJ, Isaacson JD, King MS, et al. Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. J Virol 2001 Aug; 75 (16): 7462-9
    • (2001) J Virol , vol.75 , Issue.16 , pp. 7462-7469
    • Kempf, D.J.1    Isaacson, J.D.2    King, M.S.3
  • 23
    • 0035986072 scopus 로고    scopus 로고
    • Salvage treatment with lopinavir/ritonavir (Kaletra) in HIV-infected patients failing all current antiretroviral drug families
    • Jul-Aug
    • de Mendoza C, Martin-Carbonero L, Barreiro P, et al. Salvage treatment with lopinavir/ritonavir (Kaletra) in HIV-infected patients failing all current antiretroviral drug families. HIV Clin Trials 2002 Jul-Aug; 3 (4): 304-9
    • (2002) HIV Clin Trials , vol.3 , Issue.4 , pp. 304-309
    • De Mendoza, C.1    Martin-Carbonero, L.2    Barreiro, P.3
  • 24
    • 12444330128 scopus 로고    scopus 로고
    • Efficacy of lopinavir/ritonavir in 104 multiple PI-experienced patients according to mutational patterns: data from the French ATU program [abstract no. 234 plus poster]; Oct 28-31; Athens
    • Calvez V, Cohen-Codar I, Marcelin AG, et al. Efficacy of lopinavir/ritonavir in 104 multiple PI-experienced patients according to mutational patterns: data from the French ATU program [abstract no. 234 plus poster]. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; 2001 Oct 28-31; Athens, 154
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection , pp. 154
    • Calvez, V.1    Cohen-Codar, I.2    Marcelin, A.G.3
  • 25
    • 12444309113 scopus 로고    scopus 로고
    • Study of the initial response to Kaletra® in HIV treatment-experienced patients: the ATU pre-registrational cohort in France [abstract no. P236 plus poster]; Oct 28-31; Athens
    • Ngo Van P, Cohen-Codar I, Boer F, et al. Study of the initial response to Kaletra® in HIV treatment-experienced patients: the ATU pre-registrational cohort in France [abstract no. P236 plus poster]. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; 2001 Oct 28-31; Athens, 155
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection , pp. 155
    • Ngo Van, P.1    Cohen-Codar, I.2    Boer, F.3
  • 26
    • 12444312728 scopus 로고    scopus 로고
    • Kaletra™ (ABT-378/ritonavir) in HIV-infected children at 72 weeks [poster] Jul 8-11; Buenos Aires
    • Cahn P, Renz C, Saez-Llorens X, et al. Kaletra™ (ABT-378/ritonavir) in HIV-infected children at 72 weeks [poster]. 1st International AIDS Society Conference; 2001 Jul 8-11; Buenos Aires
    • (2001) 1st International AIDS Society Conference
    • Cahn, P.1    Renz, C.2    Saez-Llorens, X.3
  • 27
    • 0003273648 scopus 로고    scopus 로고
    • Multiple dose safety, tolerability and pharmacokinetics of ABT-378 in combination with ritonavir
    • abstract no. 647; Feb 1-5; Chicago (IL)
    • Lal R, Hsu A, Granneman GR, et al. Multiple dose safety, tolerability and pharmacokinetics of ABT-378 in combination with ritonavir [abstract no. 647]. 5th Conference on Retroviruses and Opportunistic Infections; 1998 Feb 1-5; Chicago (IL)
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
    • Lal, R.1    Hsu, A.2    Granneman, G.R.3
  • 28
    • 0012864689 scopus 로고    scopus 로고
    • Pharmacokinetics of once-daily vs twice-daily Kaletra (lopinavir/ritonavir) in HIV+ subjects
    • abstract no. 126; Feb 24-28; Seattle (WA)
    • Bertz R, Foit C, Ye X, et al. Pharmacokinetics of once-daily vs twice-daily Kaletra (lopinavir/ritonavir) in HIV+ subjects [abstract no. 126]. 9th Conference on Retroviruses and Opportunistic Infections; 2002 Feb 24-28; Seattle (WA)
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections
    • Bertz, R.1    Foit, C.2    Ye, X.3
  • 29
    • 12444303004 scopus 로고    scopus 로고
    • Once-daily vs. twice-daily Kaletra (lopinavir/ritonavir) in antiretroviral-naive HIV+ patients: 48-week follow-up [poster no. 409W]; Feb 24-28; Seattle (WA)
    • Eron J, Bernstein B, King M, et al. Once-daily vs. twice-daily Kaletra (lopinavir/ritonavir) in antiretroviral-naive HIV+ patients: 48-week follow-up [poster no. 409W]. 9th Conference on Retroviruses and Opportunistic Infections; 2002 Feb 24-28; Seattle (WA)
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections
    • Eron, J.1    Bernstein, B.2    King, M.3
  • 30
    • 0003317045 scopus 로고    scopus 로고
    • Once-daily vs. twice-daily Kaletra (lopinavir/ritonavir) in antiretroviral-naive HIV+ patients: 72 Week follow-up
    • abstract no. TuPeB4445; Jul 7-12; Barcelona
    • Feinberg J, Eron J, Bernstein B, et al. Once-daily vs. twice-daily Kaletra (lopinavir/ritonavir) in antiretroviral-naive HIV+ patients: 72 week follow-up [abstract no. TuPeB4445]. 14th International AIDS Conference; 2002 Jul 7-12; Barcelona
    • (2002) 14th International AIDS Conference
    • Feinberg, J.1    Eron, J.2    Bernstein, B.3
  • 31
    • 0035794884 scopus 로고    scopus 로고
    • Improved HIV therapy with protease inhibitors (lopinavir/ritonavir)
    • Apt 2
    • Paukstadt W. Improved HIV therapy with protease inhibitors (lopinavir/ritonavir) [in German]. MMW Fortschr Med 2001 Apt 2; 143 Suppl. 1: 96-7
    • (2001) MMW Fortschr Med , vol.143 , Issue.SUPPL. 1 , pp. 96-97
    • Paukstadt, W.1
  • 32
    • 0003218579 scopus 로고    scopus 로고
    • Evaluation of the inhibitory quotient as a pharmacodynamic predictor of the virologic response to protease inhibitor therapy
    • abstract no. 7.3; Apt 2-4; Noordwijk
    • Kempf D, Hsu A, Issacson J, et al. Evaluation of the inhibitory quotient as a pharmacodynamic predictor of the virologic response to protease inhibitor therapy [abstract no. 7.3]. 2nd International Workshop on Clinical Pharmacology of HIV Therapy; 2001 Apt 2-4; Noordwijk
    • (2001) 2nd International Workshop on Clinical Pharmacology of HIV Therapy
    • Kempf, D.1    Hsu, A.2    Issacson, J.3
  • 33
    • 12444279775 scopus 로고    scopus 로고
    • Lopinavir/ritonavir protein binding through the 12 hour dosing interval: an in vivo evaluation [abstract plus poster no. 1407]; Sep 27; San Diego (CA)
    • Boffito M, Hoggard P, Meaden RE, et al. Lopinavir/ritonavir protein binding through the 12 hour dosing interval: an in vivo evaluation [abstract plus poster no. 1407]. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy; 2002 Sep 27; San Diego (CA)
    • (2002) 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Boffito, M.1    Hoggard, P.2    Meaden, R.E.3
  • 34
    • 12244294518 scopus 로고    scopus 로고
    • Discrepancies between protease inhibitor concentrations and viral load in reservoirs and sanctuary sites in human immunodeficiency virus-infected patients
    • Jan
    • Solas C, Lafeuillade A, Halfon P, et al. Discrepancies between Protease Inhibitor Concentrations and Viral Load in Reservoirs and Sanctuary Sites in Human Immunodeficiency Virus-Infected Patients. Antimicrob Agents Chemother 2003 Jan; 47 (1): 238-43
    • (2003) Antimicrob Agents Chemother , vol.47 , Issue.1 , pp. 238-243
    • Solas, C.1    Lafeuillade, A.2    Halfon, P.3
  • 35
    • 12444277990 scopus 로고    scopus 로고
    • Differential penetration of protease inhibitors [PI] and non-nucleoside reverse transcriptase inhibitors [NNRTI] into the female genital tract [GT]
    • abstract no. WePeB5966; Jul 7-12; Barcelona
    • Min SS, Corbett AH, Rezk N, et al. Differential penetration of protease inhibitors [PI] and non-nucleoside reverse transcriptase inhibitors [NNRTI] into the female genital tract [GT] (abstract no. WePeB5966). 14th International AIDS Conference; 2002 Jul 7-12; Barcelona, 71
    • (2002) 14th International AIDS Conference , pp. 71
    • Min, S.S.1    Corbett, A.H.2    Rezk, N.3
  • 36
    • 12444264606 scopus 로고    scopus 로고
    • Differential diffusion of indinavir (IDV) and lopinavir (LPV) in genital secretions of HIV-infected women [abstract plus poster no. H-1712]; Sep 27; San Diego (CA)
    • Launay O, Tod M, Louchahi K, et al. Differential diffusion of indinavir (IDV) and lopinavir (LPV) in genital secretions of HIV-infected women [abstract plus poster no. H-1712]. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy; 2002 Sep 27; San Diego (CA)
    • (2002) 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Launay, O.1    Tod, M.2    Louchahi, K.3
  • 37
    • 0037119029 scopus 로고    scopus 로고
    • Limited penetration of lopinavir into seminal plasma of HIV-1-infected men
    • Aug 16
    • Sankatsing SU, Droste J, Burger D, et al. Limited penetration of lopinavir into seminal plasma of HIV-1-infected men [letter]. AIDS 2002 Aug 16: 16 (12): 1698-700
    • (2002) AIDS , vol.16 , Issue.12 , pp. 1698-1700
    • Sankatsing, S.U.1    Droste, J.2    Burger, D.3
  • 39
    • 0033043367 scopus 로고    scopus 로고
    • In vitro metabolism of the HIV-1 protease inhibitor ABT-378: Species comparison and metabolite identification
    • Kumar GN, Jayanti V, Lee RD, et al. In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification. Drug Metab Dispos 1999; 27 (1): 86-91
    • (1999) Drug Metab Dispos , vol.27 , Issue.1 , pp. 86-91
    • Kumar, G.N.1    Jayanti, V.2    Lee, R.D.3
  • 40
    • 0030430035 scopus 로고    scopus 로고
    • Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes
    • Kumar GN, Rodrigues AD, Buko AM, et al. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther 1996; 277: 423-31
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 423-431
    • Kumar, G.N.1    Rodrigues, A.D.2    Buko, A.M.3
  • 41
    • 0032811807 scopus 로고    scopus 로고
    • Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction
    • Kumar GN, Dykstra J, Roberts EM, et al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos 1999; 27 (8): 902-8
    • (1999) Drug Metab Dispos , vol.27 , Issue.8 , pp. 902-908
    • Kumar, G.N.1    Dykstra, J.2    Roberts, E.M.3
  • 42
    • 0031035968 scopus 로고    scopus 로고
    • Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir
    • Mar
    • Kempf DJ, March KC, Kumar G, et al. Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir. Antimicrob Agents Chemother 1997 Mar; 41 (3): 654-60
    • (1997) Antimicrob Agents Chemother , vol.41 , Issue.3 , pp. 654-660
    • Kempf, D.J.1    March, K.C.2    Kumar, G.3
  • 43
    • 0035970695 scopus 로고    scopus 로고
    • ABT 378/r: A novel inhibitor of HIV-1 protease in haemodialysis
    • Mar 30
    • Izzedine H, Launay-Vacher V, Legrand M, et al. ABT 378/r: a novel inhibitor of HIV-1 protease in haemodialysis [letter]. AIDS 2001 Mar 30; 15 (5): 662-4
    • (2001) AIDS , vol.15 , Issue.5 , pp. 662-664
    • Izzedine, H.1    Launay-Vacher, V.2    Legrand, M.3
  • 44
    • 0031907041 scopus 로고    scopus 로고
    • Cytochrome P450: New nomenclature and clinical implications
    • Jan 1
    • Cupp MJ, Tracy TS. Cytochrome P450: new nomenclature and clinical implications. Am Fam Physician 1998 Jan 1; 57 (1): 107-16
    • (1998) Am Fam Physician , vol.57 , Issue.1 , pp. 107-116
    • Cupp, M.J.1    Tracy, T.S.2
  • 45
    • 0003299401 scopus 로고    scopus 로고
    • Lack of methadone dose alterations or withdrawal symptoms with lopinavir/ritonavir (Kaletra™)
    • abstract no. TuPeB 4539; Jul 7-12; Barcelona
    • Rapaport S, Maroldo-Connelly L, Patterson JB, et al. Lack of methadone dose alterations or withdrawal symptoms with lopinavir/ritonavir (Kaletra™) [abstract no. TuPeB 4539]. 14th International AIDS Conference; 2002 Jul 7-12; Barcelona, 400
    • (2002) 14th International AIDS Conference , pp. 400
    • Rapaport, S.1    Maroldo-Connelly, L.2    Patterson, J.B.3
  • 46
    • 12444295247 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between Kaletra™ (lopinavir/ritonavir or ABT- 378/r) and other non-HIV drugs [poster no. 438]; Oct 22-26; Glasgow
    • Bertz R, Hsu A, Lam W, et al. Pharmacokinetic interactions between Kaletra™ (lopinavir/ritonavir or ABT- 378/r) and other non-HIV drugs [poster no. 438]. 5th International Congress on Drug Therapy in HIV Infection; 2000 Oct 22-26; Glasgow
    • (2000) 5th International Congress on Drug Therapy in HIV Infection
    • Bertz, R.1    Hsu, A.2    Lam, W.3
  • 47
    • 0001045577 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between lopinavir/ritonavir (ABT-378r) and other non-HIV drugs
    • abstract no. P291; Oct
    • Bertz R, Hsu A, Lam W, et al. Pharmacokinetic interactions between lopinavir/ritonavir (ABT-378r) and other non-HIV drugs [abstract no. P291]. AIDS 2000 Oct; 14 Suppl. 4: 100
    • (2000) AIDS , vol.14 , Issue.SUPPL. 4 , pp. 100
    • Bertz, R.1    Hsu, A.2    Lam, W.3
  • 48
    • 12444287754 scopus 로고    scopus 로고
    • Multiple-dose Kaletra® (lopinavir/ritonavir) does not affect the pharmacokinetics of the CYP2D6 probe, desipramine [abstract plus poster no. 443-W]; Feb 24-28; Seattle (WA)
    • Bertz R, Foit C, Chiu Y-L, et al. Multiple-dose Kaletra® (lopinavir/ritonavir) does not affect the pharmacokinetics of the CYP2D6 probe, desipramine [abstract plus poster no. 443-W]. 9th Conference on Retroviruses and Opportunistic Infections; 2002 Feb 24-28; Seattle (WA)
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections
    • Bertz, R.1    Foit, C.2    Chiu, Y.-L.3
  • 49
    • 12444300936 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) of two adjusted dose regimens of lopinavir/ritonavir (LPV/r) in combination with rifampin (RIF) in healthy volunteers [abstract plus poster no. A-1821]; Sep 27; San Diego (CA)
    • La Porte CJL, Colbers EPH, Bertz R, et al. Pharmacokinetics (PK) of two adjusted dose regimens of lopinavir/ritonavir (LPV/r) in combination with rifampin (RIF) in healthy volunteers [abstract plus poster no. A-1821]. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy; 2002 Sep 27; San Diego (CA)
    • (2002) 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
    • La Porte, C.J.L.1    Colbers, E.P.H.2    Bertz, R.3
  • 50
    • 0037196929 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of evidence for increasing numbers of drugs in antiretroviral combination therapy
    • Mar 30
    • Jordan R, Gold L, Cummins C, et al. Systematic review and meta-analysis of evidence for increasing numbers of drugs in antiretroviral combination therapy. BMJ 2002 Mar 30; 324: 1-10
    • (2002) BMJ , vol.324 , pp. 1-10
    • Jordan, R.1    Gold, L.2    Cummins, C.3
  • 51
    • 12444252725 scopus 로고    scopus 로고
    • The effect of a potent, 4-drug combination (lopinavir/ritonavir, efavirenz, tenofovir DF and lamivudine) on reducing HIV unspliced mRNA and proviral DNA in PBMC [abstract plus poster no. 488-M]; Feb 24-28; Seattle (WA)
    • Mo H, Lu L, King M, et al. The effect of a potent, 4-drug combination (lopinavir/ritonavir, efavirenz, tenofovir DF and lamivudine) on reducing HIV unspliced mRNA and proviral DNA in PBMC [abstract plus poster no. 488-M]. 9th Conference on Retroviruses and Opportunistic Infections; 2002 Feb 24-28; Seattle (WA)
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections
    • Mo, H.1    Lu, L.2    King, M.3
  • 52
    • 12444345672 scopus 로고    scopus 로고
    • Effect of amprenavir on the steady-state pharmacokinetics of lopinavir/ritonavir in HIV+ and healthy subjects [abstract plus poster no. A-1823]; Sep 27; San Diego (CA)
    • Bertz RJ, Foit C, Ashbrenner E, et al. Effect of amprenavir on the steady-state pharmacokinetics of lopinavir/ritonavir in HIV+ and healthy subjects [abstract plus poster no. A-1823]. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy; 2002 Sep 27; San Diego (CA)
    • (2002) 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Bertz, R.J.1    Foit, C.2    Ashbrenner, E.3
  • 53
    • 12444346571 scopus 로고    scopus 로고
    • Assessment of the steady-state pharmacokinetic interaction of lopinavir/ritonavir with either indinavir or saquinavir in healthy subjects [abstract plus poster no. A-1822]; Sep 27; San Diego (CA)
    • Bertz RJ, Foit C, Ashbrenner E, et al. Assessment of the steady-state pharmacokinetic interaction of lopinavir/ritonavir with either indinavir or saquinavir in healthy subjects [abstract plus poster no. A-1822]. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy; 2002 Sep 27; San Diego (CA)
    • (2002) 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Bertz, R.J.1    Foit, C.2    Ashbrenner, E.3
  • 54
    • 0003314099 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of Kaletra (lopinavir/ritonavir 400/100mg BID) in HIV-infected subjects when taken with food
    • abstract no. 3.10; Apr 2-4; Noordwijk
    • Bertz R, Renz C, Foit C, et al. Steady-state pharmacokinetics of Kaletra (lopinavir/ritonavir 400/100mg BID) in HIV-infected subjects when taken with food [abstract no. 3.10]. 2nd International Workshop on Clinical Pharmacology of HIV Therapy; 2001 Apr 2-4; Noordwijk
    • (2001) 2nd International Workshop on Clinical Pharmacology of HIV Therapy
    • Bertz, R.1    Renz, C.2    Foit, C.3
  • 55
    • 12444313726 scopus 로고    scopus 로고
    • Assessment of the pharmacokinetic interaction between ABT-378/ritonavir (ABT-378/r) and efavirenz (EFV) in healthy volunteers and in HIV+ subjects [abstract no. 424 plus poster]; Sep 17-20; Toronto
    • Bertz R, Lam W, Hsu A, et al. Assessment of the pharmacokinetic interaction between ABT-378/ritonavir (ABT-378/r) and efavirenz (EFV) in healthy volunteers and in HIV+ subjects [abstract no. 424 plus poster]. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2000 Sep 17-20; Toronto, 14
    • (2000) 40th Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 14
    • Bertz, R.1    Lam, W.2    Hsu, A.3
  • 56
    • 12444249764 scopus 로고    scopus 로고
    • ABT-378/ritonavir (ABT-378/r) and efavirenz: 24-week safety/efficacy evaluation in multiple PI-experienced patients [abstract no. TuPeB3196a plus poster]; Jul 9-14; Durban
    • Clumeck N, Brun S, Xu Y, et al. ABT-378/ritonavir (ABT-378/r) and efavirenz: 24-week safety/efficacy evaluation in multiple PI-experienced patients [abstract no. TuPeB3196a plus poster]. 13th International AIDS Conference; 2000 Jul 9-14; Durban
    • (2000) 13th International AIDS Conference
    • Clumeck, N.1    Brun, S.2    Xu, Y.3
  • 57
    • 12444293553 scopus 로고    scopus 로고
    • Evaluation of the pharmacokinetics (PK) of the concurrent administration of ABT-378/ritonavir (ABT-378/r) and nevirapine (NVP) [abstract no. 782 plus poster]; Oct 23-27; Lisbon
    • Lal R, Hsu A, Bertz R, et al. Evaluation of the pharmacokinetics (PK) of the concurrent administration of ABT-378/ritonavir (ABT-378/r) and nevirapine (NVP) [abstract no. 782 plus poster]. 7th Eurpoean Conference on Clinical Aspects and Treatment of HIV-Infection; 1999 Oct 23-27; Lisbon
    • (1999) 7th Eurpoean Conference on Clinical Aspects and Treatment of HIV-Infection
    • Lal, R.1    Hsu, A.2    Bertz, R.3
  • 58
    • 12444287753 scopus 로고    scopus 로고
    • Assessment of the effect of nevirapine on the pharmacokinetics of lopinavir/ritonavir (Kaletra®) after multiple dosing in HIV-infected adults [abstract no. TuPeB4565 plus poster]; Jul 7-12; Barcelona
    • Bertz R, Foit C, Burt D, et al. Assessment of the effect of nevirapine on the pharmacokinetics of lopinavir/ritonavir (Kaletra®) after multiple dosing in HIV-infected adults [abstract no. TuPeB4565 plus poster]. 14th International AIDS Conference; 2002 Jul 7-12; Barcelona, 407
    • (2002) 14th International AIDS Conference , pp. 407
    • Bertz, R.1    Foit, C.2    Burt, D.3
  • 59
    • 0011527430 scopus 로고    scopus 로고
    • Lack of clinically relevant drug-drug interactions between tenofovir DF and efavirenz, indinavir, lamivudine and lopinavir/ritonavir in healthy subjects [abstract no. P171 plus poster]; Oct 28-31; Athens
    • Kearney BP, Flaherty J, Wolf J, et al. Lack of clinically relevant drug-drug interactions between tenofovir DF and efavirenz, indinavir, lamivudine and lopinavir/ritonavir in healthy subjects [abstract no. P171 plus poster]. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; 2001 Oct 28-31; Athens, 123
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection , pp. 123
    • Kearney, B.P.1    Flaherty, J.2    Wolf, J.3
  • 60
    • 0007887949 scopus 로고    scopus 로고
    • A multiple-dose, randomized, crossover, drug interaction study between tenofovir DF and efavirenz, indinavir, or lopinavir/ritonavir
    • Jul 8-11; Buenos Aires
    • Flaherty J, Kearney B, Wolf J, et al. A multiple-dose, randomized, crossover, drug interaction study between tenofovir DF and efavirenz, indinavir, or lopinavir/ritonavir [abstract]. 1st International AIDS Society Conference; 2001 Jul 8-11; Buenos Aires, 176
    • (2001) 1st International AIDS Society Conference , pp. 176
    • Flaherty, J.1    Kearney, B.2    Wolf, J.3
  • 61
    • 0030895312 scopus 로고    scopus 로고
    • Protease inhibitors in patients with HIV disease: Clinically important pharmacokinetic considerations
    • Mar
    • Barry M, Gibbons S, Back D, et al. Protease inhibitors in patients with HIV disease: clinically important pharmacokinetic considerations. Clin Pharmacokinet 1997 Mar; 32 (3): 194-209
    • (1997) Clin Pharmacokinet , vol.32 , Issue.3 , pp. 194-209
    • Barry, M.1    Gibbons, S.2    Back, D.3
  • 62
    • 12444250849 scopus 로고    scopus 로고
    • Strategies to counteract ABT378 plasma concentrations reduction resulting from the association of efavirenz (EFV) or nevirapine (NVP) in HIV-infected patients (pts) [poster no. P515]; Oct 28-31; Athens
    • Lamotte C, Peytavin G, de Truchis P, et al. Strategies to counteract ABT378 plasma concentrations reduction resulting from the association of efavirenz (EFV) or nevirapine (NVP) in HIV-infected patients (pts) [poster no. P515]. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; 2001 Oct 28-31; Athens
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection
    • Lamotte, C.1    Peytavin, G.2    De Truchis, P.3
  • 63
    • 0028308785 scopus 로고
    • Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers
    • Barry M, Wild M, Veal G, et al. Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers. AIDS 1994; 8 (8): F1-5
    • (1994) AIDS , vol.8 , Issue.8
    • Barry, M.1    Wild, M.2    Veal, G.3
  • 64
    • 0027480434 scopus 로고
    • Comparative pharmacokinetics of antiviral nucleoside analogues
    • Morse GD, Shelton MJ, O'Donnell AM. Comparative pharmacokinetics of antiviral nucleoside analogues. Clin Pharamacokinet 1993; 24 (2): 101-23
    • (1993) Clin Pharamacokinet , vol.24 , Issue.2 , pp. 101-123
    • Morse, G.D.1    Shelton, M.J.2    O'Donnell, A.M.3
  • 65
    • 0002105970 scopus 로고    scopus 로고
    • Concommitant administration of ABT-378/ritonavir (ABT-378/r) results in a clinically important pharmacokinetic (PK) interaction with atorvastatin (ATO) but not pravastatin (PRA)
    • abstract no. 1644; Sep 17-20; Toronto
    • Carr RA, Andre AK, Bertz RJ, et al. Concommitant administration of ABT-378/ritonavir (ABT-378/r) results in a clinically important pharmacokinetic (PK) interaction with atorvastatin (ATO) but not pravastatin (PRA) [abstract no. 1644]. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2000 Sep 17-20; Toronto, 334
    • (2000) 40th Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 334
    • Carr, R.A.1    Andre, A.K.2    Bertz, R.J.3
  • 66
    • 0037090281 scopus 로고    scopus 로고
    • Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor lopinavir-ritonavir
    • Apr 15
    • Clarke S, Mulcahy F, Bergin C, et al. Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor lopinavir-ritonavir. Clin Infect Dis 2002 Apr 15; 34 (8): 1143-5
    • (2002) Clin Infect Dis , vol.34 , Issue.8 , pp. 1143-1145
    • Clarke, S.1    Mulcahy, F.2    Bergin, C.3
  • 67
    • 0036499067 scopus 로고    scopus 로고
    • Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patients
    • Mar 1
    • Benson CA, Deeks SG, Brun SC, et al. Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patients. J Infect Dis 2002 Mar 1; 185 (5): 599-607
    • (2002) J Infect Dis , vol.185 , Issue.5 , pp. 599-607
    • Benson, C.A.1    Deeks, S.G.2    Brun, S.C.3
  • 68
    • 0037182766 scopus 로고    scopus 로고
    • Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection
    • Jun 27
    • Walmsley S, Bernstein B, King M, et al. Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection. N Engl J Med 2002 Jun 27; 346 (26): 2039-46
    • (2002) N Engl J Med , vol.346 , Issue.26 , pp. 2039-2046
    • Walmsley, S.1    Bernstein, B.2    King, M.3
  • 69
    • 0030058515 scopus 로고    scopus 로고
    • Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS
    • Feb 15
    • O'Brien WA, Hartigan PM, Martin D, et al. Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. N Engl J Med 1996 Feb 15; 334 (7): 426-31
    • (1996) N Engl J Med , vol.334 , Issue.7 , pp. 426-431
    • O'Brien, W.A.1    Hartigan, P.M.2    Martin, D.3
  • 70
    • 0032558794 scopus 로고    scopus 로고
    • HIV-1 RNA, CD4 cell count and the risk of progression to AIDS and death during treatment with HIV-1 reverse transcriptase inhibitors
    • Oct 22
    • Staszewski S, DeMasi R, Hill AM, et al. HIV-1 RNA, CD4 cell count and the risk of progression to AIDS and death during treatment with HIV-1 reverse transcriptase inhibitors. AIDS 1998 Oct 22; 12 (15): 1991-7
    • (1998) AIDS , vol.12 , Issue.15 , pp. 1991-1997
    • Staszewski, S.1    DeMasi, R.2    Hill, A.M.3
  • 71
    • 1842296349 scopus 로고    scopus 로고
    • Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection
    • Jun 15
    • Mellors JW, Munoz A, Giorgi JV, et al. Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997 Jun 15; 126: 946-54
    • (1997) Ann Intern Med , vol.126 , pp. 946-954
    • Mellors, J.W.1    Munoz, A.2    Giorgi, J.V.3
  • 72
    • 0030070991 scopus 로고    scopus 로고
    • Prognosis in HIV-1 infection predicted by the quantity of virrus in plasma
    • May 24
    • Mellors JW, Rinaldo Jr CR, Gupta P, et al. Prognosis in HIV-1 infection predicted by the quantity of virrus in plasma. Science 1996 May 24; 272: 1167-70
    • (1996) Science , vol.272 , pp. 1167-1170
    • Mellors, J.W.1    Rinaldo C.R., Jr.2    Gupta, P.3
  • 73
    • 0032788916 scopus 로고    scopus 로고
    • Joint effects of HIV-1 RNA levels and CD4+ lymphocyte cells on the risk of specific opportunistic infections
    • Williams PL, Currier JS, Swindells S. Joint effects of HIV-1 RNA levels and CD4+ lymphocyte cells on the risk of specific opportunistic infections. AIDS 1999; 13 (9): 1035-44
    • (1999) AIDS , vol.13 , Issue.9 , pp. 1035-1044
    • Williams, P.L.1    Currier, J.S.2    Swindells, S.3
  • 76
    • 12444256178 scopus 로고    scopus 로고
    • ABT-378/ritonavir: preliminary results of an early access program in Canada [abstract no. P230 plus poster]; Oct 28-31; Athens
    • Montaner J, Canadian Kaletra Early Access Study Group. ABT-378/ritonavir: preliminary results of an early access program in Canada [abstract no. P230 plus poster]. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; 2001 Oct 28-31; Athens, 152
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection , pp. 152
    • Montaner, J.1
  • 77
    • 12444321718 scopus 로고    scopus 로고
    • Efficacy and safety results of lopinavir/R based HAART treatment in expanded access program in Spain through W24 [abstract no. 235 plus poster]; Oct 28-31; Athens
    • Clotet B, Moreno S, Gonzalez Lahoz J, et al. Efficacy and safety results of lopinavir/R based HAART treatment in expanded access program in Spain through W24 [abstract no. 235 plus poster]. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; 2001 Oct 28-31; Athens, 155
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection , pp. 155
    • Clotet, B.1    Moreno, S.2    Gonzalez Lahoz, J.3
  • 78
    • 12444254958 scopus 로고    scopus 로고
    • Lopinavir/ritonavir preregistration usage in France (ATU): a 2000 and 2001 insight into the therapeutic trends and outcomes in HIV treatment-experienced patients [poster no. 237]; Oct 28-31; Athens
    • Cohen-Codar I, Boer F, Terrier R, et al. Lopinavir/ritonavir preregistration usage in France (ATU): a 2000 and 2001 insight into the therapeutic trends and outcomes in HIV treatment-experienced patients [poster no. 237]. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; 2001 Oct 28-31; Athens
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection
    • Cohen-Codar, I.1    Boer, F.2    Terrier, R.3
  • 79
    • 0032750441 scopus 로고    scopus 로고
    • Predictors of optimal virologic response to potent antiretroviral therapy
    • Oct 1
    • Powderly WG, Saag MS, Chapman S, et al. Predictors of optimal virologic response to potent antiretroviral therapy. AIDS 1999 Oct 1; 13 (14): 1873-80
    • (1999) AIDS , vol.13 , Issue.14 , pp. 1873-1880
    • Powderly, W.G.1    Saag, M.S.2    Chapman, S.3
  • 80
    • 12444315783 scopus 로고    scopus 로고
    • Kaletra (lopinavir/ritonavir) in antiretroviral-naive HIV+ patients: 3-year follow-up [abstract plus poster no. 225]; Oct 28-31; Athens
    • Thompson M, Brun S, King M, et al. Kaletra (lopinavir/ritonavir) in antiretroviral-naive HIV+ patients: 3-year follow-up [abstract plus poster no. 225]. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; 2001 Oct 28-31; Athens, 150
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection , pp. 150
    • Thompson, M.1    Brun, S.2    King, M.3
  • 81
    • 12444303003 scopus 로고    scopus 로고
    • Three-year immunologic responses in antiretroviral-naive HIV+ patients treated with lopinavir/ritonavir (Kaletra) based therapy [poster no. TuPeB4439]; Jul 7-12; Barcelona
    • Landay A, Brun S, King M, et al. Three-year immunologic responses in antiretroviral-naive HIV+ patients treated with lopinavir/ritonavir (Kaletra) based therapy [poster no. TuPeB4439]. 14th International AIDS Conference; 2002 Jul 7-12; Barcelona
    • (2002) 14th International AIDS Conference
    • Landay, A.1    Brun, S.2    King, M.3
  • 82
    • 12444251871 scopus 로고    scopus 로고
    • Failure to achieve HIV RNA =<3 copies/ml does not predict loss of virologic response to Kaletra (lopinavir/ritonavir) therapy through 3 years [poster no. 1927]; Dec; Chicago (IL)
    • Perrin L, King M, Brun S, et al. Failure to achieve HIV RNA =<3 copies/ml does not predict loss of virologic response to Kaletra (lopinavir/ritonavir) therapy through 3 years [poster no. 1927]. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; 2001 Dec; Chicago (IL)
    • (2001) 41st Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Perrin, L.1    King, M.2    Brun, S.3
  • 83
    • 12444280826 scopus 로고    scopus 로고
    • A phase III, randomized, double-blind trial of Kaletra (ABT-378/r) + stavudine (d4T) and lamivudine (3TC) vs. nelfinavir + d4T/3TC Handout accompanying oral presentation [poster]; Oct 22-26; Glasgow
    • Johnson M, Beall G, Badley A, et al. A phase III, randomized, double-blind trial of Kaletra (ABT-378/r) + stavudine (d4T) and lamivudine (3TC) vs. nelfinavir + d4T/3TC Handout accompanying oral presentation [poster]. 5th International Congress on Drug Therapy in HIV Infection; 2000 Oct 22-26; Glasgow
    • (2000) 5th International Congress on Drug Therapy in HIV Infection
    • Johnson, M.1    Beall, G.2    Badley, A.3
  • 84
    • 12444290330 scopus 로고    scopus 로고
    • Kaletra™ vs. nelfinavir in antiretroviral-naive subjects: week 60 comparison in a phase III, blinded, randomized clinical trial [abstract no. 6 plus poster]; Jul 8-11; Buenos Aires
    • Ruane P, Mendonca J, Timerman A, et al. Kaletra™ vs. nelfinavir in antiretroviral-naive subjects: week 60 comparison in a phase III, blinded, randomized clinical trial [abstract no. 6 plus poster]. 1st International AIDS Society Conference; 2001 Jul 8-11; Buenos Aires, 80
    • (2001) 1st International AIDS Society Conference , pp. 80
    • Ruane, P.1    Mendonca, J.2    Timerman, A.3
  • 85
    • 12244270725 scopus 로고    scopus 로고
    • Kaletra (lopinavir/ritonavir) therapy in single protease inhibitor experienced patients: 144-week follow-up [abstract plus poster no. 220]; Oct 28-31; Athens
    • Hicks C, Brun S, King M, et al. Kaletra (lopinavir/ritonavir) therapy in single protease inhibitor experienced patients: 144-week follow-up [abstract plus poster no. 220]. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; 2001 Oct 28-31; Athens, 147
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection , pp. 147
    • Hicks, C.1    Brun, S.2    King, M.3
  • 86
    • 12444330126 scopus 로고    scopus 로고
    • Safety and efficacy of lopinavir/ritonavir in women in a phase III study of antiretroviral-naive subjects
    • abstract no. WePeB5972; Jul 7-12; Barcelona
    • Cernohous P, Berenstein B, Mosley J, et al. Safety and efficacy of lopinavir/ritonavir in women in a phase III study of antiretroviral-naive subjects [abstract no. WePeB5972]. 14th International AIDS Conference; 2002 Jul 7-12; Barcelona, 72
    • (2002) 14th International AIDS Conference , pp. 72
    • Cernohous, P.1    Berenstein, B.2    Mosley, J.3
  • 87
    • 4644262439 scopus 로고    scopus 로고
    • Treatment of HIV+ subjects co-infected with hepatitis B or C: week 60 safety and efficacy comparison of lopinavir/ritonavir vs. nelfinavir from a phase III blinded randomized clinical trial [abstract no. P228 plus poster]; Oct 28-31; Athens
    • Bernstein B, King M, Cernohous P, et al. Treatment of HIV+ subjects co-infected with hepatitis B or C: week 60 safety and efficacy comparison of lopinavir/ritonavir vs. nelfinavir from a phase III blinded randomized clinical trial [abstract no. P228 plus poster]. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; 2001 Oct 28-31; Athens, 151
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection , pp. 151
    • Bernstein, B.1    King, M.2    Cernohous, P.3
  • 88
    • 0002371934 scopus 로고    scopus 로고
    • ABT-378/ritonavir (ABT-378/r) and efavirenz: 24 Week safety/efficacy evaluation in multiple PI experienced patients
    • abstract no. 697; Sep 17-20: Toronto
    • Becker S, Brun S, Bertz R, et al. ABT-378/ritonavir (ABT-378/r) and efavirenz: 24 week safety/efficacy evaluation in multiple PI experienced patients [abstract no. 697]. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2000 Sep 17-20: Toronto, 294
    • (2000) 40th Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 294
    • Becker, S.1    Brun, S.2    Bertz, R.3
  • 89
    • 0027122957 scopus 로고
    • 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults
    • Dec 18
    • Castro KG, Ward JW, Slutsker L, et al. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Morb Mortal Wkly Rep 1992 Dec 18; 41 (RR-17): 1-18
    • (1992) MMWR Morb Mortal Wkly Rep , vol.41 , Issue.RR-17 , pp. 1-18
    • Castro, K.G.1    Ward, J.W.2    Slutsker, L.3
  • 90
    • 0002217716 scopus 로고    scopus 로고
    • Analysis of the correlation between baseline genotypic profile and virological response to lopinavir/ritonavir in 104 multiple protease inhibitor-experienced patients treated under the lopinavir/ritonavir Authorisation Temporaire d'Utilisation program [abstract no. 90 plus poster]
    • Calvez V, Cohen Codar I, Marcelin AG, et al. Analysis of the correlation between baseline genotypic profile and virological response to lopinavir/ritonavir in 104 multiple protease inhibitor-experienced patients treated under the lopinavir/ritonavir Authorisation Temporaire d'Utilisation program [abstract no. 90 plus poster]. Antiviral Ther 2001; 6 Suppl. 1: 69-70
    • (2001) Antiviral Ther , vol.6 , Issue.SUPPL. 1 , pp. 69-70
    • Calvez, V.1    Cohen Codar, I.2    Marcelin, A.G.3
  • 91
    • 12444335437 scopus 로고    scopus 로고
    • Safety of Kaletra™: data from phase 11 and phase III clinical trials [poster]; Jul 8-11: Buenos Aires
    • Bernstein B, Moseley J, King M, et al. Safety of Kaletra™: data from phase 11 and phase III clinical trials [poster]. 1st International AIDS Society Conference; 2001 Jul 8-11: Buenos Aires
    • (2001) 1st International AIDS Society Conference
    • Bernstein, B.1    Moseley, J.2    King, M.3
  • 92
    • 12444267609 scopus 로고    scopus 로고
    • Collection of drug adverse events in pre-registrational access programs: what relevance compared to controlled studies? Analysis of the Franch ATU cohort for Kaletra® [poster no. 238]; Oct 28-31; Athens
    • Boer F, Cohen-Codard I, Terrier R, et al. Collection of drug adverse events in pre-registrational access programs: what relevance compared to controlled studies? Analysis of the Franch ATU cohort for Kaletra® [poster no. 238]. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; 2001 Oct 28-31; Athens
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection
    • Boer, F.1    Cohen-Codard, I.2    Terrier, R.3
  • 93
    • 0037103110 scopus 로고    scopus 로고
    • Serious bradyarrhythmia that was possibly induced by lopinavir-ritonavir in 2 patients with acquired immunodeficiency syndrome
    • Aug 15
    • Kikuchi Y, Genka I, Ishizaki A, et al. Serious bradyarrhythmia that was possibly induced by lopinavir-ritonavir in 2 patients with acquired immunodeficiency syndrome. Clin Infect Dis 2002 Aug 15; 35 (4): 488-90
    • (2002) Clin Infect Dis , vol.35 , Issue.4 , pp. 488-490
    • Kikuchi, Y.1    Genka, I.2    Ishizaki, A.3
  • 94
    • 12444292517 scopus 로고    scopus 로고
    • Cost-consequence comparison of lopinavir/ritonavir (LPV/r) vs. nelfinavir (NFV) therapy in treating antiretroviral naive patients using clinical trial data
    • abstract no. PIN14
    • Luo MP, Boggs B, Bernstein B, et al. Cost-consequence comparison of lopinavir/ritonavir (LPV/r) vs. nelfinavir (NFV) therapy in treating antiretroviral naive patients using clinical trial data [abstract no. PIN14]. Value Health Nov-Dec 2002; 5 (6): 566-7
    • (2002) Value Health Nov-Dec , vol.5 , Issue.6 , pp. 566-567
    • Luo, M.P.1    Boggs, B.2    Bernstein, B.3
  • 95
    • 12444250851 scopus 로고    scopus 로고
    • Economic comparison of lopinavir/r versus nelfinavir in combination with 3Tc and d4T in ARV-naive patients
    • abstract no. P301. Oct
    • Simpson KN, Voit EO, Goodman R, et al. Economic comparison of lopinavir/r versus nelfinavir in combination with 3Tc and d4T in ARV-naive patients [abstract no. P301]. AIDS 2000 Oct; 14 Suppl. 4: 103
    • (2000) AIDS , Issue.SUPPL. 4 , pp. 103
    • Simpson, K.N.1    Voit, E.O.2    Goodman, R.3
  • 96
    • 12444286566 scopus 로고    scopus 로고
    • Five-year budget impact and lifetime cost effectiveness of a lopinavir/ritonavir (LPV/r) vs. a nelfinavir (NFV) containing regimen for treatment-naive patients [abstract plus poster no. PIN13]
    • Simpson KN, Chumney E, Luo MP, et al. Five-year budget impact and lifetime cost effectiveness of a lopinavir/ritonavir (LPV/r) vs. a nelfinavir (NFV) containing regimen for treatment-naive patients [abstract plus poster no. PIN13]. Value Health Nov-Dec 2002; 5 (6): 566
    • (2002) Value Health Nov-Dec , vol.5 , Issue.6 , pp. 566
    • Simpson, K.N.1    Chumney, E.2    Luo, M.P.3
  • 101
    • 0035958773 scopus 로고    scopus 로고
    • Overview of the effectiveness of triple combination therapy in antiretroviral-naive HIV-1 infected adults
    • Bartlett JA, DeMasi R, Quinn J, et al. Overview of the effectiveness of triple combination therapy in antiretroviral-naive HIV-1 infected adults. AIDS 2001; 15 (11): 1369-77
    • (2001) AIDS , vol.15 , Issue.11 , pp. 1369-1377
    • Bartlett, J.A.1    DeMasi, R.2    Quinn, J.3
  • 102
    • 0035117801 scopus 로고    scopus 로고
    • Use of HIV protease inhibitors as pharmacoenhancers
    • Moyle G. Use of HIV protease inhibitors as pharmacoenhancers. The AIDS Reader 2001; 11 (2): 87-98
    • (2001) The AIDS Reader , vol.11 , Issue.2 , pp. 87-98
    • Moyle, G.1
  • 103
    • 0035198762 scopus 로고    scopus 로고
    • Principles and practice of HIV-protease inhibitor pharmacoenhancement
    • Apr
    • Moyle GJ, Back D. Principles and practice of HIV-protease inhibitor pharmacoenhancement. HIV Med 2001 Apr; 2 (2): 105-13
    • (2001) HIV Med , vol.2 , Issue.2 , pp. 105-113
    • Moyle, G.J.1    Back, D.2
  • 104
    • 0035717630 scopus 로고    scopus 로고
    • Combination of protease inhibitors for the treatment of HIV-I-infected patients: A review of pharmacokinetics and clinical experience
    • Dec
    • van Heeswijk RPG, Veldkamp AI, Mulder JW, et al. Combination of protease inhibitors for the treatment of HIV-I-infected patients: a review of pharmacokinetics and clinical experience. Antivir Ther 2001 Dec; 6 (4): 201-29
    • (2001) Antivir Ther , vol.6 , Issue.4 , pp. 201-229
    • Van Heeswijk, R.P.G.1    Veldkamp, A.I.2    Mulder, J.W.3
  • 105
    • 12444254959 scopus 로고    scopus 로고
    • The interim analysis of a phase IV, randomised, open-label, multi-centre trial to evaluate safety and efficacy of lopinavir (400/100mg bid) versus saquinavir/ritonavir (1000/100mg bid) in adult HIV-1 infection: The MaxCmin trial [poster no. PL-14.5]; Nov 17-21; Glasgow
    • Dragsted UB, Gerstoft J, Youle M. The interim analysis of a phase IV, randomised, open-label, multi-centre trial to evaluate safety and efficacy of lopinavir (400/100mg bid) versus saquinavir/ritonavir (1000/100mg bid) in adult HIV-1 infection: The MaxCmin trial [poster no. PL-14.5]. 6th International Congress on Drug Therapy in HIV Infection; 2002 Nov 17-21; Glasgow
    • (2002) 6th International Congress on Drug Therapy in HIV Infection
    • Dragsted, U.B.1    Gerstoft, J.2    Youle, M.3
  • 106
    • 0003185326 scopus 로고    scopus 로고
    • HIV/ADIS surveillance report 2001
    • Sep 25
    • Centers for Disease Control and Prevention. HIV/ADIS Surveillance Report 2001. HIV/AIDS Surveillance Report 2002 Sep 25; 13 (2): 1-44
    • (2002) HIV/AIDS Surveillance Report , vol.13 , Issue.2 , pp. 1-44
  • 107
    • 12444296285 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS. Fact sheet: high-income countries [online]. Available from URL: httm://www.unaids.org/barcelona/presskit/factsheets/FShighincome_en.htm [Accessed 2002 Nov 18]
    • Fact Sheet: High-income Countries [Online]
  • 108
    • 0035912569 scopus 로고    scopus 로고
    • Development of the epidemic. Clinical review: ABC of AIDS
    • May 19
    • Adler MW. Development of the epidemic. Clinical review: ABC of AIDS. BMJ 2001 May 19; 322 (7296): 1226-9
    • (2001) BMJ , vol.322 , Issue.7296 , pp. 1226-1229
    • Adler, M.W.1
  • 109
    • 0033044075 scopus 로고    scopus 로고
    • Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone
    • Altice FL, Fried/and GH, Cooney EL. Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone. AIDS 1999; 13 (8): 957-62
    • (1999) AIDS , vol.13 , Issue.8 , pp. 957-962
    • Altice, F.L.1    Friedland, G.H.2    Cooney, E.L.3
  • 110
    • 0032957797 scopus 로고    scopus 로고
    • Methadone withdrawal when starting an antiretroviral regimen including nevirapine
    • Heelon MW, Meade LB. Methadone withdrawal when starting an antiretroviral regimen including nevirapine. Pharmacotherapy 1999; 19 (4): 471-2
    • (1999) Pharmacotherapy , vol.19 , Issue.4 , pp. 471-472
    • Heelon, M.W.1    Meade, L.B.2
  • 111
    • 0003273163 scopus 로고    scopus 로고
    • Managing methadone and non-nucleoside reverse transcriptase inhibitors: Guidelines for clinical practice
    • abstract no. 88; Jan 30-Feb 2; San Francisco (CA)
    • Clarke S, Mulcahy F, Back D, et al. Managing methadone and non-nucleoside reverse transcriptase inhibitors: guidelines for clinical practice [abstract no. 88]. 7th Conference on Retroviruses and Opportunistic Infections; 2002 Jan 30-Feb 2; San Francisco (CA)
    • (2002) 7th Conference on Retroviruses and Opportunistic Infections
    • Clarke, S.1    Mulcahy, F.2    Back, D.3
  • 112
    • 0032839482 scopus 로고    scopus 로고
    • Antiretoviral-drug concentrations in semen: Implications for sexual transmission of human immunodeficiency virus type 1
    • Aug
    • Kashuba ADM, Dyer JR, Kramer LM, et al. Antiretoviral-drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1. Antimicrob Agents Chemother 1999 Aug; 43 (8): 1817-26
    • (1999) Antimicrob Agents Chemother , vol.43 , Issue.8 , pp. 1817-1826
    • Kashuba, A.D.M.1    Dyer, J.R.2    Kramer, L.M.3
  • 113
    • 0005433724 scopus 로고    scopus 로고
    • Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV
    • Vernazza PL, Troiani L, Flepp MJ, et al. Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. AIDS 2000; 14 (2): 117-21
    • (2000) AIDS , vol.14 , Issue.2 , pp. 117-121
    • Vernazza, P.L.1    Troiani, L.2    Flepp, M.J.3
  • 114
    • 0033936554 scopus 로고    scopus 로고
    • Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low-dose ritonavir
    • van Praag RME, Weverling GJ, Portegies P, et al. Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low-dose ritonavir. AIDS 2000; 14 (9): 1187-94
    • (2000) AIDS , vol.14 , Issue.9 , pp. 1187-1194
    • Van Praag, R.M.E.1    Weverling, G.J.2    Portegies, P.3
  • 115
    • 0032558795 scopus 로고    scopus 로고
    • Resistance of HIV-1 to antiretroviral agents in blood and seminal plasma: Implications for transmission
    • Eron JJ, Vernazza PL, Johnston DM, et al. Resistance of HIV-1 to antiretroviral agents in blood and seminal plasma: implications for transmission. AIDS 1998; 12 (15): F181-9
    • (1998) AIDS , vol.12 , Issue.15
    • Eron, J.J.1    Vernazza, P.L.2    Johnston, D.M.3
  • 116
    • 0032122490 scopus 로고    scopus 로고
    • Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy
    • Jul 1
    • Schrager LK, D'Souza MP. Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy. JAMA 1998 Jul 1; 280 (1): 67-71]
    • (1998) JAMA , vol.280 , Issue.1 , pp. 67-71
    • Schrager, L.K.1    D'Souza, M.P.2
  • 117
    • 0035341524 scopus 로고    scopus 로고
    • Residual human immunodeficiency virus (HIV) type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years
    • May 1
    • Günthard HF, Havlir DV, Fiscus S, et al. residual human immunodeficiency virus (HIV) type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years. J Infect Dis 2001 May 1; 183: 1318-27
    • (2001) J Infect Dis , vol.183 , pp. 1318-1327
    • Günthard, H.F.1    Havlir, D.V.2    Fiscus, S.3
  • 118
    • 0034129970 scopus 로고    scopus 로고
    • The effects of protease inhibitor therapy on human immunodeficiency virus type 1 levels in semen
    • AIDS Clinical Trials Group Protocol 850. May
    • Eron JJ, Smeaton LM, Fiscus SA, et al. The effects of protease inhibitor therapy on human immunodeficiency virus type 1 levels in semen (AIDS Clinical Trials Group Protocol 850). J Infect Dis 2000 May; 181: 1622-8
    • (2000) J Infect Dis , vol.181 , pp. 1622-1628
    • Eron, J.J.1    Smeaton, L.M.2    Fiscus, S.A.3
  • 119
    • 0032903015 scopus 로고    scopus 로고
    • Poor penetration of the male genital tract by HIV-1 protease inhibitors
    • Taylor S, Back DJ, Workman J, et al. Poor penetration of the male genital tract by HIV-1 protease inhibitors. AIDS 1999; 13 (7): 859-60
    • (1999) AIDS , vol.13 , Issue.7 , pp. 859-860
    • Taylor, S.1    Back, D.J.2    Workman, J.3
  • 120
    • 0023938848 scopus 로고
    • Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex
    • May 27
    • Henry K, Chinnock BJ, Quinn RP, et al. Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex. JAMA 1988 May 27; 259 (20): 3023-6
    • (1988) JAMA , vol.259 , Issue.20 , pp. 3023-3026
    • Henry, K.1    Chinnock, B.J.2    Quinn, R.P.3
  • 121
    • 0343630779 scopus 로고    scopus 로고
    • Nucleoside analogues achieve high concentrations in seminal plasma: Relationship between drug concentration and virus burden
    • Dec
    • Pereira AS, Kashuba ADM, Fiscus SA, et al. Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden. J Infect Dis 1999 Dec; 180: 2039-43
    • (1999) J Infect Dis , vol.180 , pp. 2039-2043
    • Pereira, A.S.1    Kashuba, A.D.M.2    Fiscus, S.A.3
  • 122
    • 0034622962 scopus 로고    scopus 로고
    • Concentrations of nevirapine, lamivudine and stavudine in semen of HIV-1-infected men
    • Taylor S, van Heeswijk RPG, Hoetelmans RMW, et al. Concentrations of nevirapine, lamivudine and stavudine in semen of HIV-1-infected men. AIDS 2000; 14 (13): 1979-84
    • (2000) AIDS , vol.14 , Issue.13 , pp. 1979-1984
    • Taylor, S.1    Van Heeswijk, R.P.G.2    Hoetelmans, R.M.W.3
  • 123
    • 18044401251 scopus 로고    scopus 로고
    • Penetration of the nucleoside analogue abacavir into the genital tract of men infected with human immunodeficiency virus type 1
    • Sep 20
    • van Praag RME, van Heeswijk RPG, Jurriaans S, et al. Penetration of the nucleoside analogue abacavir into the genital tract of men infected with human immunodeficiency virus type 1. Clin Infect Dis 2001 Sep 20; 33 (8): e91-2
    • (2001) Clin Infect Dis , vol.33 , Issue.8
    • Van Praag, R.M.E.1    Van Heeswijk, R.P.G.2    Jurriaans, S.3
  • 124
    • 0035914039 scopus 로고    scopus 로고
    • Penetration of efavirenz into the male genital tract: Drug concentrations and antiviral activity in semen and blood of HIV-1-infected men
    • Taylor S, Reynolds H, Sabin CA, et al. Penetration of efavirenz into the male genital tract: drug concentrations and antiviral activity in semen and blood of HIV-1-infected men. AIDS 2001; 15 (15): 2051-3
    • (2001) AIDS , vol.15 , Issue.15 , pp. 2051-2053
    • Taylor, S.1    Reynolds, H.2    Sabin, C.A.3
  • 125
    • 0002125830 scopus 로고    scopus 로고
    • Prolongation of life and prevention of AIDS in advanced HIV immunodeficiency with ritonavir
    • abstract no. LB6a; Jan 28-Feb 1; Washington, DC
    • Cameron B, Heath-Chiozzi M, Kravcik S, et al. Prolongation of life and rpevention of AIDS in advanced HIV immunodeficiency with ritonavir [abstract no. LB6a]. 3rd Conference on Retroviruses and Opportunistic Infections; 1996 Jan 28-Feb 1; Washington, DC, 162
    • (1996) 3rd Conference on Retroviruses and Opportunistic Infections , pp. 162
    • Cameron, B.1    Heath-Chiozzi, M.2    Kravcik, S.3
  • 126
    • 12444288295 scopus 로고    scopus 로고
    • Whitehouse Station, NJ [online]
    • Merck & Co. Inc. Crixivan® (indinavir sulfate) capsules. Product label information. Merck & Co., Inc., Whitehouse Station, NJ [online]. Available from URL: http://www.merck.com/product/usa/crixivan/cns/default.jsp [Accessed 2002 Nov 20]
    • Crixivan® (Indinavir Sulfate) Capsules. Product Label Information
  • 128
    • 0028806725 scopus 로고
    • A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection
    • Dec 7
    • Markowitz M, Saag M, Powderly WG, et al. A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection. N Engl J Med 1995 Dec 7; 333 (23): 1534-40
    • (1995) N Engl J Med , vol.333 , Issue.23 , pp. 1534-1540
    • Markowitz, M.1    Saag, M.2    Powderly, W.G.3
  • 129
    • 0032493043 scopus 로고    scopus 로고
    • A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors
    • May 7
    • Carr A, Samaras K, Burton S, et al. A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 1998 May 7; 12 (7): F51-8
    • (1998) AIDS , vol.12 , Issue.7
    • Carr, A.1    Samaras, K.2    Burton, S.3
  • 130
    • 0033583977 scopus 로고    scopus 로고
    • Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: A cohort study
    • Jun 19
    • Carr A, Samaras K, Thorisdottir A, et al. Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study. Lancet 1999 Jun 19; 353 (9170): 2093-9
    • (1999) Lancet , vol.353 , Issue.9170 , pp. 2093-2099
    • Carr, A.1    Samaras, K.2    Thorisdottir, A.3
  • 131
    • 0034457885 scopus 로고    scopus 로고
    • HIV protease inhibitor-related lipodystrophy syndrome
    • Carr A. HIV protease inhibitor-related lipodystrophy syndrome. Clin Infect Dis 2000; 30 Suppl. 2: S135-42
    • (2000) Clin Infect Dis , vol.30 , Issue.SUPPL. 2
    • Carr, A.1
  • 132
    • 0032558803 scopus 로고    scopus 로고
    • Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients
    • Dec
    • Walli R, Herfort O, Minchl GM, et al. Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients. AIDS 1998 Dec; 12 (15): F167-73
    • (1998) AIDS , vol.12 , Issue.15
    • Walli, R.1    Herfort, O.2    Minchl, G.M.3
  • 133
    • 0032891067 scopus 로고    scopus 로고
    • A risk-benefit assessment of HIV protease inhibitors
    • Apr
    • Moyle GJ, Gazzard BG. A risk-benefit assessment of HIV protease inhibitors. Drug Saf 1999 Apr; 20 (4): 299-321
    • (1999) Drug Saf , vol.20 , Issue.4 , pp. 299-321
    • Moyle, G.J.1    Gazzard, B.G.2
  • 134
    • 0033040212 scopus 로고    scopus 로고
    • Hyperlipidemia under treatment with proteinase inhibitors
    • Segerer S, Bogner JR, Walli R, et al. Hyperlipidemia under treatment with proteinase inhibitors. Infection Mar-Apr 1999; 27: 77-81
    • (1999) Infection Mar-Apr , vol.27 , pp. 77-81
    • Segerer, S.1    Bogner, J.R.2    Walli, R.3
  • 135
    • 0002981434 scopus 로고    scopus 로고
    • Lipodystrophy associated with protease inhibitors
    • Mar
    • Panse I, Vasseur E, Raffin-Sanson ML, et al. Lipodystrophy associated with protease inhibitors. Br J Dermatol 2000 Mar; 142 (3): 496-500
    • (2000) Br J Dermatol , vol.142 , Issue.3 , pp. 496-500
    • Panse, I.1    Vasseur, E.2    Raffin-Sanson, M.L.3
  • 136
    • 0033390914 scopus 로고    scopus 로고
    • Increasing morbidity from myocardial infarction during HIV protease inhibitor treatment?
    • Sep 10
    • Jutte A, Schwenk A, Franzer C, et al. Increasing morbidity from myocardial infarction during HIV protease inhibitor treatment? [letter]. AIDS 1999 Sep 10; 13 (13): 1796-7
    • (1999) AIDS , vol.13 , Issue.13 , pp. 1796-1797
    • Jutte, A.1    Schwenk, A.2    Franzer, C.3
  • 138
    • 0033396957 scopus 로고    scopus 로고
    • Fat distribution and metabolic changes in patients with HIV infection
    • Dec 24
    • Safrin S, Grunfeld C. Fat distribution and metabolic changes in patients with HIV infection. AIDS 1999 Dec 24; 13 (18): 2493-505
    • (1999) AIDS , vol.13 , Issue.18 , pp. 2493-2505
    • Safrin, S.1    Grunfeld, C.2
  • 139
    • 0033779153 scopus 로고    scopus 로고
    • The cost effectiveness of antiretroviral regimens for the treatment of HIV/AIDS
    • Oct
    • Anis AH, Guh D, Hogg RS, et al. The cost effectiveness of antiretroviral regimens for the treatment of HIV/AIDS. Pharmacoeconomics 2000 Oct; 18 (4): 393-404
    • (2000) Pharmacoeconomics , vol.18 , Issue.4 , pp. 393-404
    • Anis, A.H.1    Guh, D.2    Hogg, R.S.3
  • 140
    • 0034919021 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy: Pharmacoeconomic issues in the management of HIV infection
    • Sendi P, Palmer AJ, Gafni A, et al. Highly active antiretroviral therapy: pharmacoeconomic issues in the management of HIV infection. Pharmacoeconomics 2001; 19 (7): 709-13
    • (2001) Pharmacoeconomics , vol.19 , Issue.7 , pp. 709-713
    • Sendi, P.1    Palmer, A.J.2    Gafni, A.3
  • 141
    • 0035869435 scopus 로고    scopus 로고
    • The cost effectiveness of combination antiretroviral therapy for HIV disease
    • Mar 15
    • Freedberg KA, Losina E, Weinstein MC, et al. The cost effectiveness of combination antiretroviral therapy for HIV disease. N Engl J Med 2001 Mar 15; 344 (11): 824-31
    • (2001) N Engl J Med , vol.344 , Issue.11 , pp. 824-831
    • Freedberg, K.A.1    Losina, E.2    Weinstein, M.C.3
  • 142
    • 12444268769 scopus 로고    scopus 로고
    • GlaxoSmithKline. Research Triangle Park, NC [online]
    • GlaxoSmithKline. Agenerase® (amprenavir) Capsules. Prescribing infomation. GlaxoSmithKline. Research Triangle Park, NC [online]. Available from URL: http://www.agenerase.com [Accessed 2002 Nov 22]
    • Agenerase® (Amprenavir) Capsules. Prescribing Infomation
  • 145
    • 0003219410 scopus 로고    scopus 로고
    • Once-daily dosing of 1,600 mg saquinavir (soft-gelatin capsules; SQV-SGC) plus low dose ritonavir (RTV, 100 mg) in HIV-1-infected Thai patients: Pharmacokinetics (PK) and clinical experience (HIV-NAT 001.3)
    • Apr 2-4; Noordwijk
    • van Heeswijk R, Cardiello P, Monhaphol T, et al. Once-daily dosing of 1,600 mg saquinavir (soft-gelatin capsules; SQV-SGC) plus low dose ritonavir (RTV, 100 mg) in HIV-1-infected Thai patients: pharmacokinetics (PK) and clinical experience (HIV-NAT 001.3) [abstract]. 2nd International Workshop on Clinical Pharmacology of HIV Therapy; 2001 Apr 2-4; Noordwijk
    • (2001) 2nd International Workshop on Clinical Pharmacology of HIV Therapy
    • Van Heeswijk, R.1    Cardiello, P.2    Monhaphol, T.3
  • 146
    • 0003272998 scopus 로고    scopus 로고
    • Modulation of saquinavir steady-state pharmacokinetics with 'baby' doses of ritonavir in healthy volunteers
    • abstract no. 829; Oct 23-27; Lisbon
    • Saag MS, Kilby M, Ehrensing E, et al. Modulation of saquinavir steady-state pharmacokinetics with 'baby' doses of ritonavir in healthy volunteers [abstract no. 829]. 7th Eurpoean Conference on Clinical Aspects and Treatment of HIV-Infection; 1999 Oct 23-27; Lisbon
    • (1999) 7th Eurpoean Conference on Clinical Aspects and Treatment of HIV-Infection
    • Saag, M.S.1    Kilby, M.2    Ehrensing, E.3
  • 147
    • 0003306482 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of amprenavir combined with ritonavir as salvage therapy in HIV-1 infected patients
    • abstract no. TuPeB3305; Jul 9-14; Durban
    • Anne-Marie T, Paci-Bonaventure S, Goujard C, et al. Therapeutic drug monitoring of amprenavir combined with ritonavir as salvage therapy in HIV-1 infected patients [abstract no. TuPeB3305]. 13th International AIDS Conference; 2000 Jul 9-14; Durban, 380
    • (2000) 13th International AIDS Conference , pp. 380
    • Anne-Marie, T.1    Paci-Bonaventure, S.2    Goujard, C.3
  • 148
    • 0032710406 scopus 로고    scopus 로고
    • The steady-state plasma pharmacokinetics of indinavir alone and in combination with a low dose of ritoanvir in twice daily dosing regimens in HIV-1-infected individuals
    • Oct 1
    • van Heeswijk RPG, Veldkamp Al, Hoetelmans RMW, et al. The steady-state plasma pharmacokinetics of indinavir alone and in combination with a low dose of ritoanvir in twice daily dosing regimens in HIV-1-infected individuals. AIDS 1999 Oct 1; 13 (14): F95-9
    • (1999) AIDS , vol.13 , Issue.14
    • Van Heeswijk, R.P.G.1    Veldkamp, A.L.2    Hoetelmans, R.M.W.3
  • 149
    • 0000216152 scopus 로고    scopus 로고
    • Combination therapy with indinavir and ritonavir in antiretroviral-experienced patients
    • abstract no. 2209; Sep 26-29; San Francisco (CA)
    • O'Brien WA, Atkinson TA, Han X, et al. Combination therapy with indinavir and ritonavir in antiretroviral-experienced patients [abstract no. 2209]. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1999 Sep 26-29; San Francisco (CA), 539
    • (1999) 39th Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 539
    • O'Brien, W.A.1    Atkinson, T.A.2    Han, X.3
  • 150
    • 0003316536 scopus 로고    scopus 로고
    • Increased indinavir levels using twice daily ritonavir/indinavir ar 100/800mg improves virological response even after multiple failure
    • abstract no. 1170; Sep 17-20; Toronto
    • Casado JL, Moreno A, Marti-Belda P, et al. Increased indinavir levels using twice daily ritonavir/indinavir ar 100/800mg improves virological response even after multiple failure [abstract no. 1170]. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2000 Sep 17-20; Toronto, 301
    • (2000) 40th Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 301
    • Casado, J.L.1    Moreno, A.2    Marti-Belda, P.3


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