Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: In vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue

Drug Metabolism and Disposition

Volumn 29, Issue 11, 2001, Pages 1403-1409

  Kuperman, Alexander V ^a   Kalgutkar, Amit S ^a   Marfat, Anthony ^a   Chambers, Robert J ^a   Liston, Theodore E ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMAN DERIVATIVE; CP 199 331; CP 85 958; CYTOCHROME P450 2C11; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; HETEROCYCLIC COMPOUND; LEUKOTRIENE RECEPTOR BLOCKING AGENT; TRIFLUORO N [3 [6 (FLUOROBENZOTHIAZOL 3 YLMETHOXY) 4 HYDROXYCHROMAN 3 YLMETHYL] 4 METHOXYPHENYL]METHANESULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; DEMETHYLATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; LIVER CLEARANCE; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

ANIMALS; ANTIOXIDANTS; BENZOPYRANS; BIOTRANSFORMATION; CHROMANS; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HEPATOCYTES; HETEROCYCLIC COMPOUNDS; HUMANS; INJECTIONS, INTRAVENOUS; ISOENZYMES; LEUKOTRIENE ANTAGONISTS; MALE; MEMBRANE PROTEINS; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEUKOTRIENE; SEX CHARACTERISTICS; SULFONAMIDES;

EID: 0034776646     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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