A mechanistic approach to understanding species differences in felbamate bioactivation: Relevance to drug-induced idiosyncratic reactions

Drug Metabolism and Disposition

Volumn 28, Issue 7, 2000, Pages 814-822

  Dieckhaus, Christine M ^a   Miller, Thomas A ^a   Sofia, R Duane ^b   Macdonald, Timothy L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Wallace Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE DERIVATIVE; ACROLEIN DERIVATIVE; ALDEHYDE DEHYDROGENASE; CYTOCHROME P450; DRUG METABOLITE; ESTERASE; FELBAMATE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME POLYMORPHISM; HUMAN; IDIOPATHIC DISEASE; INTOXICATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; GLUTATHIONE; HUMANS; MALE; MASS SPECTROMETRY; PROPYLENE GLYCOLS; RATS; RATS, GUNN; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

ANIMALIA; MINK CELL FOCUS-FORMING VIRUS; RATTUS NORVEGICUS;

EID: 0033927921     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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