-
1
-
-
0029775615
-
The incidence of neutropenia and agranulocytosis in patients treated with clozapine in the UK and Ireland
-
Atkin K, Kendall F, Gould D, Freeman H, Lieberman J and O'Sullivan D (1996) The incidence of neutropenia and agranulocytosis in patients treated with clozapine in the UK and Ireland. Br J Psychiatry 169:483-488.
-
(1996)
Br J Psychiatry
, vol.169
, pp. 483-488
-
-
Atkin, K.1
Kendall, F.2
Gould, D.3
Freeman, H.4
Lieberman, J.5
O'Sullivan, D.6
-
2
-
-
0021332202
-
The respiratory burst of phagocytes
-
Babior BM (1984) The respiratory burst of phagocytes. J Clin Invest 73:599-601.
-
(1984)
J Clin Invest
, vol.73
, pp. 599-601
-
-
Babior, B.M.1
-
3
-
-
0029899926
-
Tumor-necrosis-factor-alpha and fmlp receptors are functionally linked during fmlp-stimulated activation of adherent human neutrophils
-
Balazovich KJ, Suchard SJ, Remick DG and Boxer LA (1996) Tumor-necrosis-factor-alpha and fmlp receptors are functionally linked during fmlp-stimulated activation of adherent human neutrophils. Blood 88:690-696.
-
(1996)
Blood
, vol.88
, pp. 690-696
-
-
Balazovich, K.J.1
Suchard, S.J.2
Remick, D.G.3
Boxer, L.A.4
-
5
-
-
0028176651
-
Oxidative stress as a mediator of apoptosis
-
Buttke TM and Sandatrom PA (1994) Oxidative stress as a mediator of apoptosis. Immunol Today 15:7-10.
-
(1994)
Immunol Today
, vol.15
, pp. 7-10
-
-
Buttke, T.M.1
Sandatrom, P.A.2
-
6
-
-
0031876318
-
MCl-1 is an immediate early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response
-
Chao JR, Wang JM, Lee SF, Peng HW, Lin YH, Chou CH, Huang HM, Chou CK, Kuo ML, Yen JJ and Yang-Yen HF (1998) MCl-1 is an immediate early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. Mol Cell Biol 18:4883-4898.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4883-4898
-
-
Chao, J.R.1
Wang, J.M.2
Lee, S.F.3
Peng, H.W.4
Lin, Y.H.5
Chou, C.H.6
Huang, H.M.7
Chou, C.K.8
Kuo, M.L.9
Yen, J.J.10
Yang-Yen, H.F.11
-
7
-
-
0029990612
-
The treatment of clozapine-associated agranulocytosis with granulocyte colony-stimulating factor (G-CSF)
-
Chengappa KN, Gopalani A, Haught MK, McChesney K, Baker RW and Schooler NR (1996) The treatment of clozapine-associated agranulocytosis with granulocyte colony-stimulating factor (G-CSF). Psychopharmacol Bull 32:111-121.
-
(1996)
Psychopharmacol Bull
, vol.32
, pp. 111-121
-
-
Chengappa, K.N.1
Gopalani, A.2
Haught, M.K.3
McChesney, K.4
Baker, R.W.5
Schooler, N.R.6
-
8
-
-
0028820611
-
The major histocompatibility complex region marked by hsp70-1 and hsp70-2 variants is associated with clozapine-induced agranulocytosis in 2 different ethnic-groups
-
Corzo D, Yunis JJ, Salazar M, Lieberman JA, Howard A, Awdeh Z, Alper CA and Yunis EJ (1995) The major histocompatibility complex region marked by hsp70-1 and hsp70-2 variants is associated with clozapine-induced agranulocytosis in 2 different ethnic-groups. Blood 86:3835-3840.
-
(1995)
Blood
, vol.86
, pp. 3835-3840
-
-
Corzo, D.1
Yunis, J.J.2
Salazar, M.3
Lieberman, J.A.4
Howard, A.5
Awdeh, Z.6
Alper, C.A.7
Yunis, E.J.8
-
9
-
-
0022818865
-
Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems
-
Cotgreave IA and Moldeus P (1986) Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems. J Biochem Biophys Methods 13:231-249.
-
(1986)
J Biochem Biophys Methods
, vol.13
, pp. 231-249
-
-
Cotgreave, I.A.1
Moldeus, P.2
-
10
-
-
0029057979
-
Glucocorticoid treatment inhibits apoptosis in human neutrophils -separation of survival and activation outcomes
-
Cox G (1995) Glucocorticoid treatment inhibits apoptosis in human neutrophils -separation of survival and activation outcomes. J Immunol 154:4719-4725.
-
(1995)
J Immunol
, vol.154
, pp. 4719-4725
-
-
Cox, G.1
-
11
-
-
0022862720
-
Metabolic-activation of phenol by human myeloperoxidase and horseradish-peroxidase
-
Eastmond DA, Smith MT, Ruzo LO and Rosa D (1986) Metabolic-activation of phenol by human myeloperoxidase and horseradish-peroxidase. Mol Pharmacol 30:674-679.
-
(1986)
Mol Pharmacol
, vol.30
, pp. 674-679
-
-
Eastmond, D.A.1
Smith, M.T.2
Ruzo, L.O.3
Rosa, D.4
-
12
-
-
0025746640
-
Possible role of free radical formation in clozapine (Clozaril)-induced agranulocytosis
-
Fischer V, Haar JA, Greiner L, Lloyd RV and Mason RP (1991) Possible role of free radical formation in clozapine (Clozaril)-induced agranulocytosis. Mol Pharmacol 40:846-853.
-
(1991)
Mol Pharmacol
, vol.40
, pp. 846-853
-
-
Fischer, V.1
Haar, J.A.2
Greiner, L.3
Lloyd, R.V.4
Mason, R.P.5
-
13
-
-
0031814439
-
A comparison of the covalent binding of clozapine and olanzepine to human neutrophils in vitro and in vivo
-
Gardner I, Leeder JS, Chin T, Zahid N and Uetrecht JP (1998a) A comparison of the covalent binding of clozapine and olanzepine to human neutrophils in vitro and in vivo. Mol Pharmacol 53:999-1008.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 999-1008
-
-
Gardner, I.1
Leeder, J.S.2
Chin, T.3
Zahid, N.4
Uetrecht, J.P.5
-
14
-
-
0031842867
-
A comparison of the oxidation of clozapine and olanzepine to reactive metabolites and toxicity of these metabolites to human leukocytes
-
Gardner I, Zahid N, MaCrimmon D and Uetrecht JP (1998b) A comparison of the oxidation of clozapine and olanzepine to reactive metabolites and toxicity of these metabolites to human leukocytes. Mol Pharmacol 53:991-998.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 991-998
-
-
Gardner, I.1
Zahid, N.2
MaCrimmon, D.3
Uetrecht, J.P.4
-
15
-
-
0027155108
-
Clozapine - Deciphering the risks
-
Gerson SL (1993) Clozapine - deciphering the risks. N Engl J Med 329:204-205.
-
(1993)
N Engl J Med
, vol.329
, pp. 204-205
-
-
Gerson, S.L.1
-
16
-
-
0027942066
-
G-csf and the management of clozapine-induced agranulocytosis
-
Gerson SL (1994) G-CSF and the management of clozapine-induced agranulocytosis. J Clin Psychiatry 55:139-142.
-
(1994)
J Clin Psychiatry
, vol.55
, pp. 139-142
-
-
Gerson, S.L.1
-
17
-
-
0031770078
-
Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis
-
Guest I, Sokoluk B, MacCrimmon J and Uetrecht J (1998) Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis. Toxicology 131:53-65.
-
(1998)
Toxicology
, vol.131
, pp. 53-65
-
-
Guest, I.1
Sokoluk, B.2
MacCrimmon, J.3
Uetrecht, J.4
-
18
-
-
0025835716
-
Bcl2 protein is topographically restricted in tissues characterized by apoptotic cell-death
-
Hockenbery DM, Zutter M, Hickey W, Nahm M and Korsmeyer SJ (1991) Bcl2 protein is topographically restricted in tissues characterized by apoptotic cell-death. Proc Natl Acad Sci USA 88:6961-6965.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 6961-6965
-
-
Hockenbery, D.M.1
Zutter, M.2
Hickey, W.3
Nahm, M.4
Korsmeyer, S.J.5
-
20
-
-
0026772202
-
Antimyeloperoxidase antibodies and adverse reactions to clozapine
-
Jaunkalns R, Shear NH, Sokoluk B, Gardner D, Claas F and Uetrecht JP (1992) Antimyeloperoxidase antibodies and adverse reactions to clozapine. Lancet 339: 1611-1612.
-
(1992)
Lancet
, vol.339
, pp. 1611-1612
-
-
Jaunkalns, R.1
Shear, N.H.2
Sokoluk, B.3
Gardner, D.4
Claas, F.5
Uetrecht, J.P.6
-
21
-
-
0029061402
-
Reactive oxygen species and the regulation of cell-death by the bcl-2 gene family
-
Korsmeyer SJ, Yin XM, Oltvai ZN, Veisnovack DJ and Linette GP (1995) Reactive oxygen species and the regulation of cell-death by the bcl-2 gene family. Biochim Biophys Acta 1271:63-66.
-
(1995)
Biochim Biophys Acta
, vol.1271
, pp. 63-66
-
-
Korsmeyer, S.J.1
Yin, X.M.2
Oltvai, Z.N.3
Veisnovack, D.J.4
Linette, G.P.5
-
22
-
-
0030900980
-
Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
-
Leist M, Single B, Castoldi AF, Kuhnle S and Nicotera P (1997) Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis. J Exp Med 186:1484-1486.
-
(1997)
J Exp Med
, vol.186
, pp. 1484-1486
-
-
Leist, M.1
Single, B.2
Castoldi, A.F.3
Kuhnle, S.4
Nicotera, P.5
-
23
-
-
0029555342
-
Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to cells
-
Liu ZC and Uetrecht JP (1995) Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to cells. J Pharmacol Exp Ther 275:1476-1483.
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 1476-1483
-
-
Liu, Z.C.1
Uetrecht, J.P.2
-
24
-
-
0029416850
-
The metabolic formation of reactive intermediates from clozapine: A drug associated with agranulocytosis in man
-
Maggs JL, Williams D, Pirmohamed M and Park BK (1995) The metabolic formation of reactive intermediates from clozapine: A drug associated with agranulocytosis in man. J Pharmacol Exp Ther 275:1463-1475.
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 1463-1475
-
-
Maggs, J.L.1
Williams, D.2
Pirmohamed, M.3
Park, B.K.4
-
25
-
-
0033063312
-
Induction of apoptosis by remoxipride metabolites in HL-60 and CD34+/CD19-human bone marrow progenitor cells: Potential relevance to remoxipride-induced aplastic anaemia
-
McGuiness SM, Johansson R, Lundstrom J and Ross D (1999) Induction of apoptosis by remoxipride metabolites in HL-60 and CD34+/CD19-human bone marrow progenitor cells: Potential relevance to remoxipride-induced aplastic anaemia. Chem Biol Interact 121:253-265.
-
(1999)
Chem Biol Interact
, vol.121
, pp. 253-265
-
-
McGuiness, S.M.1
Johansson, R.2
Lundstrom, J.3
Ross, D.4
-
26
-
-
0003069475
-
Agranulocytosis due to the occurrence of leucocyte-agglutinins
-
Moeschlin S and Wagner K (1952) Agranulocytosis due to the occurrence of leucocyte-agglutinins. Acta Haematol 8:29-41.
-
(1952)
Acta Haematol
, vol.8
, pp. 29-41
-
-
Moeschlin, S.1
Wagner, K.2
-
27
-
-
0032189802
-
Mcl-1 expression in human neutrophils: Regulation by cytokines and correlation with cell survival
-
Moulding DA, Quayle JA, Hart A and Edwards SW (1998) Mcl-1 expression in human neutrophils: Regulation by cytokines and correlation with cell survival. Blood 92:2495-2502.
-
(1998)
Blood
, vol.92
, pp. 2495-2502
-
-
Moulding, D.A.1
Quayle, J.A.2
Hart, A.3
Edwards, S.W.4
-
28
-
-
0025726216
-
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
-
Nicoletti I, Migliorati G, Paggliacci MC, Grigani F and Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139:271-279.
-
(1991)
J Immunol Methods
, vol.139
, pp. 271-279
-
-
Nicoletti, I.1
Migliorati, G.2
Paggliacci, M.C.3
Grigani, F.4
Riccardi, C.5
-
29
-
-
0031588392
-
Nitric oxide donor-induced apoptosis in smooth muscle cells is modulated by protein kinase C and protein kinase A
-
Nishio E and Watanabe Y (1997) Nitric oxide donor-induced apoptosis in smooth muscle cells is modulated by protein kinase C and protein kinase A. Eur J Pharmacol 339:245-251.
-
(1997)
Eur J Pharmacol
, vol.339
, pp. 245-251
-
-
Nishio, E.1
Watanabe, Y.2
-
30
-
-
0029156492
-
Primitive human hematopoietic precursors express bcl-X but not bcl-2
-
Park JR, Bernstein ID and Hockenbery DM (1995) Primitive human hematopoietic precursors express bcl-X but not bcl-2. Blood 86:868-876.
-
(1995)
Blood
, vol.86
, pp. 868-876
-
-
Park, J.R.1
Bernstein, I.D.2
Hockenbery, D.M.3
-
31
-
-
0028333937
-
Programmed cell death of the normal human neutrophil - An in-vitro model of senescence
-
Payne CM, Glasser L, Tischler ME, Wyckoff D, Cromey D, Fiederlein R and Bohnert O (1994) Programmed cell death of the normal human neutrophil - an in-vitro model of senescence. Microsc Res Tech 28:327-344.
-
(1994)
Microsc Res Tech
, vol.28
, pp. 327-344
-
-
Payne, C.M.1
Glasser, L.2
Tischler, M.E.3
Wyckoff, D.4
Cromey, D.5
Fiederlein, R.6
Bohnert, O.7
-
33
-
-
0031044590
-
Mechanism of action of clozapine-induced agranulocytosis: Current status of research and implications for drug development
-
Pirmohamed M and Park BK (1997) Mechanism of action of clozapine-induced agranulocytosis: Current status of research and implications for drug development. Cent Nerv Syst Drugs 7:139-158.
-
(1997)
Cent Nerv Syst Drugs
, vol.7
, pp. 139-158
-
-
Pirmohamed, M.1
Park, B.K.2
-
34
-
-
0028944753
-
Metabolism and bioactivation of clozapine by human liver in vitro
-
Pirmohamed M, Williams D, Madden S, Templeton E and Park Bk (1995) Metabolism and bioactivation of clozapine by human liver in vitro. J Pharmacol Exp Ther 272:984-990.
-
(1995)
J Pharmacol Exp Ther
, vol.272
, pp. 984-990
-
-
Pirmohamed, M.1
Williams, D.2
Madden, S.3
Templeton, E.4
Park, B.5
-
35
-
-
0030458422
-
Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: Identification of target cells and a potential role for modulation of apoptosis in benzene toxicity
-
Ross D, Siegel D, Schattenberg DG, Sun XMM and Moran JL (1996) Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: Identification of target cells and a potential role for modulation of apoptosis in benzene toxicity. Environ Health Perspect 104:1177-1182.
-
(1996)
Environ Health Perspect
, vol.104
, pp. 1177-1182
-
-
Ross, D.1
Siegel, D.2
Schattenberg, D.G.3
Sun, X.M.M.4
Moran, J.L.5
-
36
-
-
0027374522
-
Effects of clozapine on hematopoiesis and the cytokine system
-
Sperner-Unterweger B, Gaggl S, Fleischhacker WW, Barnas C, Herold M and Geissler D (1993) Effects of clozapine on hematopoiesis and the cytokine system. Biol Psychiatry 34:536-543.
-
(1993)
Biol Psychiatry
, vol.34
, pp. 536-543
-
-
Sperner-Unterweger, B.1
Gaggl, S.2
Fleischhacker, W.W.3
Barnas, C.4
Herold, M.5
Geissler, D.6
-
37
-
-
0031817570
-
Dibutyryl cyclic adenosine monophosphate protects mice against TNF-alpha-induced hepatocyte apoptosis accompanied by increasing heat shock protein 70 expression
-
Takano M, Arai T, Mokuno Y, Nishimura Y and Yoshikai Y (1998) Dibutyryl cyclic adenosine monophosphate protects mice against TNF-alpha-induced hepatocyte apoptosis accompanied by increasing heat shock protein 70 expression. Cell Stress Chaperones 3:109-117.
-
(1998)
Cell Stress Chaperones
, vol.3
, pp. 109-117
-
-
Takano, M.1
Arai, T.2
Mokuno, Y.3
Nishimura, Y.4
Yoshikai, Y.5
-
38
-
-
0032933969
-
The cytotoxicity of clozapine metabolites: Implications for predicting clozapine-induced agranulocytosis
-
Tschen AC, Rieder MJ, Oyewumi LK and Freeman DJ (1999) The cytotoxicity of clozapine metabolites: Implications for predicting clozapine-induced agranulocytosis. Clin Pharm Ther 65:526-532.
-
(1999)
Clin Pharm Ther
, vol.65
, pp. 526-532
-
-
Tschen, A.C.1
Rieder, M.J.2
Oyewumi, L.K.3
Freeman, D.J.4
-
39
-
-
0030992688
-
Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups
-
Turbay D, Lieberman J, Alper CA, Delgado JC, Corzo D, Yunis JJ and Yunis EJ (1997) Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups. Blood 89:4167-4174.
-
(1997)
Blood
, vol.89
, pp. 4167-4174
-
-
Turbay, D.1
Lieberman, J.2
Alper, C.A.3
Delgado, J.C.4
Corzo, D.5
Yunis, J.J.6
Yunis, E.J.7
-
40
-
-
0026645711
-
The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions
-
Uetrecht JP (1992a) The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions. Drug Metab Rev 24:299-366.
-
(1992)
Drug Metab Rev
, vol.24
, pp. 299-366
-
-
Uetrecht, J.P.1
-
41
-
-
0013677025
-
Metabolism of clozapine by neutrophils. Possible implications for clozapine-induced agranulocytosis
-
Uetrecht JP (1992b) Metabolism of clozapine by neutrophils. Possible implications for clozapine-induced agranulocytosis. Drug Saf 7:51-56.
-
(1992)
Drug Saf
, vol.7
, pp. 51-56
-
-
Uetrecht, J.P.1
-
42
-
-
0030913557
-
Structural features associated with reactive metabolite formation in clozapine analogues
-
Uetrecht J, Zahid N, Tehim A, Fu JM and Rakhit S (1997) Structural features associated with reactive metabolite formation in clozapine analogues. Chem Biol Interact 104:117-129.
-
(1997)
Chem Biol Interact
, vol.104
, pp. 117-129
-
-
Uetrecht, J.1
Zahid, N.2
Tehim, A.3
Fu, J.M.4
Rakhit, S.5
-
43
-
-
0029043888
-
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V
-
Vennes I, Haanen C, Steffens-Nakken H and Reutelingsperger C (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J Immunol Methods 184:39-51.
-
(1995)
J Immunol Methods
, vol.184
, pp. 39-51
-
-
Vennes, I.1
Haanen, C.2
Steffens-Nakken, H.3
Reutelingsperger, C.4
-
44
-
-
0029803263
-
Thiol-mediated redox regulation of neutrophil apoptosis
-
Watson RWG, Holstein OD, Nachens AB, Dackiw APB and Marshall JC (1996) Thiol-mediated redox regulation of neutrophil apoptosis. Surgery 120:150-158.
-
(1996)
Surgery
, vol.120
, pp. 150-158
-
-
Watson, R.W.G.1
Holstein, O.D.2
Nachens, A.B.3
Dackiw, A.P.B.4
Marshall, J.C.5
-
45
-
-
0030775609
-
Coupling of neutrophil apoptosis to recognition by macrophages: Coordinated acceleration by protein synthesis inhibitors
-
Whyte MKB, Savill J, Meagher LC, Lee A and Haslett C (1997) Coupling of neutrophil apoptosis to recognition by macrophages: Coordinated acceleration by protein synthesis inhibitors. J Leukoc Biol 62:195-202.
-
(1997)
J Leukoc Biol
, vol.62
, pp. 195-202
-
-
Whyte, M.K.B.1
Savill, J.2
Meagher, L.C.3
Lee, A.4
Haslett, C.5
-
46
-
-
33645634241
-
Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells
-
Wiemels J, Wiencke JK, Varykoni A and Smith MT (1999) Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:quinone oxidoreductase in transfected HL-60 cells. Chem Res Toxicol 12:467-475.
-
(1999)
Chem Res Toxicol
, vol.12
, pp. 467-475
-
-
Wiemels, J.1
Wiencke, J.K.2
Varykoni, A.3
Smith, M.T.4
-
47
-
-
0031471159
-
Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis
-
Williams DP, Pirmohamed M, Naiabitt DJ, Maggs JL and Park BK (1997) Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis. J Pharmacol Exp Ther 283:1375-1382.
-
(1997)
J Pharmacol Exp Ther
, vol.283
, pp. 1375-1382
-
-
Williams, D.P.1
Pirmohamed, M.2
Naiabitt, D.J.3
Maggs, J.L.4
Park, B.K.5
-
48
-
-
0028000264
-
Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils
-
Yousefi S, Green DR, Blaser K and Simon HU (1994) Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc Natl Acad Sci USA 91:10868-10872.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10868-10872
-
-
Yousefi, S.1
Green, D.R.2
Blaser, K.3
Simon, H.U.4
|