The development of a higher throughput reactive intermediate screening assay incorporating micro-bore liquid chromatography-micro-electrospray ionization-tandem mass spectrometry and glutathione ethyl ester as an in vitro conjugating agent

Journal of Pharmaceutical and Biomedical Analysis

Volumn 36, Issue 1, 2004, Pages 105-116

  Soglia, John R ^a   Harriman, Shawn P ^a   Zhao, Sabrina ^a   Barberia, John ^a   Cole, Mark J ^a   Boyd, James G ^a   Contillo, Leonard G ^a  

^a PFIZER INC   (United States)

Author keywords

Glutathione ethyl ester; Higher throughput in vitro screening assay; Micro bore liquid chromatography; Micro electrospray ionization; Reactive drug intermediates; Tandem mass spectrometry

Indexed keywords

AMODIAQUINE; CARBAMAZEPINE; CLOZAPINE; DICLOFENAC; FELBAMATE; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLUTATHIONE ETHYL ESTER; IMIPRAMINE; INDOMETACIN; PARACETAMOL; PIOGLITAZONE; PYROGLUTAMIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ROSIGLITAZONE; SULFAMETHOXAZOLE; VALPROIC ACID;

ARTICLE; AUTOMATION; BIOASSAY; BIOTRANSFORMATION; COMPARATIVE STUDY; CONTROLLED STUDY; DATA ANALYSIS; DRUG CONJUGATION; DRUG DETERMINATION; DRUG SCREENING; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION; EXPERIMENT; EXTRACTION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS; MASS SPECTROMETRY; METABOLITE; MONITORING; PRECIPITATION; PRIORITY JOURNAL; REACTION ANALYSIS; SCREENING; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; STANDARD; TANDEM MASS SPECTROMETRY;

BIOLOGICAL ASSAY; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; DRUG EVALUATION, PRECLINICAL; GLUTATHIONE; HUMANS; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 4444361038     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2004.04.019     Document Type: Article

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